|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Class switch recombination junctions are not affected by the absence of the immunoglobulin heavy chain E_(μ) enhancer显示文摘After encountering antigen,B-cells undergo class switch recombination(CSR)that substitutes the constant(C)μgene with Cγ,Cε,or Cα,thereby generating IgG,IgE,and IgA antibodies with new effector functions but the same antigenic specificity.1 The DNA-editing enzyme activation-induced deaminase(AID)is required for CSR by targeting specific DNA switch(S)regions preceding the C region,except Cδ.2 Sμis the donor region,while Sγ,ε,αare the acceptor regions.CSR is controlled in cis by the immunoglobulin heavy chain(IgH)3’regulatory region(3’RR).3 The 3’RR is essential to poise AID on the S acceptor region.During CSR IgH,intrachromosomal interactions(schematized in Fig.1a)are found between the 3’RR and the intronic Eμenhancer.1,4 Looping allows transcriptional binding activators to enhancers to facilitate CSR.However,CSR is only modestly influenced by Eμdeletion.5–7 During CSR,two different DNA repair pathways take place:the classical nonhomologous end joining(c-NHEJ)and the alternative end joining(A-EJ)pathways. | Hussein Issaoui Nour Ghazzaui Mélissa Ferrad François Boyer Yves Denizot | 2019 | Cellular & Molecular Immunology2019，16，7： | 1 |
| 2 | Homoeysteine enhances LDL fatty acid peroxidation, promoting microalbuminuria in type 2 diabetes显示文摘 | KASSAB A AJMI T ISSAOUI M | 2008 | Ann Clin Biochem2008，45，5： | 1 |
| 3 | Effects of olive oil and its fractions on oxidative stress and the liver's fatty acid composition in 2,4-dichlorophenoxyacetic acid-treated rats显示文摘 | Nakbi A Tayeb W Grissa A Issaoui M Dabbou S Chargui I Ellouz M Miled A Hammami M | | 0，，： | 1 |
| 4 | Evaluation of antioxidant activities of phenolic compounds from two extravirgin olive oils 显示文摘 | NAKBI A ISSAOUI M DABBOU S | 2010 | Journal of Food Composition and Analysis2010，23，： | 1 |
| 5 | Evaluation of antioxidantactivities of phenolic compounds from two extra virgin olive oils显示文摘 | NAKBI A ISSAOUI M DABBOU S | 2010 | Journal of Food Composition and Analysis2010，23，7： | 1 |
| 6 | Homocysteine enhances LDL fatty acid peroxidation, promoting microalbuminuria in type 2 diabetes 显示文摘 | Kassab A Ajmi T Issaoui M | 2008 | Ann Clin Biochem2008，45，5： | 1 |
| 7 | Homocysteine enhances LDL fattyacid peroxidation,promoting microalbuminuria in type 2 diabetes 显示文摘 | Kaesab A Ajmi T Issaoui M | 2008 | Clin Bioehem2008，45，5： | 1 |
| 8 | Homocysteine enhances LDL {arty acid peroxidation,promoting microalbuminuria in type 2 dia- betes显示文摘 | Kassab A Ajmit Issaoui M | 2008 | Ann Clin Biochem2008，45，5： | 1 |
| 9 | Effect of the grow- ing area conditions on differentiation between Chemlali and Chetoui olive oils 显示文摘 | ISSAOUI M FLAMINI G BRAHMI F | 2010 | Food Chemistry2010，119，： | 1 |
| 10 | Evaluation of antioxidant activities of phenolic compounds from two extra virgin olive oils 显示文摘 | NAKBI A ISSAOUI M DABBOU S | 2010 | J Food Compos Anal2010，23，： | 1 |
| 11 | Molecular analysis of γ1, γ3, and α class switch recombination junctions in APOBEC3-deficient mice using high-throughput sequencing显示文摘Activation-induced deaminase(AID)is required for immunoglobulin(Ig)class switch recombination(CSR),in which the constant(C)μgene of IgM is substituted with C_(γ),C_(ε),or C_(α),thereby generating IgG,IgE,and IgA antibodies,respectively,with new effector functions but the same antigenic specificity.1 AID targets specific DNA switch(S)regions preceding C regions except for Cδ.2 Sμis usually the donor region,while Sγ,ε,αare the acceptor regions.AID deaminates C into U on single-stranded DNA by targeting the WRCY(W=A/T,R=A/G,and Y=C/T)hot motif and,to a lesser extent,the SYC(S=G/C,Y=C/T)cold motif.3,4 AID is a member of the apolipoprotein B editing complex(APOBEC)family.Among APOBEC genes,a family of evolutionarily conserved cytidine deaminases,APOBEC3 is implicated in diverse cell functions including innate immunity against retroviruses.4 The DNA-editing APOBEC3 enzymes have recently attracted attention due to their involvement in cancer and potential applications in gene editing.5–7 While a single copy of each APOBEC3 gene is present in rodents,seven copies of each APOBEC3 gene are found in humans. | Hussein Issaoui Mélissa Ferrad Nour Ghazzaui Sandrine Lecardeur Jeanne Cook-Moreau François Boyer Yves Denizot | 2020 | Cellular & Molecular Immunology2020，17，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员