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| 1 | 肥胖和动脉老化:Whitehall Ⅱ队列主动脉僵硬度纵向研究显示文摘该研究旨在确定肥胖症是否中年后动脉硬化加速的独立预测因子。纳入Whitehall Ⅱ研究受试者男性3789例,女性1383例,平均年龄66岁,均接受颈-股动脉压检测,4年后再次进行测定。一般肥胖状况由体质量指数,中心肥胖由腰围和腰臀比,脂肪含量百分比由身体阻抗来评估。通过线性混合模型,对年龄、性别、种族和平均动脉压进行调整后,所有肥胖症测量指标与主动脉硬化[通过随访的脉搏波传导速度(pulse wave velocity,PWV)较基线增加值来确定]相关。 | 刘莉 叶鹏 Brunner EJ Shipley MJ Ahmadi-Abhari S Tabak AG McEniery CM Wilkinson IB Marmot MG Singh-Manoux A Kivimaki M | 2015 | 中华高血压杂志2015，23，6： | 8 |
| 2 | Review of the treatment of liver hydatid cysts显示文摘A review was carried out in Medline,LILACS and the Cochrane Library.Our database search strategy included the following terms: 'hydatid cyst','liver','management','meta-analysis' and 'randomized controlled trial'.No language limits were used in the literature search.The latest electronic search date was the 7th of January 2014.Inclusion and exclusion criteria: all relevant studies on the assessment of therapeutic methods for hydatid cysts of the liver were considered for analysis.Information from editorials,letters to publishers,low quality review articles and studies done on animals were excluded from analysis.Additionally,well-structured abstracts from relevant articles were selected and accepted for analysis.Standardized forms were designed for data extraction; two investigators entered the data on patient demographics,methodology,recurrence of HC,mean cyst size and number of cysts per group.Four hundred and fourteen articles were identified using the previously described search strategy.After applying the inclusion and exclusion criteria detailed above,57 articles were selected for final analysis: one meta-analysis,9 randomized clinical trials,5 non-randomized comparative prospective studies,7 non-comparative prospective studies,and 34 retrospective studies(12 comparative and 22 noncomparative).Our results indicate that antihelminthic treatment alone is not the ideal treatment for liver hydatid cysts.More studies in the literature support the effectiveness of radical treatment compared with conservative treatment.Conservative surgery with omentoplasty is effective in preventing postoperative complications.A laparoscopic approach is safe in some situations.Percutaneous drainage with albendazole therapy is a safe and effective alternative treatment for hydatid cysts of the liver.Radical surgery with preand post-operative administration of albendazole is the best treatment option for liver hydatid cysts due to low recurrence and complication rates. | Concepción Gomez i Gavara Rafael López-Andújar Tatiana Belda Ibáez José M Ramia ngel ngel Moya Herraiz Francisco Orbis Castellanos Eugenia Pareja Ibars Fernando San Juan Rodríguez | 2015 | World Journal of Gastroenterology2015，21，1： | 8 |
| 3 | Outcome in obscure gastrointestinal bleeding after capsule endoscopy显示文摘AIM: To investigate the clinical impact of capsule endoscopy(CE) after an obscure gastrointestinal bleeding(OGIB) episode, focusing on diagnostic work-up, followup and predictive factors of rebleeding. METHODS: Patients who were referred to Hospital del Mar(Barcelona, Spain) between 2007 and 2009 for OGIB who underwent a CE were retrospectively analyzed. Demographic data, current treatment with non-steroid antiinflammtory drugs or anticoagulant drugs, hemoglobin levels, transfusion requirements, previous diagnostic tests for the bleeding episode, as well as CE findings(significant or non-significant), work-up and patient out-comes were analyzed from electronic charts. Variables were compared by χ 2 analysis and Student t test. Risk factors of rebleeding were assessed by Log-rank test, Kaplan-Meier curves and Cox regression model. RESULTS: There were 105 patients [45.7% women, median age of 72 years old(interquartile range 56-79)] and a median follow-up of 326 d(interquartile range 123-641) included in this study. The overall diagnostic yield of CE was 58.1%(55.2% and 63.2%, for patients with occult OGIB and overt OGIB, respectively). In 73 patients(69.5%), OGIB was resolved. Multivariate analysis showed that hemoglobin levels lower than 8 g/dL at diagnosis [hazard ratios(HR) = 2.7, 95%CI: 1.9-6.3], patients aged 70 years and above(HR = 2.1, 95%CI: 1.2-6.1) and significant findings in CE(HR = 2.4, 95%CI: 1.1-5.8) were independent predictors of rebleeding. CONCLUSION: One third of the patients presented with rebleeding after CE; risk factors were hemoglobin levels < 8 g/dL, age ≥ 70 years or the presence of significant lesions. | Alex Caas-Ventura Lucia Márque Xavier Bessa Josep Maria DedeuDepartment of Gastroenterology Hospital del Mar Research Institute Pompeu Fabra University Marc Puigvehí Sílvia Delgado-Aros Ines Ana Ibáez Agustin Seoane Luis Barranco Felipe Bory Montserrat Andreu Begoa González-Suárez | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，11： | 4 |
| 4 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 5 | Successful in vivo blockade of CD25 (high-affinity interleukin 2 receptor) on T cellsby administration of humanized anti-Tac antibody to patients with psoriasis显示文摘 | Krueger JG Walters IB Miyazawa M | | 0，，： | 2 |
| 6 | Morphology and clinical outcomes of embryos after in vitro fertilization are superior to those after intracytoplasmic sperm injection显示文摘 | Hava IB Ashkenazi J Shelef M | 1997 | Fertil Steril1997，10，4： | 1 |
| 7 | The relationship between expression of Ku70 and survival in irradiated patientswith endometrial carcinoma 显示文摘 | Saygilia U Gorkayb IB Koyuncuogluc M | 2004 | Gynecologie Oncology2004，95，3： | 1 |
| 8 | Stretch-activated signaling pathways responsible for early response gene expression in fetal lung epithelial cells显示文摘 | Copland IB Post M | 2007 | J Cell Physiol2007，210，1： | 1 |
| 9 | The role of interleukin- 15 in T-cell migration and activation in rheumatoid arthritis 显示文摘 | McInnes IB al-Mughales J Field M | 1996 | Nat Med1996，2，2： | 1 |
| 10 | Protecting the underscreened women in developed countries : the value of HPV test 显示文摘 | Ib~titez R Autonell J Sard~t M | 2014 | BMC Cancer2014，14，1： | 1 |
| 11 | Glycemic Variability: A Hemoglobin Alc Independent Risk Factor for Diabetic Complications 显示文摘 | Brownlee M Hirsch IB | 2006 | JAMA2006，295，14： | 1 |
| 12 | Electrocardiographic recording of long duratian (Hoher) of 24 hours during idiopathic cardiomyopathy of the peripartum 显示文摘 | Diao M Diop IB Kane A | 2004 | Arch Mal Coeur Vaiss2004，97，1： | 1 |
| 13 | Blockade of RAGE suppresses periodontitis-associated bone loss in diabetic mice显示文摘 | Lalla E Lamster IB Feit M | 2000 | J Clin Invest2000，105，8： | 1 |
| 14 | Narrowband (312nm) UV-B suppresses interferon gamma and interleukin (IL) 12 and increases IL-4 transcripts: differential regulation of cytokines at the single-cell level 显示文摘 | Waiters IB Ozawa M Cardinale I | 2003 | Arch Dermatol2003，139，2： | 1 |
| 15 | CXCR4 expression is associated with survival in familial chronic lymphocytic leukemia,but CD38 expression is not显示文摘 | Ishibe N Albitar M Jilani IB | | 0，，： | 1 |
| 16 | Narrow- band(312 nm)UVB suppresses interferon gamma and inter- leukin(IL) 12 and increases IL-4 transcripts differential regu- lation of cytokines at the singlecell level显示文摘 | WALTERS IB OZAWA M CARDINALE I | 2003 | Arch Dermatol2003，139，2： | 1 |
| 17 | 3D rotational angiography: recent experience in the evalution of cerebral aneurysm for treat- ment显示文摘 | Ishihara S Ross IB Piotin M | 2000 | Intervent Neurorad2000，6，2： | 1 |
| 18 | Nasal immu- nization of mice with Lactobacillus casei expressing the Pneumococcal Surface Protein A:induction of antibodies, complement deposition and partial protection against Streptococcus pneumoniae challenge显示文摘 | Campos IB Darrieux M Ferreira DM | 2008 | Microb Infect2008，10，5： | 1 |
| 19 | Salivary levels of tumor necrosis factor-alpha in oral lichen planus显示文摘 | Pezelj-Ribaric S Prso IB Abram M | 2004 | Mediators Inflamm2004，13，2： | 1 |
| 20 | 3D rotational angiography:recent experience in the evaluation of cerebral aneurysms for treatment 显示文摘 | Ishihara S Ross IB Piotin M | 2000 | Intervent Neuroradiol2000，6，： | 1 |
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