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| 1 | Colorectal cancer screening: An updated review of the available options显示文摘Colorectal cancer(CRC) is a significant cause of morbidity and mortality worldwide. However,colon cancer incidence and mortality is declining over the past decade owing to adoption of effective screening programs. Nevertheless,in some parts of the world,CRC incidence and mortality remain on the rise,likely due to factors including 'westernized' diet,lifestyle,and lack of health-care infrastructure and resources. Participation and adherence to different national screening programs remain obstacles limiting the achievement of screening goals. Different modalities are available ranging from stool based tests to radiology and endoscopy with varying sensitivity and specificity. However,the availability of these tests is limited to areas with high economic resources. Recently,FDA approved a blood-based test(Epi procolon?) for CRC screening. This blood based test may serve to increase the participation and adherence rates. Hence,leading to increase in colon cancer detection and prevention. This article will discuss various CRC screening tests with a particular focus on the data regarding the new approved blood test. Finally,we will propose an algorithm for a simple cost-effective CRC screening program. | Iyad A Issa Malak Noureddine | 2017 | World Journal of Gastroenterology2017，23，28： | 49 |
| 2 | Endoscopic ultrasound guided radiofrequency ablation,for pancreatic cystic neoplasms and neuroendocrine tumors显示文摘AIM: To outline the feasibility, safety, adverse events and early results of endoscopic ultrasound(EUS)-radiofrequency ablation(RFA) in pancreatic neoplasms using a novel probe. METHODS: This is a multi-center, pilot safety feasibility study. The intervention described was radiofrequency ablation(RF) which was applied with an innovative monopolar RF probe(1.2 mm Habib EUS-RFA catheter) placed through a 19 or 22 gauge fine needle aspiration(FNA) needle once FNA was performed in patients with a tumor in the head of the pancreas. The HabibTM EUSRFA is a 1 Fr wire(0.33 mm, 0.013') with a working length of 190 cm, which can be inserted through the biopsy channel of an echoendoscope. RF power is applied to the electrode at the end of the wire to coagulate tissue in the liver and pancreas.RESULTS: Eight patients [median age of 65(range 27-82) years; 7 female and 1 male] were recruited in a prospective multicenter trial. Six had a pancreatic cysticneoplasm(four a mucinous cyst, one had intraductal papillary mucinous neoplasm and one a microcystic adenoma) and two had a neuroendocrine tumors(NET) in the head of pancreas. The mean size of the cystic neoplasm and NET were 36.5 mm(SD ± 17.9 mm) and 27.5 mm(SD ± 17.7 mm) respectively. The EUSRFA was successfully completed in all cases. Among the 6 patients with a cystic neoplasm, post procedure imaging in 3-6 mo showed complete resolution of the cysts in 2 cases, whilst in three more there was a 48.4% reduction [mean pre RF 38.8 mm(SD ± 21.7 mm) vs mean post RF 20 mm(SD ± 17.1 mm)] in size. In regards to the NET patients, there was a change in vascularity and central necrosis after EUS-RFA. No major complications were observed within 48 h of the procedure. Two patients had mild abdominal pain that resolved within 3 d. CONCLUSION: EUS-RFA of pancreatic neoplasms with a novel monopolar RF probe was well tolerated in all cases. Our preliminary data suggest that the procedure is straightforward and safe. The response ranged from complete resolution to a 50% reduction in size. | Madhava Pai Nagy Habib Hakan Senturk Sundeep Lakhtakia Nageshwar Reddy Vito R Cicinnati Iyad Kaba Susanne Beckebaum Panagiotis Drymousis Michel Kahaleh William Brugge | 2015 | World Journal of Gastrointestinal Surgery2015，7，4： | 23 |
| 3 | Probiotics for antibiotic-associated diarrhea:Do we have a verdict?显示文摘Probiotics use has increased tremendously over the past ten years.This was coupled with a surge of data relating their importance in clinical practice.Antibioticassociated diarrhea,whose frequency has risen recently,was one of the earliest targets with data published more than ten years ago.Unfortunately,available trials suffer from severe discrepancies associated with variability and heterogeneity of several factors.Most published randomized controlled trials and subsequent meta-analyses suggest benefit for probiotics in the prevention of antibiotic-associated diarrhea.The same seems to also apply when the data is examined for Clostridium difficile-associated colitis.However,the largest randomized double-blind placebo-controlled trial to date examining the use of a certain preparation of probiotics in antibiotic-associated diarrhea showed disappointing results,but it was flawed with several drawbacks.The commonest species of probiotics studied across most trials is Lactobacillus;however,other types have also shown similar benefit.Probiotics have enjoyed an impeccable safety reputation.Despite a few reports of severe infections sometimes leading to septicemia,most of the available trials confirm their harmless behavior and show similaradverse events compared to placebo.Since a consensus dictating its use is still lacking,it would be advisable at this point to suggest prophylactic use of probiotics to certain patients at risk for antibiotic-associated diarrhea or to those who suffered previous episodes. | Iyad Issa Rami Moucari | 2014 | World Journal of Gastroenterology2014，20，47： | 17 |
| 4 | Mesenteric panniculitis: Various presentations and treatment regimens显示文摘Mesenteric panniculitis is a rare, benign and chronic f ibrosing inflammatory disease that affects the adipose tissue of the mesentery of the small intestine and colon. The specific etiology of the disease is unknown. The diagnosis is suggested by computed tomography and is usually confirmed by surgical biopsies. Treatment is empirical and based on a few selected drugs. Surgical resection is sometimes attempted for def initive therapy, although the surgical approach is often limited. We report two cases of mesenteric panniculitis with two different presentations and subsequently varying treatment regimens. Adequate response was obtained in both patients. We present details of these cases as well as a literature review to compare various presentations, etiologies and potential treatment modalities. | Iyad Issa Hassan Baydoun | 2009 | World Journal of Gastroenterology2009，15，30： | 12 |
| 5 | Lipids in liver transplant recipients显示文摘Hyperlipidemia is very common after liver transplantation and can be observed in up to 71% of patients. The etiology of lipid disorders in these patients is multifactorial, with different lipid profiles observed depending on the immunosuppressive agents administered and the presence of additional risk factors, such as obesity, diabetes mellitus and nutrition. Due to recent improvements in survival of liver transplant recipients, the prevention of cardiovascular events has become more important, especially as approximately 64% of liver transplant recipients present with an increased risk of cardiovascular events. Management of dyslipidemia and of other modifiable cardiovascular risk factors, such as hypertension, diabetes and smoking, has therefore become essential in these patients. Treatment of hyperlipidemia after liver transplantation consists of life style modification, modifying the dose or type of immunosuppressive agents and use of lipid lowering agents. At the start of administration of lipid lowering medications, it is important to monitor drugdrug interactions, especially between lipid lowering agents and immunosuppressive drugs. Furthermore, as combinations of various lipid lowering drugs can lead to severe side effects, such as myopathies and rhabdomyolysis, these combinations should therefore be avoided. To our knowledge, there are no current guidelines targeting the management of lipid metabolism disorders in liver transplant recipients. This paper therefore recommends an approach of managing lipid abnormalities occurring after liver transplantation. | anna hüsing iyad kabar hartmut h schmidt | 2016 | World Journal of Gastroenterology2016，22，12： | 6 |
| 6 | Single-operator cholangioscopy for biliary complications in liver transplant recipients显示文摘AIM To evaluate cholangioscopy in addition to endoscopic retrograde cholangiopancreatography(ERCP) for management of biliary complications after liver transplantation(LT).METHODS Twenty-six LT recipients with duct-to-duct biliary reconstruction who underwent ERCP for suspected biliary complications between April and December2016 at the university hospital of Muenster were consecutively enrolled in this observational study. After evaluating bile ducts using fluoroscopy, cholangioscopy using a modern digital single-operator cholangioscopy s y s t e m(S py G la s s D S ?) wa s pe r fo r me d dur ing the same procedure with patients under conscious sedation. All patients received peri-interventional antibiotic prophylaxis and bile was collected during the intervention for microbial analysis and for antibiotic susceptibility testing.RESULTS Thirty-three biliary complications were found in a total of 22 patients, whereas four patients showed normal bile ducts. Anastomotic strictures were evident in 14(53.8%) patients, non-anastomotic strictures in seven(26.9%), biliary cast in three(11.5%), and stones in six(23.1%). A benefit of cholangioscopy was seen in 12(46.2%) patients. In four of them, cholangioscopy was crucial for selective guidewire placement prior to planned intervention. In six patients, biliary cast and/or stones failed to be diagnosed by ERCP and were only detectable through cholangioscopy. In one case, a bile duct ulcer due to fungal infection was diagnosed by cholangioscopy. In another case, signs of bile duct inflammation caused by acute cholangitis were evident. One patient developed post-interventional cholangitis. No further procedure-related complications occurred. Thirty-seven isolates were found in bile. Sixteen of these were gram-positive(43.2%), 12(32.4%) were gram-negative bacteria, and Candida species accounted for 24.3% of all isolated microorganisms. Interestingly, only 48.6% of specimens were sensitive to prophylactic antibiotics.CONCLUSION Single-operator cholangioscopy can provide important diagnostic information, helping endoscopists to plan and perform interventional procedures in LT-related biliary complications. | Anna Hüsing-Kabar Hauke Sebastian Heinzow Hartmut Hans-Jürgen Schmidt Carina Stenger Hans Ulrich Gerth Michele Pohlen Gerold Tholking Christian Wilms Iyad Kabar | 2017 | World Journal of Gastroenterology2017，23，22： | 4 |
| 7 | Paclitaxel-eluting balloon dilation of biliary anastomotic stricture after liver transplantation显示文摘AIM:To investigate the safety and effectiveness of endoscopic therapy with a paclitaxel-eluting balloon(PEB) for biliary anastomotic stricture(AS) after liver transplantation(LT).METHODS:This prospective pilot study enrolled 13 consecutive eligible patients treated for symptomatic AS after LT at the University Hospital of Münster between January 2011 and March 2014.The patients were treated by endoscopic therapy with a PEB and followed up every 8 wk by endoscopic retrograde cholangiopancreatography(ERCP).In cases of re-stenosis,further balloon dilation with a PEB was performed.Follow-up was continued until 24 mo after the last intervention.RESULTS:Initial technical feasibility,defined as successful balloon dilation with a PEB during the initial ERCP procedure,was achieved in 100% of cases.Long-term clinical success(LTCS),defined as no need for further endoscopic intervention for at least 24 mo,was achieved in 12 of the 13 patients(92.3%).The mean number of endoscopic interventions required to achieve LTCS was only 1.7 ± 1.1.Treatment failure,defined as the need for definitive alternative treatment,occurred in only one patient,who developed recurrent stenosis with increasing bile duct dilatation that required stent placement.CONCLUSION:Endoscopic therapy with a PEB is very effective for the treatment of AS after LT,and seems to significantly shorten the overall duration of endoscopic treatment by reducing the number of interventions needed to achieve LTCS. | Anna Hüsing Holger Reinecke Vito R Cicinnati Susanne Beckebaum Christian Wilms Hartmut H Schmidt Iyad Kabar | 2015 | World Journal of Gastroenterology2015，21，3： | 4 |
| 8 | Apical hypertrophic cardiomyopathy显示文摘We describe a patient with asymptomatic apical hypertrophic cardiomyopathy(AHCM)who later developed cardiac arrhythmias,and briefly discuss the diagnostic modalities,differential diagnosis and treatment option for this condition.AHCM is a rare form of hypertrophic cardiomyopathy which classically involves the apex of the left ventricle.AHCM can be an incidental finding,or patients may present with chest pain,palpitations,dyspnea,syncope,atrial fibrillation,myocardial infarction,embolic events,ventricular fibrillation and congestive heart failure.AHCM is frequently sporadic,but autosomal dominant inheritance has been reported in few families.The most frequent and classic electrocardiogram findings are giant negative T-waves in the precordial leads which are found in the majority of the patients followed by left ventricular(LV)hypertrophy.A transthoracic echocardiogram is the initial diagnostic tool in the evaluation of ACHM and shows hypertrophy of the LV apex.AHCM may mimic other conditions such as LV apical cardiac tumors,LV apical thrombus,isolated ventricular non-compaction,endomyocardial fibrosis and coronary artery disease.Other modalities,including left ventriculography,multislice spiral computed tomography,and cardiac magnetic resonance imagings are also valuable tools and are frequently used to differentiate AHCH from other conditions.Medications used to treat symptomatic patients with AHCM include verapamil,beta-blockers and antiarrhythmic agents such as amiodarone and procainamide.An implantable cardioverter defibrillator is recommended for high risk patients. | Syed Wamique Yusuf Jaya D Bathina Jose Banchs Elie N Mouhayar Iyad N Daher | 2011 | World Journal of Cardiology2011，3，7： | 4 |
| 9 | 电除颤前进行一定时间的心肺复苏对延迟的心室纤颤作用的研究显示文摘目的 :探讨对由延迟的心室纤颤引起的心脏骤停的治疗方法。方法 :将 32只延迟心室纤颤 (10分钟心室纤颤 )动物模型的大鼠随机分为 4组 (0 -min组 ,2 -min组 ,4-min组及 6 -min组 ) ,分别在心肺复苏前、心肺复苏后 2分钟、4分钟、6分钟行试验电除颤 ,对未能转复者继续心肺复苏及补救电除颤。结果 :0 -min组 ,2 -min组无大鼠能通过试验电除颤成功恢复自主心率 ,而 6 -min组有 7只大鼠 ;与另外两组相比 ,4-min组及 6 -min组具有更长的生存时间。此外 ,6 -min组恢复自主心率所需的试验电除颤次数、补救电除颤次数及总除颤能量均显著地较其他三组为低。结论 :我们认为对延迟的心室纤颤在电除颤前应进行至少 4~ 6分钟的心肺复苏。 | 易忠 Rual J.Gazmuri Julieta D.Kolarova Iyad M.Ayoub | 2002 | 广西医学2002，24，7： | 4 |
| 10 | Regressive approach for predicting bearing capacity of bored piles from cone penetration test data显示文摘In this study, the least square support vector machine(LSSVM) algorithm was applied to predicting the bearing capacity of bored piles embedded in sand and mixed soils. Pile geometry and cone penetration test(CPT) results were used as input variables for prediction of pile bearing capacity. The data used were collected from the existing literature and consisted of 50 case records. The application of LSSVM was carried out by dividing the data into three sets: a training set for learning the problem and obtaining a relationship between input variables and pile bearing capacity, and testing and validation sets for evaluation of the predictive and generalization ability of the obtained relationship. The predictions of pile bearing capacity by LSSVM were evaluated by comparing with experimental data and with those by traditional CPT-based methods and the gene expression programming(GEP) model. It was found that the LSSVM performs well with coefficient of determination, mean, and standard deviation equivalent to 0.99,1.03, and 0.08, respectively, for the testing set, and 1, 1.04, and 0.11, respectively, for the validation set. The low values of the calculated mean squared error and mean absolute error indicated that the LSSVM was accurate in predicting the pile bearing capacity. The results of comparison also showed that the proposed algorithm predicted the pile bearing capacity more accurately than the traditional methods including the GEP model. | Iyad S. Alkroosh Mohammad Bahadori Hamid Nikraz Alireza Bahadori | 2015 | Journal of Rock Mechanics and Geotechnical Engineering2015，7，5： | 2 |
| 11 | MicroRNA-101 inhibits human hepatocellular carcinoma progression through EZH2 downregulation and increased cytostatic drug sensitivity显示文摘 | Leibo Xu Susanne Beckebaum Speranta Iacob Gang Wu Gernot M. Kaiser Arnold Radtke Chao Liu Iyad Kabar Hartmut H. Schmidt Xiaoyong Zhang Mengji Lu Vito R. Cicinnati | 2013 | Journal of Hepatology2013，，： | 2 |
| 12 | Accuracy and Quality Assessment of EUS-FNA: A Single-Center Large Cohort of Biopsies显示文摘 | Benjamin Ephraim Bluen Jesse Lachter Iyad Khamaysi Yassin Kamal Leonid Malkin Ruth Keren Ron Epelbaum Yoram Kluger Arthur Hoffman | 2012 | <journal-title>Diagnostic and Therapeutic Endoscopy2012，，： | 1 |
| 13 | Therapeutic role of telmisartan against acetaminophen hepatotoxicity in mice 显示文摘 | Amr AF Abdulruhman SA Iyad JRESAT | 2012 | Eur J Pharmaco12012，693，1： | 1 |
| 14 | Treatment of Urethral Strictures from Irradiation and Other Nonsurgical Forms of Pelvic Cancer Treatment显示文摘 | Iyad Khourdaji Jacob Parke Avinash Chennamsetty Frank Burks Miroslav L. Djordjevic | 2015 | Advances in Urology2015，，： | 1 |
| 15 | Association of body position with severity of apneic events in patients with severe nonpositional obstructive sleep apnea显示文摘 | Arie Oksenberg Iyad Khamaysi Donald S | 2000 | Chest2000，118，： | 1 |
| 16 | Late Complication of Laparoscopic Sleeve Gastrectomy显示文摘 | Anthony Dakwar Ahmad Assalia Iyad Khamaysi Yoram Kluger Ahmad Mahajna E. Altintas D. C. Damin | 2013 | Case Reports in Gastrointestinal Medicine2013，，： | 1 |
| 17 | A new method for image contrast enhancement based on automatic specification of local histograms 显示文摘 | Iyad Jafar Hao Ying | 2007 | International Journal of Computer Science and Network Security2007，7，7： | 1 |
| 18 | Pineal gland turners: Experience from the SEER database 显示文摘 | Maysa AH Iyad S Amar JG | 2009 | J Neurooncol2009，94，3： | 1 |
| 19 | 钠氢离子交换抑制剂Cariporide与肾上腺素联合用于延迟心室纤颤的心肺复苏显示文摘目的 探讨联合应用钠氢离子交换抑制剂(NHE I)Cariporide与肾上腺素在心肺复苏中的效果。方法 16只历经 12min室颤的大鼠配对分为 2组 (Cariporide组及对照组 ) ,分别在心肺复苏 (CPR)前注入Cariporide或等容量的生理盐水。CPR第 2min结束前始注入肾上腺素 ,使CPP维持在 2 5mmHg以上。对照组与匹配的Cariporide组有对应的除颤时间。对心肺复苏 8min后未能自动复率大鼠进行电除颤。结果 与对照组相比 ,以同样的高度进行胸前心脏按压 ,cariporide组须较小剂量的肾上腺素便可获得较高、持续时间较长的冠脉灌注压 (P <0 0 5 ) ,较高的复苏率 (P <0 0 5 )、较少的复苏后异位室性心律失常 (P <0 0 0 1)、较好的血流动力学效果及较长的生存时间 (P <0 0 5 )。结论 联合应用Cariporide及肾上腺素可提高心室纤颤的复苏效果。 | 易忠 Rual J.Gazmuri Iyad M.Ayoub Julieta D.Kolarova | 2002 | 岭南心血管病杂志2002，8，3： | 1 |
| 20 | Alternative natural dyes in water purification:Anthocyanin as TiO2-sensitizer in meth- yl orange photo-degradation 显示文摘 | Ahed Z Nidal Z Iyad S l | 2011 | Solid State Sci2011，13，6： | 1 |
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