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| 1 | Cognitive disorder and dementia in type 2 diabetes mellitus显示文摘Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and brain.In the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative diseases.At the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are decreased.Clinical and animal model studies suggest that memory improvements are due to changes in insulin levels.Furthermore,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis development.Conversely, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, and could be a specific target for therapeutic strategies to decreasealterations associated with age-related cognitive decline. | Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela | 2022 | World Journal of Diabetes2022，13，4： | 2 |
| 2 | Antibiotic ter- penoid chlorodihydroquinones from a new marine actinomycete 显示文摘 | IRMA E S M ALEJANDRA P D PAUL R J | 2005 | J Natur Prod2005，68，6： | 1 |
| 3 | Antibiotic terpenoid chloro-dihydroquinones from a new marine actinomycete 显示文摘 | Irma E S M Alejandra P D Jensen P R | 2005 | J Nat Prod2005，68，6： | 1 |
| 4 | Antibiotic terpenoid chloro-dihydroquinones from a new marine actinomycete显示文摘 | Irma E S Alejandra P Paul R J | 2005 | J Nat Prod2005，68，： | 1 |
| 5 | Mutations in AXIN2 Cause Familial Tooth Agenesis and Predispose to Colorectal Cancer显示文摘 | Laura Lammi Sirpa Arte Mirja Somer Heikki J?rvinen P?ivi Lahermo Irma Thesleff Sinikka Pirinen Pekka Nieminen | 2004 | The American Journal of Human Genetics2004，，5： | 1 |
| 6 | Egetables collected in the cultivated Andean area of northern Chile:total and inorganic arsenic contents in raw vegetables显示文摘 | Ociel M Oscar P D Irma L | | 0，，： | 1 |
| 7 | Levels and correlates of knowledge about cancer risk factors among 13,293 public school students in Morelos,Mexico显示文摘 | Irma P Betania A Silvia R | 2004 | Preventive Medicine2004，3，9： | 1 |
| 8 | The activity of the 20S proteasome is maintained in detached wheat leaves during senescence in darkness显示文摘 | Irma R Pedro F M Susana P | 2002 | Plant Physiol Biochem2002，40，： | 1 |
| 9 | Vegetables collected in the cultivated Andean area of northern Chile:total and inorganic arsenic contents in raw vegetables 显示文摘 | Ociel M Oscar P D Irma L el al | 2002 | Journal of Agricultural and Food Chemistry2002，50，： | 1 |
| 10 | Contribution of water, bread, and vegetables ( raw and cooked )to dietary intake of inorganic arsenic in a rural village of northern Chile显示文摘 | Oscar P D Irma L Ociel M el al | 2004 | Journal of Agricultural and Food Chemistry2004，52，： | 1 |
| 11 | Parental rearing styles and personality disorders in prisoners and forensic patients显示文摘 | Irma G H Timmerman P M G E | 2005 | Clinical Psychology & Psychotherapy2005，12，3： | 1 |
| 12 | Individual venom variability in the South American rattlesnake Crotalus durissus cumanensis显示文摘 | Irma Aguilar Belsy Guerrero Ana Maria Salazar Maria E. Girón John C. Pérez Elda E. Sánchez Alexis Rodríguez-Acosta | 2007 | Toxicon2007，，2： | 1 |
| 13 | 15 Laccase 显示文摘 | Octavio L C Cristina Irma P P Ma Rieardo B R J | 2006 | Advances in Agricultural and Food Biotechnology2006，，： | 1 |
| 14 | Vegetables collected in the cultivated Andean area of northern Chile:total and inorganic arsenic contents in raw vegetables显示文摘 | Ociel M Oscar P D Irma L | 2002 | Journal of Agricultural and Food Chemistry2002，50，： | 1 |
| 15 | Contribution of water, bread and vegetables (raw and cooked) to dietary intake of inorganic arsenic in a rural village of northern Chile 显示文摘 | Oscar P D Irma L Ociel M | 2004 | Journal of Agricultural and Food Chemistry2004，52，： | 1 |
| 16 | The Global Soil Mycobiome consortium dataset for boosting fungal diversity research显示文摘Fungi are highly important biotic components of terrestrial ecosystems,but we still have a very limited understanding about their diversity and distribution.This data article releases a global soil fungal dataset of the Global Soil Mycobiome consortium(GSMc)to boost further research in fungal diversity,biogeography and macroecology.The dataset comprises 722,682 fungal operational taxonomic units(OTUs)derived from PacBio sequencing of full-length ITS and 18S-V9 variable regions from 3200 plots in 108 countries on all continents.The plots are supplied with geographical and edaphic metadata.The OTUs are taxonomically and functionally assigned to guilds and other functional groups.The entire dataset has been corrected by excluding chimeras,index-switch artefacts and potential contamination.The dataset is more inclusive in terms of geographical breadth and phylogenetic diversity of fungi than previously published data.The GSMc dataset is available over the PlutoF repository. | Leho Tedersoo Vladimir Mikryukov Sten Anslan Mohammad Bahram Abdul Nasir Khalid Adriana Corrales Ahto Agan Aída-M.Vasco-Palacios Alessandro Saitta Alexandre Antonelli Andrea C.Rinaldi Annemieke Verbeken Bobby P.Sulistyo Boris Tamgnoue Brendan Furneaux Camila Duarte Ritter Casper Nyamukondiwa Cathy Sharp César Marín D.Q.Dai Daniyal Gohar Dipon Sharmah Elisabeth Machteld Biersma Erin K.Cameron Eske De Crop Eveli Otsing Evgeny A.Davydov Felipe E.Albornoz Francis Q.Brearley Franz Buegger Genevieve Gates Geoffrey Zahn Gregory Bonito Indrek Hiiesalu Inga Hiiesalu Irma Zettur Isabel C.Barrio Jaan Pärn Jacob Heilmann-Clausen Jelena Ankuda John Y.Kupagme Joosep Sarapuu Jose G.Maciá-Vicente Joseph Djeugap Fovo József Geml Juha M.Alatalo Julieta Alvarez-Manjarrez Jutamart Monkai Kadri Põldmaa Kadri Runnel Kalev Adamson Kari A.Bråthen Karin Pritsch Kassim I.Tchan Kęstutis Armolaitis Kevin D.Hyde Kevin K.Newsham Kristel Panksep Lateef A.Adebola Louis J.Lamit Malka Saba Marcela Eda Silva Cáceres Maria Tuomi Marieka Gryzenhout Marijn Bauters Miklós Bálint Nalin Wijayawardene Niloufar Hagh-Doust Nourou S.Yorou Olavi Kurina Peter E.Mortimer Peter Meidl RHenrik Nilsson Rasmus Puusepp Rebeca Casique-Valdés Rein Drenkhan Roberto Garibay-Orijel Roberto Godoy Saleh Alfarraj Saleh Rahimlou Sergei Põlme Sergey V.Dudov Sunil Mundra Talaat Ahmed Tarquin Netherway Terry W.Henkel Tomas Roslin Vladimir E.Fedosov Vladimir G.Onipchenko WAErandi Yasanthika Young Woon Lim Meike Piepenbring Darta Klavina Urmas Kõljalg Kessy Abarenkov | 2021 | Fungal Diversity2021，，6： | 0 |
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