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| 1 | Hepatocellular carcinoma: Review of disease and tumor biomarkers显示文摘Hepatocellular carcinoma(HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative treatments is limited to early stage cancers, diagnosis in non-symptomatic individuals is crucial. International guidelines advise regular surveillance of high-risk populations but the current tools lack sufficient sensitivity for early stage tumors on the background of a cirrhotic nodular liver. A number of novel biomarkers have now been suggested in the literature, which may reinforce the current surveillance methods. In addition, recent metabonomic and proteomic discoveries have established specific metabolite expressions in HCC, according to Warburg's phenomenon of altered energy metabolism. With clinical validation, a simple and non-invasive test from the serum or urine may be performed to diagnose HCC, particularly benefiting low resource regions where the burden of HCC is highest. | Jin Un Kim Mohamed I F Shariff Mary M E Crossey Maria Gomez-Romero Elaine Holmes I Jane Cox Haddy K S Fye Ramou Njie Simon D Taylor-Robinson | 2016 | World Journal of Hepatology2016，8，10： | 13 |
| 2 | Empirical comparison of alternative stochastic volatility option pricing models: evidence from Korean KOSPI 200 index options market显示文摘 | Kim I J Kim S | 2004 | Pacific-Basin Finance Journal2004，12，： | 2 |
| 3 | 早产儿出生时气管内吸出物中的白介素-6含量增加是随后支气管肺发育不良的预测因子显示文摘Aim:We tested whether interleukin-6(IL-6)in tracheal aspirate(TA)at birth,as a marker of fetal pulmonary inflammation,can be a predictor of bronchopulmonary dysplasia(BPD)in preterm infants.Methods:A total of 75 preterm(≤32 wk)infants who were intubated in the delivery room were prospectively enrolled.Multivariate logistic regression analysis was done to determine whether IL-6 in TA at birth is an independent risk factor for BPD,and a receiver-operating characteristic curve was constructed to determine the accuracy of IL-6 in TA for predicting the risk of BPD.Results:IL-6 in TA at birth was an independent risk factor for BPD.Fetal pulmonary inflammation defined as IL-6 in TA at birth ≥316 pg/ml together with patent ductus arteriosus(PDA)additively predicted the risk of BPD.The sensitivity,specificity,and positive and negative predictive values of fetal pulmonary inflammation for the identification of BPD were 73%,71%,58%and 83%,respectively.Conclusion:IL-6 in TA at birth can be used as a predictor of BPD in combination with the presence of PDA. | Chang W. C Kim B. I Kim H. - S 郭战宏(译) | 2006 | 世界核心医学期刊文摘(儿科学分册)2006，2，8： | 2 |
| 4 | Strategies to tackle the challenges of external beam radiotherapy for liver tumors显示文摘Primary and metastatic liver cancer is an increasingly common and difficult to control disease entity.Radiation offers a non-invasive treatment alternative for these patients who often have few options and a poor prognosis.However,the anatomy and aggressiveness of liver cancer poses significant challenges such as accurate localization at simulation and treatment,management of motion and appropriate selection of dose regimen.This article aims to review the options available and provide information for the practical implementation and/or improvement of liver cancer radiation programs within the context of stereotactic body radiotherapy and image-guided radiotherapy guidelines.Specific patient inclusion and exclusion criteria are presented given the significant toxicity found in certain sub-populations treated with radiation.Indeed,certain sub-populations,such as those with tumor thrombosis or those with larger lesions treated with transarterial chemoembolization,have been shown to have significant improvements in outcome with the addition of radiation and merit special consideration.Implementing a liver radiation programrequires three primary challenges to be addressed:(1) immobilization and motion management;(2) localization;and(3) dose regimen and constraint selection.Strategies to deal with motion include simple internal target volume(ITV) expansions,non-gated ITV reduction strategies,breath hold methods,and surrogate marker methods to enable gating or tracking.Localization of the tumor and organs-at-risk are addressed using contrast infusion techniques to take advantage of different normal liver and cancer vascular anatomy,imaging modalities,and margin management.Finally,a dose response has been demonstrated and dose regimens appear to be converging.A more uniform approach to treatment in terms of technique,dose selection and patient selection will allow us to study liver radiation in larger and,hopefully,multicenter randomized studies. | Michael I Lock Jonathan Klein Hans T Chung Joseph M Herman Edward Y Kim William Small Nina A Mayr Simon S Lo | 2017 | World Journal of Hepatology2017，9，14： | 2 |
| 5 | A Multidimensional Trust Formation Model in B-to-C Ecommerce:A Conceptual Framework and Content Analyses of Academia/Practitioner Perspectives 显示文摘 | Kim D J Song Y I Braynov S B Rao H R | 2005 | Decision Support Systems2005，40，2： | 1 |
| 6 | Effect of alloying elements on elevated temperature tensile ductility of Bi added, Pb-free brass显示文摘 | Jang Y H Kim S S Kim I S | 2004 | Journal of the Korean Institute of Metals and Materials2004，42，7： | 1 |
| 7 | Electrochemical study of hydrogen embrittlement and optimum cathodic protection potential of welded high strength steel显示文摘 | KIM S J JANG S K KIM J I | 2005 | Metals and Materials International2005，11，1： | 1 |
| 8 | On the Complete Convergence for Weighted Sums of Dependent Random Variables under Condition of Weighted Integrability 显示文摘 | Baek J I Ko M H Kim T S | 2008 | J Korean Math Soc2008，45，1： | 1 |
| 9 | Hot forging of nickel-base superalloy 显示文摘 | Kim I S | 2001 | Journal of Materials Processing Technology2001，111，： | 1 |
| 10 | Random sequence analy-sis of genomie DNA of a hyperthemophile:Aquifex pyrophilus显示文摘 | Kim S S Ryu J R | 1997 | Extremophiles1997，1，3： | 1 |
| 11 | Characteristic rheological features of PVA solutions in water-containing solvents with different hydration states显示文摘 | KIM B C | 2004 | Polymer2004，45，7： | 1 |
| 12 | Behavior of double skin composite wall subjected to in- plane cyclic loading显示文摘 | Eom T S Park H G Lee C H Kim J H Chang I H | 2009 | Journal of Structural Engineering ASCE2009，135，10： | 1 |
| 13 | Raman spectroscopic evaluation of polyacrylonitrile - based carbon nanofibers prepared by electrospinning 显示文摘 | Kim C Park S H Cho J I | 2004 | Journal of Raman Spectroscopy2004，35，11： | 1 |
| 14 | Thermoelastic analysis of kick motor nozzle incorporating spatially reinforced composites 显示文摘 | Yoo J S Cho I Kim C G | 2003 | Journal of Spacecraft and Rockets2003，40，1： | 1 |
| 15 | Signaling pathways ofbisphenol A-induced apoptosis in hippocampal neuro-nal cells:role of calcium-induced reactive oxygen spe-cies,mitogen-activated protein kinases,and nuclearfactor-kappa B显示文摘 | Lee S Suk K Kim I K | 2008 | J Neurosci Res2008，86，13： | 1 |
| 16 | 显示文摘 | Kim I S Blomgren G E Kumta PN | 2004 | Power Sources2004，130，12： | 1 |
| 17 | 5-HT2A receptor gene promoter polymorphism -1438A/G and bipolar disorder显示文摘 | Chee I S Lee S W Kim J L | 2001 | Psychiatr Genet2001，11，： | 1 |
| 18 | Comparison of combined spinal epidural anesthesia and epidural anesthesia for cesarean section显示文摘 | CHOI D H KIM J A CHUNG I S | 2000 | Acta Anaesthesiol Scand2000，44，2： | 1 |
| 19 | Effects of lactate dehydrogenase suppression and glycerol-3-phosphate dehydrogenase overexpression on cellular metabolism显示文摘 | Jeong D W Cho I T Kim T S | 2006 | Mol Cell Biochem2006，2，14： | 1 |
| 20 | Novel BOD sensor using mediator-less microbial fuel cell 显示文摘 | Kim B H Chang I S Gil G C | 2003 | Biotechnology Letters2003，25，7： | 1 |
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