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| 1 | Para-aortic lymph node involvement should not be a contraindication to resection of pancreatic ductal adenocarcinoma显示文摘BACKGROUND Para-aortic lymph nodes(PALN)are found in the aortocaval groove and they are staged as metastatic disease if involved by pancreatic ductal adenocarcinoma(PDAC).The data in the literature is conflicting with some studies having associated PALN involvement with poor prognosis,while others not sharing the same results.PALN resection is not included in the standard lymphadenectomy during pancreatic resections as per the International Study Group for Pancreatic Surgery and there is no consensus on the management of these cases.AIM To investigate the prognostic significance of PALN metastases on the oncological outcomes after resection for PDAC.METHODS This is a retrospective cohort study of data retrieved from a prospectively maintained database on consecutive patients undergoing pancreatectomies for PDAC where PALN was sampled between 2011 and 2020.Statistical comparison of the data between PALN+and PALN-subgroups,survival analysis with the Kaplan-Meier method and risk analysis with univariable and multivariable time to event Cox regression analysis were performed,specifically assessing oncological outcomes such as median overall survival(OS)and disease-free survival(DFS).RESULTS 81 cases had PALN sampling and 17(21%)were positive.Pathological N stage was significantly different between PALN+and PALN-patients(P=0.005),while no difference was observed in any of the other characteristics.Preoperative imaging diagnosed PALN positivity in one case.OS and DFS were comparable between PALN+and PALN-patients with lymph node positive disease(OS:13.2 mo vs 18.8 mo,P=0.161;DFS:13 mo vs 16.4 mo,P=0.179).No difference in OS or DFS was identified between PALN positive and negative patients when they received chemotherapy either in the neoadjuvant or in the adjuvant setting(OS:23.4 mo vs 20.6 mo,P=0.192;DFS:23.9 mo vs 20.5 mo,P=0.718).On the contrary,when patients did not receive chemotherapy,PALN disease had substantially shorter OS(5.5 mo vs 14.2 mo;P=0.015)and DFS(4.4 mo vs 9.8 mo;P<0.001).PALN involvement was not identified as an independent predictor for OS after multivariable analysis,while it was for DFS doubling the risk of recurrence.CONCLUSION PALN involvement does not affect OS when patients complete the indicated treatment pathway for PDAC,surgery and chemotherapy,and should not be considered as a contraindication to resection. | Rupaly Pande Shafiq Chughtai Manish Ahuja Rachel Brown David C Bartlett Bobby V Dasari Ravi Marudanayagam Darius Mirza Keith Roberts John Isaac Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastrointestinal Surgery2022，14，5： | 2 |
| 2 | Removal of lead and cadmium ions from water using annona squamosa shell: Kinetic and equilibrium studies显示文摘 | Isaac C P J Sivakumar A | 2013 | Desalination and Water Treat- ment2013，51，40： | 1 |
| 3 | Expression of class III beta tubulin in non-small cell lung cancer is correlated with resistance to taxane chemotherapy 显示文摘 | Dumontet C Isaac S Souquet P J | 2005 | Bull Cancer2005，92，2： | 1 |
| 4 | MMCs for automotive engine applications显示文摘 | Isaacs J A Clark J P | 1996 | JOM1996，48，2： | 1 |
| 5 | Expression of class Ⅲ beta tubulin is predictive of patient outcome in patients with non-smallcell lung cancer receiving vinorelbine-based chemotherapy显示文摘 | Dumontet C Sere P Isaac S | 2005 | Lung Cancer2005，49，2： | 1 |
| 6 | Phase Ⅲ,randomized,double-blind,placebo-controlled multicenter trial of daily everolimus plus weekly trastuzumab and vinorelbine in trastuzumab-resistant,advanced breast cancer (BOLERO-3)显示文摘 | O' Regan R Ozguroglu M Andre F Toi M Jerusalem G Wilks S Isaacs C Xu B Masuda N Arena FP Yardley D Yap YS Mukhopadhyay P Douma S El-Hashimy M Taran T Sahmoud T Lebwohl D Gianni L | | 0，，15： | 1 |
| 7 | Arabidopsis SMALL AUXIN UP RNA63 promotes hypocotyl and sta- men filament elongation 显示文摘 | Chae K Isaacs C G Reeves P H | 2012 | The Plant Journal2012，71，： | 1 |
| 8 | Variation in the yon Willebrand factor gene is associated with van Willebrand factor levels and with the risk for cardiovascular disease 显示文摘 | van Schie M C de Maat M P Isaacs A | 2011 | Blood2011，117，4： | 1 |
| 9 | Incidental gallbladder cancer diagnosis confers survival advantage irrespective of tumour stage and characteristics显示文摘BACKGROUND Incidental gallbladder cancer(IGBC)represents 50%-60%of gallbladder cancer cases.Data are conflicting on the role of IGBC diagnosis in oncological outcomes.Some studies suggest that IGBC diagnosis does not affect outcomes,while others that overall survival(OS)is longer in these cases compared to non-incidental diagnosis(NIGBC).Furthermore,some studies reported early tumour stages and histopathologic characteristics as possible confounders,while others not.AIM To investigate the role of IGBC diagnosis on patients’overall survival,especially after surgical treatment with curative intent.METHODS Retrospective analysis of all patient referrals with gallbladder cancer between 2008 and 2020 in a tertiary hepatobiliary centre.Statistical comparison of patient and tumour characteristics between IGBC and NIGBC subgroups was performed.Survival analysis for the whole cohort,surgical and non-surgical subgroups was done with the Kaplan-Meier method and the use of log rank test.Risk analysis was performed with univariable and multivariable Cox regression analysis.RESULTS The cohort included 261 patients with gallbladder cancer.65%of cases had NIGBC and 35%had IGBC.A total of 90 patients received surgical treatment(66%of IGBC cases and 19%of NIGBC cases).NIGBC patients had more advanced T stage and required more extensive resections than IGBC ones.OS was longer in patients with IGBC in the whole cohort(29 vs 4 mo,P<0.001),as well as in the non-surgical(14 vs 2 mo,P<0.001)and surgical subgroups(29 vs 16.5 mo,P=0.001).Disease free survival(DFS)after surgery was longer in patients with IGBC(21.5 mo vs 8.5 mo,P=0.007).N stage and resection margin status were identified as independent predictors of OS and DFS.NIGBC diagnosis was identified as an independent predictor of OS.CONCLUSION IGBC diagnosis may confer a survival advantage independently of the pathological stage and tumour characteristics.Prospective studies are required to further investigate this,including detailed pathological analysis and molecular gene expression. | Moath Alarabiyat Syed Soulat Raza John Isaac Darius Mirza Ravi Marudanayagam Keith Roberts Manuel Abradelo David C Bartlett Bobby V Dasari Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastroenterology2022，28，18： | 1 |
| 10 | Random amplified polymorphic DNA (RAPD) markers for genetic analysis in Allium显示文摘 | Susan E W Isaac P C Slater R J | 1993 | Theor Appl Cenet1993，86，： | 1 |
| 11 | Expression of class Ⅲ-tubulin in Non-small cell lung cancer is correlated with resistance to taxane chemotherapy显示文摘 | DUMONTET C ISAAC S SOUQUET P J | 2005 | Bull Cancer2005，92，2： | 1 |
| 12 | Phase Ⅰ / Ⅱ study of sorafenib with anastrozole in patients with hormone receptor positive aromatase inhibitor resistant metastatic breast cancer显示文摘 | Isaacs C Herbolsheimer P Liu MC | 2011 | Breast Cancer Res Treat2011，125，1： | 1 |
| 13 | Atacicept, a no- vel 13 cell-targeting biological therapy for the treatment of rheumatoid arthritis显示文摘 | Bracewell C Isaacs JD Emery P | 2009 | Expert Opin Biol Ther2009，9，7： | 1 |
| 14 | Multiple antibodies to titin immunoreact with AHNAK and localize to the mitotic spindle machinery显示文摘 | WERNYI R P EWING C M ISAACS W B | 2001 | Cell Motil Cytoskeleton2001，50，： | 1 |
| 15 | MMCs for automotive engine applications显示文摘 | Mangin C Isaacs J A Clark J P | 1996 | JOM1996，48，2： | 1 |
| 16 | Stoichiometric differences in DNA molecules containing the atpA gene suggest mechanisms for the generation of mitochondrial genome diversity in maize显示文摘 | Small L D Isaac P G Leaver C J | 1987 | The EMBO Journal1987，6，4： | 1 |
| 17 | Comparisonof effects of ingested medium-and long-chain triglycer-ide on gallbladder volume and release of cholecystoki-nin and other gut peptides显示文摘 | ISAACS P E LADAS S’FORGACS I C | 1987 | Dig Dis Sci1987，32，： | 1 |
| 18 | Expression of class Ill beta tubulin in non-small cell lung cancer is correlated with resistance to taxane chemotherapy 显示文摘 | Dumontet C Isaac S Souquet P J | 2005 | Bull Cancer2005，92，2： | 1 |
| 19 | Expression of class Ul beta tubulin in non-small cell lung cancer is correlated with resistance to taxane chemotherapy显示文摘 | Dumontet C Isaac S Souquet P J | 2005 | Bull Cancer2005，92，2： | 1 |
| 20 | Lead levels in breast milk, blood plasma and intelligence quotient: a health hazard for women and infants显示文摘 | Isaac C P J Sivakumar A Kumar C R P | 2012 | Bulletin of Environmental Contamination and Toxicology2012，88，2： | 1 |
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