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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | A point mutation in a Drosophila GABA receptor confers insecticide resistance 显示文摘 | Ffrench-Constant Richard H Rocheleau Thomas A Steichen Jessica C Chalmers Alison E | 1993 | Nature (London)1993，363，： | 1 |
| 3 | Recovery of valuable elements from spent Li-batteries 显示文摘 | JESSICA F P NATALIA G B JLrLIO C A | 2008 | Journal of Hazardous Materi- als2008，150，： | 1 |
| 4 | Duodenal PKC-[delta] and Cholecystokinin Signaling Axis Regulates Glucose Production显示文摘 | Breen Danna M Yue Jessica T Y Rasmussen Brittany A Kokorovic Andrea Cheung Grace W C Lam Tony K T | 2011 | Diabetes2011，，12： | 1 |
| 5 | Novel bronsted acidic ionic liquids and their use as dual solvent-catalysts显示文摘 | Cole A C Jessica L Ioanna Ntai | 2002 | J Am Chem Soc2002，，124： | 1 |
| 6 | Novel bransted acidic ionic liquids and their use as dual solvent - catalysts显示文摘 | COLE A C JESSICA L IOANNA NTAI | 2002 | J Am Chem Soc2002，124，： | 1 |
| 7 | Angiogenic profile of breast carcinoma determines leukocyte infiltration 显示文摘 | JESSICA C A STEEGE B COEN I M | 2004 | Clin Cancer Res2004，10，21： | 1 |
| 8 | Identification ofclinical coryneform bacterial isolates: comparison of biochem-ical methods and sequence analysis of 16 S rRNA and rpoBgenes 显示文摘 | Elisabeth E A Jan W B Jessica R C | 2008 | J Clin Microbiol2008，46，3： | 1 |
| 9 | Novel Bronsted acidic ionic liquids and their use as dual solvent-catalysts显示文摘 | COLE A C JESSICA L IOANNA NTAI | 2002 | J Am Chem Soc2002，124，： | 1 |
| 10 | Circulating [alpha]Klotho influences phosphate handling by controlling FGF23 production显示文摘 | Smith Rosamund C O’Bryan Linda M Farrow Emily G Summers Lelia J Clinkenbeard Erica L Roberts Jessica L Cass Taryn A Saha Joy Broderick Carol Ma Y Linda Zeng Qing Qiang Kharitonenkov Alexei Wilson Jonathan M Guo Qianxu Sun Haijun Allen Matt | 2012 | Journal of Clinical Investigation2012，，12： | 1 |
| 11 | The 'Metabolic Memory' : Is More than Just Tight Glucose Control Necessary to Prevent Diabetic Complications? 显示文摘 | Antonio C Michael A Jessica E | 2008 | J Clin Endocrinol Metab2008，9，： | 1 |
| 12 | Tolvaptan: a new tool for the effective treatment of hyponatremia in psychotic disorders显示文摘 | Richard C Josiassen Jessica Curtis Dawn M Filmyer Brett Audino Nina Skuban Rita A Shaughnessy | 2010 | Expert Opinion on Pharmacotherapy2010，，4： | 1 |
| 13 | Novel Bronsted acidic ionic liquids and their Use as dual solvent-catalysts显示文摘 | Cole A C Jessica L Ioanna N | 2002 | J Am Chem Soc2002，124，： | 1 |
| 14 | Three Monte Carlo Programs of Polarized Light Transport into Scattering Media: Part I显示文摘 | JESSICA C RAMELLA R SCOTT A P | 2005 | Opt Express2005，13，12： | 1 |
| 15 | Wells and John Quackenbush Defining an Informativeness Metric for Clustering Gene Expression Data显示文摘 | Jessica C Mar Christine A | 2011 | Bioinfromatics2011，27，8： | 1 |
| 16 | The JAK2/STAT3 signaling pathway is required for growth of CD44^sup +^CD24^sup -^ stem cell-like breast cancer cells in human tumors显示文摘 | Marotta Lauren L C Almendro Vanessa Marusyk Andriy Shipitsin Michail Schemme Janina Walker Sarah R Bloushtain-Qimron Noga Kim Jessica J Choudhury Sibgat A Maruyama Reo Wu Zhenhua G?nen Mithat Mulvey Laura A Bessarabova Marina O Huh Sung Jin | 2011 | Journal of Clinical Investigation2011，，： | 1 |
| 17 | Trends in the management of anorectal melanoma:A multiinstitutional retrospective study and review of the world literature显示文摘BACKGROUND Anorectal melanoma(ARM)is a rare disease with a poor prognosis.Evidence on optimal treatment is limited and surgical management varies widely.We hypothesized that the frequency of abdominoperineal resection used as primary treatment of ARM has decreased over the past several decades.AIM To update our understanding of outcomes for patients with ARM and analyze management trends around the world.METHODS This is a multi-institutional,retrospective study of patients treated for ARM at 7 hospitals.Hospitals included both large,academic,tertiary care centers and smaller,general community hospitals.Using prospectively maintained institutional tumor registries,we identified 24 patients diagnosed with ARM between January 2000 and May 2019.We analyzed factors prognostic for recurrence and survival.We then used Cox regression to measure overall survival(OS)and melanoma-specific survival.We also performed a literature review to assess trends in surgical management and outcomes.RESULTS Of the 24 patients diagnosed with ARM,12(50.0%)had local,8(33.3%)regional,and 4(16.7%)distant disease at diagnosis.Median time to recurrence was 10.4 mo[interquartile range(IQR)7.5-17.2]with only 2 patients(9.3%)not developing recurrence following surgical resection.Median OS was 18.8 mo(IQR 13.5-33.9).One patient is still alive without recurrence at 21.4 mo from diagnosis;no other patient survived 5 years.Primary surgical management with abdominoperineal resection(APR)vs wide excision(WE)did not lead to differences in OS[hazard ratio=1.4(95%CI:0.3-6.8)].Review of the literature revealed geographic differences in surgical management of ARM,with increased use of WE in the United States and Europe over time and more frequent use of APR in Asia and India.There was no significant improvement in survival over time.CONCLUSION There is wide variation in the management of ARM and survival outcomes remain poor regardless of approach.Surgical management should aim to minimize morbidity. | Josh Bleicher Jessica N Cohan Lyen C Huang William Peche T Bartley Pickron Courtney L Scaife Tawnya L Bowles John R Hyngstrom Elliot A Asare | 2021 | World Journal of Gastroenterology2021，27，3： | 1 |
| 18 | Three Monte Carlo programs of polarized light transport into scattering media 显示文摘 | Jessica C R R Scott A P Steve L J | 2005 | Optics Express2005，13，12： | 1 |
| 19 | Effect of Immediate Fluid Resuscitation on the Rate, Volume, and Duration of Pulmonary Vascular Hemorrhage in a Sheep Model of Penetrating Thoracic Trauma显示文摘 | John C Sakles Matthew J Sena Derek A Knight Jessica M Davis | 1997 | Annals of Emergency Medicine1997，，3： | 1 |
| 20 | National, Regional, State, and Selected Local Area Vaccination Coverage Among Adolescents Aged 13-17 Years - United States, 2013显示文摘 | Elam-Evans Laurie D Yankey David Jeyarajah Jenny Singleton James A Curtis C Robinette MacNeil Jessica Hariri Susan | 2014 | Morbidity and Mortality Weekly Report2014，，29： | 1 |
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