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	题名	作者	年代	出处	被引量
1	SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation显示文摘Sirtuin 3(SIRT3)is a deacetylase that modulates proteins that control metabolism and protects against oxidative stress.Modulation of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac disturbances.In this study,we investigated the role of SIRT3 in inflammation and fibrosis in the heart using male mice with constitutive and systemic deletion of SIRT3 and human cardiac AC16 cells.SIRT3 knockout mice showed cardiac fibrosis and inflammation that was characterized by augmented transcriptional activity of AP-1.Consistent with this,SIRT3 overexpression in human and neonatal rat cardiomyocytes partially prevented the inflammatory and profibrotic response induced by TNF-α.Notably,these effects were associated with a decrease in the mRNA and protein levels of FOS and the DNA-binding activity of AP-1.Finally,we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its promoter.These findings highlight an important function of SIRT3 in mediating the often intricate profibrotic and proinflammatory responses of cardiac cells through the modulation of the FOS/AP-1 pathway.Since fibrosis and inflammation are crucial in the progression of cardiac hypertrophy,heart failure,and diabetic cardiomyopathy,our results point to SIRT3 as a potential target for treating these diseases.	Xavier Palomer MSilvia Román-Azcona Javier Pizarro-Delgado Ana Planavila Francesc Villarroya Brenda Valenzuela-Alcaraz Fátima Crispi Álvaro Sepúlveda-Martínez Irene Miguel-Escalada Jorge Ferrer JFrancisco Nistal Raquel García Mercy MDavidson Emma Barroso Manuel Vázquez-Carrera	2020	Signal Transduction and Targeted Therapy2020，5，1：	7
2	Imagining Stereotypes Away: The Moderation of Implicit Stereotypes Through Mental Imagery 显示文摘	Irene V Blair Jennifer E Ma Alison P Lenton	2001	Journal of Personality and Social Psychology2001，，81：	1
3	Trace of Flicker Sources by Using the Quantity of Flicker Power显示文摘	Axelberg P G V Bollen M H J Gu Irene Yu-Hua	2008	IEEE Trans on Power Delivery2008，23，1：	1
4	Genetic diversity of recent bovine viral diarrhoea viruses from the southeast of Austria ( Styria ) 显示文摘	Stefan V Irene G W Branislav D	2003	Vet Microbiology2003，91，23：	1
5	Chemical vapor desposition of AlxOyNz films 显示文摘	Jsilvestri V Irene E A Zirinsky S	1975	J Electron Mater1975，4，3：	1
6	Communication in Europe on semicarbazide and baby food 显示文摘	Anne L G Irene V G	2006	Journal of Fish Research2006，9，8：	1
7	Development and in vitro evaluation of a mucoadhesive vaginal delivery system for progesterone显示文摘	Claudia V Constantia EK Irene H	2001	J Controlled Release2001，77，3：	1
8	Infectious complications following renal transplantation显示文摘	Irene G Siapaya V	1998	Surg Clin North Am1998，78，1：	1
9	Rhizoremediation: A beneficial plant-microbe interaction显示文摘	IRENE Kuiper ELLEN L L GUIDO V B	2004	Mol PlantMicrobe Interact2004，17，1：	1
10	Levels of perfluorooc- tanesulfonate (PFOS) and perfluorooetanoate (PFOA) in blood samples from different groups of adults living in Greece 显示文摘	IRENE V DANAE C ANGELIKI F	2012	Chemosphere2012，80，10：	1
11	Dimethoate accel- erates the extinction of eyeblink conditioning in mice 显示文摘	Mauricio V H Irene C Corin D	2012	NeuroToxicology2012，33，1：	1
12	Partitioning behavior of trace elements during pilot-scale combustion of pulverized coal and coal-water slurry fuel显示文摘	Nodelman Irene G Pisupati Sarma V Miller Sharon Falcone	2000	Journal of Hazardous Materials2000，74，：	1
13	Prevention of the selection of resistant staphylococcus aureus by moxifloxacin plus doxycycline in an in vitro dynamic model:andditive effect of the combination显示文摘	ALEXANDER A F SERGEY N V IRENE Y L	2004	International Journal of Antimicrobial Agents2004，23，：	1
14	Mailed, homeobtained urine specimens: a reliable screeming approach for detecting asymptomatic Chlamydia trachomatis infection显示文摘	Irene GM van V Afke de J	1999	J Clin Microbiol1999，37，：	1
15	Functional properties of glycated soy 11 Gglycinin显示文摘	Achouri A Irene BJ Yaylayan V	2005	Journal of Food Sci- ence2005，70，4：	1
16	M ailed, homeobtained urine specimens: a reliable screem ing approach for detecting asymptomatic Chlamydia trachomatis infection显示文摘	Servaas AM Irene GM van V A fke de J	1999	J Clin M icrobiol1999，37，：	1
17	Prevention of the selection of resistant Staphylococcus aureus by moxifloxacin plus doxycycline in an in vitro dynamic model : an additive effect of the combination 显示文摘	Alexander A F Sergey N V Irene Y L	2004	International Journal of Antimicrobial Agents2004，23，5：	1
18	Silicon mitigates cadmium inhibitory effects in young maize plants显示文摘	Marek V Alexander L Miroslava L Eiichi T Irene L	2009	Environment and Experiment Botany2009，67，1：	1
19	Synthesis and multi-target biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents 显示文摘	Elisabet V Irene S Manuela B	2014	J Med Chem2014，57，6：	1
20	Interleukin-6 and other solubl factors in peritoneal fluid and endometriomas and their relation to pain and aromatase expression 显示文摘	Irene V Pedro A Adolfo C	2010	J Reprod Immuno12010，84，：	1

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