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| 1 | Development of an antibody that neutralizes soluble IgE and eliminates IgE expressing B cells显示文摘免疫球蛋白 E (IgE ) 在过敏气喘起一个关键作用并且是为 monoclonal 抗体的一个临床上验证的目标。治疗学的 anti-IgE 抗体块在 IgE 和 Fc epsilon 之间的相互作用(Fcε) 受体,它消除或最小化,但是做过敏显型不典型地由 B 房间削减 IgE 的进行中的生产。我们产生了有潜力抵销可溶的 IgE 并且通过抗体依赖者消除表示 IgE B 房间的高亲密关系的 anti-IgE 抗体(MEDI4212 ) 调停房间的 cytotoxicity。MEDI4212 变体被产生在 fucosylation 在抗体或改变的 Fc 区域包含变化以便为 Fcγ 提高抗体亲密关系; RIIIa。所有 MEDI4212 变体与比得上的亲密关系跳了到人的 IgE 野类型(WT ) 抗体。每变体被显示禁止在 IgE 和 Fcε 之间的相互作用; RI,它翻译了成 Fcγ 的有势力抑制;调停 RI 的功能回答。重要地,所有变体在表示房间的膜 IgE 的表面同样跳了到 IgE。然而, MEDI4212 变体为 Fcγ 表明了提高的亲密关系;包括在位置 158 点的多态的变体的 RIIIa。在 Fcγ 的改进;导致的 RIIIa 绑定在用两个都设计的房间线和类的基于的试金交换了的房间增加了受动器功能人的 IgE B 房间。通过它 IgE 的优异抑制,我们预计那受动器功能提高了 MEDI4212 也许能抵销可溶的 IgE 的高水平并且在他们区分并且变得 IgE secreting 血浆房间以前,由消除表示 B 房间的 IgE 提供增加的长期的利益。 | Andrew C. Nyborg Anna Zacco Rachel Ettinger M. Jack Borrok Jie Zhu Tom Martini Rob Woods Christine Kiefer Michael A. Bowen E. Suzanne Cohenz Ronald Herbst Herren Wu Steven Coats | 2016 | Cellular & Molecular Immunology2016，13，3： | 3 |
| 2 | Air pollution removal by urban trees and shrubs in the United States显示文摘 | David J. Nowak Daniel E. Crane Jack C. Stevens | 2006 | Urban Forestry & Urban Greening2006，，3： | 2 |
| 3 | Work,family and health:the expanding role of EAP professionals显示文摘 | BEACH R H STEVEN MARTIN K JACK | 1995 | Employee Counselling Today1995，7，4： | 1 |
| 4 | Impaired Red Blood Cell Deformability after Transfusion of Stored Allogeneic Blood but Not Autologous Salvaged Blood in Cardiac Surgery Patients显示文摘 | Osman N. Salaria Viachaslau M. Barodka Charles W. Hogue Dan E. Berkowitz Paul M. Ness Jack O. Wasey Steven M. Frank | 2014 | Anesthesia & Analgesia2014，，6： | 1 |
| 5 | Copyright Protection for the Electronic Distribution of Text Documents显示文摘 | Jack T B Steven L Nicholas F M | 1999 | Proceedings of the IEEE1999，87，7： | 1 |
| 6 | Radiosurgery to the Surgical Cavity as Adjuvant Therapy for Resected Brain Metastasis显示文摘 | Jared R. Robbins Samuel Ryu Steven Kalkanis Chad Cogan Jack Rock Benjamin Movsas Jae Ho Kim Mark Rosenblum | 2012 | Neurosurgery2012，，5： | 1 |
| 7 | Urban Free Falls and Patterns of Renal Injury: A 20-Year Experience with 396 Cases显示文摘 | Steven B. Brandes Jack W. McAninch | 1999 | The Journal of Trauma: Injury, Infection, and Cri1999，，： | 1 |
| 8 | Kangaroo care is effective in diminishing pain response in preterm neonates 显示文摘 | Johnston CC Stevens B Pinelli J Gibbins S Filion F Jack A | 2003 | Arch Pediatr Adolesc Med2003，157，11： | 1 |
| 9 | Barriers to successful treatment completion in child sexual abuse survivors显示文摘 | Paul Mc Pherson Philip Scribano Jack Stevens | 2012 | Journal of Interpersonal Violence2012，27，1： | 1 |
| 10 | Copyright Protection for the Electronic Distribution of Text Documents显示文摘 | Jack T Brassil Steven Low Nicholas F Maxemehuk | 1999 | Proc of the IEEE1999，87，7： | 1 |
| 11 | Absorption,tissue distribution,metabolism,and excretion of moxidectin in cattle显示文摘 | Jack Zulalian Steven J Stout Adrian R da Cunha | 1994 | Journal of Agricultural and Food Chemistry1994，42，2： | 1 |
| 12 | Copyright Protection for the Electronic Distribution of Text Documents显示文摘 | Jack T Brassil Steven Low Nicholas F Maxemchuk | 1999 | Proceedings of the IEEE1999，87，7： | 1 |
| 13 | Copyright Protection for Eled Ronic Distribution of Text Documents显示文摘 | Jack T B Steven L Nicholas F M | 1999 | Proceedings of the IEEE1999，87，7： | 1 |
| 14 | Forebrain neurogenesis after focal Ischemic and traumatic brain injury显示文摘 | Steven G. Kernie Jack M. Parent | 2009 | Neurobiology of Disease2009，，2： | 1 |
| 15 | Antagonists to Human and Mouse Vascular Endothelial Growth Factor Receptor 2 Generated by Directed Protein Evolution In Vitro显示文摘 | Elena V. Getmanova Yan Chen Laird Bloom Jochem Gokemeijer Steven Shamah Veena Warikoo Jack Wang Vincent Ling Lin Sun | 2006 | Chemistry & Biology2006，，5： | 1 |
| 16 | Personal exposures to fine particulate matter and black carbon in households cooking with biomass fuels in rural Ghana显示文摘 | Eleanne D.S. Van Vliet Kwakupoku Asante Darby W. Jack Patrick L. Kinney Robin M. Whyatt Steven N. Chillrud Livesy Abokyi Charles Zandoh Seth Owusu-Agyei | 2013 | Environmental Research2013，，： | 1 |
| 17 | Physical Activity and Public Health in Older Adults: Recommendation from the American College of Sports Medicine and the American Heart Association显示文摘 | MIRIAM E. NELSON W. JACK REJESKI STEVEN N. BLAIR PAMELA W. DUNCAN JAMES O. JUDGE ABBY C. KING CAROL A. MACERA CARMEN CASTANEDA-SCEPPA | 2007 | Medicine & Science in Sports & Exercise2007，，8： | 1 |
| 18 | The human HLA specific monoclonal antibody W6/32 recognizes a discontinuous epitope within the α2 domain of murine H-2Db显示文摘 | Dr. Richard T. Maziarz John Fraser Jack L. Strominger Steven J. Burakoff | 1986 | Immunogenetics1986，，3： | 1 |
| 19 | Analysis of miR-137 expression and rs1625579 in dorsolateral prefrontal cortex显示文摘 | Ilaria Guella Adolfo Sequeira Brandi Rollins Linda Morgan Federica Torri Theo G.M. van Erp Richard M. Myers Jack David Barchas Alan F. Schatzberg Stanley J. Watson Huda Akil William E. Bunney Steven G. Potkin Fabio Macciardi Marquis P. Vawter | 2013 | Journal of Psychiatric Research2013，，9： | 1 |
| 20 | The early dislocation rate in primary total hip arthroplasty following the posterior approach with posterior soft-tissue repair 1 1 No benefits or funds were received in support of this study.显示文摘 | Steven H Weeden Wayne G Paprosky Jack W Bowling | 2003 | The Journal of Arthroplasty2003，，6： | 1 |
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