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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Increasing diabetes self-management education in community settings显示文摘 | Susan L Norris Phyllis J Nichols Carl J Caspersen Russell E Glasgow Michael M Engelgau Leonard Jack Susan R Snyder Vilma G Carande-Kulis George Isham Sanford Garfield Peter Briss David McCulloch | 2002 | American Journal of Preventive Medicine2002，，4： | 2 |
| 3 | Biological souring and mitigation in oil reservoirs 显示文摘 | Gieg L M Jack T R Foght J M | 2011 | Applied Microbiology and Biotechnology2011，92，2： | 1 |
| 4 | Self-reported abstinence effects in the first month after smoking cessation显示文摘 | WARD M M SWAN G E JACK L M | 2001 | Addict Behav2001，26，3： | 1 |
| 5 | The homeotic gene APETALA3 of Arabidopsis thaliana encodes a MADS-box and is expressed in petals and stamens 显示文摘 | JACK T BROCKMAN L L MEYEROWITZ E M | 1992 | Cell1992，68，4： | 1 |
| 6 | Mannose-binding lectin:targeting the microbial world for complement attack and opsonophagecytosis 显示文摘 | Jack D L Klein N J Turner M W | 2001 | Immunol Rev2001，180，： | 1 |
| 7 | Copyright Protection for the Electronic Distribution of Text Documents显示文摘 | Jack T B Steven L Nicholas F M | 1999 | Proceedings of the IEEE1999，87，7： | 1 |
| 8 | Comparative mieroarray analysis and pulmonary changes in brown norway rats exposed to ovalbumin and concentrated air particulates 显示文摘 | Brooke L H David M R Jack R H | 2009 | Toxicological Sciences2009，108，： | 1 |
| 9 | The homeotic gene APETALA3 of Arabidopsis thaliana encodes a MADS-box and is expressed in petals and stamens显示文摘 | Jack T Brockmmi L L Meverowitz E M | 1992 | Cell1992，68，4： | 1 |
| 10 | Micromechanics for fiber volume percent with a photo cure vinyl, ester composite显示文摘 | Richard C P Jack E L Michael S M | 2007 | PolymerComposites2007，28，3： | 1 |
| 11 | Impaired microRNA processing enhances cellular transformation and tumorigenesis显示文摘 | Kumar M S Lu J Mercer K L Golub T R Jacks T | 2007 | Nat Genet2007，39，： | 1 |
| 12 | Ethnic entrexreneurshix: Do values matter 显示文摘 | Michael M Minet S Jack L | 2002 | New England Journal of En- trexreneurshix2002，，5： | 1 |
| 13 | Anti-microbial activities of mannose-binding lectin显示文摘 | Jack D L Turner M W | 2003 | Biochem Soc Trans2003，31，4： | 1 |
| 14 | Modified self-organising map for automated novelty detection applied to vibration signal monitoring 显示文摘 | Wong M L D Jack L B Nandi A K | 2006 | Mechanical Systems and Signal Processing2006，20，： | 1 |
| 15 | Reduced lignin content and altered lignin composition in transgenic tobacco down-regulated in expression of L-phenylalanine ammonia-lyase or cinnamate 4-hydroxylase显示文摘 | Vincent J H S Weiting N Jack W B Hans G J Sameer A M Paul A H Chris L and Richard A D | | 0，，： | 1 |
| 16 | A unique eclipsed 2-D coordination polymer with removable iodine molecules in the open- channel strueture显示文摘 | JACK Y L BABB A M | 2003 | Chem Commun2003，12，： | 1 |
| 17 | Superconductivity up to 29 K inSrFe2As2 and BaFe2As2 at high pressures显示文摘 | Patricia L Alireza Y T Chris Ko Jack Gillett Chiara M Petrone Jacqueline M Cole Gilbert G Lonzarich Suchitra E Sebastian | 2009 | Journal of Physics: Condensed Matter2009，，1： | 1 |
| 18 | Copyright Protection for Eled Ronic Distribution of Text Documents显示文摘 | Jack T B Steven L Nicholas F M | 1999 | Proceedings of the IEEE1999，87，7： | 1 |
| 19 | Molecular characterization of resistance plasmids in epidemiologically unrelated strains of multiresistant Haemophilus in fluenzae显示文摘 | Jack L Godelieve V Patrick D M | 1993 | J Infect Dis1993，168，7： | 1 |
| 20 | The homeotic gene APETALA3 of Arabidopsis thaliana encodes a MADS box and is expressed in petals and stamens显示文摘 | Jack T Brockman L L Meyerowitz E M | 1992 | Cell1992，68，4： | 1 |
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