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| 1 | Prolonged high-fat-diet feeding promotes non-alcoholic fatty liver disease and alters gut microbiota in mice显示文摘BACKGROUND Non-alcoholic fatty liver disease (NAFLD) has become an epidemic largely due to the worldwide increase in obesity. While lifestyle modifications and pharmacotherapies have been used to alleviate NAFLD, successful treatment options are limited. One of the main barriers to finding safe and effective drugs for long-term use in NAFLD is the fast initiation and progression of disease in the available preclinical models. Therefore, we are in need of preclinical models that (1) mimic the human manifestation of NAFLD and (2) have a longer progression time to allow for the design of superior treatments. AIM To characterize a model of prolonged high-fat diet (HFD) feeding for investigation of the long-term progression of NAFLD. METHODS In this study, we utilized prolonged HFD feeding to examine NAFLD features in C57BL/6 male mice. We fed mice with a HFD (60% fat, 20% protein, and 20% carbohydrate) for 80 wk to promote obesity (Old-HFD group, n = 18). A low-fat diet (LFD)(14% fat, 32% protein, and 54% carbohydrate) was administered for the same duration to age-matched mice (Old-LFD group, n = 15). An additional group of mice was maintained on the LFD (Young-LFD, n = 20) for a shorter duration (6 wk) to distinguish between age-dependent and age-independent effects. Liver, colon, adipose tissue, and feces were collected for histological and molecular assessments.RESULTS Prolonged HFD feeding led to obesity and insulin resistance. Histological analysis in the liver of HFD mice demonstrated steatosis, cell injury, portal and lobular inflammation and fibrosis. In addition, molecular analysis for markers of endoplasmic reticulum stress established that the liver tissue of HFD mice have increased phosphorylated Jnk and CHOP. Lastly, we evaluated the gut microbial composition of Old-LFD and Old-HFD. We observed that prolonged HFD feeding in mice increased the relative abundance of the Firmicutes phylum. At the genus level, we observed a significant increase in the abundance of Adercreutzia, Coprococcus, Dorea, and Ruminococcus and decreased relative abundance of Turicibacter and Anaeroplasma in HFD mice. CONCLUSION Overall, these data suggest that chronic HFD consumption in mice can mimic pathophysiological and some microbial events observed in NAFLD patients. | Kandy T Velázquez Reilly T Enos Jackie E Bader Alexander T Sougiannis Meredith S Carson Ioulia Chatzistamou James A Carson Prakash S Nagarkatti Mitzi Nagarkatti E Angela Murphy | 2019 | World Journal of Hepatology2019，11，8： | 6 |
| 2 | Neuroprotective and anti-inflammatory effects of a therapy combining agonists of nicotinic α7 and σ1 receptors in a rat model of Parkinson’s disease显示文摘To date there is no treatment able to stop or slow down the loss of dopaminergic neurons that characterizes Parkinson’s disease.It was recently observed in a rodent model of Alzheimer’s disease that the interaction between the α7 subtype of nicotinic acetylcholine receptor(α7-nAChR)and sigma-1 receptor(σ1-R)could exert neuroprotective effects through the modulation of neuroinflammation which is one of the key components of the pathophysiology of Parkinson’s disease.In this context,the aim of the present study was to assess the effects of the concomitant administration of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide(PHA)543613 as an α7-nAChR agonist and 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate(PRE)-084 as aσ1-R agonist in a well-characterized 6-hydroxydopamine rat model of Parkinson’s disease.The animals received either vehicle separately or the dual therapy PHA/PRE once a day until day 14 postlesion.Although no effect was noticed in the amphetamine-induced rotation test,our data has shown that the PHA/PRE treatment induced partial protection of the dopaminergic neurons(15-20%),assessed by the dopamine transporter density in the striatum and immunoreactive tyrosine hydroxylase in the substantia nigra.Furthermore,this dual therapy reduced the degree of glial activation consecutive to the 6-hydroxydopamine lesion,i.e,the 18 kDa translocation protein density and glial fibrillary acidic protein staining in the striatum,and the CD11b and glial fibrillary acidic protein staining in the substantia nigra.Hence,this study reports for the first time that concomitant activation of α7-nAChR andσ1-R can provide a partial recovery of the nigro-striatal dopaminergic neurons through the modulation of microglial activation.The study was approved by the Regional Ethics Committee(CEEA Val de Loire n°19)validated this protocol(Authorization N°00434.02)on May 15,2014. | Steven Vetel Laura Foucault-Fruchard Claire Tronel Frédéric Buron Jackie Vergote Sylvie Bodard Sylvain Routier Sophie Sérrière Sylvie Chalon | 2021 | Neural Regeneration Research2021，16，6： | 3 |
| 3 | Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12显示文摘 | Birgit Oppmann Robin Lesley Bianca Blom Jackie C Timans Yuming Xu Brisdell Hunte Felix Vega Nancy Yu Jing Wang Komal Singh Francesca Zonin Elena Vaisberg Tatyana Churakova Man-ru Liu Daniel Gorman Janet Wagner Sandra Zurawski Yong-Jun Liu John S Abrams Ke | 2000 | Immunity2000，，5： | 2 |
| 4 | Long-lasting symptoms and diagnostics in a patient with unrecognized right sided heart failure: Why listening to the heart is so important显示文摘M Ebstein is usually diagnosed in early childhood or ad-olescence. The young woman in our case complainted of fatigue and shortness of breath, on physical exami-nation she showed signs of heart failure with raised central venous pressure, palpable liver, an a cardiac murmer. Based on these findings she should have been referred to a cardiologist in an early stage after which transthoracic echocardiography resulted in the correct diagnosis. In this case the anomaly was missed for many years by different specialists and the patient was treated for liver disease, while she was suffering from liver congestion due to right-sided heart failure. | Liesbeth C de Vette Jasper J Brugts Jacky S McGhie Jolien W Roos-Hesselink | 2014 | World Journal of Cardiology2014，6，5： | 1 |
| 5 | Separation of concerns and the extended object machine显示文摘 | Frederic D Jacky E Remy S | 2004 | ADVICE:Journal of Aspect Orientation2004，1，1： | 1 |
| 6 | Pseudopodial actin dynamics control epithelial-mesenchymal transition in meta- static cancer cells 显示文摘 | Jay S Anat M Jackie CT | 2010 | Cancer Res2010，70，： | 1 |
| 7 | Adeno-Associated Virus Vectors for Therapeutic Gene Transfer显示文摘 | Jackie L Stilwell S Samulski R J | 2003 | Biotechniques2003，34，1： | 1 |
| 8 | Paying doctors by salary: a controlled study of general practitioner behaviour in England 显示文摘 | Toby G Bonnie S Jacky W | 2003 | Health Policy2003，，64： | 1 |
| 9 | Conversion of carbon dioxide into methanol with silanes over N-Het erocyclic carbene catalysts显示文摘 | Nurhanna S R Zhang Y G Jackie Y | 2009 | Angewandte Chemie Int Ed2009，121，18： | 1 |
| 10 | Gene-centric Association Signals for Lipids and Apolipoproteins Identified via the HumanCVD BeadChip显示文摘 | Philippa J. Talmud Fotios Drenos Sonia Shah Tina Shah Jutta Palmen Claudio Verzilli Tom R. Gaunt Jacky Pallas Ruth Lovering Kawah Li Juan Pablo Casas Reecha Sofat Meena Kumari Santiago Rodriguez Toby Johnson Stephen J. Newhouse Anna Dominiczak Nilesh J. S | 2009 | The American Journal of Human Genetics2009，，5： | 1 |
| 11 | Synthesis and application of supramolecular templated mesoporous materials显示文摘 | Ying Jackie Y Mehnert Christian P Wong Michael S | 1999 | Angewandte Chemie International Edition(S1521-3773)1999，38，12： | 1 |
| 12 | A Discrete Multitone Transceiver System forHDSL Applications显示文摘 | CHOW JACKY S | 1991 | IEEEJSAC1991，9，6： | 1 |
| 13 | An in-plane, bi-directional electrothermal MEMS actuator显示文摘 | Venditti Roberto Lee Jacky S H Sun Yu | 2006 | Journal of Micromechanics and Microengineering2006，16，10： | 1 |
| 14 | Project-based learning and the role of learning bounda-ries 显示文摘 | HARRY S JACKY S STEPHANE L MIKE B LINDA E SUE N | 2004 | Organization Studies2004，25，9： | 1 |
| 15 | Optimising oscillation frequency in oscillatory tillage显示文摘 | Gholamhossein S John F Jacky D | 2010 | Soil & Tillage Research2010，106，2： | 1 |
| 16 | Prevalence of the American Heart Association's 'Ideal cardiovascular health' metrics in a rural, cross-sectional, community-based study: The heart of New Ulm project显示文摘 | Jacqueline I Arthur S Jackie L | 2013 | J Am Heart Assoe2013，2，00： | 1 |
| 17 | Articular involvement in patients with relapsing polychondritis 显示文摘 | Gunaydin I Daikeler T Jacki S | 1998 | Rheumatol Int1998，18，3： | 1 |
| 18 | Synthesis and cell-imaging applications of glutathione-capped CdTe quantum dots显示文摘 | ZHENG Y G GAO S J JACKIE Y Y | 2007 | Adv Mater2007，19，3： | 1 |
| 19 | In vitro gastrointestinalmethod to estimate relative bioavailable cadmium in contaminatedsoil显示文摘 | JACKIE LS NICHOLAS T B and JITAO S | 2003 | Environ Sci Technol2003，37，7： | 1 |
| 20 | Behavioral and pharmacological therapies for late-life isomnia?:A randomized controlled trial显示文摘 | Charles M Cheryl C Jackie S | 1999 | JAMA1999，281，： | 1 |
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