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| 1 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 2 | Ambient air levels of volatile organic compounds in Latin American and Asian cities 显示文摘 | Ivan L G Christopher J S | 1998 | Chemosphere1998，36，11： | 1 |
| 3 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 4 | Gene expression polymor- phisms and ESTs associated with gravitropic response of subterranean branch meristems and growth habit in Leymus wildryes]显示文摘 | Parminder K Ivan W M Steven R L Bushman B S Alvaro G H Kim W R Liu L Mark A M | 2008 | Plant Science2008，175，3： | 1 |
| 5 | Steam-injection strategy and energetics of steam - assisted gravity drainage 显示文摘 | Ian D G Joseph K Ivan L | 2007 | SPE 977422007，，： | 1 |
| 6 | A tunable 1×4 silicon CMOS photonic wavelength multiplexer/demultiplexer for dense optical interconnects显示文摘 | XZZheng S B Ivan G L Li | 2010 | Opt Express2010，18，5： | 1 |
| 7 | Small delay approximation of stochastic delay differential equations显示文摘 | STEVE G IVAN L'H ANDReL | 1999 | Physical Review E1999，59，4： | 1 |
| 8 | Gaba shunt in developing soybean seeds is associated with hypoxia显示文摘 | BARRY J S CAIG S W WAYNE A S LUCIE G T IVAN J O DAVID B L | 1995 | Physiologia Plantarum1995，94，： | 1 |
| 9 | Dimethoate-induced toxic cardiac failure in the guinea pig显示文摘 | Marosi G Ivan J Nagymajitenyi L | 1985 | Arch Toxicol1985，57，： | 1 |
| 10 | Nitrous oxide sources and sinks in coastal aquifers and coupled estuarine receiving waters显示文摘 | MICHAEL G L ROBERT D IVAN V | 2003 | The Science of the Total Environment2003，309，： | 1 |
| 11 | Global fire emissions and the contribution of deforestation, savanna, forest, agricultural, and peat fires (1997-2009)显示文摘 | Ivan der Werf G R Randerson J T Giglio L | 2010 | Atmospheric Chemis- try and Physics2010，10，11： | 1 |
| 12 | The catalytic reduction of carbon dioxide to carbon onion particles by platinum catalysts显示文摘 | Marco G C Ivan P L Luis R V | 2005 | Carbon2005，43，： | 1 |
| 13 | Indoor Air Pollutants and Health in the United Arab Emirates显示文摘 | Yeatts Karin B El-Sadig Mohamed Leith David Kalsbeek William Al-Maskari Fatma Couper David Funk William E Zoubeidi Taoufik Chan Ronna L Trent Chris B Davidson Christopher A Boundy Maryanne G Kassab Maamoon M Hasan Mohamed Y Rusyn Ivan Gibso | 2012 | EN2012，，5： | 1 |
| 14 | Comparison of microinjection (Piezo-Electric) and cell fusion for nuclear transfer success with different cell types in cattle显示文摘 | Cesare G Irina L Ivan V | 2002 | Cloning and stem cell2002，4，3： | 1 |
| 15 | ALA (5-aminolevulinic acid)-induced protoporphyrin Ⅸ fluorescence in the endoscopic diagnostic and control of pharyngo-laryngeal cancer显示文摘 | Csanady M Kiss J G Ivan L | 2004 | Eur Arch Oto-Rhino-Laryngol2004，261，： | 1 |
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