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| 1 | Anti-tumor activity of wogonin, an extract from Scutellaria baicalensis, through regulating different signaling pathways显示文摘Wogonin is a plant flavonoid compound extracted from Scutellaria baicalensis(Huang-Qin or Chinese skullcap) and has been studied thoroughly by many researchers till date for its anti-viral, anti-oxidant, anti-cancerous and neuro-protective properties. Numerous experiments conducted in vitro and in vivo have demonstrated wogonin's excellent tumor inhibitory properties. The anticancer mechanism of wogonin has been ascribed to modulation of various cell signaling pathways, including serine-threonine kinase Akt(also known as protein kinase B) and AMP-activated protein kinase(AMPK) pathways, p53-dependent/independent apoptosis, and inhibition of telomerase activity. Furthermore, wogonin also decreases DNA adduct formation with a carcinogenic compound 2-Aminofluorene and inhibits growth of drug resistant malignant cells and their migration and metastasis, without any side effects. Recently, newly synthesized wogonin derivatives have been developed with impressive anti-tumor activity. This review is the succinct appraisal of the pertinent articles on the mechanisms of anti-tumor properties of wogonin. We also summarize the potential of wogonin and its derivatives used alone or as an adjunct therapy for cancer treatment. Furthermore, pharmacokinetics and side effects of wogonin and its analogues have also been discussed. | Do Luong Huynh Neelesh Sharma Amit Kumar Singh Simrinder Singh Sodhi ZHANG Jiao-Jiao Raj Kumar Mongre Mrinmoy Ghosh Nameun Kim Yang Ho Park Dong Kee Jeong | 2017 | Chinese Journal of Natural Medicines2017，15，1： | 32 |
| 2 | TP53 codon 72 Arg/Arg polymorphism is associated with a higher risk for inflammatory bowel disease development显示文摘AIM: To investigate the association between tumor protein 53(TP53) codon 72 polymorphisms and the risk for inflammatory bowel disease(IBD) development.METHODS: Numerous genetic and epigenetic drivers have been identified for IBD including the TP53 gene. Pathogenic mutations in TP53 gene have only been reported in 50% of colorectal cancer(CRC) patients. A single nucleotide polymorphism(SNP) in the TP53 gene resulting in the presence of either arginine(Arg)or proline(Pro) or both at codon 72 was shown to alter TP53 tumor-suppressor properties. This SNP has been investigated as a risk factor for numerous cancers,including CRC. In this study we analyzed TP53 codon 72 polymorphism distribution in 461 IBD,181 primary sclerosing cholangitis patients and 62 healthy controls. Genotyping of TP53 was performed by sequencing and restriction fragment length polymorphism analysis of genomic DNA extracted from peripheral blood. RESULTS: The most frequent TP53 genotype in IBD patients was Arg/Arg occurring in 54%-64% of cases(and in only 32% of controls). Arg/Pro was the most prevalent genotype in controls(53%) and less common in patients(31%-40%). Pro/Pro frequency was not significantly different between controls and IBD patients. CONCLUSION: The data suggests that the TP53 codon 72 Arg/Arg genotype is associated with increased risk for IBD development. | Natalia Volodko Mohamed Salla Bertus Eksteen Richard N Fedorak Hien Q Huynh Shairaz Baksh | 2015 | World Journal of Gastroenterology2015，21，36： | 9 |
| 3 | Nutritional care in hospitalized patients with chronic liver disease显示文摘AIM: To evaluate the practice of nutritional assessment and management of hospitalised patients with cirrhosis and the impact of malnutrition on their clinical outcome.METHODS: This was a retrospective cohort study on patients with liver cirrhosis consecutively admitted to the Department of Gastroenterology and Hepatology at the Royal Adelaide Hospital over 24 mo. Details were gathered related to the patients' demographics, disease severity, nutritional status and assessment, biochemistry and clinical outcomes. Nutritional status was assessed by a dietician and determined by subjective global assessment. Estimated energy and protein requirements were calculated by Simple Ratio Method. Intake was estimated from dietary history and/or food charts, and represented as a percentage of estimated daily requirements. Median duration of follow up was 14.9(0-41.4) mo. RESULTS: Of the 231 cirrhotic patients(167 male, age: 56.3 ± 0.9 years, 9% Child-Pugh A, 42% ChildPugh B and 49% Child-Pugh C), 131(57%) had formal nutritional assessment during their admission and 74(56%) were judged to have malnutrition. In-hospitalcaloric(15.6 ± 1.2 kcal/kg vs 23.7 ± 2.3 kcal/kg, P = 0.0003) and protein intake(0.65 ± 0.06 g/kg vs 1.01 ± 0.07 g/kg, P = 0.0003) was significantly reduced in patients with malnutrition. Of the malnourished cohort, 12(16%) received enteral nutrition during hospitalisation and only 6(8%) received ongoing dietetic review and assessment following discharge from hospital. The overall mortality was 51%, and was higher in patients with malnutrition compared to those without(HR = 5.29, 95%CI: 2.31-12.1; P < 0.001). CONCLUSION: Malnutrition is common in hospitalised patients with cirrhosis and is associated with higher mortality. Formal nutritional assessment, however, is inadequate. This highlights the need for meticulous nutritional evaluation and management in these patients. | Dep K Huynh Shane P Selvanderan Hugh AJ Harley Richard H Holloway Nam Q Nguyen | 2015 | World Journal of Gastroenterology2015，21，45： | 6 |
| 4 | 绩效反馈、习得性无助与创造力的关系研究——失败学习行为的有中介的调节作用显示文摘以往有关反馈对创造力的研究仍未得到一致的研究结论,其作用机制仍待进一步探索中。文章基于习得性无助理论和经验学习理论,引入习得性无助作为中介变量、失败学习行为作为调节变量,构建一个有中介的调节模型,系统探讨了绩效反馈对创造力的作用机制。通过325名员工的样本数据,发现:积极反馈会削弱员工的习得性无助;消极反馈则会引发员工的习得性无助;积极反馈通过抑制习得性无助提升员工创造力;消极反馈则通过引发习得性无助削弱员工创造力;失败学习行为负向调节绩效反馈和习得性无助的关系,同时还通过习得性无助为中介正向调节绩效反馈和创造力的关系。最后,根据研究结论提出管理实践启示和未来研究方向。 | HUYNH TUAN QUY 张昊民 马君 | 2016 | 华东经济管理2016，30，5： | 5 |
| 5 | Interleukin-1βinduces human cementoblasts to support osteoclastogenesis显示文摘Injury of the periodontium followed by inflammatory response often leads to root resorption. Resorption is accomplished by osteoclasts and their generation may depend on an interaction with the cells in direct contact with the root, the cementoblasts.Our study aimed to investigate the role of human cementoblasts in the formation of osteoclasts and the effect of interleukin(IL)-1β hereupon. Extracted teeth from healthy volunteers were subjected to sequential digestion by type I collagenase and trypsin.The effect of enzymatic digestion on the presence of cells on the root surface was analyzed by histology. Gene expression of primary human cementoblasts(p HCB) was compared with a human cementoblast cell line(HCEM). The p HCBs were analyzed for their expression of IL-1 receptors as well as of receptor activator of nuclear factor kappa-B ligand(RANKL) and osteoprotegerin(OPG). In a co-culture system consisting of osteoclast precursors(blood monocytes) and p HCBs, the formation of osteoclasts and their resorptive activity was assessed by osteo-assay and ivory slices. The cells obtained after a 120 min enzyme digestion expressed the highest level of bone sialoprotein, similar to that of HCEM. This fraction of isolated cells also shared a similar expression pattern of IL-1 receptors(IL1-R1 and IL1-R2). Treatment with IL-1β potently upregulated RANKL expression but not of OPG. p HCBs were shown to induce the formation of functional osteoclasts. This capacity was significantly stimulated by pretreating the p HCBs with IL-1β prior to their co-culture with human blood monocytes. Our study demonstrated that cementoblasts have the capacity to induce osteoclastogenesis, a capacity strongly promoted by IL-1β. These results may explain why osteoclasts can be formed next to the root of teeth. | nam c-n huynh vincent everts prasit pavasant ruchanee s ampornaramveth | 2017 | International Journal of Oral Science2017，9，4： | 5 |
| 6 | Exposure to air pollutants in Vietnam:Assessing potential risk for tourists显示文摘Tourism can form an important component of a nation's GDP,and Vietnam is among the most visited countries in Southeast Asia.Most studies on personal exposure focus on the general population,or occupational cohorts with exposure to specific pollutants.However,short-term exposure to air pollutants while visiting regions with high levels of air pollution can lead to acute health effects.A personal exposure study was conducted across three cities in Vietnam to estimate exposure to particulate matter(PM_(2.5)) and black carbon for tourists.Measurements were conducted during the wet season in 2014 in Ho Chi Minh City,Da Lat and Nha Trang using portable instrumentation.Average 24-hr PM_(2.5) and BC exposures were estimated as 18.9 ± 9.24 and 3.41 ± 1.33 μg/m^3 and among the three cities,Ho Chi Minh was found to have the highest PM_(2.5) concentrations.Environmental tobacco smoke,commuting and street food stands were found to contribute to highest levels of exposure to PM_(2.5) and BC across all cities. | Pallavi Pant Whitney Huynh Richard E.Peltier | 2018 | Journal of Environmental Sciences2018，30，11： | 4 |
| 7 | 习得性无助、精神型领导与科技创新型人才创造力的关系研究显示文摘从习得性无助理论视角入手,以精神型领导作为情景变量,构建一个跨层次调节效应模型。通过48家企业294名科技创新型人才为样本,本研究发现:习得性无助会削弱科技创新型人才的创造力、精神型领导通过跨层次增强科技创新型人才的创造力。同时,精神型领导还通过跨层次效应正向调节习得性无助对科技创新型人才创造力的消极影响。 | HUYNH TUAN QUY 张昊民 马君 | 2016 | 科学管理研究2016，34，3： | 4 |
| 8 | 习得性无助对员工创造力的影响机制研究——变革型领导的跨层次调节作用显示文摘本文基于习得性无助理论视角,以长三角地区42家企业283名员工为样本,系统探讨了习得性无助对创造力的影响机理。研究结果表明:(1)习得性无助与员工创造力负相关;(2)习得性无助与员工内在动机负相关;(3)习得性无助通过内在动机中介效应负向影响员工创造力;(4)变革型领导正向调节习得性无助对员工创造力的负向关系;(5)变革型领导正向调节习得性无助对员工内在动机的负向关系。最后,根据研究结论提出管理实践启示以及对研究局限和未来展望进行了讨论。 | 张昊民 HUYNH Tuan-quy 马君 | 2016 | 预测2016，35，1： | 3 |
| 9 | 急性Vogt-小柳-原田综合征黄斑相干光断层扫描观察显示文摘目的观察急性Vogt-小柳-原田综合征(VKH综合征)的相干光断层扫描(OCT)图像特征以及与临床的关联。探讨新型频域OCT在急性VKH综合征结构特征和定量分析中的临床价值。方法回顾分析临床确诊的急性VKH综合征21例(42眼)的OCT检查资料。所有患者接受最佳矫正视力(BCVA)、直接或间接检眼镜、裂隙灯显微镜+前置镜检查和荧光素眼底血管造影(FFA)检查。5线扫描(5 line Raster)模式下通过中心凹的水平+垂直两条扫描线的分析,对黄斑区视网膜各层结构变化的细微结构进行观察,用软件自带cliaper功能模块手工测量黄斑中心小凹厚度(FT)、神经上皮脱离高度(SRD)、神经上皮厚度(SRT)。在立方体(Cube)扫描模式下,采用软件自带的功能模块对黄斑中心厚度(CFT)、黄斑中心凹体积(V)、平均厚度(AT)进行测量。回顾分析时,重点分析黄斑区视网膜各层结构变化的细微结构,以及OCT图像特征与视力的相互关系。结果所有急性VKH综合征患者均可见后极部浆液性视网膜脱离。FT(r=0.2,P=0.00),SRD(r=0.83,P=0.00),CFT(r=0.81,P=0.000),AT(r=0.59,P=0.0001)和V(r=0.58,P=0.0001)值与初始视力呈负相关。视网膜色素上皮(RPE)上存在膜结构的35眼,平均视力为0.86±0.40logMAR,差于无膜结构的7眼(P=0.0074)。结论频域OCT可对急性VKH综合征特征性的黄斑改变进行定性及定量的观察,具有一定的诊断与鉴别诊断价值。VKH综合征的OCT图像特征性表现为:治疗前的渗出性视网膜脱离,'膜样'、'隔状'结构和RPE皱折,以及激素治疗后的'颗粒样'结构。存在'膜样'结构视力更差,FT和神经上皮脱离高度可能可反映脉络膜炎症的程度和疾病的严重程度。 | 薛康 Nancy Huynh 常青 周旻 | 2013 | 中国眼耳鼻喉科杂志2013，13，2： | 3 |
| 10 | COVID-19 vaccination intention among healthcare workers in Vietnam显示文摘Objective:To assess the acceptance of coronavirus disease(COVID-19)vaccine among healthcare workers at two general hospitals in Vietnam when it is available.Methods:A cross-sectional study was conducted using a convenience sampling from January to February 2021 among 410 healthcare workers at two general hospitals in Vietnam via a selfadministered questionnaire.A multivariable regression analysis was performed to determine predictors of vaccine acceptance including the demographic factors,COVID-19 knowledge,and vaccine beliefs based on the domains of Health Belief Model.Results:Among 410 healthcare workers,76.10%showed vaccination willingness.Predictors of acceptance were determined that the group reporting as“vaccine acceptance”was more likely to be positive towards the perceived susceptibility and severity of COVID-19(OR 2.45;95%CI 1.48-4.06,P<0.05),perceived benefits of vaccination,and cues to action(OR 4.36;95%CI 2.35-8.09,and OR 5.49;95%CI 2.84-10.61,respectively,all P<0.001),but less likely to have the perceived barriers to vaccination(OR 0.19;95%CI 0.09-0.38;P<0.001)compared with the no acceptance group.Besides,people who had a good knowledge regarding the severity of illness were 3.37 times more likely to have identified as vaccine acceptance(OR 3.37;95%CI 1.04-10.86,P<0.05).The demographic factors were also associated with willingness to receive the vaccine,with participants who were staff and received COVID-19 information from relatives were less likely to accept the vaccine over those who were doctors and not receiving information from relatives(OR 0.36;95%CI 0.13-0.96,and OR 0.37;95%CI 0.17-0.78,respectively,all P<0.05).Conclusions:A rate of willingness to get vaccinated against COVID-19 was relatively high with discrepancies between occupation,receiving information from relatives,knowledge toward the severity of illness,and the elements of Health Belief Model.The findings will provide information for the management authorities to develop relevant interventions to promote COVID-19 vaccination uptake. | Giao Huynh Thien Thuan Tran Han Thi Ngoc Nguyen Le An Pham | 2021 | Asian Pacific Journal of Tropical Medicine2021，14，4： | 3 |
| 11 | 乳化鱼油对冻藏期间狭鳕鱼糜热凝胶持水性和冰结晶形成的影响(英文)显示文摘评估乳化鱼油对冻藏期间狭鳕鱼糜热凝胶持水性和冰结晶形成的影响。鱼糜经盐擂后,加入5%鱼油经乳化制得乳化鱼糜热凝胶。随后用快速冻结和慢速冻结2种方式冻结样品并评估其在冻藏期间热凝胶品质的变化。研究结果表明:与对照相比,乳化热凝胶在冻藏期间的解冻损失和压榨损失均有降低。显微观察结果显示经3个月冻藏后乳化热凝胶内的冰结晶平均粒径与其对照相比均有减小,其中快速冻结乳化样品为7.2μm,对照样品为13.1μm,慢速冻结乳化样品为13.7μm,对照样品为31.2μm。以上结果表明乳化鱼油可能对冻藏期间的热凝胶的冰结晶形成和其分布的影响而导致其持水性不同。 | 牛丽琼 HUYNH Thi Thu Huong 贾茹 高元沛 中澤奈穂 大迫一史 岡﨑惠美子 | 2016 | 食品科学2016，37，20： | 3 |
| 12 | 生皮的无盐浸酸体系显示文摘1 引言
在生皮鞣制成蓝皮的过程中,浸酸步骤是必不可少的,它使得铬鞣剂能够顺利地渗透到胶原纤维基质间。浸酸工序通常使用无机酸(如硫酸)、有机酸(如甲酸)或两者的混合物,通过添加中性盐(常用NaCl)来抑制胶原在酸性介质中的膨胀。这种浸酸方式廉价且有效,但是它所产生的高浓度盐存在于制革废水中将是一个严重的环境问题,尤其在沿海地区,这种制革废水是决不允许流人海域的。 | Peter M Pojer Chi P Huynh 杨永伟(编译) | 2012 | 西部皮革2012，，18： | 3 |
| 13 | Bilateral endogenous endophthalmitis secondary to group B streptococcal sepsis显示文摘 | Wu Ziqiang Huang Jingjing Huynh, Scott Sadda, Srinivas | 2014 | Chinese Medical Journal2014，，10： | 3 |
| 14 | AN ENSEMBLE MODEL OF ARIMA AND ANN WITH RESTRICTED BOLTZMANN MACHINE BASED ON DECOMPOSITION OF DISCRETE WAVELET TRANSFORM FOR TIME SERIES FORECASTING显示文摘 | Warut Pannakkong Songsak Sriboonchitta Van-Nam Huynh | 2018 | Journal of Systems Science and Systems Engineering2018，27，5： | 3 |
| 15 | A Pattern-Based Method for the Identification of MicroRNA Binding Sites and Their Corresponding Heteroduplexes显示文摘 | Kevin C. Miranda Tien Huynh Yvonne Tay Yen-Sin Ang Wai-Leong Tam Andrew M. Thomson Bing Lim Isidore Rigoutsos | 2006 | Cell2006，，6： | 3 |
| 16 | Calibrating a structured light stripe system: a novel approach 显示文摘 | HUYNH D Q OWENS R A | 1999 | Internation al Journal of Computer Vision1999，33，1： | 2 |
| 17 | Preventing crash in stock market:The role of economic policy uncertainty during COVID‑19显示文摘This paper investigates the impact of economic policy uncertainty(EPU)on the crash risk of US stock market during the COVID-19 pandemic.To this end,we use the GARCHS(GARCH with skewness)model to estimate daily skewness as a proxy for the stock market crash risk.The empirical results show the significantly negative correlation between EPU and stock market crash risk,indicating the aggravation of EPU increase the crash risk.Moreover,the negative correlation gets stronger after the global COVID-19 outbreak,which shows the crash risk of the US stock market will be more affected by EPU during the epidemic. | Peng‑Fei Dai Xiong Xiong Zhifeng Liu Toan Luu Duc Huynh Jianjun Sun | 2021 | Financial Innovation2021，7，1： | 2 |
| 18 | Forecasting cryptocurrency returns and volume using search engines显示文摘In the context of the debate on the role of cryptocurrencies in the economy as well as their dynamics and forecasting,this brief study analyzes the predictability of Bitcoin volume and returns using Google search values.We employed a rich set of established empirical approaches,including a VAR framework,a copulas approach,and non-parametric drawings,to capture a dependence structure.Using a weekly dataset from 2013 to 2017,our key results suggest that the frequency of Google searches leads to positive returns and a surge in Bitcoin trading volume.Shocks to search values have a positive effect,which persisted for at least a week.Our findings contribute to the debate on cryptocurrencies/Bitcoins and have profound implications in terms of understanding their dynamics,which are of special interest to investors and economic policymakers. | Muhammad Ali Nasir Toan Luu Duc Huynh Sang Phu Nguyen Duy Duong | 2019 | Financial Innovation2019，5，1： | 2 |
| 19 | Angiogenic Remodeling in Pediatric EoE Is Associated With Increased Levels of VEGF-A, Angiogenin, IL-8, and Activation of the TNF-α–NFκB Pathway显示文摘 | Rabindranath Persad Hien Q. Huynh Li Hao Jacqueline R. Ha Consolato Sergi Rahul Srivastava Sujata Persad | 2012 | Journal of Pediatric Gastroenterology and Nutrition2012，，3： | 2 |
| 20 | 六岁儿童黄斑厚度测量及其相关因素分析显示文摘目的 观察正常6岁儿童黄斑厚度特征,分析其与眼轴、性别、屈光状态和种族的关系.方法 随机抽取悉尼市区34所小学中平均年龄为6岁的1543名儿童.采用光相干断层扫描(OCT)测定其黄斑中心环(CM)、内环(IM)、外环(OM)厚度,对比分析不同性别、种族儿童间黄斑厚度的差异.所有儿童均采用光学生物测量仪测定眼轴长度,自动屈光仪RK-F1测量屈光状态,分析CM、IM、OM厚度与眼轴、屈光状态的关系.结果 儿童CM、IM和OM厚度均呈正态分布,分别为193.6、264.3、236.7μm,各环之间差异有统计学意义(t=0.40,0.08,0.20;P值均<0.05).男性CM、IM、OM厚度分别为194.2、264.9、229.0 μm,女性CM、IM、OM厚度分别为189.3、262.5、231.5μm.两者比较,男性CM和IM厚度较女性厚,差异有统计学意义(t=0.15,0.11;P值均<0.05).白种人CM、IM、OM厚度分别为196.0、265.2、237.5μm,东亚人CM、IM、OM厚度分别为186.0、262.3、236.5μm,中东人CM、IM、OM厚度分别为193.4、263.7、233.8μm.白种人、中东人CM和IM厚度较东亚人厚,差异有统计学意义(t=0.12,0.15;P值均<0.05),3者间OM厚度差异无统计学意义(t=0.16,P=0.6).IM和OM厚度随眼轴增长而明显变薄(P<0.05),CM、IM和OM厚度随远视度数增加而变厚(P<0.05).结论 正常6岁儿童的黄斑厚度呈正态分布,性别、种族,眼轴和屈光度明显影响黄斑的厚度. | 王秀英 Son C. Huynh Elena Rochtchina Paul Mitchell | 2010 | 中华眼底病杂志2010，26，5： | 2 |
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