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| 1 | IgD class switch recombination is not controlled through the immunoglobulin heavy chain 3′ regulatory region super-enhancer显示文摘In secondary lymphoid organs,mature B cells express membrane immunoglobulin(Ig)of M and D isotypes(IgM and IgD,respectively)of the same specificity through alternative splicing of a pre-mRNA encompassing the VDJ variable region and Cμand Cδheavy chain constant exons.1 After encountering antigen,B cells undergo class switch recombination(CSR)by which the Cμgene is substituted with Cγ,Cεor Cα,thereby generating IgG,IgE and IgA antibodies of the same antigenic specificity but with new effector functions.CSR requires the DNA-editing enzyme activation-induced deaminase(AID). | Hussein Issaoui Nour Ghazzaui Alexis Saintamand Yves Denizot François Boyer | 2017 | Cellular & Molecular Immunology2017，14，10： | 6 |
| 2 | The IgH 3′ regulatory region super-enhancer does not control IgA class switch recombination in the B1 lineage显示文摘The bone marrow-derived B2 population represents the vast majority of bone marrow,blood,lymph node and splenic B-cells.Mouse B1 B-cells mostly originate during embryonic life in the liver and represent the main B-cell population in the pleural and peritoneal cavities.1,2,3,4,5 B1 and B2 B-cells differ in their origin,antigen specificity,cell surface markers,tissue distribution and capacity for class switch recombination(CSR).Schematically,B1 B-cells appear earlier than B2 B-cells during fetal development and maintain their self-renewal ability throughout their life. | Hussein Issaoui Nour Ghazzaui Alexis Saintamand Claire Carrion Christelle Oblet Yves Denizot | 2018 | Cellular & Molecular Immunology2018，15，3： | 4 |
| 3 | High-throughput sequencing reveals similar molecular signatures for class switch recombination junctions for theγandαisotypes显示文摘INTRODUCTION After encountering an antigen,B cells undergo class switch recombination(CSR),which substitutes the Cμgene with Cγ,Cε,or Cαto generate IgG,IgE,and IgA antibodies with the same antigenic specificity but new effector functions.1 The DNAediting enzyme activation-induced deaminase(AID)is essential for CSR by targeting switch(S)regions preceding Cμ(namely,the Sμdonor region)and the Cγ,Cε,and Cαgenes(namely,the Sγ,ε,αacceptor regions).1 Cis-and trans-controlled DNA double strand beaks are generated during this process.2–6 Recruitment of DNA repair factors that facilitate the end-joining process is a crucial step of class switch recombination.Two pathways are implicated in this end joining.The classical non-homogenous end joining(c-NHEJ)pathway ligates DNA ends with no or little homology.By contrast,the alternative end joining(A-EJ)pathways is used to ligate DNA ends that have microhomology. | ussein Issaoui Nour Ghazzaui Alexis Saintamand Yves Denizot François Boyer | 2019 | Cellular & Molecular Immunology2019，16，1： | 2 |
| 4 | Uracil-DNA glycosylase is not implicated in the choice of the DNA repair pathway during B-cell class switch recombination显示文摘Mature B-cells express membrane IgM and IgD(of same specificity)through alternative splicing of a pre-mRNA encompassing constant(C)μand Cδgenes.After encountering antigen,Bcells undergo class switch recombination(CSR)that substitutes the Cμgene with Cγ,Cε,or Cα,thereby generating IgG,IgE,and IgA antibodies with the same antigenic specificity but new effector functions.DNA-editing enzyme activation-induced deaminase(AID)is essential for CSR by targeting switch(S)regions preceding Cμ(namely,the Sμdonor region)and the Cγ,Cε,and Cαgenes(namely,the Sγ,ε,αacceptor regions).1,2 CSR is controlled in cis by IgH locus super-enhancers3 and in trans by a wide spectrum of enzymes and proteins.1,2 Among them,the role of the uracil DNA glycosylase(UNG)remains controversial.UNG is a key enzyme of base excision repair,which carries out faithful repair.Some authors estimate that during CSR,the UNG enzymatic activity removes the AID-induced dC to dU converted base of singlestrand DNA,generating abasic sites and leading to DNA strand breaks.1 For other authors,the role of UNG is to stabilize the S–S synapse and to recruit DNA repair factors that facilitate the endjoining process.4,5 Thus,the classical non-homogenous end joining pathway would be increased over the alternative end joining(A-EJ)pathway in UNG-deficient mice,4 suggesting an intriguing role of UNG in promoting the A-EJ pathway. | Nour Ghazzaui Hussein Issaoui Alexis Saintamand Yves Denizot François Boyer | 2019 | Cellular & Molecular Immunology2019，16，1： | 2 |
| 5 | Class switch recombination junctions are not affected by the absence of the immunoglobulin heavy chain E_(μ) enhancer显示文摘After encountering antigen,B-cells undergo class switch recombination(CSR)that substitutes the constant(C)μgene with Cγ,Cε,or Cα,thereby generating IgG,IgE,and IgA antibodies with new effector functions but the same antigenic specificity.1 The DNA-editing enzyme activation-induced deaminase(AID)is required for CSR by targeting specific DNA switch(S)regions preceding the C region,except Cδ.2 Sμis the donor region,while Sγ,ε,αare the acceptor regions.CSR is controlled in cis by the immunoglobulin heavy chain(IgH)3’regulatory region(3’RR).3 The 3’RR is essential to poise AID on the S acceptor region.During CSR IgH,intrachromosomal interactions(schematized in Fig.1a)are found between the 3’RR and the intronic Eμenhancer.1,4 Looping allows transcriptional binding activators to enhancers to facilitate CSR.However,CSR is only modestly influenced by Eμdeletion.5–7 During CSR,two different DNA repair pathways take place:the classical nonhomologous end joining(c-NHEJ)and the alternative end joining(A-EJ)pathways. | Hussein Issaoui Nour Ghazzaui Mélissa Ferrad François Boyer Yves Denizot | 2019 | Cellular & Molecular Immunology2019，16，7： | 1 |
| 6 | Freestanding CVD boron doped diamond single crystals: A substrate for vertical power electronic devices显示文摘 | Achard J Issaoui R Tallaire A | 2012 | Physica Status Solidi(a)2012，209，16： | 1 |
| 7 | Evaluation of freestanding boron-doped diamond grown by chemical vapor deposition as substrates for vertical power electronic devices显示文摘 | ISSAOUI R ACHARD J TALLAIRE A | 2012 | Applied Physics Letters2012，100，12： | 1 |
| 8 | Using metric-based filte- ring to improve design pattern detection approaches 显示文摘 | Issaoui I Bouassida N Ben Abdallah H | 2015 | Innova- tions in Systems and Software Engineering2015，11，1： | 1 |
| 9 | A New approach for inter- active design pattern recommendation 显示文摘 | Issaoui I Bouassida N Ben Abdallah H | 2015 | Lecture Notes on Soft- ware Engineering2015，3，3： | 1 |
| 10 | Evaluation of an automa-ted multi-phase approach for patterns discovery 显示文摘 | Bouassida N Ben Abdallah H Issaoui I | 2013 | International Journal of Software Engineering and Knowledge Engineering2013，23，10： | 1 |
| 11 | Homoeysteine enhances LDL fatty acid peroxidation, promoting microalbuminuria in type 2 diabetes显示文摘 | KASSAB A AJMI T ISSAOUI M | 2008 | Ann Clin Biochem2008，45，5： | 1 |
| 12 | Evaluation of antioxidant activities of phenolic compounds from two extra virgin olive oils显示文摘 | A. Nakbi M. Issaoui S. Dabbou N. Koubaa A. Echbili M. Hammami N. Attia | 2010 | Journal of Food Composition and Analysis2010，，7： | 1 |
| 13 | Effects of olive oil and its fractions on oxidative stress and the liver's fatty acid composition in 2,4-dichlorophenoxyacetic acid-treated rats显示文摘 | Nakbi A Tayeb W Grissa A Issaoui M Dabbou S Chargui I Ellouz M Miled A Hammami M | | 0，，： | 1 |
| 14 | Evaluation of antioxidant activities of phenolic compounds from two extravirgin olive oils 显示文摘 | NAKBI A ISSAOUI M DABBOU S | 2010 | Journal of Food Composition and Analysis2010，23，： | 1 |
| 15 | Evaluation of antioxidantactivities of phenolic compounds from two extra virgin olive oils显示文摘 | NAKBI A ISSAOUI M DABBOU S | 2010 | Journal of Food Composition and Analysis2010，23，7： | 1 |
| 16 | Homocysteine enhances LDL fatty acid peroxidation, promoting microalbuminuria in type 2 diabetes 显示文摘 | Kassab A Ajmi T Issaoui M | 2008 | Ann Clin Biochem2008，45，5： | 1 |
| 17 | Homocysteine enhances LDL fattyacid peroxidation,promoting microalbuminuria in type 2 diabetes 显示文摘 | Kaesab A Ajmi T Issaoui M | 2008 | Clin Bioehem2008，45，5： | 1 |
| 18 | Homocysteine enhances LDL {arty acid peroxidation,promoting microalbuminuria in type 2 dia- betes显示文摘 | Kassab A Ajmit Issaoui M | 2008 | Ann Clin Biochem2008，45，5： | 1 |
| 19 | Effect of the grow- ing area conditions on differentiation between Chemlali and Chetoui olive oils 显示文摘 | ISSAOUI M FLAMINI G BRAHMI F | 2010 | Food Chemistry2010，119，： | 1 |
| 20 | Influence of oxygen addition on the crystal shape of CVD boron doped diamond显示文摘 | ISSAOUI R ACHARD J SILVA F | 2011 | Phys Status Solid:A2011，208，9： | 1 |
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