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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Fungicidal activity of ce-cropin A显示文摘 | Delucca A Bland J M Jacks T J | 1997 | Antimicro Agents Chemo1997，41，2： | 2 |
| 3 | Biological souring and mitigation in oil reservoirs 显示文摘 | Gieg L M Jack T R Foght J M | 2011 | Applied Microbiology and Biotechnology2011，92，2： | 1 |
| 4 | 显示文摘 | Kashiwagia T Du F M Douglas Jack | 2005 | Nature Mater2005，4，12： | 1 |
| 5 | The homeotic gene APETALA3 of Arabidopsis thaliana encodes a MADS-box and is expressed in petals and stamens 显示文摘 | JACK T BROCKMAN L L MEYEROWITZ E M | 1992 | Cell1992，68，4： | 1 |
| 6 | Chain scission resists for extreme ultra violet lithography based on high performance polysulfonecontaining polymers显示文摘 | Lawrie K J Blakey I Blinco J P Cheng H H Gronheid R Jack K S Pollentier I Leeson M J Younkin T R Whittaker A K | 2011 | Journal of Materials Chemistry2011，21，： | 1 |
| 7 | A big step in the study of small cell lung cancer显示文摘 | Minna J D Kurie J M Jacks T | 2003 | Cancer Cell2003，4，： | 1 |
| 8 | Copyright Protection for the Electronic Distribution of Text Documents显示文摘 | Jack T B Steven L Nicholas F M | 1999 | Proceedings of the IEEE1999，87，7： | 1 |
| 9 | Diagnosis, assessment, and treatment of bone turnover abnormalities in renal osteodystrophy显示文摘 | Kevin J Martin Klaus Olgaard Jack W Coburn Giorgio M Coen Masafumi Fukagawa Craig Langman Hartmut H Malluche James T McCarthy Shaul G Massry Otto Mehls Isidro B Salusky Justin M Silver Miroslaw T Smogorzewski Eduardo M Slatopolsky Linda McCann | 2004 | American Journal of Kidney Diseases2004，，3： | 1 |
| 10 | The homeotic gene APETALA3 of Arabidopsis thaliana encodes a MADS-box and is expressed in petals and stamens显示文摘 | Jack T Brockmmi L L Meverowitz E M | 1992 | Cell1992，68，4： | 1 |
| 11 | In-line filtration reduces severe complications and length of stay on pediatric intensive care unit:A prospective,randomized,controlled trial显示文摘 | Jack T Boehne M Brent BE | | 0，，6： | 1 |
| 12 | A population-based study of the drug interaction between proton pump inhibitors and clopidogrel显示文摘 | Juurlink David N Gomes Tara Ko Dennis T Szmitko Paul E Austin Peter C Tu Jack V Henry David A Kopp Alex Mamdani Muhammad M | 2009 | Canadian Medical Association. Journal2009，，7： | 1 |
| 13 | Impaired microRNA processing enhances cellular transformation and tumorigenesis显示文摘 | Kumar M S Lu J Mercer K L Golub T R Jacks T | 2007 | Nat Genet2007，39，： | 1 |
| 14 | Magnetic resonance imaging of Alzheimer's pathology in the brains of living transgenic mice: a new tool in Alzheimer's disease research 显示文摘 | Jack CR Marjanska M Wengenack T | 2007 | Neuroscientis2007，13，： | 1 |
| 15 | Retrospective comparison of azithromycin,clarithromycin,and erythromycin for the treatment of foals with Rhodococcus equi pneumonia显示文摘 | Giguere S Jacks S Roberts G D Hernandez J Long M T Ellis C | | 0，，： | 1 |
| 16 | Attenuated livevaccine usage affects accurate measures of virus diversity and mu-tation rates in avian corona virus infectious bronchitis virus显示文摘 | McKinley E T Jack wood M W Hilt D A | 2011 | Virus Research2011，158，12： | 1 |
| 17 | Genetically engineered mouse models of cancer reveal new insights about the antitumor immune response显示文摘 | DuPage M Jacks T | 2013 | Curt Opin Immunol2013，25，2： | 1 |
| 18 | A parameter estimation approach to time-delay estimation and signal detection显示文摘 | Jack M Riley J B Plant | 1980 | IEEE Transaction on ASSP1980，，1： | 1 |
| 19 | Randomized, prospective comparison of first - and second - generation cephalosporins as infection prophylaxis for cardiac surgery 显示文摘 | Jack J C Theresa M B Joseph T W | 1993 | Am J Surg1993，166，6： | 1 |
| 20 | Characterization and sur face properties of amino-acid-modified carbonate-containing hydroxyapatite particles显示文摘 | Jack K S Vizcarra T G Trau M | 2007 | Langmuir2007，23，12： | 1 |
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