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| 1 | 在精神分裂症和听觉的幻觉的多模式的 morphometry 和功能的磁性的回声成像显示文摘 AIM:To validate a multimodal[structural and functional magnetic resonance(MR)]approach as coincidence brain clusters are hypothesized to correlate with clinical severity of auditory hallucinations.METHODS:Twenty-two patients meeting Diagnostic and Statistical Manual of Mental Disorders(fourth edition,DSM-Ⅳ)criteria for schizophrenia and experiencing persistent hallucinations together with 28 healthy controls were evaluated with structural and functional MR imaging with an auditory paradigm designed to replicate those emotions related to the patients’hallucinatory experiences.Coincidence maps were obtained by combining structural maps of gray matter reduction with emotional functional increased activation.Abnormal areas were correlated with the brief psychiatric rating scale(BPRS)and the psychotic symptom rating scale(PSYRATS)scales.RESULTS:The coincidence analysis showed areas with coexistence gray matter reductions and emotional activation in bilateral middle temporal and superior temporal gyri.Significant negative correlations between BPRS and PSYRATS scales were observed.BPRS scores were negatively correlated in the middle temporal gyrus(right)(t=6.86,P=0.001),while negative PSYRATS correlation affected regions in both the superior temporal gyrus(left)(t=7.85,P=0.001)and middle temporal gyrus(left)(t=4.97,P=0.002).CONCLUSION:Our data identify left superior and middle temporal gyri as relevant areas for the understanding of auditory hallucinations in schizophrenia.The use of multimodal approaches,sharing structural and functional information,may demonstrate areas specifically linked to the severity of auditory hallucinations. | Gracián García-Martí Eduardo Jesús Aguilar Luis Martí-Bonmatí M José Escartí Julio Sanjuán | 2012 | World Journal of Radiology2012，4，4： | 3 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Current and novel approaches in the pharmacological treatment of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is one of the most lethal malignant tumours worldwide.The mortality-to-incidence ratio is up to 91.6%in many countries,representing the third leading cause of cancer-related deaths.Systemic drugs,including the multikinase inhibitors sorafenib and lenvatinib,are first-line drugs used in HCC treatment.Unfortunately,these therapies are ineffective in most cases due to late diagnosis and the development of tumour resistance.Thus,novel pharmacological alternatives are urgently needed.For instance,immune checkpoint inhibitors have provided new approaches targeting cells of the immune system.Furthermore,monoclonal antibodies against programmed cell death-1 have shown benefits in HCC patients.In addition,drug combinations,including first-line treatment and immunotherapy,as well as drug repurposing,are promising novel therapeutic alternatives.Here,we review the current and novel pharmacological approaches to fight HCC.Preclinical studies,as well as approved and ongoing clinical trials for liver cancer treatment,are discussed.The pharmacological opportunities analysed here should lead to significant improvement in HCC therapy. | Fernanda Villarruel-Melquiades María Eugenia Mendoza-Garrido Claudia M García-Cuellar Yesennia Sánchez-Pérez Julio Isael Pérez-Carreón Javier Camacho | 2023 | World Journal of Gastroenterology2023，29，17： | 2 |
| 4 | The impact of household consumption patterns on emissions in Spain显示文摘 | Rosa D Alfredo M Julio S | 2010 | Energy Economics2010，32，1： | 1 |
| 5 | DNAadenine methylase is essential for viability and plays a role in the pathognesis of Yersinia Pseudotuberculosis and Vibrio Cholerae显示文摘 | Julio S M Heithoff D M Provenzano D | 2001 | Infect Immun2001，69，12： | 1 |
| 6 | Phylogenetic and functional analysis of Arabidopsis RCI2 genes显示文摘 | Joaquín M María L Julio S | 2007 | Journal of Experimental Botany2007，58，： | 1 |
| 7 | Developmental and stress regulation of RCI2A and RCI2B,two cold-inducible genes of arabidopsis encoding highly conserved hydrophobic proteins显示文摘 | Joaquín M Rafael C Julio S | 2001 | Plant Physiology2001，125，： | 1 |
| 8 | Performance of Drought Indices for Ecological, Agricultural, and Hydrological Applications显示文摘 | Vicente-Serrano Sergio M Beguería Santiago Lorenzo-Lacruz Jorge Camarero Jesús Julio López-Moreno Juan I Azorin-Molina Cesar Revuelto Jesús Morán-Tejeda Enrique Sanchez-Lorenzo Arturo | 2012 | EN2012，，10： | 1 |
| 9 | A state-of-the-art review on shear-friction 显示文摘 | SANTOS P M D JULIO E N B S | 2012 | Engineering Structures2012，45，： | 1 |
| 10 | Nitriteinhibition of denitrification by pseudomonas fluorescens 显示文摘 | Almeida J S Julio S M Reis M A M Carrondo M J T | 1995 | Biotechnology and Bioengineering1995，46，3： | 1 |
| 11 | DNA adenine methylase is essential for viability and plays role in the pathogenesis of Yersinia Pseudotuberculosis and Vibrio cholerae显示文摘 | Heithoff D M Provenzano D Klose K E Sinsheimer R L Low D A Mahan M J | 2001 | Infect Immun2001，69，12： | 1 |
| 12 | Introduction: mixing in microfluidics显示文摘 | JULIO M OTTINO S W | 2004 | Philosophical of Transactions of the Royal Society of London: A2004，152，912： | 1 |
| 13 | Fuzzy controller design, evaluation, parallel and hierarchical combination with a PID controller显示文摘 | JAIME F JOAO L A JULIO S M | 1999 | Elsevier Science on Microprooessors and Microsystems1999，22，： | 1 |
| 14 | Nitrite inhibition of denitrifieation by Pseudomonas fluorescens 显示文摘 | Almeida J S Julio S M Reis M A M | 1995 | Biotechnol Bioeng1995，46，3： | 1 |
| 15 | Parametric and Nonparametric Analyses of Repeated Ordinal Categorical Data显示文摘 | Julio M S Frederico Z P Patricia R | 2004 | Biometrieal Journal2004，46，4： | 1 |
| 16 | Acetophenones and terpenoids from Senecio gallicus 显示文摘 | Julio G U J De Pascual T Isidro S M | 1987 | Phytochemistry1987，26，4： | 1 |
| 17 | Macroeconomic Conditions and Capital Raising 显示文摘 | Erel I Julio B Kim W Weisbach M S | 2010 | Social Science Electronic Publishing2010，25，2： | 1 |
| 18 | Climatic impacts and drought control of radial growth and seasonal wood formation in Pinus halepensis显示文摘 | Pasho E Julio Camarero J Vicente- Serrano S M | 2012 | Trees-Structure and Function2012，26，6： | 1 |
| 19 | Extraction of coffee diterpenes and coffeeoil using supercritical carbon dioxide显示文摘 | JULIO M A A DELCIO S | 2007 | Food Chemistry2007，101，3： | 1 |
| 20 | Antioxidant Effects of D002 on the in Vitro Susceptibility of Whole Plasma in Healthy Volunteers显示文摘 | Roberto Menéndez Rosa Más Ana Mar??a Amor Yohanys Pérez Rosa Mar??a González Julio Fernández Vivián Molina Sonia Jiménez | 2001 | Archives of Medical Research2001，，5： | 1 |
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