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| 1 | Management of pancreaticobiliary disease using a new intra-ductal endoscope:The Texas experience显示文摘AIM:To evaluate a new single-operator mini-endoscope, Spyglass,for its performance,feasibility and safety in the management of pancreaticobiliary disease. METHODS:In a multicenter retrospective analysis of patients undergoing intraductal endoscopy,we evaluated 128 patients(71 men,mean age 57.6 years).Indications were therapeutic(TX)in 72(56%) and diagnostic(DX)in 56(44%). RESULTS:Peroral endoscopy was performed in 121 and percutaneous in seven.TX indications included CBD stones in 41,PD stones in six,and biliary strictures in 25.DX indications included abnormal LFT’s in 15, abnormal imaging in 38 and cholangiocarcinoma staging in three.Visualization of the stone(s)was considered good in 31,fair in six,and poor in four. Advancement of the electrohydraulic lithotripsy probe was not possible in three patients and proper targeting of the lesion was partial in four patients.A holmium laser was used successfully in three patients.Ductal clearance was achieved in 37 patients after one procedure and in four patients after two procedures.Diagnosis of biliary strictures was modified in 20/29 and confirmed to be malignant in 10/23.Of the modified patients,no diagnosis was available in 17.Spyglass demonstrated malignancy in 8/17 and non-malignancy in nine.Suspected pathology by imaging studies and abnormal LFT’s was modified in 43/63(66%).Staging of cholangiocarcinoma demonstrated multicentric cholangiocarcinoma in 2/3.There was no morbidity associated with the use of Spyglass. CONCLUSION:Spyglass Spyscopeis a first generation, single operator miniature endoscope that can evaluate and treat various biliary and pancreatic tract diseases. | Douglas S Fishman Paul R Tarnasky Sandeep N Patel Isaac Raijman | 2009 | World Journal of Gastroenterology2009，15，11： | 22 |
| 2 | Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia–reperfusion: Therapeutic potential of mitochondrially targeted antioxidants显示文摘 | Partha Mukhopadhyay B?la Horváth Zsuzsanna Zsengell?r Sándor Bátkai Zongxian Cao Malek Kechrid Eileen Holovac Katalin Erd?lyi Galin Tanchian Lucas Liaudet Isaac E. Stillman Joy Joseph Balaraman Kalyanaraman Pál Pacher | 2012 | Free Radical Biology and Medicine2012，，5： | 2 |
| 3 | Development of prostate cancer treatment : the good news显示文摘 | Denmeade S R Isaacs J T | 2004 | Prostate2004，58，： | 1 |
| 4 | Improving purchasing productivity at IBM with a normative decision support system显示文摘 | Bender P S Brown R W Isaac H | 1985 | Interfaces1985，15，： | 1 |
| 5 | Assessment and validation of a microinjection method for kinetic analysis of Ca2+i in individual cells undergoing apoptosis显示文摘 | TOMBAL B DENMEADE S R ISAACS J T | 1999 | Cell Calcium1999，25，： | 1 |
| 6 | Crystal structure of an integral membrane light-harvesting complex from photosynthtic bacteria显示文摘 | McDermott G Prince S M Freer A A Hawthorthwaite-Lawless A M Papiz M Z Cogdell R J Isaacs N W | 1995 | Nature1995，374，6： | 1 |
| 7 | Random amplified polymorphic DNA (RAPD)markers for genetic analysis in Allium 显示文摘 | Wilkie S E Isaac P G Slater R J | 1993 | Theor Appl Genet1993，86，： | 1 |
| 8 | Transplantation of neonatal porcine islets and sertoli cel s into nonimmunosuppressed nonhuman primate s显示文摘 | Isaac JR Skinner S E l iot R | | 0，，01： | 1 |
| 9 | The future is now: Model‐based clinical trial design for Alzheimer’s disease显示文摘 | K Romero K Ito JA Rogers D Polhamus R Qiu D Stephenson R Mohs R Lalonde V Sinha Y Wang D Brown M Isaac S Vamvakas R Hemmings L Pani LJ Bain B Corrigan | 2015 | Clin. Pharmacol. Ther2015，，3： | 1 |
| 10 | Selective Serotonin Reuptake Inhibitors (SSRIs) inhibit insulin se- cretion and action in pancreatic 13 cells显示文摘 | Isaac R Boura-Halfon S Gurevitch D | 2013 | Journal of Bi- ological Chemistry2013，288，8： | 1 |
| 11 | Phase Ⅲ,randomized,double-blind,placebo-controlled multicenter trial of daily everolimus plus weekly trastuzumab and vinorelbine in trastuzumab-resistant,advanced breast cancer (BOLERO-3)显示文摘 | O' Regan R Ozguroglu M Andre F Toi M Jerusalem G Wilks S Isaacs C Xu B Masuda N Arena FP Yardley D Yap YS Mukhopadhyay P Douma S El-Hashimy M Taran T Sahmoud T Lebwohl D Gianni L | | 0，，15： | 1 |
| 12 | Random amplified po- lusis in TAG, Allinm显示文摘 | Wilie S E Isaac P G Slater R J | 1993 | Theoretical and Applied Ge- netics1993，86，： | 1 |
| 13 | Construction and testing of microsatellite database containing more than 500 tomato varieties显示文摘 | Bredemeijer G Cooke R Ganal M Peeters R Isaac P Noordijk Y Rendell S Jackson J Roder M Wendehake K Dijcks M Amelaine M Wickaert V Bertrand L Vosman B | 2002 | Theoretical and Applied Genetics2002，105，67： | 1 |
| 14 | The stereochemistry of high pressure aldehyde addition to allylstannanes显示文摘 | ISAACS N S MARSHALL R L YOUNG D J | 1992 | Tetrahedron Lett1992，33，： | 1 |
| 15 | Constrt~ction and analysis of a microsatellite-based database of European wheat varieties 显示文摘 | Roder M Wendehake K Korzun V Bredemeijer G Laborie D Bertrand L Isaac P Rendell S Jackson J Cooke R Vosrnan B Ganal M | 2002 | Theoretical and Applied Genetics2002，106，1： | 1 |
| 16 | Random amplified polymorphic DNA (RAPD) markers for genetic analysis in Allinm 显示文摘 | WILIE S E ISAAC P G SLATER R J | 1993 | Theor Appl Genet1993，86，： | 1 |
| 17 | Chemical, ther- mal, and ultrasonic stability of hybrid nanoparticles and nanoparticle multilayer films 显示文摘 | ISAACS S R CHOO H KO W B | 2006 | Chemistry of Materials2006，18，1： | 1 |
| 18 | Experimental investigation of response of monolithic and bilayer plates to impul- sive loads显示文摘 | Amini M R Isaacs J B Nemat-Nasser S | 2010 | Impact Engineering2010，37，1： | 1 |
| 19 | Endovenous la- ser treatment of the incompetent greater saphenous vein 显示文摘 | Min R J Zimmet S E Isaacs M N | 2001 | J Vase Interv Radio2001，12，10： | 1 |
| 20 | Prevalence of depression in consecutive patients with type 2 diabetes mellitus of 5-year duration and its impact on glycemic control显示文摘 | MATHEW C S DOMINIC M ISAAC R | 2012 | Indian Journal of Endocrinology & Metabolism2012，16，5： | 1 |
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