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| 1 | Influence of hepatitis viruses on clinico-pathological profiles and long-term outcome in patients undergoing surgery for hepatocellular carcinoma显示文摘BACKGROUND: The global risk of hepatocellular carcinoma(HCC) is largely due to hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. In recent years, however, an increased prevalence of non-viral HCC has been noted. The clinical impact of the presence/absence of viral infections in HCC remains controversial. The present study aimed to assess the effect of hepatitis viruses on demographics, clinical and pathological features and long-term outcome in a large cohort of Romanian patients who underwent surgery for HCC. METHODS: The study included 404 patients with HCC who had undergone resection, transplantation or radiofrequency ablation at a single institution between 2001 and 2010. The patients were divided into four groups: 85 patients with hepatitis B virus infection (HBV group), 164 patients with hepatitis C virus infection (HCV group), 39 patients with hepatitis B and C virus co-infection (HBCV group), and 116 patients without viral infection (non-BC group). RESULTS: The patients of both HBV (56.0±11.3 years) and HBCV groups (56.0±9.9 years) were significantly younger than those of the HCV (61.0±8.5 years, P=0.001) and non-BC groups(61.0±13.0 years, P=0.002). Interestingly, the prevalence of liver cirrhosis was significantly lower in the non-BC group (47%)than in any other subsets (72%-90%, P<0.002). Furthermore, the non-BC patients were more advanced according to the Barcelona Clinic Liver Cancer stages than the patients of the HCV or HBCV groups (P<0.020); accordingly, they were more frequently assessed beyond the Milan criteria than any other groups (P=0.001). No significant differences in the disease-free or overall survival rates were observed among these groups. CONCLUSIONS: Patients with non-viral HCC are diagnosed at advanced ages and stages, a situation plausibly due to the poor effectiveness of cancer surveillance in community practice. The presence of viral infections does not appear to impair the longterm prognosis after surgical treatment in patients with HCC; however, there is a trend for worse disease-free survival rates in HBCV patients, though statistical significance was not reached. | Anna-Maria Tanase Traian Dumitrascu Simona Dima Razvan Grigorie Agnes Marchio Pascal Pineau Irinel Popescu | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，2： | 7 |
| 2 | Determination of the 5-fluorouracil and Nl(2-furanidyl)uracil in the presence of tegafur by zero-crossing first derivative spectrometry 显示文摘 | IRINEL B DANA M AUREL T | 2002 | J Pharm Biomed Anal2002，30，： | 1 |
| 3 | In vitro hepatic differentiation of human bone marrow mesenchymal stem cells under differential exposure to liver-specific factors显示文摘 | Mihaela Chivu Simona O. Dima Cosmin I. Stancu Camelia Dobrea Valentina Uscatescu Laura G. Necula Coralia Bleotu Cristiana Tanase Radu Albulescu Carmen Ardeleanu Irinel Popescu | 2009 | Translational Research2009，，3： | 1 |
| 4 | Deliberate external pancreatic fistula after pancreaticoduodenectomy performed in the setting of acute pancreatitis, and its internalization through fistula-jejunostomy显示文摘To the Editor:Many patients with tumors of the pancreatic head or of the ampulla of Vater require endoscopic manipulation of the duodenal papilla in order to achieve tumor biopsy or for common bile duct stenting.These interventional endoscopy approaches may lead to acute pancreatitis.The iatrogenic acute pancreatitis will influence the surgical strategy in patients scheduled for pancreaticoduodenectomy(PD).Due to the small number of cases,the surgical strategy in patients who require PD in the context of acute pancreatitis has not been standardized. | Sorin T Alexandrescu Andrei C Zlate Razvan T Grigorie Mihnea Ionescu Irinel Popescu | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，1： | 1 |
| 5 | Rheumatoid arthritis 显示文摘 | Lars Klareskog Anca Irinel Catrina Stephen Paget | 2009 | The Lancet2009，373，2： | 1 |
| 6 | High plasma levels of COL10A1 are associated with advanced tumor stage in gastric cancer patients显示文摘BACKGROUND Gastric cancer(GC)remains an aggressive malignancy with a high rate of mortality,being the third leading cause of cancer-related death.More than one million newly diagnosed cases and 782685 deaths due to GC were reported in 2018.GC is characterized by limited effective treatment options and the lack of consistent biomarkers for the diagnosis and prognosis of these patients.The discovery of new biomarkers useful in the early diagnosis of GC is mandatory.AIM To evaluate the potential of COL10A1 as a circulating biomarker for the diagnosis and prognosis of gastric adenocarcinoma patients.METHODS Plasma and tissue obtained from 49 patients with gastric adenocarcinoma have been used in exploring the expression of COL10A1.Real-time PCR and western blot techniques were used to evaluate COL10A1 level in gastric tumor tissue compared to normal adjacent tissue.The circulating level of COL10A1 was also evaluated by ELISA in plasma of gastric adenocarcinoma patients.Survival analysis was made in order to evaluate the potential of COL10A1 as a biomarker for the diagnosis and prognosis of gastric adenocarcinoma patients.RESULTS Our results showed a significant increase in COL10A1 gene expression and protein levels in gastric tumor tissue compared to adjacent normal tissue(P<0.05).COL10A1 seems to show an elevated expression from the beginning of carcinogenesis,in the early stages,and its increased level remains elevated during cancer progression.A significant increase of COL10A1 plasma level in gastric adenocarcinoma patients was also identified.Moreover,increased COL10A1 plasma level was associated with poor survival of the patients.Plasma COL10A1 performed a diagnostic value in GC with area under the receiver operating characteristic curve(AUC)of 0.9171(P=0.0002),sensitivity of 87.76%,and specificity of 100.0%.Furthermore,this study demonstrated the potential role of plasma COL10A1 in the early detection of GC,as in the early stage,we obtained an AUC of 0.8789(P=0.0030),sensitivity of 81.25%,and specificity of 100.0%.CONCLUSION Circulating expression level of COL10A1 is significantly increased in gastric adenocarcinoma patients being associated with poor survival and is a potential biomarker for early detection of GC. | Laura Necula Lilia Matei Denisa Dragu Ioana Pitica Ana Iulia Neagu Coralia Bleotu Simona Dima Irinel Popescu Carmen C Diaconu Mihaela Chivu-Economescu | 2020 | World Journal of Gastroenterology2020，26，22： | 1 |
| 7 | Resection for Hilar Cholangiocarcinoma: Analysis of Prognostic Factors and the Impact of Systemic Inflammation on Long-term Outcome显示文摘 | Traian Dumitrascu Dragos Chirita Mihnea Ionescu Irinel Popescu | 2013 | Journal of Gastrointestinal Surgery2013，，： | 1 |
| 8 | Rheumatoid arthritis显示文摘 | Lars Klareskog Anca Irinel Catrina Stephen Paget | 2009 | The Lancet2009，，9664： | 1 |
| 9 | Rheumatoid arthritis显示文摘 | Lars Klareskog Anca Irinel Catrina Stephen Paget | 2009 | The Lancet2009，，9664： | 1 |
| 10 | Neuroendocrine tumours of the ampulla of Vater: clinico-pathological features, surgical approach and assessment of prognosis显示文摘 | Traian Dumitrascu Simona Dima Vlad Herlea Victor Tomulescu Mihnea Ionescu Irinel Popescu | 2012 | Langenbeck’s Archives of Surgery2012，，6： | 1 |
| 11 | Rheumatoid arthritis显示文摘 | Lars Klareskog Anca Irinel Catrina Stephen Paget | 2009 | The Lanoet Seminar2009，373，9664： | 1 |
| 12 | Posterior versus standard approach in pancreatoduodenectomy: a case-match study显示文摘 | Traian Dumitrascu Leonard David Irinel Popescu | 2010 | Langenbeck’s Archives of Surgery2010，，6： | 1 |
| 13 | The inhibitor of death receptors signaling,FLICE-inhibitory protein defines a new loss of tumor progression factors显示文摘 | Mounira D Valentina S Anca Irinel C | 1999 | Exp Med1999，190，： | 1 |
| 14 | Antitumor necrosis factor therapy increases synovial osteoprotegerin expression in rheumatoid arthritis显示文摘 | Anca Irinel Catrina Erikaf Klint Sofia Ernestam | 2006 | Arthritis & Rheumatism2006，54，1： | 1 |
| 15 | Recurrence Patterns and Prognostic Factors in Patients with Hepatocellular Carcinoma in Noncirrhotic Liver: A Multi-Institutional Analysis显示文摘 | Dean J. Arnaoutakis Michael N. Mavros Feng Shen Sorin Alexandrescu Amin Firoozmand Irinel Popescu Matthew Weiss Christopher L. Wolfgang Michael A. Choti Timothy M. Pawlik | 2014 | Annals of Surgical Oncology2014，，1： | 1 |
| 16 | Rheumatoid arthritis显示文摘 | Lars Klareskog Anca Irinel Catrina Stephen Paget | | 0，，02： | 1 |
| 17 | Male gender and increased body mass index independently predicts clinically relevant morbidity after spleen-preserving distal pancreatectomy显示文摘AIM To identify risk factors for clinically relevant complications after spleen-preserving distal pancreatectomy(SPDP). No previous studies explored potential predictors of morbidity after SPDP.METHODS The data of 41 patients who underwent a SPDP in a single surgical center between 2000 and 2015 were retrospectively reviewed from a prospectively maintained electronic database established in our Department of Surgery. The database included demographic, clinical, bioumoral, pathological, intraoperative and postoperative parameters. Uni-and multivariate ana-lyses were performed to assess potential predictors of clinically relevant morbidity. Postoperative morbidity was defined as in-hospital complications and mortality was assessed at 90 d. Clinically relevant morbidity was defined as complication ≥ grade 2 Dindo.RESULTS Overall morbidity rate was 34.1%(14 patients): grade Ⅰ(6 patients, 14.6%), grade Ⅱ(2 patients, 4.8%), grade Ⅲa(1 patient, 2.4%), and grade Ⅲb(5 patients, 12.2%). A number of 5 patients(12.2%) required re-laparotomy for postoperative complications. There was no postoperative mortality. Thus, at least one clinically relevant complication occurred in 8 patients(19.5%). Univariate analysis identified male gender(P = 0.034), increased body mass index(P = 0.002) and neuroendocrine pathology(P = 0.013) as statistically significant risk factors. Multivariate analysis identified male gender [odds ratio(OR): 1.29, 95%CI: 1.07-1.55, P = 0.005] and increased body mass index(OR: 23.18, 95%CI: 1.72-310.96, P = 0.018) as the only independent risk factors of clinically relevant morbidity after SPDP.CONCLUSION Male gender and increased body mass index are independently associated with increased risk of clinically relevant morbidity after SPDP. These findings may assist a surgeon in clinical decision-making to better select patients suitable for SPDP. | Traian Dumitrascu Mihai Eftimie ANDra Aiordachioae Cezar Stroescu Simona Dima Mihnea Ionescu Irinel Popescu | 2018 | World Journal of Gastrointestinal Surgery2018，10，8： | 0 |
| 18 | 类风湿关节炎显示文摘类风湿关节炎是一种系统性、炎性自身免疫性疾病。、对其分子机制的深入理解促进了以免疫系统特定组分为靶点的新型生物制剂的研发:这些治疗方法使得类风湿关节炎的病程和表现得以改观,也改变了该病对患者及社会的影响。关于类风湿关节炎主要亚类的发病机制中环境因素与易感基因及免疫系统之间的交互作用出现了一些新的认识对于关节炎症纵向病程和分子病理学方面的研究促使治疗策略发生转变,如早期应用缓解病情药物以积极控制病情,以及明确的可量化的治疗目标。 | Lars Klareskog Anca Irinel Catrina Stephen Paget 李覃(译) | 2009 | 世界临床医学2009，，9： | 0 |
| 19 | On the Semivalues and the Least Square Values Average Per Capita Formulas and Relationships显示文摘在这份报纸,合作可转让的实用程序游戏的 Semivalues 和最少平方值能以 2 游戏,借助于我们把一般水准称为人均的公式的典型函数的值平均的 n 被表示,这被显示出。而且公式的术语象更早考虑的 Shapley 价值的盒子一样,能在平行,和一个算法被计算被导出。从这些结果,因而,每二价值上面提到比赛的 Shapley 价值容易从给定的比赛被获得,并且这个事实给另一个计算机会,一旦 Shapley 价值的计算高效地被做。关键词 Shapley 价值 - Semivalues - 最不方形的价值 - 平均人均的公式 - Banzhaf 价值先生(2000 ) 题目分类 | Irinel DRAGAN | 2006 | Acta Mathematica Sinica,English Series2006，22，5： | 0 |
| 20 | Severe liver trauma with complex portal and common bile duct avulsion:A case report and review of the literature显示文摘BACKGROUND Given its size and location,the liver is the third most injured organ by abdominal trauma.Thanks to recent advances,it is unanimously accepted that the nonoperative management is the current mainstay of treatment for hemodynamically stable patients.However,those patients with hemodynamic instability that generally present with severe liver trauma associated with major vascular lesions will require surgical management.Moreover,an associated injury of the main bile ducts makes surgery compulsory even in the case of hemodynamic stability,thereby imposing therapeutic challenges in the tertiary referral hepato-biliopancreatic centers’setting.CASE SUMMARY We present the case of a 38-year-old male patient with The American Association for the Surgery of Trauma grade V liver injury and an associated right branch of portal vein and common bile duct avulsion,due to a crush polytrauma.The patient was referred to the nearest emergency hospital and because of the hemorrhagic shock,damage control surgery was performed by means of ligation of the right portal vein branch and right hepatic artery,and hemostatic packing.Afterwards,the patient was referred immediately to our tertiary hepato-bilio-pancreatic center.We performed depacking,a right hepatectomy and Roux-en-Y hepaticojejunostomy.On the 9th postoperative day,the patient developed a high output anastomotic bile leak that required a redo of the cholangiojejunostomy.The postoperative period was marked by a surgical incision site of incomplete evisceration that was managed non-operatively by negative wound pressure.The follow-up was optimal,with no complications at 55 mo.CONCLUSION In conclusion,the current case clearly supports that a favorable outcome in severe liver trauma with associated vascular and biliary injuries is achieved thru proper therapeutic management,conducted in a tertiary referral hepato-bilio-pancreatic center,where a stepwise and complex surgical approach is mandatory. | Bianca Mitricof Alin Kraft Florentina Anton Alexandru Barcu Darina Barzan Carmen Haiducu Vladislav Brasoveanu Irinel Popescu Cosmin Alec Moldovan Florin Botea | 2023 | World Journal of Clinical Cases2023，11，16： | 0 |
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