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| 1 | Neuropathophysiology of functional gastrointestinal disorders显示文摘The investigative evidence and emerging concepts in neurogastroenterology implicate dysfunctions at the levels of the enteric and central nervous systems as underlying causes of the prominent symptoms of many of the functional gastrointestinal disorders. Neurogastroenterological research aims for improved understanding of the physiology and pathophysiology of the digestive subsystems from which the arrays of functional symptoms emerge. The key subsystems for defecation-related symptoms and visceral hyper- sensitivity are the intestinal secretory glands, the musculature and the nervous system that controls and integrates their activity. Abdominal pain and discomfort arising from these systems adds the dimension of sensory neurophysiology. This review details current concepts for the underlying pathophysiology in terms of the physiology of intestinal secretion, motility, nervous control, sensing function, immuno-neural communication and the brain-gut axis. | Jackie D Wood | 2007 | World Journal of Gastroenterology2007，13，9： | 17 |
| 2 | 特立独行的第二脑--肠神经系统显示文摘肠神经系统(enteric nervous system, ENS)由分布在肠壁的黏膜下及肌间两个神经丛组成,能独立地控制和调节胃肠的消化和吸收功能,被称为机体的第二脑(the second brain)或肠脑(gut brain)。ENS相对于中枢神经系统(central nervous system,CNS),在神经元的性能和环路上有着明显的独特性。ENS和CNS通过交感和副交感神经以及外周初级感觉神经组成反馈环路(脑-肠轴),影响个体的情绪、食欲和行为等其他功能。肠神经功能异常引起的胃肠功能紊乱不仅导致消化功能异常,还引起内脏痛及情绪和行为异常,如肠易激综合征(irritable bowel syndrome, IBS),严重影响病人的生活质量。然而,从世界范围来看,对ENS研究的深入程度和投入规模远低于对CNS的研究,在中国尤其如此。回顾ENS的研究历史,一个突出的问题是忽视了ENS的神经元及其神经网络和功能活动的特异性。本文将简介ENS结构和功能,举例重点阐述ENS独有的特性和重要意义,以期使更多的基础和临床研究领域的同仁们加深对ENS独特性的认识,促进ENS和相关疾病研究的进展。 | 李军华 段睿 李俍 WOOD Jackie D 望西玉 舒友生 王过渡 | 2020 | 生理学报2020，72，3： | 17 |
| 3 | Hu蛋白作为豚鼠小肠肌间丛神经元标志物的研究显示文摘比较 5种神经元标志物在小肠肌间丛神经元中的特异性。应用新发现的神经元标志物Hu蛋白 ,对豚鼠肠神经系统 (ENS)的小肠肌间丛神经元进行免疫荧光染色研究 ,并与其他神经元标志物MAP 2 ,PGP 9 5 ,NSE ,TUJ 1进行比较。结果表明 :Hu蛋白主要分布于神经元胞浆中 ,神经元核也有较浅的染色 ,尤其在whole mount上 ,每个神经元都清晰可见。MAP 2作为神经元标志物 ,也能显示完好的细胞形态 ,但由于粗大神经纤维的强染色 ,使神经元计数不准确。PGP 9 5 ,NSE和TUJ 1对体外培养的小肠肌间丛神经元染色良好 ,但在whole mount上 ,神经纤维强染色 ,无法计数分析。结果提示在豚鼠肠神经系统小肠肌间丛神经元的计数研究中 ,Hu蛋白是理想的神经元标志物。 | 林中 胡宏镇 Jackie D Wood | 2002 | 基础医学与临床2002，22，3： | 6 |
| 4 | Neuroprotective and anti-inflammatory effects of a therapy combining agonists of nicotinic α7 and σ1 receptors in a rat model of Parkinson’s disease显示文摘To date there is no treatment able to stop or slow down the loss of dopaminergic neurons that characterizes Parkinson’s disease.It was recently observed in a rodent model of Alzheimer’s disease that the interaction between the α7 subtype of nicotinic acetylcholine receptor(α7-nAChR)and sigma-1 receptor(σ1-R)could exert neuroprotective effects through the modulation of neuroinflammation which is one of the key components of the pathophysiology of Parkinson’s disease.In this context,the aim of the present study was to assess the effects of the concomitant administration of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide(PHA)543613 as an α7-nAChR agonist and 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate(PRE)-084 as aσ1-R agonist in a well-characterized 6-hydroxydopamine rat model of Parkinson’s disease.The animals received either vehicle separately or the dual therapy PHA/PRE once a day until day 14 postlesion.Although no effect was noticed in the amphetamine-induced rotation test,our data has shown that the PHA/PRE treatment induced partial protection of the dopaminergic neurons(15-20%),assessed by the dopamine transporter density in the striatum and immunoreactive tyrosine hydroxylase in the substantia nigra.Furthermore,this dual therapy reduced the degree of glial activation consecutive to the 6-hydroxydopamine lesion,i.e,the 18 kDa translocation protein density and glial fibrillary acidic protein staining in the striatum,and the CD11b and glial fibrillary acidic protein staining in the substantia nigra.Hence,this study reports for the first time that concomitant activation of α7-nAChR andσ1-R can provide a partial recovery of the nigro-striatal dopaminergic neurons through the modulation of microglial activation.The study was approved by the Regional Ethics Committee(CEEA Val de Loire n°19)validated this protocol(Authorization N°00434.02)on May 15,2014. | Steven Vetel Laura Foucault-Fruchard Claire Tronel Frédéric Buron Jackie Vergote Sylvie Bodard Sylvain Routier Sophie Sérrière Sylvie Chalon | 2021 | Neural Regeneration Research2021，16，6： | 3 |
| 5 | A prospective feasibility study of sub-millisievert abdominopelvic CT using iterative reconstruction in Crohn’s disease显示文摘 | Siobhan B O’Neill Patrick D Mc Laughlin Lee Crush Owen J O’Connor Sebastian R Mc Williams Orla Craig Anne Marie Mc Garrigle Fiona O’Neill Jackie Bye Max F. Ryan Fergus Shanahan Michael M Maher | 2013 | European Radiology2013，，： | 2 |
| 6 | Separation of concerns and the extended object machine显示文摘 | Frederic D Jacky E Remy S | 2004 | ADVICE:Journal of Aspect Orientation2004，1，1： | 1 |
| 7 | Repeated administration of synthetic oligodoxynucleotides expressing CpG motifys provides long-term protection against bacterial infection 显示文摘 | Dennis M Klinman D M Jackie C | 1999 | Infection and Immunity1999，67，11： | 1 |
| 8 | A study of polychlorinated dibenzo-p-dioxins and dibenzofurans in the atmosphere of Hong Kong 显示文摘 | Sin D W-m Jacky Y C Peter K-k L | 2002 | Chemosphere2002，，47： | 1 |
| 9 | R&D activity in Cana- da: Does corporate ownership structure matter? 显示文摘 | Jackie D V Laurin C Bozec Y | 2010 | Canadian Journal of Administrative Studies2010，27，2： | 1 |
| 10 | The Use of Multi-resolution Analyse and Wavelet Transform for Merging SPOT PanChromatic and MultiSpectral Image Data显示文摘 | Broud G D Jacky G Jean M C | 1996 | PE&RS1996，，9： | 1 |
| 11 | The use of multiresolution analyse and wavelet transform for merging SPOT panchromatic and multiSpectral image data显示文摘 | Broud G D Jacky G Jean M C | 1996 | PE&ES1996，，： | 1 |
| 12 | IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4 + T Cells显示文摘 | Stefan Pflanz Jackie C Timans Jeanne Cheung Rency Rosales Holger Kanzler Jonathan Gilbert Linda Hibbert Tatyana Churakova Marilyn Travis Elena Vaisberg Wendy M Blumenschein Jeanine D Mattson Janet L Wagner Wayne To Sandra Zurawski Terrill K McClanahan Dan | 2002 | Immunity2002，，6： | 1 |
| 13 | The operating microscope in dental practice:minimally invasive restorations显示文摘 | Perrin P Jacky D Hotz P | 2002 | Schweiz Monatsschr Zahnmed2002，112，7： | 1 |
| 14 | Prevalence of and Risk Factors for Hepatic Steatosis and Nonalcoholic Fatty Liver Disease in People With Type 2 Diabetes: the Edinburgh Type 2 Diabetes Study显示文摘 | Williamson Rachel M Price Jackie F Glancy Stephen Perry Elisa Nee Lisa D Hayes Peter C Frier Brian M Van Look Liesbeth A F Johnston Geoffrey I Reynolds Rebecca M Strachan Mark W J | 2011 | Diabetes Care2011，，5： | 1 |
| 15 | Large-scale sequence analysis of avian influenza isolates显示文摘 | Obenauer JC Jackie D Mehta PK | 2006 | Science2006，311，5767： | 1 |
| 16 | Geographic and developmental variation in expression of the circadian rhythm gene, timeless, in the pitcher-plant mosquito, Wyeomyia smithii 显示文摘 | Mathias D Jacky L Bradshaw W E | 2005 | Journal of Insect Physiology2005，51，6： | 1 |
| 17 | Wood, Enteric nervous system: reflexes, pattern generators and motility 显示文摘 | Jackie D | 2008 | Gastroenterology2008，24，2： | 1 |
| 18 | Optimising oscillation frequency in oscillatory tillage显示文摘 | Gholamhossein S John F Jacky D | 2010 | Soil & Tillage Research2010，106，2： | 1 |
| 19 | The use of muhiresolution analysis and wavelets transform for merging SPOT panchromatic and multispectral images data显示文摘 | Bruno G D Jacky G Chassery J M | 1996 | Photogrammetric Engineer & Remote Sensing1996，62，： | 1 |
| 20 | Synthesis of hexagonally packedmesoporous TiO2 by a modified Sol-gel method显示文摘 | ANTONELLI D M JACKIE Y Y | 1995 | Angew Chem Int Ed Eng1995，34，18： | 1 |
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