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| 1 | Hypoxia inducible factor-1αaccumulation in steatotic liver preservation:Role of nitric oxide显示文摘AIM:To examine the relevance of hypoxia inducible factor(HIF-1)and nitric oxide(NO)on the preservation of fatty liver against cold ischemia-reperfusion injury(IRI). METHODS:We used an isolated perfused rat liver model and we evaluated HIF-1αin steatotic and non-steatotic livers preserved for 24 h at 4℃in University of Wisconsin and IGL-1 solutions,and then subjected to 2 h of normothermic reperfusion.After normoxic reperfusion,liver enzymes,bile production,bromosulfophthalein clearance,as well as HIF-1αand NO[endothelial NO synthase(eNOS)activity and nitrites/nitrates]were also measured.Other factors associated with the higher susceptibility of steatotic livers to IRI,such as mitochondrial damage and vascular resistance were evaluated. RESULTS:A significant increase in HIF-1αwas found in steatotic and non-steatotic livers preserved in IGL-1 after cold storage.Livers preserved in IGL-1 showed a significant attenuation of liver injury and improvement in liver function parameters.These benefits were enhanced by the addition of trimetazidine(an antiischemic drug),which induces NO and eNOS activation, to IGL-1 solution.In normoxic reperfusion,the presence of NO favors HIF-1αaccumulation,promoting also the activation of other cytoprotective genes,such as hemeoxygenase-1. CONCLUSION:We found evidence for the role of the HIF-1α/NO system in fatty liver preservation,especially when IGL-1 solution is used. | Mohamed Amine Zaouali Ismail Ben Mosbah Eleonora Boncompagni Hassen Ben Abdennebi Maria Teresa Mitjavila Ramon Bartrons Isabel Freitas Antoni Rimola Joan Roselló-Catafau | 2010 | World Journal of Gastroenterology2010，16，28： | 11 |
| 2 | Lobe-Specific Heterogeneity and Matrix Metalloproteinase Activation after Ischemia/Reperfusion Injury in Rat Livers显示文摘 | Giuseppina Palladini Andrea Ferrigno Vittoria Rizzo Eleonora Boncompagni Plinio Richelmi Isabel Freitas Stefano Perlini Mariapia Vairetti | 2012 | Toxicologic Pathology2012，，5： | 2 |
| 3 | Mapping public support for innovation: A comparison of policy alignment in the UK and France显示文摘 | Isabel Maria Bodas Freitas Nick von Tunzelmann | 2008 | Research Policy2008，，9： | 2 |
| 4 | Map-ping Public Support for Innovation:A Comparison of Policy Alignment in the UK and France显示文摘 | Isabel Maria Bodas Freitas Nick von Tunzelmann | 2008 | Research Policy2008，37，： | 1 |
| 5 | Finding the right partners: institu- tional and personal modes of governance of university in- dustry interactions显示文摘 | ISABEL MARIA BODAS FREITAS ALDO GEUNAC FEDERICA ROSSI | 2013 | Research Policy2013，，42： | 1 |
| 6 | University-industry collaboration and innovation in emer- gent and mature industries in new industrialized countries 显示文摘 | ISABEL MARIA BODAS FREITAS ROSANE ARGOU MARQUESC EVANDO MIRRA DE PAULA E SILVA | 2013 | Research Policy2013，，42： | 1 |
| 7 | Tumor microenvironment and hemorheologicao abnormalities seminars 显示文摘 | Gianfranco Baronzio MD Isabel freitas MD Hau C Kwaan MD Ph D | 2003 | In Thrombosis And Hemostasis2003，29，5： | 1 |
| 8 | Colonic Metastasis of a Lung Carcinoma With Ileocolic Fistula显示文摘 | Isabel Bastos Dário Gomes Hermano Gouveia Diniz de Freitas | 1998 | Journal of Clinical Gastroenterology1998，，4： | 1 |
| 9 | Analysing knowledge transfer channels between universities and industry:To what degree do sectors also matter显示文摘 | Rudi Bekkers Isabel Maria Bodas Freitas | | 0，，37： | 1 |
| 10 | Mapping Public support for Innovation:A Comparison of Policy Alignment in the UK and France显示文摘 | Bodas Freitas Isabel Maria Nick von Tunzelmann | | 0，，09： | 1 |
| 11 | Montreal Cognitive Assessment (MoCA): Validation Study for Vascular Dementia显示文摘 | Sandra Freitas Mário R. Sim?es Lara Alves Margarida Vicente Isabel Santana | 2012 | Journal of the International Neuropsychological Society2012，，： | 1 |
| 12 | Analysing knowledge transfer channels between universities and industry: To what degree do sectors also matter?显示文摘 | Bekkers R Maria Isabel and Freitas Bodas | 2008 | Research Policy2008，37，10： | 1 |
| 13 | Mapping public support for innovation:A comparison of policy alignment in the UK and France显示文摘 | Isabel Maria Bodas Freitas Nick von Tunzelmann | 2008 | Research Policy2008，37，： | 1 |
| 14 | Chemical characterization and antioxidant activities of oligomeric and polymeric procyanidin fractions from grape seeds显示文摘 | Isabel Spranger Baoshan Sun Ana M. Mateus Vítor de Freitas Jorge M. Ricardo-da-Silva | 2007 | Food Chemistry2007，，： | 1 |
| 15 | Mapping pub- lic support for innovation:a comparison of policy alignment in the UK and France显示文摘 | Isabel Maria Bodas Freitas Nick yon Tunzelmann | 2008 | Research Policy2008，37，： | 1 |
| 16 | The Kyoto mechanisms and the diffusion of renewable energy technologies in the BRICS显示文摘 | Isabel Maria Bodas Freitas Eva Dantas Michiko Iizuka | 2012 | Energy Policy2012，，42： | 1 |
| 17 | Difference in technology transfer between science-based and development based industries: Transfer mechanisms and barriers显示文摘 | Victor Gilsing Rudi Bekkers Isabel Maria Bodas Freitas Marianne Van Dersteen | 2011 | Technovation2011，，9： | 1 |
| 18 | Information systems and organizational memory: A literature review 显示文摘 | Victor Freitas de Azeredo Barros Isabel Ramos Gilberto Perez | 2015 | Journal of Information Systems and Technology Management2015，，12： | 1 |
| 19 | Differences in technology transfer between science-based and development-based industries: Transfer mechanisms and barriers显示文摘 | Victor Gilsing Rudi Bekkers Isabel Maria Bodas Freitas Marianne van der Steen | 2011 | Technovation2011，，12： | 1 |
| 20 | Fractionation of red wine polyphenols by solid-phase extraction and liquid chromatography显示文摘 | Baoshan Sun M. Concei??o Leandro Victor de Freitas M. Isabel Spranger | 2006 | Journal of Chromatography A2006，，1： | 1 |
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