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	题名	作者	年代	出处	被引量
1	低剂量睾酮疗法降低TM3睾丸间质细胞的氧化损伤显示文摘睾酮替代疗法对老年男性及性腺机能减退症的治疗是有意义的。然而,外源性睾酮对睾丸间质细胞的作用尚不清楚,需要进一步阐明。本研究表明睾酮补充疗法能降低睾丸间质细胞的氧化损伤。本文用睾丸间质细胞TM3作为体外细胞模型。研究发现睾酮剂量为100nmol L-1治疗时可以产生细胞保护作用,但睾酮补充剂量≥500nmol L-1时就会产生细胞毒作用。在睾酮剂量为100nmol L-1治疗时能够显著降低ROS的产生,脂质过氧化物含量,缺氧诱导因子(HIF)-1α的稳定性和活性。睾酮剂量为500nmol L-1时产生的活性氧比100nmol L-1时增加了1.72倍。与对照组相比,睾酮剂量为50nmol L-1时类固醇激素合成急性调节蛋白(STAR)的表达增加了1.58倍(P〈0.01).睾酬补充疗法降低了化学性诱导缺氧。低剂量睾酮补充疗法治疗睾丸间质细胞通过降低ROS和脂质过氧化物,增加StAR蛋白表达,减缓缺氧应激即降低HIF-1α测子的稳定性性产生细胞保护作用。研究中发现当睾酮剂量≥500nmol L-1时,氧化损伤增加。为阐明睾酮替代疗法的效果,需进一步阐明睾丸间质细胞中华酮量效关系受哪种机制调控。	Thomas IS Hwang Tien-Ling Liao Ji-Fan Lin Yi-Chia Lin Shu-Yu Lee Yen-Chun Lai Shu-Huei Kao	2011	Asian Journal of Andrology2011，13，3：	2
2	Tumor targetability and antitumot Effect of docetaxel-loaded hydrophobically modified glycol chitosan nanoparticles显示文摘	Hwang HY Kim IS Kwon IC	2008	J Control Release2008，128，1：	1
3	Early pyeloplasty for recovery of parenchymal thickness in children with unilateral ureteropelvic junction obstruction显示文摘	Kim SO Yu HS Hwang IS	2014	Urol Int2014，92，4：	1
4	Fructose-induced insulin resistance and hypertension in rats显示文摘	Hwang IS Ho H Hoffman B	1987	Hypertension1987，10，：	1
5	The cytochrome 2C192 and 3 alleles attenuate response to clopidogrel similarly in East Asian patients undergoing elective percutaneous coronary intervention显示文摘	Hwang SJ Jeong YH Kim IS		0，，01：	1
6	Eye-hand synergy and intermittent be- haviors during target-directed tracking with visual and non- visual information显示文摘	Huang CT Hwang IS	2012	PLoS ONE2012，7，51：	1
7	In vitro activities of carbapenem/sulbactam combination,colistin,colistin/rifampicin combination and tigecycline against carbapenem-resistant Acinetobacter baumannii显示文摘	Song JY Kee SY Hwang IS	2007	J Antimicrob Chemother2007，60，：	1
8	Peripheral distribution and gene expression of adrenomedullin in rat:possible source of blood adrenomedullin显示文摘	Hwang IS Tang F	2000	Neuropeptide2000，34，1：	1
9	Osteogenic responses of human mesenchymal stromal cells to static stretch 显示文摘	Kim IS Song YM Hwang SJ	2010	J Dent Res2010，89，10：	1
10	Fructose-induced insulin resistance and hypertension in rats 显示文摘	Ho H Hoffman B	1987	Hypertension1987，10，：	1
11	Dose sparing strategy with intradermal influenza vaccination in patients with solid cancer显示文摘	Jo YM Song JY Hwang IS	2009	J Med Virol2009，81，4：	1
12	In vitro activities of carbapenem/sulbactam combination, colistin, colistin/rifampicin combination and tigecycline against carbapenem-resistant Acinetobacter baumannii 显示文摘	Song JY Kee SY Hwang IS	2007	J Antimicrob Chemother2007，60，2：	1
13	In vitro activities of carbapenem/sulbactam combination, colistin, colistin/rifampicin combination and tigecycline against carbapenem-resistant Acinetobacter baumannii显示文摘	Song JY Kee SY Hwang IS	2007	J Antimicrob Chemotber2007，60，2：	1
14	Tumor targetability and antitumor effect of docetaxel loaded hydrophobically modified glycol chitosan nanoparticles显示文摘	Hwang HY Kim IS Kwon IC	2008	J Control Release2008，128，1：	1
15	Tumor targetability and antitumor effect of docetaxel-loaded hydrophobically modified glycol chitosan nanoparticles显示文摘	Hwang HY Kim IS Kwon IC	2008	J Control Release2008，128，1：	1
16	The novel biological action of antimiembial peptides via apoptosis induction 显示文摘	Cho J Hwang IS Cho H	2012	Microbiol Bio- technol2012，22，11：	1
17	Fructose - induced insulin resistance and hypertension in rats 显示文摘	Hwang IS Ho H Hoffman BB	1987	Hypertension1987，10，5：	1
18	In vitro activities of carbapenem/sulbactam combination, colistin, colistin/rifampiein combination and tigecycline against carbpenem-resistant Acinetobacter baumannii 显示文摘	Song JY Kee SY Hwang IS	2007	J Antimicrob Chemother2007，60，2：	1
19	Addi,g cilostazol to dual antiplatelet therapy achieves greater platelet inhibition than high maintenance dose clopidogrel in patients with acute myocardial infarction: Results of the adjunctive cilostazol versus high maintenance dose clopidogrel in patients with AM1 ( AC- CEL-AMI) study 显示文摘	Jeong YH Hwang JY Kim IS	2010	Circ Cardiovasc Interv2010，3，1：	1
20	Osteogenic responses ofhuman mesenchymal stromal cells to static stretch显示文摘	Kim IS Song YM Hwang SJ	2010	JDent Res2010，89，10：	1

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