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| 1 | Segmentation of Hematoxylin-Eosin stained breast cancer histopathological images based on pixel-wise SVM classifier显示文摘Hematoxylin-Eosin(HE) staining is the routine diagnostic method for breast cancer(BC), and large amounts of HE stained histopathological images are available for analysis. It is emergent to develop computational methods to efficiently and objectively analyze these images, with the aim of providing potentially better diagnostic and prognostic information for BC. This work focuses on analyzing our in-house HE stained histopathological images of breast cancer tissues. Since tumor nests(TNs) and stroma morphological characteristics can reflect the biological behaviors of breast invasive ductal carcinoma(IDC), accurate segmentation of TNs and the stroma is the first step towards the subsequent quantitative analysis. We first propose a method based on the pixel-wise support vector machine(SVM) classifier for segmenting TNs and the stroma, then extract four morphological characters related to the TNs from the images and investigate their relationships with the patients' 8-year disease free survival(8-DFS). The evaluation result shows that the classification based segmentation method is able to distinguish between TNs and stroma with 87.1% accuracy and 80.2% precision,suggesting that the proposed method is promising in segmenting HE stained IDC histopathological images. The Kaplan-Meier survival curves show that three morphological characters(number of TNs, total perimeter, and average area of TNs) in the images have statistical correlations with 8-DFS of the patients, illustrating that the segmented images can help to identify new morphological factors in IDC TNs for the prediction of BC prognosis. | QU AiPing CHEN JiaMei WANG LinWei YUAN JingPing YANG Fang XIANG QingMing MASKEY Ninu YANG GuiFang LIU Juan LI Yan | 2015 | Science China(Information Sciences)2015，58，9： | 12 |
| 2 | Targeting autophagy using small-molecule compounds to improve potential therapy of Parkinson’s disease显示文摘Parkinson’s disease(PD),known as one of the most universal neurodegenerative diseases,is a serious threat to the health of the elderly.The current treatment has been demonstrated to relieve symptoms,and the discovery of new small-molecule compounds has been regarded as a promising strategy.Of note,the homeostasis of the autolysosome pathway(ALP)is closely associated with PD,and impaired autophagy may cause the death of neurons and thereby accelerating the progress of PD.Thus,pharmacological targeting autophagy with small-molecule compounds has been drawn a rising attention so far.In this review,we focus on summarizing several autophagy-associated targets,such as AMPK,m TORC1,ULK1,IMPase,LRRK2,beclin-1,TFEB,GCase,ERRα,C-Abelson,and as well as their relevant small-molecule compounds in PD models,which will shed light on a clue on exploiting more potential targeted small-molecule drugs tracking PD treatment in the near future. | Kai Zhang Shiou Zhu Jiamei Li Tingting Jiang Lu Feng Junping Pei Guan Wang Liang Ouyang Bo Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 9 |
| 3 | Disturbance of hippocampal H2S generation contributes to CUMS-induced depression-like behavior: involvement in endoplasmic reticulum stress of hippocampus显示文摘长期的无法预言的温和压力淫液模型是消沉的一个广泛地使用的试验性的模型。在马头鱼尾的怪兽的外长的导致压力的 neuronal 房间死亡仔细与消沉的致病被联系。过多、延长的 endoplasmic 蜂窝胃嗯压力扳机房间死亡。氢硫化物 H 2 S,第三内长的发信号 gasotransmitter,作为 neuromodulator 和 neuroprotectant 在大脑功能起一个重要作用。我们假设了内长的 H 2 S 产生并且嗯在马头鱼尾的怪兽的应力可能涉及导致淫液的像消沉的行为。因此,集中于是否达到高潮的现在的学习扰乱内长的 H 2 S 和起来调整嗯在马头鱼尾的怪兽的应力并且是否外长的 H 2 S 阻止导致淫液的象压抑一样行为。结果证明对待淫液的老鼠展出像消沉的行为并且海马趾嗯包括调整葡萄糖的蛋白质的起来调整的层次的压力回答 78, CCAAT/enhancer 有约束力的蛋白质相应蛋白质,和劈开的 caspase-12 表示,当时 H 2 在马头鱼尾的怪兽的 S 在对待淫液的老鼠被压制。而且,外长的 H 2 S 阻止导致淫液的像消沉的行为。这些数据显示导致淫液的像消沉的行为与内长的 H 2 S 产生并且嗯在马头鱼尾的怪兽的应力并且建议了那内长的 H 2 S 并且嗯应力是消沉的新奇处理目标。 | Huiying Tan Wei Zou Jiamei Jiang Ying Tian Zhifang Xiao Lili Bi Haiying Zeng Xiaoqing Tang | 2015 | Acta Biochimica et Biophysica Sinica2015，47，4： | 8 |
| 4 | A Hazard Assessment Method for Potential Earthquake-Induced Landslides – A Case Study in Huaxian County, Shaanxi Province显示文摘The hazard assessment of potential earthquake-induced landslides is an important aspect of the study of earthquake-induced landslides. In this study, we assessed the hazard of potential earthquake-induced landslides in Huaxian County with a new hazard assessment method. This method is based on probabilistic seismic hazard analysis and the Newmark cumulative displacement assessment model. The model considers a comprehensive suite of information, including the seismic activities and engineering geological conditions in the study area, and simulates the uncertainty of the intensity parameters of the engineering geological rock groups using the Monte Carlo method. Unlike previous assessment studies on ground motions with a given exceedance probability level, the hazard of earthquake-induced landslides obtained by the method presented in this study allows for the possibility of earthquake-induced landslides in different parts of the study area in the future. The assessment of the hazard of earthquake-induced landslides in this study showed good agreement with the historical distribution of earthquake-induced landslides. This indicates that the assessment properly reflects the macroscopic rules for the development of earthquake-induced landslides in the study area, and can provide a reference framework for the management of the risk of earthquakeinduced landslides and land planning. | LIU Jiamei GAO Mengtan WU Shuren WANG Tao WU Jian | 2016 | Acta Geologica Sinica(English Edition)2016，90，2： | 8 |
| 5 | Effects of nape acupuncture combined with swallowing rehabilitation on dysphagia in pseudobulbar palsy显示文摘OBJECTIVE: To evaluate the therapeutic effects of nape acupuncture combined with rehabilitative swallowing training for dysphagia caused by pseudobulbar palsy, and to compare it with rehabilitative swallowing training alone, and to observe the improvement in quality of life after the therapy.METHODS: One hundred patients were randomly divided into two groups: the rehabilitative swallowing training group(control group, n = 50) and the nape acupuncture combined with rehabilitative swallowing training group(experimental group,n = 50). Each group had 8 weeks' therapy, 5 times a week. Patients in the control group received rehabilitative swallowing training, while those in the experimental group received nape acupuncture therapy based on swallowing rehabilitation. The out-comes were assessed by the repetitive saliva-swallowing test(RSST), water swallow test(WST), standardized swallowing assessment(SSA), and a swallow quality-of-life questionnaire(SWAL-QOL). Correlations of onset age, onset frequency and lesion location with the efficacy of the acupuncture treatment were also observed.RESULTS: The scores for RSST, WST, and SSA in both groups were lower than before the therapy(P <0.001), although the changes were more marked in the experimental group than in the control group(RSST and WST, P < 0.005; SSA, P < 0.001). Both groups recorded changes in SWAL-QOL index after the therapy(P < 0.001); and the experimental group scored higher than the control group(P < 0.001). The efficacy of acupuncture was not correlated with location(P > 0.05), but was related to onset age(P < 0.05) and onset frequency(P < 0.01).CONCLUSION: Nape acupuncture combined with rehabilitative swallowing training has an effect on dysphagia caused by pseudobulbar palsy and improves quality of life. | Liu Xiaoping Chen Feiyu Chu Jiamei Bao Yehua | 2018 | Journal of Traditional Chinese Medicine2018，38，1： | 7 |
| 6 | Fault location of distribution networks based on multi-source information显示文摘In order to promote the development of the Internet of Things(IoT),there has been an increase in the coverage of the customer electric information acquisition system(CEIAS).The traditional fault location method for the distribution network only considers the information reported by the Feeder Terminal Unit(FTU)and the fault tolerance rate is low when the information is omitted or misreported.Therefore,this study considers the influence of the distributed generations(DGs)for the distribution network.This takes the CEIAS as a redundant information source and solves the model by applying a binary particle swarm optimization algorithm(BPSO).The improved Dempster/S-hafer evidence theory(D-S evidence theory)is used for evidence fusion to achieve the fault section location for the distribution network.An example is provided to verify that the proposed method can achieve single or multiple fault locations with a higher fault tolerance. | Wenbo Li Jianjun Su Xin Wang Jiamei Li Qian Ai | 2020 | Global Energy Interconnection2020，3，1： | 7 |
| 7 | Nicotinamide adenine dinucleotide phosphate oxidase activation and neuronal death after ischemic stroke显示文摘Nicotinamide adenine dinucleotide phosphate oxidase(NOX) is a multisubunit enzyme complex that utilizes nicotinamide adenine dinucleotide phosphate to produce superoxide anions and other reactive oxygen species. Under normal circumstances, reactive oxygen species mediate a number of important cellular functions, including the facilitation of adaptive immunity. In pathogenic circumstances, however,excess reactive oxygen species generated by NOX promotes apoptotic cell death. In ischemic stroke, in particular, it has been shown that both NOX activation and derangements in glucose metabolism result in increased apoptosis. Moreover, recent studies have established that glucose, as a NOX substrate, plays a vital role in the pathogenesis of reperfusion injury. Thus, NOX inhibition has the potential to mitigate the deleterious impact of hyperglycemia on stroke. In this paper, we provide an overview of this research,coupled with a discussion of its implications for the development of NOX inhibition as a strategy for the treatment of ischemic stroke. Both inhibition using apocynin, as well as the prospect of developing more specific inhibitors based on what is now understood of the biology of NOX assembly and activation, will be highlighted in the course of our discussion. | Jiamei Shen Radhika Rastogi Xiaokun Geng Yuchuan Ding | 2019 | Neural Regeneration Research2019，14，6： | 6 |
| 8 | Calculation Model for the Propagation of Audible Noise from High Voltage Transmission Lines显示文摘Audible noise from high voltage transmission lines’ corona discharge has become one of the decisive factors affecting design of high voltage transmission lines, thus it is very important to study the spatial propagation characteristics of audible noise for its accurate pre- diction. A calculation model for the propagation of audible noise is presented in this paper, which is based on the basic equation of the sound wave and can involve the influences of the atmosphere absorption and ground effects. The effects of different ground impedances and the atmospheric attenuation on the distribution of sound pressure level are discussed in this paper. The results show that the atmospheric absorp- tion may increase the attenuation of the audible noise, and the ground surface affects both the amplitude and phase of the sound. The spatial distribution fluctuates considering the ground effects. The atmospheric attenuation and the ground effect are closely related to the frequency of the noise. In the frequency range of the audible noise, the influence of atmospheric attenuation on the spatial propagation characteristics is more obvious in high frequency while ground has significant influences in low frequency. | LI Xuebao CUI Xiang LU Tiebing HE Jiamei | 2013 | 高电压技术2013，39，8： | 6 |
| 9 | Thermogravimetric study of the effect of a PVA oxygen-insulating barrier on the spontaneous combustion of coal显示文摘Coal samples in the air for three months were characterized by Thermogravimetric Analysis (TGA). The effect of a PVA oxygen-insulating barrier on the spontaneous combustion of coal was examined. The moisture loss activation energy, oxidation activation energy and combustion activation energy were calculated by an integral method using the Coats-Redfen formula. The results show that the tendency for spontaneous combustion of three coal samples (judged by the activation energy) falls in the order: CYW>YJL>SW. The oxidation activation energy and combustion activation energy of coal protected by the PVA oxygen-insulating barrier increased. A significant increase in the combustion activation energy was noted, especially for the CYW coal where the in-crease was 28.53 kJ/mol. Hence, oxidation of the protected coal samples was more difficult. The PVA oxygen-insulating barrier helps to prevent spontaneous combustion of the coal. | MENG Xianhang CHU Ruizhi WU Guoguang XU Hongfeng ZHU Jiamei WANG Zhihua | 2010 | Mining Science and Technology2010，20，6： | 5 |
| 10 | Recent Progress of Two-Dimensional Thermoelectric Materials显示文摘Thermoelectric generators have attracted a wide research interest owing to their ability to directly convert heat into electrical power.Moreover,the thermoelectric properties of traditional inorganic and organic materials have been significantly improved over the past few decades.Among these compounds,layered two-dimensional(2D)materials,such as graphene,black phosphorus,transition metal dichalcogenides,IVA–VIA compounds,and MXenes,have generated a large research attention as a group of potentially high-performance thermoelectric materials.Due to their unique electronic,mechanical,thermal,and optoelectronic properties,thermoelectric devices based on such materials can be applied in a variety of applications.Herein,a comprehensive review on the development of 2D materials for thermoelectric applications,as well as theoretical simulations and experimental preparation,is presented.In addition,nanodevice and new applications of 2D thermoelectric materials are also introduced.At last,current challenges are discussed and several prospects in this field are proposed. | Delong Li Youning Gong Yuexing Chen Jiamei Lin Qasim Khan Yupeng Zhang Yu Li Han Zhang Heping Xie | 2020 | Nano-Micro Letters2020，12，3： | 5 |
| 11 | Mild closed head traumatic brain injury-induced changes in monoamine neurotransmitters in the trigeminal subnuclei of a rat model:mechanisms underlying orofacial allodynias and headache显示文摘Our recent findings have demonstrated that rodent models of closed head traumatic brain injury exhibit comprehensive evidence of progressive and enduring orofacial allodynias, a hypersensitive pain response induced by non-painful stimulation. These allodynias, tested using thermal hyperalgesia, correlated with changes in several known pain signaling receptors and molecules along the trigeminal pain pathway, especially in the trigeminal nucleus caudalis. This study focused to extend our previous work to investigate the changes in monoamine neurotransmitter immunoreactivity changes in spinal trigeminal nucleus oralis, pars interpolaris and nucleus tractus solitaries following mild to moderate closed head traumatic brain injury, which are related to tactile allodynia, touch-pressure sensitivity, and visceral pain. Our results exhibited significant alterations in the excitatory monoamine, serotonin, in spinal trigeminal nucleus oralis and pars interpolaris which usually modulate tactile and mechanical sensitivity in addition to the thermal sensitivity. Moreover, we also detected a robust alteration in the expression of serotonin, and inhibitory molecule norepinephrine in the nucleus tractus solitaries, which might indicate the possibility of an alteration in visceral pain, and existence of other morbidities related to solitary nucleus dysfunction in this rodent model of mild to moderate closed head traumatic brain injury. Collectively, widespread changes in monoamine neurotransmitter may be related to orofacial allodynhias and headache after traumatic brain injury. | Golam Mustafa Jiamei Hou Rachel Nelson Shigeharu Tsuda Mansura Jahan Naweed S.Mohammad Joseph V.Watts Floyd J.Thompson Prodip Bose | 2017 | Neural Regeneration Research2017，12，6： | 5 |
| 12 | Regulation of microbiota–GLP1 axis by sennoside A in diet-induced obese mice显示文摘Sennoside A(SA) is a bioactive component of Chinese herbal medicines with an activity of irritant laxative, which is often used in the treatment of constipation and obesity. However, its activity remains unknown in the regulation of insulin sensitivity. In this study, the impact of SA on insulin sensitivity was tested in high fat diet(HFD)-induced obese mice through dietary supplementation. At a dosage of 30 mg/kg/day, SA improved insulin sensitivity in the mice after 8-week treatment as indicated by HOMA-IR(homeostatic model assessment for insulin resistance) and glucose tolerance test(GTT). SA restored plasma level of glucagon-like peptide 1(GLP1) by 90% and mRNA expression of Glp1 by 80% in the large intestine of HFD mice. In the mechanism, SA restored the gut microbiota profile, short chain fatty acids(SCFAs), and mucosal structure in the colon. A mitochondrial stress was observed in the enterocytes of HFD mice with ATP elevation, structural damage, and complex dysfunction. The mitochondrial response was induced in enterocytes by the dietary fat as the same responses were induced by palmitic acid in the cell culture. The mitochondrial response was inhibited in HFD mice by SA treatment. These data suggest that SA may restore the function of microbiota–GLP1 axis to improve glucose metabolism in the obese mice. | Jiamei Le Xiaoying Zhang Weiping Jia Yong Zhang Juntao Luo Yongning Sun Jianping Ye | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 5 |
| 13 | Monitoring of atmospheric radionuclides from the Fukushima nuclear accident and assessing their impact on Xi'an, China显示文摘Aerosol radionuclides (131I, 134Cs, 137Cs) and gaseous radioactive xenon (133Xe) were monitored at Xi'an, China following the accident at the Fukushima nuclear power plant in March 2011. The additional annual effective dose attributable to the Fukushima emissions was much lower than the public annual effective dose from natural radiation, according to Chinese national standards. The monitoring results were compared with data from other countries as well as with the radionuclide concentrations observed in Xi'an after the Chernobyl nuclear accident in 1986. Possible transport pathways of the released radionuclides from Fukushima to Xi'an were investigated. The occurrence of an anticyclone in the Pacific Ocean region and the extended period over which the radionuclides were released made the determination transport pathways complex, but divergence in the plume and easterly flow evidently brought the initial suite of radionuclides to Xi'an. | LIU LongBo WU Shan CAO JunJi XIE Feng SHI QuanLin ZHANG ChangYun TANG HanBing HE XiaoBin ZHANG Rong CHEN LiYun WEI GuanYi ZHANG ZhiHong ZHANG JiaMei DANG HaiJun | 2013 | Chinese Science Bulletin2013，58，13： | 4 |
| 14 | Tuning filament composition and microstructure of 3D-printed bioceramic scaffolds facilitate bone defect regeneration and repair显示文摘It is still a challenge to optimize the component distribution and microporous structures in scaffolds for tailoring biodegradation(ion releasing)and enhancing bone defect repair within an expected time stage.Herein,the core–shell-typed nonstoichiometric wollastonite(4%and 10%Mg-doping calcium silicate;CSiMg4,CSiMg10)macroporous scaffolds with microporous shells(adding~μ10 μm PS microspheres into shell-layer slurry)were fabricated via 3D printing.The initial mechanical properties and bio-dissolution(ion releasing)in vitro,and osteogenic capacity in vivo of the bioceramic scaffolds were evaluated systematically.It was shown that endowing high-density micropores in the sparingly dissolvable CSiMg10 or dissolvable CSiMg4 shell layer inevitably led to nearly 30%reduction of compressive strength,but such micropores could readily tune the ion release behaviour of the scaffolds(CSiMg4@CSiMg10 vs.CSiMg4@CSiMg10-p;CSiMg10@CSiMg4 vs.CSiMg10@CSiMg4-p).Based on the in rabbit femoral bone defect repair model,the 3D μCT reconstruction and histological observation demonstrated that the CSiMg4@CSiMg10-p scaffolds displayed markedly higher osteogenic capability than the other scaffolds after 12weeks of implantation.It demonstrated that core–shell bioceramic 3D printing technique can be developed to fabricate single-phase or biphasic bioactive ceramic scaffolds with accurately tailored filament biodegradation for promoting bone defect regeneration and repair in some specific pathological conditions. | Yi Chen Jiaping Huang Jiamei Liu Yingming Wei Xianyan Yang Lihong Lei Lili Chen Yanmin Wu Zhongru Gou | 2021 | Regenerative Biomaterials2021，8，2： | 3 |
| 15 | Capacity Configuration of Hybrid CSP/PV Plant for Economical Application of Solar Energy显示文摘Concentrating solar power(CSP)technology has received increasing attention in recent years because of its distinct advantage for dispatchable power generation from solar energy.However,owing to its highly levelized costs of electricity,CSP plants are less competitive than photovoltaic(PV)power plants.To overcome this drawback and suppress PV power fluctuations,the concept of a hybrid CSP/PV power plant is proposed and developed.A capacity configuration method based on filtering and checking is proposed to seek a relationship between the capacity configuration of a hybrid CSP/PV system and the cost of solar energy.Co-content hybrid systems with different ratios of CSP capacity and PV capacity are modeled,and their comprehensive performance is investigated.Simulations and comparisons with a standalone CSP system focused on annual energy generation,capacity factor,levelized cost of electricity,and possibility for loss of power supply show that the hybrid CSP/PV systems possess different features depending on their capacity configurations.The results indicate that the proposed method can supply a convenient and simple operation pattern that favors engineering utilization and extension. | Fei Li Canbing Li Kai Sun Jiamei Zhang Hua Li | 2020 | Chinese Journal of Electrical Engineering2020，6，2： | 3 |
| 16 | Circadian locomotor output cycles kaput accelerates atherosclerotic plaque formation by upregulating plasminogen activator inhibitor-1 expression显示文摘 | Qixia Jiang Hua Liu Shengyun Wang Jiamei Wang Yehua Tang Zhiqing He Feng Wu Zhigang Huang Xiaoliang Cong Ru Ding Chun Liang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，9： | 3 |
| 17 | Efficacy and Safety of Yanggan Jian in Hepatitis B Virusrelated Decompensated Cirrhosis:A Randomized,Doubleblind,Controlled Trial显示文摘Background and Aims:The aim was to evaluate the efficacy and safety of Yanggan Jian(YGJ)in HBV-infected patients with decompensated cirrhosis.Methods:This randomized,double-blind controlled trial enrolled 160 patients with HBV-related decompensated cirrhosis who were already receiving or about to start antiviral therapy.Patients were randomly assigned to receive YGJ or placebo for 24 weeks,and were followed-up to 36 weeks.The primary outcome was the proportion of patients with a≥2 point reduction in Child-Turcotte-Pugh(CTP)score from baseline at week 24.Secondary outcomes were CTP class and score,serum liver function indices,mortality,incidence of hepatocellular carcinoma and variceal bleeding.Results:The proportion of patients with a CTP score reduction≥2 was significantly greater in the YGJ than in the placebo group(p=0.009);the percentage of patients with CTP class C was significantly less than that in the placebo group(p<0.05),and the YGJ group had a significantly greater mean change from baseline in CTP score at week 24(p=0.034).The improvement in measured values and change from baseline of prothrombin time,serum albumin,platelets,cholinesterase,international normalized ratio,and activated partial thromboplastin time were significantly better with YGJ than with placebo.Between-group differences in cumulative rates of variceal bleeding,hepatocellular carcinoma,death,or the frequency of any adverse event(AE),AEs related to treatment,or discontinuation because of AEs were not significant.Conclusions:YGJ significantly improved CTP scores and hepatic synthetic and reserve function in patients with HBV-related decompensated cirrhosis,and was safe and well tolerated. | Long Chen Chaoqun Zhao Weili Yao Wei Liu Hua Zhang Yongping Mu Hong Cai Dongying Xue Chengbao Wang Wan’e Wang Yuehong Lin Jiamei Chen Ping Liu | 2023 | Journal of Clinical and Translational Hepatology2023，11，1： | 3 |
| 18 | A piezoelectric tracked vehicle with potential application to planetary exploration显示文摘A piezoelectric driving method for rover vehicles is proposed in this paper. Employing this method, a tracked vehicle driven by friction forces from a frame mounted with piezoelectric elements was developed. The vehicle is designed with no driver sprocket, no idler-wheel and no supporting bogie wheels, and the vehicle thus requires no lubrication and has potential application in planetary exploration. The frame consists of a pair of piezoelectric transducers. Each transducer comprises four annular parts jointed by beams adhered with piezoelectric ceramics. The tracks are set to the outer surface of the annular parts by means of track tension. Traveling rotating waves are generated by piezoelectric transducers in the annular parts, which generate microscopic elliptical motions at the interface of the tracks. The microscopic elliptical motions from the piezoelectric transducers drive the track vehicle to move. Finite elements analysis was carried out to verify the operation principle using commercial software ANSYS. Piezoelectric transducers were fabricated, assembled and tested to validate the concepts of the proposed rover vehicle and confirm the simulation results. A prototype vehicle with mass of 0.57 kg moves at a speed of 4.3 mm/s at a driving voltage of 250 V and operating frequency of 65.53 kHz. | JIN JiaMei QIAN Fu YANG Ying ZHANG JianHui ZHU KongJun | 2012 | Chinese Science Bulletin2012，57，11： | 3 |
| 19 | Genetic variation of Porphyra yezoensis by using AFLP1显示文摘Genetic variation of 11 lines of Porphyra yezoensis from the coastline of Kagoshima ofJapan, Qingdao, Nantong, Putuo and Nanji Islands of China were studied by using amplified fragmentlength polymorphism (AFLP). 778 bands were obtained with AFLP analysis of 16 primer combina-tions, among which 15 were unique, about 98.07% were polymorphic. The AFLP data showed thatthe closest genetic distance was 0.180 between two Kagoshima samples, and the farthest one was 0.397between Kagoshima No. 1 and Nantong No. 9 line. The genetic distance showed that the variation waswithin the inner species scope. Neighbor-joining cluster and UPGMA cluster indicated that samples fromKagoshima and Qingdao were with high similarity and either with the samples of Nantong, Putuo andNanji Islands. P. yezoensis in China shared high genetic diversity, and the genetic distance showed posi-tive correlation with the geographic distance. | Rui Yang, Biqian Liu, Qijun Luo, Yajun Wang, Jiamei Bao Marine Biotechnology Institution, Ningbo University,Ningbo 315211,China.E-mail:yangrui @ nbu.edu.cn | 2003 | Acta Oceanologica Sinica2003，22，3： | 2 |
| 20 | Co-delivery of photosensitizer and diclofenac through sequentially responsive bilirubin nanocarriers for combating hypoxic tumors显示文摘Considering that photodynamic therapy(PDT)-induced oxygen consumption and microvascular damage could exacerbate hypoxia to drive more glycolysis and angiogenesis, a novel approach to potentiate PDT and overcome the resistances of hypoxia is avidly needed. Herein, morpholine-modified PEGylated bilirubin was proposed to co-deliver chlorin e6, a photosensitizer, and diclofenac(Dc). In acidic milieu, the presence of morpholine could enable the nanocarriers to selectively accumulate in tumor cells, while PDT-generated reactive oxidative species(ROS) resulted in the collapse of bilirubin nanoparticles and rapid release of Dc. Combining with Dc showed a higher rate of apoptosis over PDT alone and simultaneously triggered a domino effect, including blocking the activity and expression of lactate dehydrogenase A(LDHA), interfering with lactate secretion, suppressing the activation of various angiogenic factors and thus obviating hypoxia-induced resistance-glycolysis and angiogenesis. In addition, inhibition of hypoxia-inducible factor-1a(HIF-1a) by Dc alleviated hypoxia-induced resistance. This study offered a sequentially responsive platform to achieve sufficient tumor enrichment, on-demand drug release and superior anti-tumor outcomes in vitro and in vivo. | Yang Zhou Fan Tong Weilong Gu Siqin He Xiaotong Yang Jiamei Li Yue-Dong Gao Huile Gao | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 2 |
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