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| 1 | New perspectives in occult hepatitis C virus infection显示文摘Occult hepatitis C virus (HCV) infection, defined as the presence of HCV RNA in liver and in peripheral blood mononuclear cells (PBMCs) in the absence of detectable viral RNA in serum by standard assays, can be found in anti-HCV positive patients with normal serum levels of liver enzymes and in anti-HCV negative patients with persistently elevated liver enzymes of unknown etiology. Occult HCV infection is distributed worldwide and all HCV genotypes seem to be involved in this infection. Occult hepatitis C has been found not only in anti-HCV positive subjects with normal values of liver enzymes or in chronic hepatitis of unknown origin but also in several groups at risk for HCV infection such as hemodialysis patients or family members of patients with occult HCV. This occult infection has been reported also in healthy populations without evidence of liver disease. Occult HCV infection seems to be less aggressive than chronic hepatitis C although patients affected by occult HCV may develop liver cirrhosis and even hepatocellular carcinoma. Thus, anti-HCV negative patients with occult HCV may benefit from antiviral therapy with pegylated-interferon plus ribavirin. The persistence of very low levels of HCV RNA in serum and in PBMCs, along with the maintenance of specific T-cell responses against HCV-antigens observed during a long-term follow-up of patients with occult hepatitis C, indicate that occult HCV is a persistent infection that is not spontaneously eradicated. This is an updated report on diagnosis, epidemiology and clinical implications of occult HCV with special emphasis on anti-HCV negative cases. | Vicente Carreño Javier Bartolomé Inmaculada Castillo Juan Antonio Quiroga | 2012 | World Journal of Gastroenterology2012，18，23： | 5 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Copper(Ⅰ)-contai- ning supported ionic liquid membranes for carbon mon- oxide/nitrogen separation 显示文摘 | Gabriel Z Inmaculada O Ane U | 2013 | Journal of MembraneScience2013，438，： | 1 |
| 4 | Usefulness of D-optimal designs and multicriteria optimization in laborious analytical procedures Application to the extraction of quinolones from eggs 显示文摘 | INMACULADA G LUIS S CRUZ O M | 2005 | J Chromatogr A2005，1085，： | 1 |
| 5 | Quantification of uncertainties involved in the conformational study of polymers by light scattering显示文摘 | Inmaculada S Baudilio O | 2011 | European Polymer Journal2011，47，12： | 1 |
| 6 | The Primary Obesity Surgery Endolumenal (POSE) procedure: one-year patient weight loss and safety outcomes显示文摘 | Gontrand López-Nava Brevière Inmaculada Bautista-Casta?o Amaya Jimenez Teresa de Grado Juan Pedro Fernandez-Corbelle | 2014 | Surgery for Obesity and Related Diseases2014，，： | 1 |
| 7 | Ionotropic glutamate receptor subunits are differentially regulated in the motoneuronal pools of the rat hypoglossal nucleus in response to axotomy显示文摘 | Gontzal García Del Ca?o Inmaculada Gerrikagoitia Manuel Sarasa Carlos Matute Luis Martínez-Millán | 2000 | Journal of Neurocytology2000，，7： | 1 |
| 8 | Application of supereritical CO2 etraction for the elimination of odorant volatile compounds from winemaking inactive dry yeast preparation显示文摘 | MARIA P B INMACULADA A O MENDIOLA J A | 2010 | Journal of Agricultural and Food Chemistry2010，58，6： | 1 |
| 9 | Role of specific components from commercial inactive dry yeast winemaking preparations on the growth of wine lactic acid bacteria 显示文摘 | Inmaculada A O Maria A P Almudcna G R | 2010 | Journal of Agricultural and Food Chemistry2010，58，14： | 1 |
| 10 | Production of xyloglucanolytic enzymes by Trichoderma viride, Paecilomyces farinosus, Wardomyces inflatus, and Pleurotus ostreatus 显示文摘 | Mohamed T Juan A O Inmaculada G R | 2002 | Mycologia2002，94，： | 1 |
| 11 | Detection of anti- Leishmania infantum antibodies in sylvatic lagomorphs from an epidemic area of Madrid using the indirect immunofluorescence antibody test显示文摘 | Inmaculada Moreno Julio álvarez Nerea García Santiago de la Fuente Irene Martínez Eloy Marino Alfredo Tora?o Joaquin Goyache Felipe Vilas Lucas Domínguez Mercedes Domínguez | 2014 | Veterinary Parasitology . 2014 (3-4)2014，，： | 1 |
| 12 | Radiation protection for the interventional cardiologist:Practical approach and innovations显示文摘Use of ionizing radiation during cardiac catheterization interventions adversely impacts both the patients and medical staff.In recent years,radiation dose in cardiac catheterization interventions has become a topic of increasing interest in interventional cardiology and there is a strong interest in reducing radiation exposure during the procedures.This review presents the current status of radiation protection in the cardiac catheterization laboratory and summarizes a practical approach for radiation dose management for minimizing radiation exposure.This review also presents recent innovations that have clinical potential for reducing radiation during cardiac interventions. | Alejandro Gutierrez-Barrios Dolores Cañadas-Pruaño Inmaculada Noval-Morillas Livia Gheorghe Ricardo Zayas-Rueda German Calle-Perez | 2022 | World Journal of Cardiology2022，14，1： | 0 |
| 13 | Present and future management of viral hepatitis显示文摘Viral hepatitis can result in important morbidity and mortality,with its impact on health conditioned by the specific type of hepatitis,the geographical region of presentation and the development and access to new drugs,among other factors.Most acute presentation forms are self-limiting and may even go unnoticed,with just a small percentage of cases leading to acute liver failure that may necessitate transplantation or even cause the death of the patient.However,when they become chronic,as in the case of hepatitis B virus and C virus,unless they are diagnosed and treated adequately they may have severe consequences,like cirrhosis or hepatocarcinoma.Understanding of the mechanisms of transmission,the pathogenesis,the presence of vaccinations and the development over recent years of new highly-efficient,potent drugs have meant that we are now faced with a new scenario in the management of viral hepatitis,particularly hepatitis B virus and hepatitis C virus.The spectacular advances in hepatitis C virus treatment have led the World Health Organization to propose the objective of its eradication by 2030.The key aspect to achieving this goal is to ensure that these treatments reach all the more vulnerable population groups,in whom the different types of viral hepatitis have a high prevalence and constitute a niche that may perpetuate infection and hinder its eradication.Accordingly,microelimination programs assume special relevance at the present time. | Rocío González Grande Inmaculada Santaella Leiva Susana López Ortega Miguel Jiménez Pérez | 2021 | World Journal of Gastroenterology2021，27，47： | 0 |
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