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| 1 | Pharmacological effects of Astragaloside IV: a literature review显示文摘OBJECTIVE: To review the pharmacological effects and mechanisms of action of Astragaloside IV in Huangqi (Radix Astragali Mongolici). METHODS: Aticles focusing on Astragaloside IV in English and Chinese in databases were collected and reviewed in order to summarize the latest extraction separation, pharmacokinetics, and the pharmacological effects of astrageloside IV. RESULTS: Protective effects of Astrageloside IV on the cardiovascular system, immune, digestive, nervous system were identified, and the action mechanisms were associated with regulation of the calcium balance, anti-oxydant, antiapoptosis, antivirus, and so on. CONCLUSION: Astrageloside IV has broad application prospects, especially in cardiovascular diseases, digestive diseases, cancer and other modern high incidence, high-risk diseases, and could be developed as a medicine. | Shuang Ren Hua Zhang Yongping Mu Mingyu Sun Ping Liu | 2013 | Journal of Traditional Chinese Medicine2013，33，3： | 57 |
| 2 | CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells显示文摘 | Yongping Zhang Xingying Zhang Chen Cheng Wei Mu Xiaojuan Liu Na Li Xiaofei Wei Xiang Liu Changqing Xia Haoyi Wang | 2017 | Frontiers of Medicine2017，11，4： | 9 |
| 3 | Reduning injection for fever, rash, and ulcers in children with mild hand, foot, and mouth disease: a randomized controlled clinical study显示文摘OBJECTIVE: To assess the efficacy and safety of Reduning injection for fever, rash, and ulcers in children with mild hand, foot, and mouth disease(HFMD). METHODS: A stratified-block randomized, double-blind, parallel-controlled, and multicenter clinical trial was conducted with 360 patients in five hospitals across China: Quanzhou Children's Hospital, Shijiazhuang No. 5 Hospital, Shanghai Public Health Centre, Hunan Provincial Children's Hospital, and Kaifeng Children's Hospital. Patients were randomized into three groups with 120 in each. Group A was treated with Western Medicine, group B with Reduning injection, a Chinese herbal medicine, and group C with both Reduning injection and Western Medicine. Results were compared for treatment efficacy and safety on HFMD. The clinical outcomes were observed as follows: fever and onset time of antifebrile effect(time to bring the body temperature down ≥0.5℃ after medication); cumulative time for fever recovery(body temperature recovering to normal and lasting more than 24 h without medication); cumulative time for rash disappearance(without new rashes or ulcers appearing and the original ones fading away); and cumulative time for mouth ulcer disappearance. RESULTS: For the onset time of the antifebrile effect, there was no statistical difference between groups A and B(P>0.05) and groups B and C(P> 0.05). However, there was a statistical difference between groups A and C(P<0.05), and the effect in group C was the best. For the cumulative time for rash disappearance, there was no statistical difference between groups A and B(P>0.05). There were statistical differences between groups A and C, and groups B and C(P<0.05), and the effect in group C was the best. For the cumulative time for mouth ulcers disappearance, there were no statistical differences among the three groups(P>0.05). CONCLUSION: Reduning injection with Western Medicine for symptomatic treatment is most effective for mild HFMD. No adverse reactions were observed. | Guoliang Zhang Jie Zhao Liyun He Shiyan Yan Ziqiang Zhuo Haojie Zheng Yongping Mu Shuangjie Li Xi Zhang Jihan Huang Xiuhui Li Jianping Liu Hehe Wan Chaoyu Wei Wei Xiao | 2013 | Journal of Traditional Chinese Medicine2013，33，6： | 7 |
| 4 | Effect of quercetin on the expression of Bcl-2/Bax apoptotic proteins in endometrial cells of lipopolysaccharide-induced-abortion mice显示文摘OBJECTIVE: To explore the effect of quercetin on the expressions of Bcl-2/Bax apoptotic proteins in endometrial cells in mice with abortion induced by lipopolysaccharide.METHODS: For in vivo experiment, twenty five Kunming mice were randomly divided into five groups at day 4 of pregnancy, with 5 mice per group. The mice were treated with lipopolysaccharide(LPS)through tail vein intravenous injection at day 4 of pregnancy, followed by different concentrations of quercetin by oral gavage consecutively at days 5 to6 of pregnancy. On day 7 of gestation, the mice were sacrificed and the histopathological changes of the uterus tissues were observed. Immunohistochemical staining was applied to the detection of Bcl-2/Bax apoptotic proteins in the endometrial cells. For in vitro experiment, the primary endometrial cells werecultured using a uterus tissue mass culturing method sampled at day 4.5 of pregnancy. The cells were treated with LPS with or without different dosages of quercetin, respectively, for 12 h after 80% confluence. The expression of Bcl-2/Bax apoptotic proteins were detected by western blotting.RESULTS: Both the in vivo and in vitro experiments showed decreased expression of Bcl-2 and enhanced expression of Bax after LPS treatment, leading to a decreased Bcl-2/Bax ratio. The expression of Bcl-2 significantly increased while the expression of Bax was significantly elevated, in the LPS plus quercetin group compared to the LPS only group.CONCLUSION: These results suggest that quercetin has protective effect by partially regulating the expression of Bcl-2/Bax proteins, which in turn inhibits endometrial cell apoptosis and benefits the embryo implantation. | Wang Xiaodan Yan Yongping Yang Liu Li Mu Zhong Xiuhui | 2016 | Journal of Traditional Chinese Medicine2016，36，6： | 7 |
| 5 | Gene editing in T cell therapy显示文摘The adoptive transfer of engineered T cells for the treatment of cancer, autoimmunity, and infectious disease is a rapidly growing field that has shown great promise. Gene editing holds tremendous potential for further improvements of T cell therapy. Here we review the applications of gene editing in various T cell therapies, focusing on antiviral strategies and cancer immunotherapies, and discuss the challenges and future prospects. | Yongping Zhang Wei Mu Haoyi Wang | 2017 | Journal of Genetics and Genomics2017，44，9： | 3 |
| 6 | Efficacy and Safety of Yanggan Jian in Hepatitis B Virusrelated Decompensated Cirrhosis:A Randomized,Doubleblind,Controlled Trial显示文摘Background and Aims:The aim was to evaluate the efficacy and safety of Yanggan Jian(YGJ)in HBV-infected patients with decompensated cirrhosis.Methods:This randomized,double-blind controlled trial enrolled 160 patients with HBV-related decompensated cirrhosis who were already receiving or about to start antiviral therapy.Patients were randomly assigned to receive YGJ or placebo for 24 weeks,and were followed-up to 36 weeks.The primary outcome was the proportion of patients with a≥2 point reduction in Child-Turcotte-Pugh(CTP)score from baseline at week 24.Secondary outcomes were CTP class and score,serum liver function indices,mortality,incidence of hepatocellular carcinoma and variceal bleeding.Results:The proportion of patients with a CTP score reduction≥2 was significantly greater in the YGJ than in the placebo group(p=0.009);the percentage of patients with CTP class C was significantly less than that in the placebo group(p<0.05),and the YGJ group had a significantly greater mean change from baseline in CTP score at week 24(p=0.034).The improvement in measured values and change from baseline of prothrombin time,serum albumin,platelets,cholinesterase,international normalized ratio,and activated partial thromboplastin time were significantly better with YGJ than with placebo.Between-group differences in cumulative rates of variceal bleeding,hepatocellular carcinoma,death,or the frequency of any adverse event(AE),AEs related to treatment,or discontinuation because of AEs were not significant.Conclusions:YGJ significantly improved CTP scores and hepatic synthetic and reserve function in patients with HBV-related decompensated cirrhosis,and was safe and well tolerated. | Long Chen Chaoqun Zhao Weili Yao Wei Liu Hua Zhang Yongping Mu Hong Cai Dongying Xue Chengbao Wang Wan’e Wang Yuehong Lin Jiamei Chen Ping Liu | 2023 | Journal of Clinical and Translational Hepatology2023，11，1： | 3 |
| 7 | 5'capped and 3'polyA-tailed sgRNAs enhance the efficiency of CRISPR-Cas9 system显示文摘Dear Editor,The clustered regularly interspaced short palindromic repeats(CRISPR)-associated(Cas)system is an adaptive immune system in a variety of bacteria and archaea(Terns and Terns,2011).The most commonly used Streptococcus pyogenes type II CRISPR-Cas9 system consists of Cas9 nuclease and two short RNAs,crRNA and tracrRNA,which can be linked together forming one chimeric single guide RNA(sgRNA)(Jinek et al.,2012). | Wei Mu Yongping Zhang Xutong Xue Lei Liu Xiaofei Wei Haoyi Wang | 2019 | Protein & Cell2019，10，3： | 1 |
| 8 | Zinc influences on brain development, pituitary and thyroid function in iodine-deficient pregnant and neonatal rats显示文摘BACKGROUND:Zinc(Zn) has been shown to greatly influence brain development.Zn supplements may reduce injury to cell membranes of the thyroid gland due to iodine deficiency.OBJECTIVE:To establish an iodine deficiency rat model using low-iodine food,which was supplemented with compound Zn and Zn gluconate,to observe the effects of Zn on brain development,as well as pituitary gland and thyroid gland function in iodine-deficient rats.DESIGN,TIME AND SETTING:Randomized grouping study of neural development was performed in the central laboratory of Shandong Institute for Prevention and Treatment of Endemic Disease from 1998 to 1999.MATERIALS:A total of 270 Wistar,female rats,one month after weaning,were used in this study,includ-ing 150 pregnant and 120 neonatal rats.Rats were randomly divided into six groups:normal control,model,iodine,compound Zn,iodine and compound Zn,and zinc gluconate.Each group contained 25 pregnant rats and 20 neonatal rats.METHODS:The pregnant rats and 20 neonatal rats,and well as the normal group,were fed standard chow and allowed free access to tap water(containing 5 μg/L iodine and 1 mg/L Zn).The remaining five groups were fed low-iodine chow.However,the model group received distilled water,the iodine group received po-tassium-iodide distilled water(containing 300 μg/L iodine),the compound Zn group received distilled wa-ter and intragastrically administrated 10 mL/kg compound Zn solution,once per day,the iodine and com-pound Zn group received distilled water with 300 μg/L iodine and intragastrically administrated 10 mL/kg compound Zn solution,once per day.All treatments lasted 90 days.MAIN OUTCOME MEASURES:All pregnant rats were sacrificed on the day 21 of pregnancy.Body mass,number and rate of fetal absorption,as well as fetal death and malformation,were determined.Thyroid and pituitary gland weights were measured,as well as serum levels of thyroid hormone,gonadotropin,and sex hormones.In the experimental study of neonatal rats,the animals normally gave birth at day 21.At day 45 after birth of the neonatal rats,thyroid and pituitary gland weights were measured,and protein,DNA,and RNA concentrations were measured.RESULTS:Pregnant rats in the iodine group exhibited decreased urine iodine and body mass(F = 7.37,P < 0.01),increased thyroid absolute and relative weight(F = 7.01,50.27,P < 0.01),as well as decreased T4 and FT4(F = 7.01,29.32,P < 0.01) and increased T3 and FT3(F = 41.20,5.94,P < 0.01).Gonadotropic and sex-ual hormones were abnormal.The pregnant rats displayed decreased weight gain,and the rates of malforma-tion,dead,and absorbed fetuses were increased.Compared with the control group,the neonatal rats with io-dine deficiency exhibited lower brain weights(P < 0.01).Brain protein,DNA,and RNA,concentrations were decreased,with a rate of RNA/DNA(F = 5.70,55.86,25.65,5.44,P < 0.01).Body mass was gradually in-creased(F = 6.74,P < 0.01),and the thyroid glands were enlarged(F = 50.01,76.13,P < 0.01).Following Zn administration,thyroid gland weight was decreased in pregnant rats(P < 0.01).Thyroid hormone,gonad-otropic hormones,and sexual hormones were restored to some degree.Fetal weight was increased,and the rates of malformation,dead,and absorbed fetuses were decreased.At the same time,neonatal rats gained body weight,displayed decreased thyroid gland weight,as well as increased protein,DNA,and RNA con-centrations in the brain.The ratio of RNA/DNA and protein/DNA increased following Zn administration(P < 0.01).CONCLUSION:Zn supplementation may decrease the degree of goiter,ameliorate thyroid hormone disor-der,as well as gonadotropic and sexual hormone disorders,and increase protein,DNA,and RNA content.Zn supplementation antagonized reproductive abnormalities in pregnant rats,decreased fetal growth,and dis-turbed brain development in neonatal rats as a result of iodine deficiency. | Xiaoxia Yang Jianchao Bian Xin Wang Haiming Wang Yongping Liu Shuzhen Wang Zhichun Mu Xinluan Li | 2008 | Neural Regeneration Research2008，3，9： | 0 |
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