|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Therapeutic approaches to non-alcoholic fatty liver disease: past achievements and future challenges显示文摘BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver injury and mortality in Western countries and China. However, as to date, there is no direct and effective therapy for this disease. The aim of this review is to analyze the key progress and challenges of main current therapeutic approaches in NAFLD. DATA SOURCE: We carried out a PubMed search of English-language articles relevant to NAFLD therapy. RESULTS: There are two major therapeutic strategies for NAFLD treatment: (1) lifestyle interventions (including weight reduction, dietary modification and physical exercise) and (2) pharmaceutical therapies. Lifestyle interventions, particularly chronic and moderate intensity exercise, are the most effective and recognized clinical therapies for NAFLD. For pharmaceutical therapies, although their effects and mechanisms have been extensively investigated in laboratory studies, they still need further tests and investigations in clinical human trials. CONCLUSION: Future advancement of NAFLD therapy should focus on the mechanistic studies on cell based and animal models and human clinical trials of exercise, as well as the combination of lifestyle intervention and pharmaceutical therapy specifically targeting main signaling pathways related to lipid metabolism, oxidative stress and inflammation. | Jia Xiao Rui Guo Man Lung Fung Emily C Liong George L Tipoe | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，2： | 14 |
| 2 | Purified human bone marrow multipotent mesenchymal stem cells regenerate infarcted myocardium in experimental rats显示文摘 | Zhang S Jia Z Ge J Gong L Ma Y Li T Guo J Chen P Hu Q Zhang P Liu Y Li Z Ma K Li L Zhou C | 2006 | 中国生物学文摘2006，20，5： | 5 |
| 3 | SPSBl-mediated HnRNP A1 alternative splicing and cell ubiquitylation regulates migration in EGF signaling显示文摘细胞外的信号被显示了影响拼接的其他的 pre-mRNA;然而,分子的机制和导致信号的拼接的规定的生物意义仍然保持大部分未知。这里,我们报导那个表皮的生长因素(EGF ) 通过一个著名拼接管理者的 ubiquitylation 导致拼接的变化, hnRNP A1。EGF 发信号 upregulates 一个 E3 ubiquitin (Ub ) ligase 适配器,敏捷的包含域的 SOCS 盒子蛋白质 1 (SPSB1 ) ,它结合离氨酸 29 连接 polyUb 链到 hnRNP A1 上的成员 Elongin B/C-Cullin 建筑群。重要地, hnRNP A1 的 SPSB1 和 ubiquitylation 在驾驶 EGF 的房间移植有一个关键角色。机械学地,和 SR 蛋白质 kinases (SRPK ) 的激活的 hnRNP A1 的导致 EGF 的 ubiquitylation 导致拼接的 Rac1 的 upregulation isoform, Rac1b,支持房间活动性。这些调查结果解开在蛋白质 ubiquitylation 并且在 EGF/EGF 受体发信号的其他的拼接之间的新奇串音,并且在 modulating 房间移植识别新 EGF/SPSB1/hnRNP A1/Rac1 轴,它可以为癌症治疗有重要含意。 | Feng Wang Xing Fu Peng Chen Ping Wu Xiaojuan Fan Na Li Hong Zhu Ting-Ting Jia Hongbin Ji Zefeng Wang Catherine C L Wong Ronggui Hu Jingyi Hui | 2017 | Cell Research2017，27，4： | 5 |
| 4 | Design and establishment of warehouse on literature of acupunture-moxibustion methods 显示文摘 | Wang J L Li R L Jia C S | 2011 | World J Acu-moxi2011，21，3： | 1 |
| 5 | Design and establishment of datewarehouse on literature of acupuncture and moxibustion met-hods显示文摘 | Wang J L Li R L Jia C S | 2011 | World J Acu-moxi2011，21，3： | 1 |
| 6 | A research on the grain growth of WC-Co cemented carbide显示文摘 | Sun L Jia C C Xian M | 2007 | Internatinal Journal of Refractory Metals and Hard Materials2007，25，： | 1 |
| 7 | S-nitrosohaemoglobin:a dynamic activity of blood involved in vascular control显示文摘 | Jia L Bonaventura C Bonavertura J | 1996 | Nature1996，380，657： | 1 |
| 8 | Chemical separation of bioactive licorice compounds using capillary electrophoresis 显示文摘 | JIA C PAUL L | 2007 | Journal of Liquid Chromatography & Related Technologies2007，30，： | 1 |
| 9 | Systematic review on the effectiveness of embedding catgut therapy for simple obesi- ty显示文摘 | Zhang X P Jia C S Wand J L | 2013 | World J Acu-moxi2013，23，3： | 1 |
| 10 | Metabolomic identification of potential phospholipid biomarkers for chronic glomerulonephritis by using high performance liquid chromatography-mass spectrometry显示文摘 | JIA L WANG C ZHAO S | 2007 | J Chromatogr B Analyt Technol Biomed Life Sci2007，860，1： | 1 |
| 11 | Morphological characters, inheritance and response to exogenous hormones of a cotton super-dwarf mutant of Gossypium hirsutum 显示文摘 | Zhang C Sun J L Jia Y H etal | 2011 | Plant Breeding2011，130，1： | 1 |
| 12 | Microchim Acta显示文摘 | Jia X Y Han Y Liu X L Duan T C Chen H T | 2010 | 171(1-2):492010，171，12： | 1 |
| 13 | Activation of telomerase by human cytomegalovirus 显示文摘 | Strt K Liu C Rahbar A Zhu Q Liu L Wolmer- Solberg N Lou F Liu Z Shen J Jia J Kyo S Bj6rkholm M Sj6berg J S6derberg-Naucl6r C Xu D | 2009 | J Natl Cancer Inst2009，101，7： | 1 |
| 14 | Axl as a downstream effector of TGF- !31 via PI3K/Akt-PAK1 signaling pathway promotes tumor inva- sion and chemoresistance in breast carcinoma 显示文摘 | LI Y JIA L LIU C | 2015 | Tumor Biol2015，36，2： | 1 |
| 15 | Enhanced visible-light photocatalytic activity of g-C3 N4/Zn2GeO4 heterojunctions with effective interfaces based on band match显示文摘 | Sun L Qi Y Jia C | 2014 | Nanoscale2014，6，： | 1 |
| 16 | Effect of discharge pulsating on microarc oxidation coatings on Ti6A14V alloy显示文摘 | Wang Y M Jia D C Gun L X | 2005 | Mater Chem Phys2005，90，： | 1 |
| 17 | Rh2 Synergistically Enhances Paclitaxel or Mitoxantrone in Prostate Cancer Models显示文摘 | Eberding A Madera C Fazli L Jia W Goldenberg L | 2006 | J Urol2006，175，： | 1 |
| 18 | Direct observation of continuous electric dipole rotation in flux- closure domains in ferroelectric Pb ( Zr, Ti ) 03 显示文摘 | Jia C L Urban K W Alexe M | 2011 | Science2011，331，6023： | 1 |
| 19 | Exploration of 16 candidate genes identifies the association of IDE with Alzheimer's disease in Han Chinese显示文摘 | Wang F Shu C Jia L | 2012 | Neurobiol Aging2012，33，10： | 1 |
| 20 | Effects of genotypes and bagging practice on content of β-carotene in apple fruits显示文摘 | Jia D J Fan L M Liu G S Shen J L Liu C L Yuan Y B | | 0，，04： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员