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| 1 | Diabetic cardiomyopathy:Pathophysiology,diagnostic evaluation and management显示文摘Diabetes affects every organ in the body and cardiovascular disease accounts for two-thirds of the mortality in the diabetic population.Diabetes-related heart disease occurs in the form of coronary artery disease(CAD),cardiac autonomic neuropathy or diabetic cardiomyopathy(DbCM).The prevalence of cardiac failure is high in the diabetic population and DbCM is a common but underestimated cause of heart failure in diabetes.The pathogenesis of diabetic cardiomyopathy is yet to be clearly defined.Hyperglycemia,dyslipidemia and inflammation are thought to play key roles in the generation of reactive oxygen or nitrogen species which are in turn implicated.The myocardial interstitium undergoes alterations resulting in abnormal contractile function noted in DbCM.In the early stages of the disease diastolic dysfunction is the only abnormality,but systolic dysfunction supervenes in the later stages with impaired left ventricular ejection fraction.Transmitral Doppler echocardiography is usually used to assess diastolic dysfunction,but tissue Doppler Imaging and Cardiac Magnetic Resonance Imaging are being increasingly used recently for early detection of DbCM.The management of DbCM involves improvement in lifestyle,control of glucose and lipid abnormalities,and treatment of hypertension and CAD,if present.The role of vasoactive drugs and antioxidants is being explored.This review discusses the pathophysiology,diagnostic evaluation and management options of DbCM. | Joseph M Pappachan George I Varughese Rajagopalan Sriraman Ganesan Arunagirinathan | 2013 | World Journal of Diabetes2013，4，5： | 57 |
| 2 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 3 | 性腺功能减退患者的生育能力保护:研究进展显示文摘越来越多的年轻人和中年人有治疗性腺功能减退症(雄激素含量缺乏相关症状)的需求,其症状包括抑郁症,性冷淡,勃起功能障碍,疲劳。然而,睾酮补充疗法(包括使用天然和合成的类固醇)引起的睾丸功能衰退的患者人数正在增加,特别是那些年轻的运动员,外源性类固醇的使用对这些人的睾丸功能产生了消极影响。外源性睾酮治疗可以影响下丘脑垂体性腺轴的自然调节,造成生精功能受损,可能会导致严重后果,例如无精子症等男性不育症。对于那些患有性腺功能减退症的育龄男性,选择治疗方法时,保护生育能力很重要。研究显示,人绒毛膜促性腺激素(HCG)不仅可以治疗那些睾酮补充疗法引起的无精子症,还有助于维持升高的睾丸内睾酮水平。此外,选择性雌激素受体调节剂常与人绒毛膜促性腺激素联合使用治疗性腺功能减退症,该疗法不仅可以提高总睾酮水平,还有助于保护这些患者的生精功能。 | Ranjith Ramasamy Joseph M Armstrong Larry I Lipshultz | 2015 | Asian Journal of Andrology2015，17，2： | 4 |
| 4 | MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca^sup 2+^ overload and cell death显示文摘 | Aurora Arin B Mahmoud Ahmed I Luo Xiang Johnson Brett A van Rooij Eva Matsuzaki Satoshi Humphries Kenneth M Hill Joseph A Bassel-Duby Rhonda Sadek Hesham A Olson Eric N | 2012 | EN2012，，4： | 2 |
| 5 | Strategies to tackle the challenges of external beam radiotherapy for liver tumors显示文摘Primary and metastatic liver cancer is an increasingly common and difficult to control disease entity.Radiation offers a non-invasive treatment alternative for these patients who often have few options and a poor prognosis.However,the anatomy and aggressiveness of liver cancer poses significant challenges such as accurate localization at simulation and treatment,management of motion and appropriate selection of dose regimen.This article aims to review the options available and provide information for the practical implementation and/or improvement of liver cancer radiation programs within the context of stereotactic body radiotherapy and image-guided radiotherapy guidelines.Specific patient inclusion and exclusion criteria are presented given the significant toxicity found in certain sub-populations treated with radiation.Indeed,certain sub-populations,such as those with tumor thrombosis or those with larger lesions treated with transarterial chemoembolization,have been shown to have significant improvements in outcome with the addition of radiation and merit special consideration.Implementing a liver radiation programrequires three primary challenges to be addressed:(1) immobilization and motion management;(2) localization;and(3) dose regimen and constraint selection.Strategies to deal with motion include simple internal target volume(ITV) expansions,non-gated ITV reduction strategies,breath hold methods,and surrogate marker methods to enable gating or tracking.Localization of the tumor and organs-at-risk are addressed using contrast infusion techniques to take advantage of different normal liver and cancer vascular anatomy,imaging modalities,and margin management.Finally,a dose response has been demonstrated and dose regimens appear to be converging.A more uniform approach to treatment in terms of technique,dose selection and patient selection will allow us to study liver radiation in larger and,hopefully,multicenter randomized studies. | Michael I Lock Jonathan Klein Hans T Chung Joseph M Herman Edward Y Kim William Small Nina A Mayr Simon S Lo | 2017 | World Journal of Hepatology2017，9，14： | 2 |
| 6 | Preferred risk allocation in target cost contracts in con- struction显示文摘 | Joseph H L Chan Daniel W M Chan Patrick T I Lam | 2011 | Facilities2011，29，1314： | 1 |
| 7 | Studies on rubber bound p-phenylene diamine antioxidant in natural rubber显示文摘 | Avirah S Geetha M I Joseph R | 1996 | Kautschuk Gummi Kunststoffe1996，49，12： | 1 |
| 8 | Self-lubricated transport of aqueous foams in horizontal conduits显示文摘 | Bncend M I Joseph D D | | 0，，12： | 1 |
| 9 | Ribosomal internal transcribed spacer 2 ( ITS2 ) exhibits a common core of secondary structure in vertebrates and yeast 显示文摘 | JOSEPH N KRAUSKOPF E VERA M I | 1999 | Nucleic Acids Res1999，27，23： | 1 |
| 10 | Polymorphismsin eggshell organic matrix genes are associated witheggshell quality measurementvs in pedigree Rhode Is-land Red hens显示文摘 | Dunn I C Joseph N T Bain M | 2009 | Anim Genet2009，40，1： | 1 |
| 11 | Inhibition of Adenovirus Infection and Adenain by Green Tea Catechins 显示文摘 | JOSEPH M ANGELIQUE R LISE I | 2003 | Antiviral Research2003，，58： | 1 |
| 12 | Ray path deviationin a non-hemispherical dome显示文摘 | JOSEPH R I THOMAS M E | 2001 | SPIE2001，4375，： | 1 |
| 13 | The use of bortezomib as a rescue treatment for acute antibody-mediated rejection: report of three cases and review of literature显示文摘 | Tzvetanov I Spaggiari M Joseph J | 2012 | Transplant Proc2012，44，10： | 1 |
| 14 | Ribosomal internal transcribed spacer 2 (ITS2) exhibits a common core of secondary structure in vertebrates and yeast显示文摘 | JOSEPH N KRAOSKOPF E VERA M I | 1999 | Nucleic Acids Res1999，27，： | 1 |
| 15 | Steady-state noise analysis of spontaneous and stimulated Brillouin scattering in optical fibers显示文摘 | Jenkins R B Sova R M Joseph R I | 2007 | Journal of Lightwave Technology2007，25，3： | 1 |
| 16 | Discriminant Analysis of Edible Oils and Fats by FTIR, FT-NIR and FT-Raman Spectroscopy显示文摘 | HONG Y JOSEPH I MANISH M | 2005 | Food Chemistry2005，93，： | 1 |
| 17 | Synthesis of benzyl bromides with hexabromoacetone:an alternative path to drug intermediates显示文摘 | Joseph K M Sanchez I L | | 0，，01： | 1 |
| 18 | Dissolution kinetics of polycrystalline calcium sulfate-based materials: influence of chemical modification 显示文摘 | Fisher R D Mbogoro M M Snowden M E Joseph M B Covington J A Unwin P R Walton R I | 2011 | ACSApplied Materials & Interfaces2011，3，9： | 1 |
| 19 | Novel hepatic progenitor cell surface markers in the adult rat liver显示文摘 | YOVCHEV M I GROZDANOV P N JOSEPH B | 2007 | Hepatology2007，45，1： | 1 |
| 20 | Movement - Based Location Update and Selective Paging for PCS Networks 显示文摘 | Akyildiz I F Joseph S M H Lin Y B | 1996 | IEEE/ACM Transactions on Networking1996，4，4： | 1 |
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