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| 1 | 围手术期患者的安全:正确的患者、正确的手术、正确的部位——一项多因素、跨部门的干预性研究显示文摘背景为围手术期患者提供安全的环境非常重要。基于这一点,我们在围手术期实施了“患者安全第一”的政策。方法在干预性研究的第一阶段(2001—2002年),我们首先制定并实施干预性研究中组织和教育方面的内容。2003至2005年为研究的实施阶段。根据我们的零忍受原则,在手术等候区内一旦发现患者的麻醉或手术准备工作中有重大差错,该患者就被送回病房(失败),并等到差错得到纠正后再进行手术。结果共有15856例患者参加了研究。在研究实施阶段的3年中,有112例患者被送回病房(0.71%)。与2003年的数据相比,2004年和2005年发生的重大错误明显减少,且有统计学意义(2003、2004和2005年的数据分别为1.04%、0.59%和0.49%)。而且,逐步逻辑回归方法分析结果显示,手术前准备不充分所致重大错误的发生率逐年下降,具有统计学意义(比值比=1.48,95%CI:1.16~1.87)。此外,在2003、2004和2005年中,各年的失败发生平均间隔时间分别为6.6、11.2和14.7天(P〈0.03)。最后,不仅患者手术前准备工作在研究期间有显著改善(P〈0.0001);而且,使患者手术前准备工作评分为100%的可能性也有明显增加(P〈0.001)。结论教育和提高认识能减少围手术期的错误发生率。但是,即使有详细规划的制度,也无法达到无差错的环境。因此,检查和全面分析应该持续不断地进行。 | Edna Zohar Yossi Noga Ehud Davidson Margalit Kantor Brian Fredman 周全红(译) 江伟(校) | 2008 | 麻醉与镇痛2008，4，4： | 5 |
| 2 | TGF-β信号缺陷是否是人类癌症中的致命弱点?显示文摘癌细胞中的存活信号可激活mTOR-哺乳动物雷帕霉素靶蛋白。mTOR可抑制TGF-β信号,后者可使细胞周期停滞于G1后期,因此,活化后的mTOR可防止细胞周期停滞于TGF-β介导的检验点。雷帕霉素可重新激活TGF-β信号,从而导致G1期细胞停滞。在人类癌症中,TGF-β信号通常发生缺陷,相反,在雷帕霉素作用下,TGF-β信号缺陷的癌细胞不发生G1期停滞,而发生凋亡。因此,在基于雷帕霉素的抗癌治疗策略中,TGF-β信号缺陷可能是癌细胞的致命弱点。 | David A.Foster Noga Gadir | 2008 | 癌症2008，27，8： | 3 |
| 3 | Parental acceptability of the watchful waiting approach in pediatric acute otitis media显示文摘AIM: To determine parental knowledge about acute otitis media(AOM) and its antibiotic therapy, antibiotic resistance and the willingness to comply with the watchful waiting(WW) approach in primary care settings in southern Israel.METHODS: The study was conducted in 3 primary care clinics and the pediatric emergency room of Soroka University Medical Center. Questionnaires(20 questions on education background, previous AOM experience, knowledge on antimicrobial resistance and attitude vs the WW approach) were filled by 600 parents(150 at each centers) of children < 6 years of age.RESULTS: Mothers represented 69% of parents; 2% had an education of < 10 school years, 46% had high-school education and 17% had an academic degree. 69% parents reported previous experience with AOM and 56% thought that antibiotics represent the only treatment for AOM. Knowledge on bacterial resistance to antibiotics was reported by 57% of the parents; 86% parents were willing to accept/probably accept the WW approach for their children. Logistic regression analysis revealed a significant association between parental education and knowledge about bacterial resistance to antibiotics and that previous experience with AOM was significantly associated with reluctance to accept the WW approach. More parents with knowledge on bacterial resistance were willing to accept the WW approach compared with parents without such knowledge. No correlation was found between the education level and willingness to accept the WW approach. CONCLUSION: A significant correlation was found between previous parental education and experience with AOM and the knowledge about antibiotic use, bacterial resistance and acceptance of the WW approach. | Arnon Broides Olga Bereza Noga Lavi-Givon Yariv Fruchtman Eli Gazala Eugene Leibovitz | 2016 | World Journal of Clinical Pediatrics2016，5，2： | 2 |
| 4 | Multiscale patterning of a metallic glass using sacrificial imprint lithography显示文摘Bulk metallic glasses(BMGs)have been developed as a means to achieve durable multiscale,nanotextured surfaces with desirable properties dictated by topography for a multitude of applications.One barrier to this achievement is the lack of a bridging technique between macroscale thermoplastic forming and nanoimprint lithography,which arises from the difficulty and cost of generating controlled nanostructures on complex geometries using conventional top-down approaches.This difficulty is compounded by the necessary destruction of any resulting reentrant structures during rigid demolding.We have developed a generalized method to overcome this limitation by sacrificial template imprinting using zinc oxide(ZnO)nanostructures.It is established that such structures can be grown inexpensively and quickly with tunable morphologies on a wide variety of substrates out of solution,which we exploit to generate the nanoscale portion of the multiscale pattern through this bottom-up approach.In this way,we achieve metallic structures that simultaneously demonstrate features from the macroscale down to the nanoscale,requiring only the top-down fabrication of macro/microstructured molds.Upon detachment of the formed part from the multiscale molds,the ZnO remains embedded in the surface and can be removed by etching in mild conditions to both regenerate the mold and render the surface of the BMGs nanoporous.The ability to pattern metallic surfaces in a single step on length scales from centimeters down to nanometers is a critical step toward fabricating devices with complex shapes that rely on multiscale topography for their intended functions,such as biomedical and electrochemical applications. | Jonathan P.Singer Candice I.Pelligra Noga Kornblum Youngwoo Choo Manesh Gopinadhan Punnathat Bordeenithikasem Jittisa Ketkaew Seng Fatt Liew Hui Cao Jan Schroers Chinedum O.Osuji | 2015 | Microsystems & Nanoengineering2015，1，1： | 2 |
| 5 | A novel family of peptide antibiotics for fish显示文摘 | Noga E J Piseidins S U | 2003 | Drug News Perspect2003，16，： | 1 |
| 6 | Evaluation of the bitterness of green tea catechins by a cell-based assay with the human bitter taste receptor hTAS2R39显示文摘 | Masataka Narukawa Chiaki Noga Yohei Ueno Tsutomu Sato Takumi Misaka Tatsuo Watanabe | 2011 | Biochemical and Biophysical Research Communications2011，，4： | 1 |
| 7 | Anti-inflammatory properties of montelukasl, a leukotriene receptor antago- nist in patients with asthma and nasal polyposis显示文摘 | Schaper C Noga O Koch B | 2011 | J In- vestig Allergol Clin Immunol2011，21，1： | 1 |
| 8 | Primary structure and cellular localization of callinectin, an antimicrobial peptide from the blue crab 显示文摘 | Noga E J Stone K L Wood A | 2011 | Developmental & Comparative Immunology2011，35，4： | 1 |
| 9 | Chronicity of pain associated with spinal cord injury:A longitu- dinal analysis 显示文摘 | Cruz- AlmeidaY Martinez- ArizalaA Widerstrom- Noga EG | 2005 | J Rehabil Res Dev2005，42，5： | 1 |
| 10 | Endopye|oto- my for ureteropelvic junction stenosis 显示文摘 | Szewczyk W Szkodny A Noga A | 1992 | Int Urot Nephrol1992，24，： | 1 |
| 11 | Yttrium-90–ibritumomab tiuxetan (Zevalin) combined with high-dose BEAM chemotherapy and autologous stem cell transplantation for chemo-refractory aggressive non-Hodgkin’s lymphoma显示文摘 | Avichai Shimoni S. Tzila Zwas Yakov Oksman Izhar Hardan Noga Shem-Tov Ronit Yerushalmi Abraham Avigdor Isaac Ben-Bassat Arnon Nagler | 2007 | Experimental Hematology2007，，4： | 1 |
| 12 | Diagnostic value of HepParl, pCEA, CD10, and CD34 expression in separating hepatocellular carcinoma from metastatic carcinoma in fine-needle aspiration cytology 显示文摘 | Saad R S Luckasevic T M Noga C M | 2004 | Diagn Cytopathol2004，30，1： | 1 |
| 13 | Long-term treatment with oral silednafil is safe and improves functional capacity and hemodynamics in patients with puhnonary arterial hypertension 显示文摘 | Michelakis ED Tymchak W Noga M l | 2003 | Circulation2003，108，17： | 1 |
| 14 | Perioperative patient Safety:correct patient, correct surgery, correct side-a multifaceted,cross-organization,interventional study显示文摘 | Zohar E Noga Y Davidson E | 2007 | Anesth Analg2007，105，2： | 1 |
| 15 | Proton Magnetic Resonance Spectroscopy of the Thalamus in Patients with Chronic Neuropathic Pain after Spinal Cord Injury显示文摘 | Pattany PM Yezierski RP Noga EGW | 2002 | Am J Neuroradiol2002，23，6： | 1 |
| 16 | Effect of hydrogen peroxide production and the Fenton reaction on membrane composition of Streptococcus pneumonia 显示文摘 | Stella Pesakhov Rachel Benisty Noga Sikron | 2007 | Biochimica et Biophysica Acta (BBA)- Biomembranes2007，1768，3： | 1 |
| 17 | Optimal therapeutic strategies in ovarian epithelial cancer in 1997显示文摘 | Piccart MJ Noga ret JM | 1997 | Rev Med Brus1997，18，： | 1 |
| 18 | An unexpected requirement for phosphatidylethanolamine N - methyltransferase in the secretion of very low density lipoproteins显示文摘 | NOGA A A ZHAO Y VANCE D E | 2002 | J Biol Chem2002，277，42： | 1 |
| 19 | 显示文摘 | Swaisgood CM French EL Noga C | 2000 | Am J Pathol2000，157，： | 1 |
| 20 | A graph-theoretic game and its application to the k-serve problem显示文摘 | NOGA A RICHARD M K DAVID P | 1995 | SIAM Journal on Computing1995，24，1： | 1 |
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