|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 文献快报(8):童年至成年期不同BMI变化轨迹预示心血管代谢风险的差异显示文摘生命历程中体质量指数(BMI)变化轨迹与成年期心血管疾病的关联尚未明确。来自澳大利亚塔斯马尼亚大学孟席斯医学研究中心、芬兰图尔库大学Magnussen教授带领的团队分析了著名的"芬兰青年人群心血管风险研究"(Cardiovascular Risk in Young Finns Study)的2 631名受试对象在1980年(6-18岁)和2011年随访期(34-49岁)BMI数据,并探讨了其与成年期(34-49岁)心血管疾病危险因素,包括2型糖尿病、高危脂蛋白水平、高血压和颈动脉内膜增厚的关联。 | BUSCOT M THOMSON R J JUONALA M 孙莹 | 2018 | 中国学校卫生2018，39，10： | 7 |
| 2 | 健康领域的文化能力显示文摘1背景
尽管人类对其他社会的兴趣纵贯历史的各个阶段,但是检验不同文化概念对人类健康实践的影响从20世纪才开始,当时是伴随着长期的人类学田野调查产生的,这些田野调查揭露了不同文化之间相关卫生实践的多样性、复杂性和连续性。 | Napier A D Ancarno C Butler B Calabrese j Chater A Chatterjee H Guesnet F Home R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams AC Willott C Wilson J Woolf K | 2016 | 中国卫生政策研究2016，9，2： | 5 |
| 3 | 补体B因子是代谢综合征模型代谢与心血管特征的一个决定因素显示文摘补体B因子(complenment factor B,CFB)在2型糖尿病及心血管病患者脂肪组织及血清中水平升高,但与疾病发病机制的因果关系不明确。自发性高血压大鼠(spontaneously hypertensive rats,SHR)脂肪组织及血清中CFB也升高。为明确CFB在代谢综合征中的作用,研究者在SHR中敲除Cfb基因。 | 赵狄 练桂丽 Coan PM Barrier M Alfazema N Carter RN Marion de Procé S Dopico XC Garcia Diaz A Thomson A Jackson-Jones LH Moyon B Webster Z Ross D Moss J Arends MJ Morton NM Aitman TJ | 2017 | 中华高血压杂志2017，25，8： | 3 |
| 4 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 5 | 文化、不平等性与卫生服务提供显示文摘1动态不平等性对基层医疗卫生人力的影响
政治、社会、文化、专业群体皆建立在一致且常规的人类行为之上。当遭受巨大变革和内外压力时,这些群体会变得十分脆弱。尤其在动荡时期,这些群体往往更关注社会和文化的差异性,而非二者的一致性。尽管社会中的个体思维和行为会呈现较大的差异,但对健康的感知具有统一性,并在更广范围人群内尤为突出,这主要归因于文化价值观的作用。广义的文化心态会随着时间和地理位置的不同而不同,就像健康的社会决定因素也会因文化类型的不同而产生差异。 | Napier A D Ancarno C Butler B Calabrese J Chater A Chatterjee H Guesnet F Horne R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams A C Willott C Wilson J Woolf K | 2016 | 中国卫生政策研究2016，9，3： | 2 |
| 6 | A custom microarray platform for analysis of microRNA gene expression显示文摘 | PARKER J PEROU C M | 2004 | Nat Methods2004，1，： | 1 |
| 7 | The promoter of a basic PR1-like gene,AtPRB1,from Arabidopsis establishes an organ-specific expression pattern and responsiveness to ethylene and methyl jasmonate显示文摘 | SANTAMARIA M Thomson C J Read N D | 2001 | Plant Molecular Biology2001，47，： | 1 |
| 8 | Results of a Summer Academy to Increase Minority Student Access to Allied Health and Other Health Professions显示文摘 | Thomson W A Denk J P Miller L M | 1991 | J Allied Health1991，21，1： | 1 |
| 9 | Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR- II , a receptor member of the TGF-beta famity显示文摘 | THOMSON J R MACHADO R D PAUCIULO M W | 2000 | Journal of Medical Gene- tics2000，37，10： | 1 |
| 10 | 医疗卫生保健文化的反思及促进健康与文化融合的建议显示文摘1医疗卫生保健文化的反思1.1健康文化与医学知识如果医务人员有充足的时间对患者进行诊断并帮助患者进行社区护理,就可在节省卫生费用的同时改善健康结果。整合型社区护理能缩小不同文化背景和群体健康需求的差异。然而,全球范围内对整合型社区护理的投入较少,原因之一就是20世纪对临床服务的重视弱化了卫生服务提供过程中的同情心理。当然,患者也对医学知识存在显性和隐性的影响(特别是当其因不遵医嘱而受到指责时)。 | Napier A D Ancarno C Butler B Calabrese J Chater A Chatterjee H Guesnet F Horne R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams A C Willott C Wilson JWoolf K | 2016 | 中国卫生政策研究2016，9，4： | 1 |
| 11 | Isolation of a primate embryonic stem cell显示文摘 | KALISHMAN T G GOLOS M | 1995 | Proc Natl Ccad Sci1995，92，17： | 1 |
| 12 | Fabrication of biodegradable polymer scaffolds to engineer trabe-cular bone显示文摘 | Thomson R C Yaszemski M J Powers J M | 1995 | Journal of Biomaterials Science-polymer Edition1995，7，1： | 1 |
| 13 | On the robust estimation of power spectra, coherences, and transfer functions显示文摘 | Chave A D Thomson D J Ander M E | 1987 | Journal of Geophysical Research1987，92，1： | 1 |
| 14 | Characterizing the Saltol quantitative trait locus for salinity tolerance in rice 显示文摘 | Thomson M J Ocampo M Egdane J Rahman M A Sajise A G Adorada D L Tumimbang-Raiz E Blumwald E Seraj Z I Singh R K Gregorio G B Ismail A M | 2010 | Rice2010，3，2： | 1 |
| 15 | A microRNA polycistrou as a potential human oncogene 显示文摘 | He L Thomson J M Hemann M T | 2005 | Nature2005，435，7043： | 1 |
| 16 | Small angle X-ray scattering of wheat seed-storage proteins: α, у-and ω-gliadins and the high molecular weight (HMW) subunits of glutenin显示文摘 | THOMSON N H MILES M J POPINEAU Y | 1999 | Biochimica et Biophysica Aeta1999，1430，2： | 1 |
| 17 | Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factors 显示文摘 | Woods K Thomson J M Hammond S M | 2007 | J Biol Chem2007，282，4： | 1 |
| 18 | Late Jurassic macrosofossil assemblage from Jason Peninsula,Graham Land:evidence for a significant northward extension of the Latady Formation显示文摘 | RILEY T R CRAME J A THOMSON M R A | 1997 | Antartic Science1997，9，4： | 1 |
| 19 | Rebound of a coal tar creosote plume following partial source zone treatment with permanganate 显示文摘 | THOMSON N R FRASER M J LAMARCHE C | 2008 | Journal of Contaminant Hydrology2008，102，1： | 1 |
| 20 | PpATG9 encodes a novel membrane protein that traffics to vacuolar membranes, which sequester peroxisomes during pexoph- agy in Pichia pastoris 显示文摘 | Chang T Schroder L A Thomson J M | 2005 | Molecular Biology of the Cell2005，16，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员