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| 1 | Pretreated Oenan the Javanica extract increases anti-inflammatory cytokines, attenuates gliosis, and protects hippocampal neurons following transient global cerebral ischemia in gerbils显示文摘Recently,we have reported that Oenanthe javanica extract(OJE)displays strong neuroprotective effect against ischemic damage after transient global cerebral ischemia.However,neuroprotective mechanisms of OJE have not been fully identified.Thus,this study investigated the neuroprotection of OJE in the hippocampal CA1 area and its anti-inflammatory activity in gerbils subjected to 5 minutes of transient global cerebral ischemia.We treated the animals by intragastrical injection of OJE(100 and 200 mg/kg)once daily for 1 week prior to transient global cerebral ischemia.Neuroprotection of OJE was observed by immunohistochemistry for neuronal nuclear antigen and histofluorescence staining for Fluoro-Jade B.Immunohistochemistry of glial fibrillary acidic protein and ionized calcium-binding adapter molecule 1 was done for astrocytosis and microgliosis,respectively.To investigate the neuroprotective mechanisms of OJE,we performed immunohistochemistry of tumor necrosis factor-alpha and interleukin-2 for pro-inflammatory function and interleukin-4 and interleukin-13 for anti-inflammatory function.When we treated the animals by intragastrical administration of 200 mg/kg of OJE,hippocampal CA1 pyramidal neurons were protected from transient global cerebral ischemia and cerebral ischemia-induced gliosis was inhibited in the ischemic hippocampal CA1 area.We also found that interleukin-4 and-13 immunoreactivities were significantly increased in pyramidal neurons of the ischemic CA1 area after OJE pretreatment,and the increased immunoreactivities were sustained in the CA1 pyramidal neurons after transient global cerebral ischemia.However,OJE pretreatment did not increase interleukin-2 and tumor necrosis factor-alpha immunoreactivities in the CA1 pyramidal neurons.Our findings suggest that pretreatment with OJE can protect neurons and attenuate gliosis from transient global cerebral ischemia via increasing expressions of interleukin-4 and-13.The experimental plan of this study was reviewed and approved by the Institutional Animal Care and Use Committee(IACUC)in Kangwon National University(approval No.KW-160802-1)on August 10,2016. | Joon Ha Park In Hye Kim Ji Hyeon Ahn YooHun Noh Sung-Su Kim Tae-Kyeong Lee Jae-Chul Lee Bich-Na Shin Tae Heung Sim Hyun Sam Lee Jeong Hwi Cho In Koo Hwang Il Jun Kang Jong Dai Kim Moo-Ho Won | 2019 | Neural Regeneration Research2019，14，9： | 6 |
| 2 | An Activity of Lowering Blood-glucose Levels According to Preparative Condition of Silkworm Powder显示文摘 | Kang Sun Ryu Heui Sam Lee Sung Hyun Chung | 1997 | Koeran J Seric Sci1997，39，1： | 1 |
| 3 | An Activity,of,Lowering Blood-glucose Levels According to Preparative Condi-tion of Silkworm Powder显示文摘 | Kang Sun Ryu Heui Sam Lee Sung Hyun Chung | 1997 | Koeran J Seric Sci1997，39，1： | 1 |
| 4 | δ-Integration of endo/exo-glucanase and β-glucosidase genes unto the yeast chromosomes for direct conversion of cellulose to ethanol显示文摘 | Kwang Myung Cho Young Je Yoo Hyun Sam Kang | 1999 | Enzyme and Microbial Technology1999，25，： | 1 |
| 5 | An activity of lowering blood-glucose levels according to preparative condition of silkworm powder显示文摘 | Kang Sun Ryu Heui Sam Lee Sung Hyun Chung | 1997 | Korean Serie Sci1997，39，4： | 1 |
| 6 | Chlorogenic acid, an antioxidant principle from the aerial parts of Artemisia iwayomogi that acts on 1,1-diphenyl-2-picrylhydrazyl radical显示文摘 | Soon Shin Kim Chung Kyu Lee Sam Sik Kang Hyun Ah Jung Jae Sue Choi | 1997 | Archives of Pharmacal Research1997，，： | 1 |
| 7 | Antiinflammatory activity of naturally occurring flavone and flavonol glycosides显示文摘 | Song Jin Lee Kun Ho Son Hyeun Wook Chang Jae Chul Do Keun Young Jung Sam Sik Kang Hyun Pyo Kim | 1993 | Archives of Pharmacal Research1993，，1： | 1 |
| 8 | Chemical constituents of the root of Dystaenia takeshimana and their anti-inflammatory activity显示文摘 | Ju Sun Kim Jin Cheul Kim Sang Hee Shim Eun Ju Lee Wen Yi Jin Kihwan Bae Kun Ho Son Hyun Pyo Kim Sam Sik Kang Hyeun Wook Chang | 2006 | Archives of Pharmacal Research2006，，： | 1 |
| 9 | In Vitro Free Radical and ONOO- Scavengers from Sophora flavescens显示文摘 | Hee Jin Jung Sam Sik Kang Sook Kyung Hyun Jae Sue Choi | 2005 | Archives of Pharmacal Research2005，，5： | 1 |
| 10 | Cholinesterase and BACE1 inhibitory diterpenoids from Aralia cordata显示文摘 | Hyun Ah Jung Eun Ju Lee Ju Sun Kim Sam Sik Kang Je-Hyun Lee Byung-Sun Min Jae Sue Choi | 2009 | Archives of Pharmacal Research2009，，10： | 1 |
| 11 | Anti-inflammatory activity of the constituents of the roots of Aralia continentalis显示文摘 | Hyun Lim Hyun Ah Jung Jae Sue Choi Yeong Shik Kim Sam Sik Kang Hyun Pyo Kim | 2009 | Archives of Pharmacal Research2009，，9： | 1 |
| 12 | Antioxidant constituents and a new triterpenoid glycoside from Flos Lonieerae显示文摘 | Chtm-Whan Choi Hyun Ah Jung Sam Sik Kang | 2007 | Arch Pharm Res2007，30，1： | 1 |
| 13 | An activity of lowering blood-glucose levels according to preparative condition of silkworm powder显示文摘 | KANG SUN RYU HEUI SAM LEE SUNG HYUN CHUNG | 1997 | Koeran J Seric Sci1997，39，1： | 1 |
| 14 | Supraspinatus tendon tears: comparison of 3D US and MR arthrography with surgical correlation显示文摘 | Chang Ho Kang Sam Soo Kim Jung Hyuk Kim Kyoo Byung Chung Yun Hwan Kim Yu-Whan Oh Woong-Kyo Jeong Baek Hyun Kim | 2009 | Skeletal Radiology2009，，11： | 1 |
| 15 | An Activity of Lowering Blood-glucose Levels According to Preparative Condition of Silkworm Powder显示文摘 | Kang Sun Ryu Heui Sam Lee Sung Hyun Chung | 1997 | Koeran J Seric Sci1997，39，1： | 1 |
| 16 | Constituents from the fruiting bodies of Ganoderma applanatum and their aldose reductase inhibitory activity显示文摘 | Sang Hyun Lee Sang Hee Shim Ju Sun Kim Sam Sik Kang | 2006 | Archives of Pharmacal Research2006，，6： | 1 |
| 17 | Hyperoside prevents oxidative damage induced by hydrogen peroxide in lung fibroblast cells via an antioxidant effect显示文摘 | Mei Jing Piao Kyoung Ah Kang Rui Zhang Dong Ok Ko Zhi Hong Wang Ho Jin You Hee Sun Kim Ju Sun Kim Sam Sik Kang Jin Won Hyun | 2008 | BBA - General Subjects2008，，： | 1 |
| 18 | Anti-inflammatory and anti-arthritic activity of total flavonoids of the roots of Sophora flavescens显示文摘 | Jeong Ho Jin Ju Sun Kim Sam Sik Kang Kun Ho Son Hyun Wook Chang Hyun Pyo Kim | 2010 | Journal of Ethnopharmacology2010，127，： | 1 |
| 19 | Sedative action of spinosin显示文摘 | Kuk Hyun Shin Chung Kyu Lee Won Sick Woo Sam Sik Kang | 1978 | Archives of Pharmacal Research1978，，1： | 1 |
| 20 | An activity of lowering blood-glucose level according to preparative condition of silkworm powder 显示文摘 | Kang Sun Ryu Heui Sam Lee Sung Hyun Chung | 1997 | Koeran J Sericsci1997，39，1： | 1 |
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