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| 1 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 2 | Echinococcosis显示文摘 | Donald P McManus Wenbao Zhang Jun Li Paul B Bartley | 2003 | The Lancet2003，，9392： | 2 |
| 3 | Rapid and efficient reprogramming of human fetal and adult blood CD34~ cells into mesenchymal stem cells with a single factor显示文摘进体的干细胞的皮房间的直接变换在再生药打开了新治疗学的可能性。这里,我们证明人的导致的间充质的干细胞(iMSCs ) 能高效地从绳索血(CB ) 被产生 - 或由有一个单个因素的直接 reprogramming 的成年的外部血(PB )-CD34+ 房间, OCT4。面对一个 GSK3 禁止者, 16% OCT4-transduced CD34 + 房间在 2 个星期以内被变换成 iMSCs。有效直接 reprogramming 与两 episomal 被完成调停向量的短暂 OCT4 表示和 lentiviral 调停向量的 OCT4 transduction。iMSCs 快车 MSC 标记,类似于骨头髓(BM ) 在形态学的 -MSCs,并且在 vitro multilineage 区别能力拥有,还与 BM-MSCs 相比有一个更大的 proliferative 能力。类似于 BM-MSCs,植入的 iMSCs 形式骨头和结缔组织,并且是在老鼠的 non-tumorigenic。然而, BM-MSCs 不而 iMSCs 确实形成肌肉纤维,显示 iMSCs 的一个潜在的功能的优点。另外,我们观察到 OCT4 表示的高水平为起始的 reprogramming 和最佳的 iMSC 自强被要求,当 OCT4 表示的减小为 multilineage 区别被要求时。我们的方法将贡献病人特定的 iMSCs 的产生,它能在再生药有应用。这发现可以也为血房间的直接变换便于策略的发展进临床的重要性的房间的另外的类型。 | Xianmei Meng Rui-Jun Su David J Baylink Amanda Neises Jason B Kiroyan Wayne Yuk-Wai Lee Kimberly J Payne Daila S Gridley Jun Wang K-H William Lau Gang Li Xiao-Bing Zhang | 2013 | Cell Research2013，23，5： | 2 |
| 4 | Unsatisfying antiviral therapeutic effect in patients with mother-tochild transmissed chronic hepatitis B virus infection: a prospective multi-center clinical study显示文摘Background:Few data are available regarding the progression of liver disease and therapeutic efficacy in chronic hepatitis B(HBV)carriers infected by mother-to-child transmission(MTCT).This study aimed to investigate these two aspects by comparing the adult chronic HBV carriers in MTCT group with those in horizontal transmission group.Methods:The 683 adult chronic HBV patients qualified for liver biopsy including 191 with MTCT and 492 with horizontal transmission entered the multi-center prospective study from October 2013 to May 2016.Biopsy results from 217 patients at baseline and 78 weeks post antiviral therapy were collected.Results:Patients infected by MTCT were more likely to have e antigen positive(68.6%vs.58.2%,x^2=-2.491,P=0.012)than those with horizontal transmission.However,in patients with MTCT,levels of alkaline phosphatase(ALP)(P=0.031),Fibroscan(P=0.013),N-terminal propeptide of Type III procollagen(PIIINP)(P=0.014),and Laminin(LN)(P=0.006)were high,in contrast to the patients with horizontal transmission for whom the levels of albumin(ALB)(P=0.041),matrix metalloproteinase-3(MMP-3)(P=0.001)were high.The 47.2% of patients with MTCT and 36.8%of those with horizontal transmission had significant liver fibrosis(P=0.013).Following antiviral therapy for 78 weeks,21.2%and 38.0%patients with MTCT and horizontal transmission acquired hepatitis B e antigen(HBeAg)clearance,respectively(P=0.043),and the virological response rates were 54.7%and 74.1%in the MTCT and horizontal groups,respectively(P=0.005).MTCT was a risk factor for HBeAg clearance and virological response.Conclusion:Adult patients with MTCT were more prone to severe liver diseases,and the therapeutic efficacy was relatively poor,which underlined the importance of earlier,long-term treatment and interrupting perinatal transmission. | Jun Li Xiao-Qin Dong Zhao Wu An-Lin Ma Shi-Bin Xie Xu-Qing Zhang Zhan-Qing Zhang Da-Zhi Zhang Wei-Feng Zhao Guo Zhang Jun Cheng Qing Xie Jun Li Zhi-Qiang Zou Ying-Xia Liu Gui-Qiang Wang Hong Zhao China Hepatitis B Related Fibrosis Assessment Research Group | 2019 | Chinese Medical Journal2019，，22： | 2 |
| 5 | A Hierarchical Real-Time Control Architecture for a Semi-Autonomous Underwater Vehicle 显示文摘 | Li J H Jun B H Pan M L | 2005 | Ocean Engineering2005，32，13： | 1 |
| 6 | An adjustable approach to fuzzy soft set based decision making显示文摘 | Feng F Jun Y B Liu X Y Li L F | 2010 | Journal of Computational and Applied Mathematics2010，60，： | 1 |
| 7 | Maize HapMap2 identifies extant variation from a genome in flux 显示文摘 | Jer-Ming Chia Chi Song Peter J Bradbury Denise Cos- tich Natalia de Leon John Doebley Robert J Elshire Brandon Gaut Laura Geller Jeffrey C Glaubitz Michael Gore Kate E Guill Jim Holland Matthew B Hufford Jinsheng Lai Meng Li Xin Liu Yanli Lu Richard Mc- Combie Rebecca Nelson Jesse Poland Boddupalli M Prasanna Tanja Pyhajarvi Tingzhao Rong Rajandeep S Sekhon Qi Sun Maud I Tenaillon Feng Tian Jun Wang Xun Xu Zhiwu Zhang Shawn M Kaeppler Jef- frey Ross-lbarra Michael D McMullen Edward S Buck- ler Gengyun Zhang Yunbi Xu Doreen Ware | 2012 | Nat Genet2012，，44： | 1 |
| 8 | Water-solution properties of a hydrophobically modified poly(N- isopropylacrylamide) 显示文摘 | XIANG Y S JUN B LI | 2000 | Journal of Applied Polymer Science2000，75，： | 1 |
| 9 | Aprotic and aqueous Li-O2 batteries显示文摘 | Lu Jun Li Li Park J B | 2014 | Chemical Reviews2014，114，： | 1 |
| 10 | Determining Salinity Threshold Level for Castor Bean Emergence and Stand Establishment显示文摘 | Zhou Guisheng Ma B L Li Jun Feng Chaonian Lu Jianfei Qin Pei | 2010 | Crop Science2010，，5： | 1 |
| 11 | Stability for parametric implicit vector equilibrium problems显示文摘 | Huang Nan -jing Jun Li Thompson H B | 2006 | Mathematical and Computer Modeling2006，43，1112： | 1 |
| 12 | Antimalarial artesu-nate protects sepsis model mice against heat-killedEscherichia coli challenge by decreasing TLR4,TLR9 mRNA expressions and transcription factorNF-kappa B activation显示文摘 | Li B Zhang R Li Jun | 2008 | Int Immunopharmacol2008，8，3： | 1 |
| 13 | Nanostructured energetic composites of CL- 20 and binders synthesized by sol gel methods 显示文摘 | LI Jun Thomas B B | 2006 | Propellants Explosives Pyrotechnics2006，31，1： | 1 |
| 14 | Echinococcosis显示文摘 | Donald P McManus Wenbao Zhang Jun Li Paul B Bartley | 2003 | 2003 (9392)2003，，9392： | 1 |
| 15 | Point to point navigation of underactuatcd ships 显示文摘 | LI J H LEE P M JUN B H | 2008 | Aummatica2008，44，12： | 1 |
| 16 | Echinococcosis显示文摘 | Donald P McManus Wenbao Zhang Jun Li Paul B Bartley | 2003 | The Lancet2003，，9392： | 1 |
| 17 | Membrane development for vanadium redox flow batteries显示文摘 | Schwenzer B Zhang Jianlu Kim S Li Jiyu Liu Jun Yang Zhenguo | | 0，，： | 1 |
| 18 | Point-to-point navigation of underactuated ships显示文摘 | LI J LEE P JUN B | 2008 | Automatica2008，44，12： | 1 |
| 19 | Point to point navigation of underactuated ships显示文摘 | LI Jihong LEE P M JUN B H | 2008 | Automatica2008，44，12： | 1 |
| 20 | Organizing for Enterprise in China: what can we Learn from the Chinese Micro, Small,and Medium Enterprise De- velopment Experience显示文摘 | Allan Gibb A Jun Li B | 2003 | Futures2003，，35： | 1 |
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