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| 1 | Is cholecystectomy a reasonable treatment option for simple gallbladder polyps larger than 10 mm?显示文摘AIM: To determine the relevance of the 10-mm size criterion of the generally accepted surgical indication for gallbladder polyps(GBPs).METHODS: We collected data of patients who were confirmed to have GBPs through cholecystectomy at Samsung Medical Center between January 1997 andDecember 2012.Among the patients who underwent cholecystectomy for GBP, those with a definite evidence for malignancy such as adjacent organ invasion, metastasis on preoperative imaging studies, polyp larger than 20 mm, absence of preoperative imaging study results, and patients having gallstones were excluded.We retrospectively collected and analyzed information on patient's clinical characteristics, symptoms, ultrasonographic findings, and blood laboratory tests.RESULTS: A total of 836 patients who had undergone cholecystectomy were retrospectively analyzed.Seven hundred eighty patients(93%) had benign polyps, whereas 56 patients(7%) had malignant polyps.Of the 56 patients with malignancy, 4 patients(7%) had borderline GBP(10-12 mm) and a patient had small GBP(< 10 mm) with T2 stage.We conducted an ROC curve analysis to verify the 10-mm size criteria(AUC = 0.887, SD = 0.21, P < 0.001).In the ROC curve for polyp size and malignancy, sensitivity and specificity of the 10-mm size criterion was 98.2% and 19.6%, respectively.The specificity of the 11-mm and 12-mm size criteria was 44.6% and 56%, respectively, whereas the sensitivity of these two size criteria was similar.We defined the GBPs of 10 to 12 mm as a borderline-sized GBP, which were found in 411 patients(49%).In this group, there was a significant difference in age between patients with benign and malignant GBPs(47 years vs 60 years, P < 0.05).CONCLUSION: GBPs larger than 13 mm need immediate excision whereas for borderline-sized GBPs detected in young patients, careful medical observation can be a rational decision. | Hye Yon Park Se Hoon Oh Kwang Hyuck Lee Jong Kyun Lee Kyu Taek Lee | 2015 | World Journal of Gastroenterology2015，21，14： | 9 |
| 2 | Absolute monocyte and lymphocyte count prognostic score for patients with gastric cancer显示文摘AIM:To measure the prognostic significance of absolute monocyte count/absolute lymphocyte count prognostic score(AMLPS) in patients with gastric cancer.METHODS:We retrospectively examined the combination of absolute monocyte count(AMC) and absolute lymphocyte count(ALC) as prognostic variables in a cohort of 299 gastric cancer patients who underwent surgical resection between 2006 and 2013 and were followed at a single institution.Both AMC and ALC were dichotomized into two groups using cut-off points determined by receiving operator characteristic curve analysis.An AMLPS was generated,which stratified patients into three risk groups:low risk(both low AMC and high ALC),intermediate risk(either high AMC or low ALC),and high risk(both high AMC and low ALC).The primary objective of the study was to validate the impact of AMLPS on both disease-free survival(DFS) and overall survival(OS),and the second objective was to assess the AMLPS as an independent prognostic factor for survival in comparison with known prognostic factors.RESULTS:Using data from the entire cohort,the most discriminative cut-off values of AMC and ALC selected on the receiver operating characteristic curve were 672.4/μL and 1734/μL for DFS and OS.AMLPS risk groups included 158(52.8%) patients in the lowrisk,128(42.8%) in the intermediate-risk,and 13(4.3%) in the high-risk group.With a median followup of 37.2 mo(range:1.7-91.4 mo),five-year DFS rates in the low-,intermediate-,and high-risk groups were 83.4%,78.7%,and 19.8%,respectively.And fiveyear OS rates in the low-,intermediate-,and high-risk groups were 89.3%,81.1%,and 14.4%,respectively.On multivariate analysis performed with patient- and tumor-related factors,we identified AMLPS,age,and pathologic tumor-node-metastasis stage as the most valuable prognostic factors impacting DFS and OS.CONCLUSION:AMLPS identified patients with a poor DFS and OS,and it was independent of age,pathologic stage,and various inflammatory markers. | Wan Kyu Eo Da Wun Jeong Hye Jung Chang Kyu Yeoun Won Sung Il Choi Se Hyun Kim Sung Wook Chun Young Lim Oh Tae Hwa Lee Young Ok Kim Ki Hyung Kim Yong Il Ji Ari Kim Heung Yeol Kim | 2015 | World Journal of Gastroenterology2015，21，9： | 6 |
| 3 | Is the AIM65 score useful in predicting outcomes in peptic ulcer bleeding?显示文摘AIM:To evaluate the applicability of AIMS65 scores in predicting outcomes of peptic ulcer bleeding.METHODS:This was a retrospective study in a single center between January 2006 and December 2011.We enrolled 522 patients with upper gastrointestinal haemorrhage who visited the emergency room.Highrisk patients were regarded as those who had rebleeding within 30 d from the first endoscopy as well as those who died within 30 d of visiting the Emergency room.A total of 149 patients with peptic ulcer bleeding were analysed,and the AIMS65 score was used to retrospectively predict the high-risk patients.RESULTS:A total of 149 patients with peptic ulcer bleeding were analysed.The poor outcome group comprised 28 patients[male:23(82.1%)vs female:5(10.7%)]while the good outcome group included 121patients[male:93(76.9%)vs female:28(23.1%)].The mean age in each group was not significantly different.The mean serum albumin levels in the poor outcome group were slightly lower than those in the good outcome group(P=0.072).For the prediction of poor outcome,the AIMS65 score had a sensitivity of35.5%(95%CI:27.0-44.8)and a specificity of 82.1%(95%CI:63.1-93.9)at a score of 0.The AIMS65 score was insufficient for predicting outcomes in peptic ulcer bleeding(area under curve=0.571;95%CI:0.49-0.65).CONCLUSION:The AIMS65 score may therefore not be suitable for predicting clinical outcomes in peptic ulcer bleeding.Low albumin levels may be a risk factor associated with high mortality in peptic ulcer bleeding. | Sung Hoon Jung Jung Hwan Oh Hye Yeon Lee Joon Won Jeong Se Eun Go Chan Ran You Eun Jung Jeon Sang Wook Choi | 2014 | World Journal of Gastroenterology2014，20，7： | 6 |
| 4 | Splenic hamartoma: A case report and review of the literature显示文摘Splenic hamartoma is a rare benign malformation, composed of an anomalous mixture of normal splenic elements, often found incidentally while working up other complaints or at autopsy. A splenic mass was incidentally found while evaluating the effects of a traffic accident in a 63-year-old woman. Abdominal computed tomography revealed a well-defined splenic mass with rim enhancement. The patient underwent splenectomy. The resected spleen contained a well-defined mass lesion measuring 3.5 cm × 3.0 cm. Microscopic examination revealed disorganized slit-like vascular channels lined by plump endothelial cells without atypia. The cells lining the vascular channels were positive for CD8, CD31, CD34 and vimentin. Endothelial cells that are positive for CD8 are a key feature that differentiates hamartoma from other vascular lesions of the spleen. Although this tumor is very rare, it must be included in the differential diagnosis of splenic mass-forming lesions. | Jongmin Sim Hye In Ahn Hulin Han Young Jin Jun Abdul Rehman Se Min Jang Kiseok Jang Seung Sam Paik | 2013 | World Journal of Clinical Cases2013，1，7： | 4 |
| 5 | 来自一项艾日布林联合吉西他滨对比紫杉醇联合吉西他滨作为HER2阴性转移性乳腺癌的一线化疗的Ⅱ期、多中心、随机试验的包含神经病变相关量表的生活质量结果:韩国癌症研究组试验(KCSG BR13-11)显示文摘背景与目的一项比较艾日布林联合吉西他滨(eribulin plus gemcitabine,EG)或紫杉醇联合吉西他滨(paclitaxel plus gemcitabine,PG)作为转移性乳腺癌(metastatic breast cancer,MBC)患者一线化疗方案的II期临床试验发现,EG方案的神经毒性较低,但疗效与PG方案相似。在本研究中,我们分析了该临床实验中的癌症患者生命质量测评量表–紫杉烷(functional assessment of cancer therapy-taxane,FACT-Taxane)问卷评分以确定他们的生活质量(quality of life,QoL)。方法使用韩国版的FACT-Taxane问卷评估QoL。在评估基线之后,前12个疗程中每2个疗程评估1次QoL,之后每3个疗程评估1次QoL。使用线性混合模型评估EG组和PG组QoL的差异。结果在118例入组患者中,117例在基线时回复了FACT-Taxane问卷,PG组中有1例患者没有回复。EG组和PG组之间的基线QoL评分没有差异。在治疗期间,除了第11个疗程外,在第2–13个化疗疗程后,PG组紫杉烷亚量表评分显著高于EG组(均P<0.05)。神经病变特异性分析显示PG组患者的神经病症状比EG组患者更早出现且更严重(P<0.001)。结论在我们的QoL分析中,与PG方案相比,EG方案延迟并减少神经病变的发生。因此,艾日布林是MBC一线化疗药物紫杉醇的合理替代品。 | Ji‑Yeon Kim Seri Park Seock‑Ah Im Sung‑Bae Kim Joohyuk Sohn Keun Seok Lee Yee Soo Chae Ki Hyeong Lee Jee Hyun Kim Young‑Hyuck Im Tae‑Yong Kim Kyung‑Hun Lee Jin‑Hee Ahn Gun Min Kim In Hae Park Soo Jung Lee Hye Sook Han Se Hyun Kim Kyung Hae Jung Yeon Hee Park Korean Cancer Study Group | 2019 | 癌症2019，38，8： | 2 |
| 6 | Factors Predictive of Adverse Events Following Endoscopic Papillary Large Balloon Dilation: Results from a Multicenter Series显示文摘 | Soo Jung Park Jin Hong Kim Jae Chul Hwang Ho Gak Kim Don Haeng Lee Seok Jeong Sang-Woo Cha Young Deok Cho Hong Ja Kim Jong Hyeok Kim Jong Ho Moon Sang-Heum Park Takao Itoi Hiroyuki Isayama Hirofumi Kogure Se Joon Lee Kyo Tae Jung Hye Sun Lee Todd H. Baron | 2013 | Digestive Diseases and Sciences2013，，4： | 2 |
| 7 | Sinkihwan-gamibang ameliorates puromycin amino nucleoside-induced nephrotic syndrome显示文摘Nephrotic syndrome(NS)is a kidney disease characterized by hypertriglyceridemia,massive proteinuria,hypo-albuminemia and peripheral edema.Sinkihwan-gamibang(SKHGMB)was recorded in a traditional Chinese medical book named“Bangyakhappyeon(方藥合編)”and its three prescriptions Sinkihwan,Geumgwe-sinkihwan,and Jesaeng-sinkihwan belong to Gamibang.This study confirmed the effect of SKHGMB on renal dysfunction in an NS model induced by puromycin aminonucleoside(PAN).The experimental NS model was induced in male Sprague Dawley(SD)rats through injection of PAN(50 mg·kg^(-1))via the femoral vein.SKHGMB not only reduced the size of the kidneys increased due to PAN-induced NS,but also decreased proteinuria and ascites.In addition,SKHGMB significantly ameliorated creatinine clearance,creatinine,and blood urea nitrogen.SKHGMB relieved glomeruli dilation and tubules fibrosis in the glomeruli of the NS model.SKHGMB inhibited the protein and mRNA levels of the NLRP3 inflammasome including NLRP3,ASC,and pro-caspase-1 in NS rats.SKHGMB reduced the protein and mRNA levels of fibrosis regulators in NS rats.The results indicated that SKHGMB exerts protective effects against renal dysfunction by inhibiting of renal inflammation and fibrosis in NS rats. | Lee Hyeon Kyoung Jang Youn Jae Na Se Won Kim Hye Yoom Han Bywig Hyuk Lee Yun Jung Lee Ho Sub Yoon Jung Joo Kang Dae Gill | 2022 | Chinese Journal of Natural Medicines2022，20，3： | 2 |
| 8 | Immunomodulatory effect of caffeic acid phenethyl ester in Balb/c mice显示文摘 | Jae Hyun Park Jong Kwon Lee Hyung Soo Kim Seung Tae Chung Juno H. Eom Kyung A. Kim Se Jin Chung Soon Young Paik Hye Young Oh | 2004 | International Immunopharmacology2004，，3： | 2 |
| 9 | Diversity of Rotavirus Strain Circulated in Gwangju, Republic of Korea显示文摘 | Min Ji Kim Hye Sook Jeong Seon Gyeong Kim Se Mi Lee Sun Hee Kim Hye-Young Kee Eun-hye Jo Hye-jung Park Dong-Ryong Ha Eun Sun Kim Kye-Won Seo Jae Keun Chung | 2014 | Osong Public Health and Research Perspectives2014，，： | 1 |
| 10 | A comparison of sufentanil and fentanyl for patient controlled epidural analgesia in arthroplasty显示文摘 | Hye Rim Jeon Won Seok Chae Se Jin Lee | 2011 | Korean J Anesthesiol2011，60，1： | 1 |
| 11 | Non-HDL-cholesterol/HDL-cholesterol is a better predictor of metabolic syndrome and insulin resistance than apolipoprotein B/apolipoprotein A1显示文摘 | Se Won Kim Jae Hwan Jee Hye Jeong Kim Sang-Man Jin Sunghwan Suh Ji Cheol Bae Sun Wook Kim Jae Hoon Chung Yong-Ki Min Myung-Shik Lee Moon-Kyu Lee Kwang-Won Kim Jae Hyeon Kim | 2013 | International Journal of Cardiology2013，，： | 1 |
| 12 | Quality of life outcomes including neuropathy-associated scale from a phase II,multicenter,randomized trial of eribulin plus gemcitabine versus paclitaxel plus gemcitabine as first-line chemotherapy for HER2-negative metastatic breast cancer:Korean Cancer Study Group Trial(KCSG BR13-11)显示文摘Background: A phase II clinical trial of the comparison between eribulin plus gemcitabine (EG) and paclitaxel plus gemcitabine (PG) as first-line chemotherapy for patients with metastatic breast cancer (MBC) found that the EG regimen was less neurotoxic, but was similar in efficacy to the PG regimen. In the present study, we analyzed functional assessment of cancer therapy-taxane (FACT-Taxane) questionnaires from patients in this clinical trial to determine their quality of life (QoL). Methods: QoL was assessed using the Korean version of the FACT-Taxane questionnaires. After baseline assessment, QoL was assessed every 2 cycles for 12 cycles and every 3 cycles thereafter. The linear mixed model was used to evaluate the difference in QoL between the EG and PG arms. Results: Of the 118 enrolled patients, 117 responded to the FACT-Taxane questionnaires at baseline, 1 in the PG arm did not. Baseline QoL scores were not different between the EG and PG arms. During treatment, taxane subscale scores were significantly higher in the PG arm than in the EG arm after 2-13 cycles of chemotherapy (all P < 0.05), except for the 11th cycle. Neuropathy-specific analysis showed that patients in the PG arm had earlier and more severe neuropathic symptoms than those in the EG arm (P < 0.001). Conclusions: In our QoL analysis, the EG regimen delayed and decreased neuropathy as compared with the PG regimen. Therefore, eribulin would be a reasonable substitute for paclitaxel as first-line chemotherapy for MBC. | Ji-Yeon Kim Seri Park Seock-Ah Im Sung-Bae Kim Joohyuk Sohn Keun Seok Lee Yee Soo Chae Ki Hyeong Lee Jee Hyun Kim Young-Hyuck Im Tae-Yong Kim Kyung-Hun Lee Jin-Hee Ahn Gun Min Kim In Hae Park Soo Jung Lee Hye Sook Han Se Hyun Kim Kyung Hae Jung Yeon Hee Park Korean Cancer Study Group | 2019 | Cancer Communications2019，39，1： | 1 |
| 13 | Neuronal differentiation of embryonic midbrain cells by upregulation of peroxisome proliferator-activated receptor-gamma via the JNK-dependent pathway显示文摘 | Ki Sook Park Rhee Da Lee Sun-Kyung Kang Soon Young Han Kui Lae Park Ki Hwa Yang Youn Sook Song Hye Ji Park Yoot Mo Lee Yeo Pyo Yun Ki Wan Oh Dae Joong Kim Young Won Yun Se Jin Hwang Sung Eun Lee Jin Tae Hong | 2004 | Experimental Cell Research2004，，2： | 1 |
| 14 | Free radicals are involved in the damage to protein synthesis after anoxia/aglycemia and NMDA exposure显示文摘 | Chatten-Brown J Hye SE | 2000 | Brain Res2000，857，12： | 1 |
| 15 | Structural and functional characterization of HP0377, a thioredoxin‐fold protein from Helicobacter pylori显示文摘 | Ji Young Yoon Jieun Kim Doo Ri An Sang Jae Lee Hyoun Sook Kim Ha Na Im Hye‐Jin Yoon Jin Young Kim Soon‐Jong Kim Byung Woo Han Se Won Suh | 2013 | Acta Cryst D2013，，5： | 1 |
| 16 | Free radicals are involved in the damage to protein synthesis after anoxia/aglycemia and NMDA exposure显示文摘 | Monje ML Chatten-Brown J Hye SE | 2000 | Brain Res2000，857，12： | 1 |
| 17 | A phase I study of nimotuzumab in combination with radiotherapy in stages IIB–IV non-small cell lung cancer unsuitable for radical therapy: Korean results显示文摘 | Hye Jin Choi Joo Hyuk Sohn Chang Geol Lee Hyo Sub Shim Ik-Jae Lee Woo Ick Yang Ji Eun Kwon Se Kyu Kim Moo-Suk Park Ju Hee Lee Joo Hang Kim | 2010 | Lung Cancer2010，，： | 1 |
| 18 | CT imaging spectrum of pancreatic serous tumors: Based on new pathologic classification显示文摘 | Hye Young Sun Se Hyung Kim Min A. Kim Jae Young Lee Joon Koo Han Byung Ihn Choi | 2009 | European Journal of Radiology2009，，2： | 1 |
| 19 | Nrf2‐mediated liver protection by sauchinone, an antioxidant lignan, from acetaminophen toxicity through the PKCδ‐GSK3β pathway显示文摘 | Hee Yeon Kay Young Woo Kim Da Hye Ryu Sang Hyun Sung Se Jin Hwang Sang Geon Kim | 2011 | British Journal of Pharmacology2011，，： | 1 |
| 20 | Free radicals are involved in the damage to protein synthesis after anoxia/aglycemia and NMDA exposure显示文摘 | Monje ML Chatten-Brown J Hye SE | 2000 | Brain Res2000，857，12： | 1 |
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