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| 1 | Update on the treatment of type 2 diabetes mellitus显示文摘To achieve good metabolic control in diabetes and keep long term, a combination of changes in lifestyle and pharmacological treatment is necessary. Achieving near-normal glycated hemoglobin significantly, decreases risk of macrovascular and microvascular complications. At present there are different treatments, both oral and injectable, available for the treatment of type 2 diabetes mellitus(T2DM). Treatment algorithms designed to reduce the development or progression of the complications of diabetes emphasizes the need for good glycaemic control. The aim of this review is to perform an update on the benefits and limitations of different drugs, both current and future, for the treatment of T2 DM. Initial intervention should focus on lifestyle changes. Moreover, changes in lifestyle have proven to be beneficial, but for many patients is a complication keep long term. Physicians should be familiar with the different types of existing drugs for the treatment of diabetes and select the most effective, safe and better tolerated by patients. Metformin remains the first choice of treatment for most patients. Other alternative or second-line treatment options should be individualized depending on the characteristics of each patient. This article reviews the treatments available for patients with T2 DM, with an emphasis on agents introduced within the last decade. | Juan Jose Marin-Penalver Iciar Martin-Timon Cristina Sevillano-Collantes Francisco Javier del Canizo-Gomez | 2016 | World Journal of Diabetes2016，7，17： | 37 |
| 2 | WJD 5^(th) Anniversary Special Issues(2): Type 2 diabetes Type 2 diabetes and cardiovascular disease: Have all risk factors the same strength?显示文摘Diabetes mellitus is a chronic condition that occurs when the body cannot produce enough or effectively use of insulin.Compared with individuals without diabetes,patients with type 2 diabetes mellitus have a considerably higher risk of cardiovascular morbidity and mortality,and are disproportionately affected by cardiovascular disease.Most of this excess risk is it associated with an augmented prevalence of well-known risk factors such as hypertension,dyslipidaemia and obesity in these patients.However the improved cardiovascular disease in type 2 diabetes mellitus patients can not be attributed solely to the higher prevalence of traditional risk factors.Therefore other non-traditional risk factors may be important in people with type 2 diabetes mellitus.Cardiovascular disease is increased in type 2 diabetes mellitus subjects due to a complex combination of various traditional and non-traditional risk factors that have an important role to play in the beginning and the evolution of atherosclerosis over its long natural history from endothelial function to clinical events.Many of these risk factors could be common history for both di-abetes mellitus and cardiovascular disease,reinforcing the postulate that both disorders come independently from'common soil'.The objective of this review is to highlight the weight of traditional and non-traditional risk factors for cardiovascular disease in the setting of type 2 diabetes mellitus and discuss their position in the pathogenesis of the excess cardiovascular disease mortality and morbidity in these patients. | Iciar Martín-Timón Cristina Sevillano-Collantes Amparo Segura-Galindo Francisco Javier del Caizo-Gómez | 2014 | World Journal of Diabetes2014，5，4： | 32 |
| 3 | Forest Biodiversity Assessment in Peruvian Andean Montane Cloud Forest显示文摘Cloud forests are unusual and fragile habitats, being one of the least studied and least understood ecosystems. The tropical Andean dominion is considered one of the most significant places in the world as regards biological diversity, with a very high level of endemism. The biodiversity was analysed in an isolated remnant area of a tropical montane cloud forest known as the 'Bosque de Neblina de Cuyas', in the North of the Peruvian Andean range. Composition, structure and dead wood were measured or estimated. The values obtained were compared with other cloud forests. The study revealed a high level of forest biodiversity, although the level of biodiversity differs from one area to another: in the inner areas, where human pressure is almost inexistent, the biodiversity values increase. The high species richness and the low dominance among species bear testimony to this montane cloud forest as a real enclave of biodiversity. | Alicia Ledo Sonia Condés Iciar Alberdi | 2012 | Journal of Mountain Science2012，9，3： | 5 |
| 4 | Mechanisms of hypoglycemia unawareness and implications in diabetic patients显示文摘Hypoglycemia unawareness(HU) is defined at the onset of neuroglycopenia before the appearance of autonomic warning symptoms.It is a major limitation to achieving tight diabetes and reduced quality of life.HU occurs in approximately 40% of people with type 1 diabetesmellitus(T1DM) and with less frequency in T2 DM.Though the aetiology of HU is multifactorial,possible mechanisms include chronic exposure to low blood glucose,antecedent hypoglycaemia,recurrent severe hypoglycaemia and the failure of counter-regulatory hormones.Clinically it manifests as the inability to recognise impeding hypoglycaemia by symptoms,but the mechanisms and mediators remain largely unknown.Prevention and management of HU is complex,and can only be achieved by a multifactorial intervention of clinical care and structured patient education by the diabetes team.Less know regarding the impact of medications on the development or recognition of this condition in patients with diabetes.Several medications are thought to worsen or promote HU,whereas others may have an attenuating effect on the problem.This article reviews recent advances in how the brain senses and responds to hypoglycaemia,novel mechanisms by which people with insulin-treated diabetes develop HU and impaired counter-regulatory responses.The consequences that HU has on the person with diabetes and their family are also described.Finally,it examines the evidence for prevention and treatment of HU,and summarizes the effects of medications that may influence it. | Iciar Martín-Timón Francisco Javier del Canizo-Gómez | 2015 | World Journal of Diabetes2015，6，7： | 3 |
| 5 | Analysis of volatile compounds by GC–MS of a dry fermented sausage: chorizo de Pamplona显示文摘 | Diana Ansorena Olga Gimeno Iciar Astiasarán José Bello | 2001 | Food Research International2001，，1： | 2 |
| 6 | Universal and rapid salt extraction of high qualitygenomic DNA for PCR based techniques显示文摘 | SALAH M ICIAR M | 1997 | Nucleic Acids Res1997，25，22： | 1 |
| 7 | Universal and rapid salt-extraction of high quality genomic DNA for PCR-based techniques显示文摘 | Salah M A Iciar M | 1997 | Nucleic Acids Research1997，25，22： | 1 |
| 8 | Estimation of freezing storage time and quality changes in hake ( Merluccius merluccius , L.) by low field NMR显示文摘 | Isabel Sánchez-Alonso Iciar Martinez Javier Sánchez-Valencia Mercedes Careche | 2012 | Food Chemistry2012，，3： | 1 |
| 9 | Composition of p~tt6s elaborated with mackerel flesh (Scomber scombrus) and tuna liver (Thunnus thynnus): comparison with commercial fish p~t6s显示文摘 | Yolanda Aquerreta Iciar Astiasarfin | 2002 | Food Chemistry2002，2，77： | 1 |
| 10 | Species identification of formed fishery products and high pressure-treated fish by electrophoresis:a collaborative study显示文摘 | Monique Etienne Marc Jér(o)me Jo(e)l Fleurence Hartmut Rehbein Rainer Kündiger Rogério Mendes Helena Costa and Iciar Martínez | 2001 | Food Chemistry2001，72，1： | 1 |
| 11 | Species identification of cooked fish by urea isoelectric focusing and sodium dodecylsulfate polyacrylamide gel electrophoresis:a collaborative study显示文摘 | Hartmut Rehbein Rainer Kündiger Ingrid Malmheden Yman Monica Ferm Monique Etienne Marc Jerome Anne Craig lan Mackie Flemming Jessen Iciar Martinez | 1999 | Food Chemistry1999，67，4： | 1 |
| 12 | Postmortem muscle protein degradation during ice -storage of Arctic(Pandalus borealis ) and tropical ( Penaeus japonic us andPenaeus monodon) shrimps : a comparative electrophoretic andimmunological study显示文摘 | Iciar Martinez Tone Jakobsen Friis Mercedes Careche | 2001 | Journal of the Science of Food andAgriculture2001，81，： | 1 |
| 13 | Universal and rapid salt-extraction of high quality genomic DNA for PCR-basee techniques显示文摘 | Salah M A Iciar M | 1997 | Nucleic Acids Res1997，25，22： | 1 |
| 14 | Universal and rapid salt-extraction ofhigh quality genomic DNA for PCR-based techniques显示文摘 | Salah M A Iciar M | 1997 | Nucl Acids Res1997，25，46： | 1 |
| 15 | Universal and rapid salt-extraction of high quality genomic DNA for PCR-based techniques显示文摘 | Salah M A Iciar M | 1997 | Nucleic Acids Research1997，22，25： | 1 |
| 16 | Universal and rapid salt-extraction of high quality genomic DNA for PCR-based techniques 显示文摘 | Salah M Aljanabi Iciar Martinez | | Nuleic Acids Research !9970，，： | 1 |
| 17 | Universal and rapid salt-extraction of high quality genomic DNA for PCR-based techniques显示文摘 | Salah M A Iciar M | 1997 | Nucleic Acids Reserch1997，22，25： | 1 |
| 18 | Analysis of volatile compounds by GC-MS of a dry fermented sausage : chorizo de Pamplona显示文摘 | Diana Anasorena Olga Gimeno Iciar Astiasaran | 2001 | Food Research International2001，34，： | 1 |
| 19 | Species identification in meat products by RAPD analysis显示文摘 | Iciar Martineza Ingrid Malmheden Yman | 1998 | Food Research International1998，31，67： | 1 |
| 20 | Cloning, expression and functional characterization of chicken CCR6 and its ligand CCL20 显示文摘 | ICIAR M MAGALI B CLAIRE B | 2009 | Molecular Immunology2009，47，： | 1 |
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