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| 1 | Thioredoxin interacting protein,a key molecular switch between oxidative stress and sterile inflammation in cellular response显示文摘Tissue and systemic inflammation have been the main culprit behind the cellular response to multiple insults and maintaining homeostasis.Obesity is an independent disease state that has been reported as a common risk factor for multiple metabolic and microvascular diseases including nonalcoholic fatty liver disease(NAFLD),retinopathy,critical limb ischemia,and impaired angiogenesis.Sterile inflammation driven by high-fat diet,increased formation of reactive oxygen species,alteration of intracellular calcium level and associated release of inflammatory mediators,are the main common underlying forces in the pathophysiology of NAFLD,ischemic retinopathy,stroke,and aging brain.This work aims to examine the contribution of the pro-oxidative and pro-inflammatory thioredoxin interacting protein(TXNIP)to the expression and activation of NLRP3-inflammasome resulting in initiation or exacerbation of sterile inflammation in these disease states.Finally,the potential for TXNIP as a therapeutic target and whether TXNIP expression can be modulated using natural antioxidants or repurposing other drugs will be discussed. | Islam N Mohamed Luling Li Saifudeen Ismael Tauheed Ishrat Azza B El-Remessy | 2021 | World Journal of Diabetes2021，12，12： | 6 |
| 2 | Efficacy and Safety of Anticoagulation on Patients With Cirrhosis and Portal Vein Thrombosis显示文摘 | María Gabriela Delgado Susana Seijo Ismael Yepes Linette Achécar Maria Vega Catalina ángeles García–Criado Juan G. Abraldes Joaquín de la Pe?a Rafael Ba?ares Agustín Albillos Jaume Bosch Juan Carlos García–Pagán | 2012 | Clinical Gastroenterology and Hepatology2012，，7： | 3 |
| 3 | Second-look surgery plus hyperthermic intraperitoneal chemotherapy for patients with colorectal cancer at high risk of peritoneal carcinomatosis:Does it really save lives?显示文摘The treatment of peritoneal carcinomatosis (PC) of colorectal origin with cytoreductive surgery(CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) has a 5-year recurrence-free or cure rate of at least 16%, so it is no longer labeled as a fatal disease, and offers prolonged survival for patients with a low peritoneal carcinomatosis index. Metachronous PC of colorectal origin is so predictable that there is a model which has been used to successfully determine the individual risk of each patient. Patients at risk are clearly identified; those with the highest risk have small peritoneal nodules present in the first surgery (70% probability of developing PC), ovarian metastases(60%), perforated tumor onset or intraoperative tumor rupture(50%). Current clinical, biological and imaging techniques still lack sufficient sensitivity to diagnose PC in its initial stages, when CRS plus HIPEC has a greater impact and a higher cure rate. Second-look surgery with HIPEC or prophylactic HIPEC at the time of the first intervention have been proposed as means of preventing and/or anticipating clinical or radiological relapse in at-risk patients. Both techniques have shown a significant decrease in peritoneal relapses and should be considered essential weapons in the management of colorectal cancer. | Delia Cortes-Guiral Dominique Elias Pedro Antonio Cascales-Campos Alfredo Badía Yébenes Ismael Guijo Castellano Ana Isabel León Carbonero JoséIgnacio Martín Valadés Jesus Garcia-Foncillas Damian Garcia-Olmo | 2017 | World Journal of Gastroenterology2017，23，3： | 3 |
| 4 | Multi-objective optimization minimizing cost and life cycle emissions of stand-alone PV–wind–diesel systems with batteries storage显示文摘 | Rodolfo Dufo-López José L. Bernal-Agustín José M. Yusta-Loyo José A. Domínguez-Navarro Ignacio J. Ramírez-Rosado Juan Lujano Ismael Aso | 2011 | Applied Energy2011，，11： | 2 |
| 5 | Comparative paralytic shellfish toxin profiles in two marine bivalves during outbreaks of Gymnodinium catenatum (Dinophyceae) in the Gulf of California显示文摘 | ISMAEL Gárate-Lizárraga JOS J Bustillos-Guzmán ROSALBA Alonso-Rodríguez | 2004 | Marine Pollution Bulletin2004，48，： | 1 |
| 6 | Geotechnical properties of oil-contaminated Kuwait sand 显示文摘 | AL-SANAD H A EID W K ISMAEL N F | 1995 | Journal of Geotechnical Engineering1995，121，5： | 1 |
| 7 | Aging effect on oil contaminated Kuwaiti sand 显示文摘 | Alsanad H A Ismael N F | 1997 | Journal of Geoteehnieal and Geoenvironmental Engineering1997，123，33： | 1 |
| 8 | Behavior of laterally loaded bored piles in cemented sands显示文摘 | ISMAEL N F | 1990 | Journal of Geotechnical Engineering ASCE1990，116，11： | 1 |
| 9 | Aging effect on oil-contaminated Kuwait sand 显示文摘 | AL-SANAD H A ISMAEL N F | 1997 | Journal of Geotechnical and Geoenvironmental Engineering1997，123，3： | 1 |
| 10 | Colonization of intensive care unit patients by pesudoomonas aeruginsa显示文摘 | ISMAEL N A | 1993 | J Hospi Infect1993，25，4： | 1 |
| 11 | Ferric sulphate/chloride leaching of zinc and minor elements from a sphalerite concentrate显示文摘 | SANTOS S M C MACHADO R M CORREIA M J N REIS M T A ISMAEL M R C CARVALHO J M R | 2010 | Minerals Engineering2010，23，8： | 1 |
| 12 | Assessment of the levels of anabolic compounds in Kuwait meat industry: optimization of a multiresidue method and the results of a preliminery survey显示文摘 | Talat S Ismael N Nisar A | 1999 | Food Control1999，10，： | 1 |
| 13 | Predictors of Acute Esophagitis in Lung Cancer Patients Treated With Concurrent Three-Dimensional Conformal Radiotherapy and Chemotherapy显示文摘 | Núria Rodríguez Manuel Algara Palmira Foro Marti Lacruz Anna Reig Ismael Membrive Joan Lozano José Luis López Jaime Quera Enric Fernández-Velilla Xavier Sanz | 2009 | International Journal of Radiation Oncology, Biology, Physics2009，，： | 1 |
| 14 | Behavior of laterally loaded bored piles in cemented sands显示文摘 | ISMAEL N | 1990 | Journal of Geotechnical Engineering1990，116，11： | 1 |
| 15 | Ground-penetrat ing radar= a tool for monitoring bridge scour显示文摘 | Anderson N L Ismael A M Thitimakorn T | 2007 | ENVIRON MENTAL g> ENGINEERING GEOSCIENCE2007，13，1： | 1 |
| 16 | Effects of metoclopramide on gastric motility measured by short-term bio-impedance显示文摘AIM:To analyze the accuracy of short-term bio-impedance as a means of measuring gastric motility.METHODS: We evaluated differences in the short-term electrical bio-impedance signal from the gastric region in the following conditions: (1) fasting state, (2) after the administration of metoclopramide (a drug that induces an increase in gastric motility) and (3) after food ingestion in 23 healthy volunteers. We record-ed the real component of the electrical impedance signal from the gastric region for 1000 s. We performed a Fast Fourier Transform (FFT) on this data and then compared the signal among the fasting, medicated, and postprandial conditions using the median of the area under the curve, the relative area under the curve and the main peak activity.RESULTS: The median of the area under the curve of the frequency range in the region between 2-8 cycles per minute (cpm) decreased from 4.7 cpm in the fasting condition to 4.0 cpm in the medicated state (t=3.32, P=0.004). This concurred with the decrease seen in the relative area under the FFT curve in the region from 4 to 8 cpm from 38.3% to 26.6% (t=2.81, P=0.012) and the increase in area in the region from 2 to 4 cpm from 22.4% to 27.7%, respectively (t=-2.5, P=0.022). Finally the main peak position also decreased in the region from 2 to 8 cpm. Main peak activity in the fasting state was 4.72 cpm and declined to 3.45 cpm in the medicated state (t=2.47, P=0.025). There was a decrease from the fasting state to the postprandial state at 3.02 cpm (t=4.0, P=0.0013). CONCLUSION: Short-term electrical bio-impedance can assess gastric motility changes in individuals experiencing gastric stress by analyzing the area medians and relative areas under the FFT curve. | María-Raquel Huerta-Franco Miguel Vargas-Luna Kathleen M Capaccione Etna Yaez-Roldán Ulises Hernández-Ledezma Ismael Morales-Mata Teodoro Córdova-Fraga | 2009 | World Journal of Gastroenterology2009，15，38： | 1 |
| 17 | Functional Inhibition of Aquaporin‐3 With a Gold‐Based Compound Induces Blockage of Cell Proliferation显示文摘 | Ana Serna Ana Galán‐Cobo Claudia Rodrigues Ismael Sánchez‐Gomar Juan José Toledo‐Aral Teresa F. Moura Angela Casini Gra?a Soveral Miriam Echevarría | 2014 | J. Cell. Physiol2014，，11： | 1 |
| 18 | Behavior of laterally loaded bored piles in cemented sands显示文摘 | ISMAEL N F | 1990 | Geoteehnieal Engineering ASCE1990，116，11： | 1 |
| 19 | Geotechnical Properties of Oil-Contaminated Kuwaiti Sand显示文摘 | Alsanad H A Eid W K Ismael N F | 1995 | Journal of Geotechnical Engineering1995，121，5： | 1 |
| 20 | Geotechnical properties of oil contaminated Kuwaiti sand 显示文摘 | AL-SANAD H A EID W K ISMAEL N F | 1995 | Journal of Geotechnical Engineering1995，121，5： | 1 |
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