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	题名	作者	年代	出处	被引量
1	Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 ⁺ T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。	Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel	2015	Cell Research2015，25，2：	14
2	Destructible surfactants based on a silicon-oxygen bond显示文摘	Ward M D	1982	J Org Chem1982，47，11：	1
3	STAT3 activation of miR -21 and miR - 181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer 显示文摘	Iliopoulos D Jaeger SA Hirsch HA	2010	Mol Cell2010，39，4：	1
4	Type II meta- caspases Atmc4 and Atmc9 of Arabidopsis thaliana cleave suhstrates after arginine and lysine显示文摘	VERCAMMEN D VAN DE COTTE B DE JAEGER G l	2004	J Biol Chem2004，279，45：	1
5	The floating shoulder-clinical and radiological results after intramedullary stabilization of the clavicle in cases with minor displacement of the scapular neck fracture显示文摘	Izadpanah K Jaeger M Maier D	2012	J Trauma Acute Care Surg2012，72，2：	1
6	Optimization and applications of echo state networks with leaky integrator neurons 显示文摘	JAEGER H LUKOSEVICIUS M POPOVICI D	2007	Neural Networks2007，20，3：	1
7	Grafting of a Thin Layer of Poly (organophosphazene) Containing Succinic Anhydride Groups onto Poly (vinyl- alcohol) and Poly (ethylene-co-vinylalcohol) 显示文摘	Jaeger R D Gengembre L	1998	Polymer1998，39，5：	1
8	STAT3 activa- tion of miR-21 and miR-181b-1 via FFEN and CYLD are part of the epigenetic switch linking inflammation to can- cer显示文摘	Iliopoulos D Jaeger SA Hirsch HA	2010	Mol Cell2010，39，4：	1
9	Surfaetant quaternary ammonium hydrotris (I - pyrazoly) borates 显示文摘	JAEGER D A MENDOZA A BRAGDON J	2005	Langmuir2005，21，：	1
10	Oxaliplatin,5-fluorouracil and lencovorin every two weeks in patients with advanced gastric cancer;preliminary results of a multicentar,phase Ⅱ study显示文摘	Al-Batran SE JaegerE Jaeger D	2003	proc Am Soc Clin Oncol2003，22，：	1
11	Hepatic clearance and retention of aluminium: studies in the isolated perfused rat liver 显示文摘	Whihelm M Jaeger D E Cablitz H S	1996	Toxicology Letters1996，89，3：	1
12	The Inflence of Involvement on Purchase Intention for New World Wine 显示文摘	HOLLEBEEK L D JAEGER S R BRODIE R J	2007	Food Quality and Preference2007，18，8：	1
13	The floating shoul- der- clinical and radiological results after intramedullary stabilization of the clavicle in cases with minor displace- ment of the scapular neck fracture 显示文摘	Izadpanah K Jaeger M Maier D	2012	J Trauma Acute Care Surg2012，72，2：	1
14	Boosting heterologous protein production in transgenic dicotyledonous seeds using Phaseolus vulgaris regulatory sequences显示文摘	JAEGER G D SCHEFER S JACOBS A	2002	Nat Biotechnol2002，20，12：	1
15	Flocculation and stabilization of colloidal silica by the adsorption of poly-diallyldimethyl-ammoniumchloride (PDADMAC) and of copolymers of DADMAC with N-methyl-N-vinyl-acetamide (NMVA) 显示文摘	Bauer D Killmann E Jaeger W	1998	Colloid Polym Sci1998，276，8：	1
16	STAT3 activation of miR -21 and miR - 181b - 1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer 显示文摘	Iliopoulos D Jaeger SA Hirsch HA	2010	Mol Cell2010，39，4：	1
17	The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘	International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M	2010	Science2010，330，6010：	1
18	Force distribution in a granular medium显示文摘	MUETH D M JAEGER H M NAGEL S R	1997	APS Phys Rev E1997，57，3：	1
19	STAT3 activation of miR-21 and miR- 181 b- 1via PTEN and CYLD are part of the epi- genetic switch linking inflammation to cancer显示文摘	Iliopoulos D Jaeger SA Hirseh HA	2010	Mol Cell2010，39，4：	1
20	STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer显示文摘	Iliopoulos D Jaeger SA Hirsch HA		0，，04：	1

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