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| 1 | Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage显示文摘 | Kyoung-Han Kim Yun Hye Kim Joe Eun Son Ju Hee Lee Sarah Kim Min Seon Choe Joon Ho Moon Jian Zhong Kiya Fu Florine Lenglin Jeong-Ah Yoo Philip J Bilan Amira Klip Andras Nagy Jae-Ryong Kim Jin Gyoon Park Samer MI Hussein Kyung-Oh Doh Chi-chung Hui Hoon-Ki Sung | 2017 | Cell Research2017，27，11： | 9 |
| 2 | Clinical course of subepithelial lesions detected on upper gastrointestinal endoscopy显示文摘AIM:To evaluate the natural history of subepithelial lesions.METHODS:We reviewed the medical records of 104 159 patients who underwent upper gastrointestinal endoscopy at the Center for Health Promotion of Samsung Medical Center between 1996 and 2003.Subepithelial lesions were detected in 795 patients(0.76%);252 patients were followed using upper gastrointestinal endoscopy for 82.5 ± 29.2 mo(range,12-160 mo;median,84 mo;1st quartile,60 mo;3rd quartile,105 mo).The median interval of follow-up endoscopy was 12 mo(range,6-105 mo;1st quartile,12 mo;3rd quartile,24 mo).RESULTS:The mean patient age was 53 years(range,22-80 years),and the male-to-female ratio was 2.36:1(177/75).The lesion size at initial measurement averaged 8.9 mm(range,2-25 mm;median,8 mm;1st quartile,5 mm;3rd quartile,10 mm).Of the 252 lesions,244(96.8%) were unchanged and 8(3.2%) were significantly increased in size(from 12.9 ± 6.0 to 21.2 ± 12.2 mm) after a mean interval of 59.1 ± 27.5 mo(range,12-86 mo).Surgical resection of lesions was performed when the lesions were ≥ 3 cm in diameter.Two lesions were diagnosed as gastrointestinal stromal tumors with an intermediate or high risk of malignancy and one lesion was classified as a schwannoma.CONCLUSION:Most small subepithelial lesions do not change as shown by endoscopic examination,and regular follow-up with endoscopy may be considered in small,subepithelial lesions,especially lesions < 1 cm in size. | Yeun Jung Lim Hee Jung Son Jong-Soo Lee Young Hye Byun Hyun Joo Suh Pool Lyul Rhee Jae J Kim Jong Chul Rhee | 2010 | World Journal of Gastroenterology2010，16，4： | 6 |
| 3 | Prediction of clinically actionable genetic alterations from colorectal cancer histopathology images using deep learning显示文摘BACKGROUND Identifying genetic mutations in cancer patients have been increasingly important because distinctive mutational patterns can be very informative to determine the optimal therapeutic strategy. Recent studies have shown that deep learning-based molecular cancer subtyping can be performed directly from the standard hematoxylin and eosin(H&E) sections in diverse tumors including colorectal cancers(CRCs). Since H&E-stained tissue slides are ubiquitously available, mutation prediction with the pathology images from cancers can be a time-and cost-effective complementary method for personalized treatment.AIM To predict the frequently occurring actionable mutations from the H&E-stained CRC whole-slide images(WSIs) with deep learning-based classifiers.METHODS A total of 629 CRC patients from The Cancer Genome Atlas(TCGA-COAD and TCGA-READ) and 142 CRC patients from Seoul St. Mary Hospital(SMH) were included. Based on the mutation frequency in TCGA and SMH datasets, we chose APC, KRAS, PIK3CA, SMAD4, and TP53 genes for the study. The classifiers were trained with 360 × 360 pixel patches of tissue images. The receiver operating characteristic(ROC) curves and area under the curves(AUCs) for all the classifiers were presented.RESULTS The AUCs for ROC curves ranged from 0.693 to 0.809 for the TCGA frozen WSIs and from 0.645 to 0.783 for the TCGA formalin-fixed paraffin-embedded WSIs.The prediction performance can be enhanced with the expansion of datasets. When the classifiers were trained with both TCGA and SMH data, the prediction performance was improved.CONCLUSION APC, KRAS, PIK3CA, SMAD4, and TP53 mutations can be predicted from H&E pathology images using deep learning-based classifiers, demonstrating the potential for deep learning-based mutation prediction in the CRC tissue slides. | Hyun-Jong Jang Ahwon Lee J Kang In Hye Song Sung Hak Lee | 2020 | World Journal of Gastroenterology2020，26，40： | 3 |
| 4 | Effective preparation ofmontmorillonite/polyurethane nanocomposites by introducingcationic groups into the polyurethane main chain显示文摘 | Eun H J Jie Y Ji Hye Hong | 2007 | EuropeanPolymer Journal2007，43，： | 1 |
| 5 | Predictive factors for early clin- ical improvement after intra - arterial thrombolytic therapy in acute ischemic stroke 显示文摘 | Hye S J Hyun JK Chang WK | 2014 | Journal of Stroke and Cerebrovascular Disea- ses2014，，： | 1 |
| 6 | The clinical features of drug-induced Liver injury observed through liver biopsy: fo- cus on relevancy to autoimmune hepatitis显示文摘 | HYE Y J JAE Y J SOUNG W J | 2012 | Cfin Mol Hep- atology2012，18，2： | 1 |
| 7 | Expression and Functional Characterization of Three Squelene Synthase Genes Associated with Saponin Biosynthesis in Panax ginseng显示文摘 | Kim T D Han J Y Hye Huh G ct el | 2011 | Plant Cell Physiology2011，52，1： | 1 |
| 8 | Functional regu- lation of adipose-derived stem cells by PDGF-D 显示文摘 | HYE KIM J GYU PARK S KIM WK | 2015 | Stern Cells2015，33，2： | 1 |
| 9 | Safety assessment of transgenic potatoes with soybean glycinin by feeding studies in rats显示文摘 | Wataru H Keiko M Hye J | 1999 | Bioscience Biotechnology and Biochemistry1999，63，11： | 1 |
| 10 | Long-Range Ordered Single-Crystal Graphene on High-Quality Heteroepitaxial Ni Thin Films Grown on MgO ( 111 ) 显示文摘 | TAKAYUKI I HYE J P | 2011 | American Chemical Society2011，11，1： | 1 |
| 11 | Safety assessment of Hce genetically modified with soybean glycinin by feeding studies on rats 显示文摘 | Keiko M Wataru H Hye J | 2000 | Bioscience Biotechnology and Biochemistry2000，64，9： | 1 |
| 12 | Characteristics of ZnO-B2OrSiO2-CaO glass frits prepared by spray pyrolysis as inorganic binder for Cu electrode 显示文摘 | YOUNG J H DAE S J HYE Y K | 2011 | J Alloy Compd2011，509，： | 1 |
| 13 | White blood cell count and abdominalfat distribution in female obese adolescents 显示文摘 | K1M J A HYE S P | 2008 | Metabolismclinical & Experimental2008，57，10： | 1 |
| 14 | Characterization of human liver cytochrome P450 enzymes involved in the metabolism of a new H^+/K^+ -ATPase inhibitor KR- 60436 显示文摘 | HYE Y J HYE WL HUI HK | 2005 | Toxicol Lett2005，155，1： | 1 |
| 15 | Serum vascular endothelial growth factor in pediatric patients with community-acquired pneumonia and pleural effusion 显示文摘 | Seong H C Eun Y P Hye L J | 2006 | J Korean Med Sci2006，21，4： | 1 |
| 16 | Structural features of cephalosporin acylase reveal the basis of autocatalytic activation 显示文摘 | Ki J C Jin K K Ji - Hye L | 2009 | Biochem Biophys Res Commun2009，390，2： | 1 |
| 17 | The phos-phoinositide 3-kinapendent activation of Btk is required for op-timal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cell显示文摘 | Hye Sun Kuehn Emily J Swindle Mi-Sun Kim | 2008 | J Immunol2008，181，11： | 1 |
| 18 | Purification and antimicrobial function of ubiquitin isolated from the gill of Pacific oyster, Crassostrea gigas显示文摘 | Jung K S Min J L Hye J G | 2013 | Molecular Immunology2013，53，12： | 1 |
| 19 | MAPK Activation is necessary to the apoptotic death of KB cells induced by the essential oil isolated from Artemisia iwayomogi 显示文摘 | JEONG D C MI R J HYE Y K | 2009 | J Ethnopharmacol2009，123，2： | 1 |
| 20 | Free radicals are involved in the damage to protein synthesis after anoxia/aglycemia and NMDA exposure显示文摘 | Chatten-Brown J Hye SE | 2000 | Brain Res2000，857，12： | 1 |
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