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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 3 | Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation显示文摘 | D.L Lacey E Timms H.-L Tan M.J Kelley C.R Dunstan T Burgess R Elliott A Colombero G Elliott S Scully H Hsu J Sullivan N Hawkins E Davy C Capparelli A Eli Y.-X Qian S Kaufman I Sarosi V Shalhoub G Senaldi J Guo J Delaney W.J Boyle | 1998 | Cell1998，，2： | 4 |
| 4 | 脊髓损伤后残存自主神经功能载录国际标准显示文摘近年来,脊髓损伤神经学分类园际标准(International Stand- ards for the Neurological Classification of Spinal Cord Injury, ISNCSCI)被用来记载脊髓损伤后运动和感觉功能的损害,目前该标准已是第六版。1992年第一份国际认可的标准出版时,曾进行了较大的修订,修订内容包括完全性损伤与不完全性损伤的定义, | MS Alexander AB Jackson W Donovan DE Graves SL Elliott A Krassioukov AW Sheel I Estoresl B Green A Gousse NL Braekett D Cardenas M Kennelly A-K Karlason F Biering-Sorensen K Krogh T Linsenmeyer R Marino J Ditunno CJ Mathias I Perkash G Creasey G Schilero J Wecht B Schurch V Dietz J Sonksen S Stiens D Bodner LA Wuermser J-J Wyndaele 周谋望 刘楠 S Charlifue | 2010 | 中华物理医学与康复杂志2010，32，4： | 2 |
| 5 | Use of serology in reptile medicine显示文摘 | Elliott R J | 2002 | Seminars in Avian and Exotic Pet Medicine2002，11，1： | 1 |
| 6 | Active isolation of structure vibration on a multiple-degree-of-freedom system,part Ⅰ:dynamics of the system显示文摘 | Gardonio P Elliott S J and Pirmington R J | 1997 | Journal of Sound and Vibration1997，207，1： | 1 |
| 7 | Fractionation of polyethylene显示文摘 | FRSNCIS P S COOKE R C Jr ELLIOTT J H | 1958 | J Polym Sci1958，31，123： | 1 |
| 8 | Pulmonary Artery Sling显示文摘 | Pawade A De Leval M R Elliott M J | 1992 | Ann Thorac Surg1992，54，5： | 1 |
| 9 | Comparison of in vitro activities of gatifloxacin and ciprofloxacin against four taxa of rapidly growing mycobacteria 显示文摘 | Brown - Elliott BA Wallace R J Crist CJ | 2002 | Antimicrob Agents Chemother2002，46，10： | 1 |
| 10 | Scientific charge-coupled devices 显示文摘 | Janesick J R Elliott T Collins S | 1987 | Optical Engineering1987，26，8： | 1 |
| 11 | Oxy-fuel combustion technology for coal-fired power generation显示文摘 | BUHRE B J P ELLIOTT L K SHENG C D GUPTA R P WALL T F | 2005 | Prog Energy Combust2005，31，4： | 1 |
| 12 | Identification and quantification of amines in the equine caecum显示文摘 | BAILEY S R MARR C M ELLIOTT J | 2003 | Research in Veterinary Science2003，74，2： | 1 |
| 13 | Discrete-time nonlin-ear filtering algorithms using Gauss-Hermite quadrature显示文摘 | ARASARATNAM I HAYKIN S ELLIOTT R J | 2007 | Pro-ceedings of the IEEE2007，95，5： | 1 |
| 14 | Option pricing and filtering with hidden Markov modulated pure-jump processes显示文摘 | Elliott R J Siu T K | 2013 | Applied Mathematical Finance2013，20，1： | 1 |
| 15 | Transformation of the homobasidiomycete Coprinus bilanatus to 5-fluoroindole resistance using a mutant trp3 gene from Coprinus cinereu显示文摘 | Bhattiprolu G R Challen M P Elliott T J | 1993 | Mycol Res1993，97，11： | 1 |
| 16 | Corruption, Governance and FDI Location in China: A Province -level Analysis 显示文摘 | Cole M A Elliott R J Zhang J | 2009 | Journal of Development Studies2009，45，9： | 1 |
| 17 | A quantitative study of the interactions of bacillus anthracis edema factor and lethal factor with activated protective Antigen显示文摘 | Elliott JL Mogridge J Collier R J | 2000 | Biochem2000，39，22： | 1 |
| 18 | In Search of Environmental Spillovers显示文摘 | Albornoz F Cole M A Elliott R J | | 0，，01： | 1 |
| 19 | N',2 -diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists Ⅱ显示文摘 | ELLIOTT J M CARLING R W CHICCHI G G | 2006 | Bioorg Med Chem Lett2006，16，22： | 1 |
| 20 | Strategies for the active control of flexural vibration on a beam显示文摘 | Brennan M J Elliott S J Pinnington R J | 1995 | Journal of Sound and Vibration1995，186，4： | 1 |
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