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1Mycoplasma infections and different human carcinomas显示文摘AIM To explore relationships between human carcinomas and mycoplasma infection.METHODS Monoclonal antibody PD4, which specifically recognizes a distinct protein from mycoplasma hyorhinis, was used to detect mycoplasma infection in different paraffinembedded carcinoma tissues with immunohistochemistry. PCR was applied to amplify the mycoplasma DNA from the positive samples for confirming immunohistochemistry.RESULTS Fifty of 90 cases (56%) of gastric carcinoma were positive for mycoplasma hyorhinis. In other gastric diseases, the mycoplasma infection ratio was 28% (18/49) in chronic superficial gastritis, 30% (14/ 46) in gastric ulcer and 37% (18/ 49) in intestinal metaplasia. The difference is significant with gastric cancer (X2=12.06, P<0.05). In colon carcinoma, the mycoplasma infection ratio was 55.1% (32/58), but it was 20.9% (10/49) in adenomarous polyp (X2=13.46, P<0.005).Gastric and colon cancers with high differentiation had a higher mycoplasma infection ratio than those with low differentiation (P< 0.05). Mycoplasma infection in esophageal cancer, lung cancer, breast cancer and glioma was 50.9% (27/53), 52.6% (31/ 59), 39.7%(25/63) and 41% (38/91), respectively. The mycoplasma DNA was successfully amplified with the DNA extracted from the cancer tissues that were positive for mycoplasma infection (detected with antibody PD4).CONCLUSION There was high correlation between mycoplasma infection and different cancers, which suggests the possibility of an association between the two. The mechanism involved in oncogenesis by mycoplasma remains unknown.Su Huang Ji You Li Jan Wu Lin Meng Cheng Chao Shou Beijing Institute for Cancer Research, Peking University School of Oncology, Beijing 100034. ChinaSu Huang, received B. A from Jiangxi Medical College of China in 1994. Now she is a graduate student pursuing a Ph. D degree at the Peking University School of Oncology. 2001World Journal of Gastroenterology2001,7,2:18
2Diagnostic yield of small bowel capsule endoscopy depends on the small bowel transit time显示文摘AIM:To investigate whether the small bowel transit time(SBTT)influences the diagnostic yield of capsule endoscopy(CE).METHODS:Six hundred and ninety-one consecutive CE procedures collected in a database were analyzed.SBTT and CE findings were recorded.A running mean for the SBTT was calculated and correlated to the diagnostic yield with a Spearman's correlation test.Subgroup analyses were performed for the various indications for the procedure.RESULTS:There was a positive correlation between the diagnostic yield and SBTT(Spearman's rho 0.58,P <0.01).Positive correlations between diagnostic yield and SBTT were found for the indication obscure gastrointestinal bleeding(r=0.54,P<0.01),for polyposis and carcinoid combined(r=0.56,P<0.01)and for the other indications(r=0.90,P<0.01),but not for suspected Crohn's disease(r=-0.40).CONCLUSION:The diagnostic yield in small bowel capsule endoscopy is positively correlated with the small bowel transit time.This is true for all indications except for suspected Crohn's disease.Jessie Westerhof Jan J Koornstra Reinier A Hoedemaker Wim J Sluiter Jan H Kleibeuker Rinse K Weersma 2012World Journal of Gastroenterology2012,18,13:10
3正常人额面QRS电轴的年龄趋势以及对肢体导联QRS波振幅的影响显示文摘目的调查和评估正常人额面QRS电轴的年龄趋势以及对肢体导联QRS波振幅的影响。方法采集5360例(男性3614例、女性1746例,年龄范围18~84岁)正常健康人12导联心电图分为5个年龄组,计算和分析各年龄组额面QRS电轴的中位数以及肢体导联QRS波振幅的中位数和96%的正常范围上、下限。结果随年龄增长,男、女额面QRS中位数电轴一致性地逐渐向左(上)偏移大约27°(从70°偏移到43°,P<0.001)。Ⅰ和aVL导联的R波振幅随年龄增长显著增加(P<0.001),而下壁导联Ⅱ、Ⅲ和aVF的R波振幅随年龄增长显著降低(P>0.001)。肢体导联R波振幅随年龄的变化趋势与额面QRS电轴的年龄趋势相一致。结论正常人额面QRS电轴随年龄增长逐渐向左(上)偏移,呈现明确的年龄趋势。QRS电轴的生理性演变可引起肢体导联QRS波振幅呈现明显的年龄差异。显然,把一个相同的左心室肥大心电图诊断标准应用到不同年龄组人群是不合适的。吴杰 Jan A Kors Peter R Rijnbeek Gerard van Herpen 徐春芳 陆再英 2006中华心律失常学杂志2006,10,3:8
4Pancreaticoduodenectomy: a comparison of superior approach with classical Whipple's technique显示文摘BACKGROUND: Pancreaticoduodenectomy (PD) is the standard procedure for resecting tumors arising from the periampullary area and the pancreatic head. Nevertheless this procedure is inherently difficult and associated with high morbidity and mortality. Besides, the technique applied for exposing the portal and superior mesenteric veins is time-consuming, difficult and associated with the risk of major venous injury. Recently we have introduced a modified approach for making this part of the procedure quick, safe and bloodless, which constitutes the subject of this study. METHODS: Patients who underwent pylorus preserving pancreaticoduodenectomy (PPPD) either by superior approach technique (group 1) or by classical Whipple's technique (group 2) were retrospectively identified. Age-sex composition, body mass index (BMI), total operative time, operative blood loss, intraoperative blood transfusion requirement, morbidity, mortality and length of hospital stay were compared between the two groups. RESULTS: Between January 1997 and December 2011, 72 patients underwent PPPD by the superior approach technique (group 1) and 38 underwent PPPD by the classical Whipple's technique (group 2) at our institution. Statistically significant differences were observed in operative time (208.1±46.3 minutes in group 1 vs 322.0±33.8 minutes in group 2), operative blood loss (601.0±250.3 mL in group 1 vs 1371.5±471.8 mL in group 2), and intraoperative blood transfusion requirement [10 (13.9%) patients in group 1 and 24 (63.2%) in group 2]. Among 18 (16.4%) obese patients, significant differences in operativetime, operative blood loss and intraoperative blood transfusion requirement were observed between groups 1 and 2. There was no significant inter-group difference in complication rate among obese patients, but comparing obese patients with normal weight patients revealed higher rates of complications like pancreatic fistula (27.8% vs 6.5%), delayed gastric emptying (16.7% vs 5.4%), and infective complications like wound infection and intra abdominal collection (44.4% vs 5.4%). CONCLUSIONS: On the basis of analytical data, we conclude that the superior approach technique is effective for PD compared with the classical Whipple's technique. It allows fast, safe and virtually bloodless dissection for exposure of the superior mesenteric and portal veins during early steps of PD. PD is normally a difficult and tedious procedure carrying a remote risk of major venous injury leading to substantial blood loss.Omar Javed Shah Mushtaq A Gagloo Irfan Jan Khan Rayees Ahmad Saleema Bano 2013Hepatobiliary & Pancreatic Diseases International2013,12,2:8
5固定低剂量三联抗高血压药物与常规治疗对斯里兰卡轻度至中度高血压患者血压控制的疗效差异:一项随机临床试验显示文摘控制不良的高血压是全球领先的公共卫生问题,需要新的治疗策略。该研究评估低剂量三联抗高血压药物治疗是否能达到比常规治疗更好的血压控制。研究者纳入2016年2月至2017年5月在斯里兰卡11所城市医院诊所就诊的需要开始抗高血压治疗(未治疗的患者)或接受单药治疗的患者,进行低剂量三联降压与常规治疗比较的随机、开放性试验,随访至2017年10月。Web-ster R Salam A de Silva HA Selak V Stepien S Rajapakse S Amarasekara S Amarasena N Billot L de Silva AP Fernando M Guggilla R Jan S Jayawardena J Maulik PK Mendis S Munasinghe J Naik N Prabhakaran D Ranasinghe G Thom S Tisserra N Senaratne V Wijekoon S Wijeyasingam S Rodgers A Patel A 刘莉 叶鹏 2018中华高血压杂志2018,26,12:7
6Noninvasive indocyanine green plasma disappearance rate predicts early complications,graft failure or death after liver transplantation显示文摘BACKGROUND:Early detection of graft malfunction or postoperative complications is essential to save patients and organs after orthotopic liver transplantation (OLT).Predictive tests for graft dysfunction are needed to enable earlier implementation of organ-saving interventions following transplantation.This study was undertaken to assess the value of indocyanine green plasma disappearance rates (ICG-PDRs) for predicting postoperative complications,graft dysfunction and patient survival following OLT.METHODS:Eighty-six patients undergoing OLT were included in this single-centre trial.ICG-PDR was assessed daily for the first 7 days following OLT.Endpoints were graft loss or death within 30 days and postoperative complications,graft loss,or death within 30 days.RESULTS:Postoperative complications of 31 patients included deaths (12 patients) or graft losses.ICG-PDR was significantly different in patients whose endpoints were graft loss or death beginning from day 3 and in those whose endpoints were graft loss,death,or postoperative complications beginning from day 4 after OLT.For day 7 measurements,receiver operating characteristic curve analysis revealed an ICG-PDR cut-off for predicting death or graft loss of 9.6% per min (a sensitivity of 75.0%,a specificity of 72.6%,positive predictive value 0.35 negative predictive value 0.94).For prediction of graft loss,death or postoperative complications,the ICG-PDR cut-off was 12.3%per min (a sensitivity of 68.9%,a specificity of 66.7%,positive predictive value 0.57,negative predictive value 0.77).CONCLUSIONS:ICG-PDR measurements on postoperative day 7 are predictive of early patient outcomes following OLT.The added value over that of routinely determined laboratory parameters is low.Lutz Schneider Martin Spiegel Sebastian Latanowicz Markus A Weigand Jan Schmidt Jens Werner Wolfgang Stremmel Christoph Eisenbach 2011Hepatobiliary & Pancreatic Diseases International2011,10,4:6
7Management and outcome of hepatocellular adenoma with massive bleeding at presentation显示文摘AIM To evaluate outcome of acute management and risk of rebleeding in patients with massive hemorrhage due to hepatocellular adenoma(HCA). METHODS This retrospective cohort study included all consecutive patients who presented to our hospital with massive hemorrhage(grade Ⅱ or Ⅲ) due to ruptured HCA and were admitted for observation and/or intervention between 1999-2016. The diagnosis of HCA was based on radiological findings from contrastenhanced magnetic resonance imaging(MRI) or pathological findings from biopsy or resection of the HCA. Hemorrhage was diagnosed based on findings from computed tomography or MRI. Medical records were reviewed for demographic features, clinical presentation, tumor features, initial and subsequent management, short-and long-term complications and patient and lesion follow-up. RESULTS All patients were female(n = 23). Treatment in the acute phase consisted of embolization(n = 9, 39.1%), conservative therapy(n = 13, 56.5%), andother intervention(n = 1, 4.3%). Median hemoglobin level decreased significantly more on days 0-3 in the intervention group than in the patients initially treated conservatively(0.9 mmol/L vs 2.4 mmol/L respectively, P = 0.006). In total, 4 patients suffered severe shortterm complications, which included hypovolemic shock, acute liver failure and abscess formation. After a median follow-up of 36 mo, tumor regression in nonsurgically treated patients occurred with a median reduction of 76 mm down to 25 mm. Four patients underwent secondary(elective) treatment(i.e., tumor resection) to address HCA size of > 5 cm and/or desire for future pregnancy. One case of rebleeding was documented(4.3%). None of the patients experienced long-term complication(mean follow-up time: 36 mo). CONCLUSION With a 4.3% risk of rebleeding, secondary(elective) treatment of HCA after massive hemorrhage may only be considered in patients with persistent HCA > 5 cm.Anne J Klompenhouwer Robert A de Man Maarten GJ Thomeer Jan NM Ijzermans 2017World Journal of Gastroenterology2017,23,25:5
8Surgical management of complicated hydatid cysts of the liver显示文摘AIM: To review the clinical presentation and surgical management of complicated hydatid cysts of the liver and to assess whether conservative surgery is adequate in the management of complicated hydatid cysts of liver.METHODS:The study was carried out at Sher-i-Kashmir Institute of Medical Science,Srinagar,Kashmir,India.Sixty nine patients with hydatid disease of the liver were surgically managed from April 2004 to October 2005 with a follow up period of three years.It included 27 men and 42 women with a median age of 35 years.An abdominal ultrasound,computed tomography and serology established diagnosis.Patients with jaundice and high suspicion of intrabiliary rupture were subjected to preoperative endoscopic retrograde cholangiography.Cysts with infection,rupture into the biliary tract and peritoneal cavity were categorized as complicated cysts.Eighteen patients(26%)had complicated cysts and formed the basis for this study.RESULTS:Common complications were infection(14%),intrabiliary rupture(9%)and intraperitoneal rupture(3%).All the patients with infected cysts presented with pain and fever.All the patients with intrabiliary rupture had jaundice,while only four with intrabiliary rupture had pain and only two had fever.Surgical procedures performed in complicated cysts were:infection-omentoplasty in three and external drainage in seven;intrabiliary rupture-omentoplasty in two and internal drainage in four patients.Two patients with intraperitoneal rupture underwent external drainage.There was no mortality.The postoperative morbidity was 50%in complicated cysts and 16%in uncomplicated cysts.CONCLUSION:Complicated hydatid cyst of the liver can be successfully managed surgically with good long term results.Ajaz A Malik Shams UL Bari Ruquia Amin Masooda Jan 2010World Journal of Gastrointestinal Surgery2010,2,3:4
9IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice显示文摘Petrasek Jan Bala Shashi Csak Timea Lippai Dora Kodys Karen Menashy Victoria Barrieau Matthew Min So-Yun Kurt-Jones Evelyn A Szabo Gyongyi 2012EN2012,,10:4
10Serrated adenoma of the stomach:Case report and literature review显示文摘Gastric serrated adenomas are histologically characterized by protruding glands with lateral saw tooth-like indentations lined with stratified dysplastic cells containing abundant eosinophilic cytoplasm.Since the first case of gastric serrated adenoma found in 2001,18 additional cases have been reported.Gastric serrated adenomas have a particular proclivity to progress to invasive carcinoma;75% or 15 of the 20 cases now in record-including the present one-exhibited invasive carcinoma.The 20 th case of gastric serrated adenoma reported here differs from the preceding ones in as much as it evolved in a patient with Lynch syndrome,implying that this adenoma phenotype may develop not only sporadically but also in patients with hereditary traits.Carlos A Rubio Jan Bjrk 2013World Journal of Gastrointestinal Endoscopy2013,5,5:4
11Putting things in place for fertilization: discovering roles for importin proteins in cell fate and spermatogenesis显示文摘Importin 蛋白质原来通过原子毛孔在蛋白质运输为他们的中央角色被描绘,唯一的细胞内部的入口到原子核。这个重要函数必须紧被调整由抄写因素和另外的原子蛋白质控制存取到 genomic DNA,到完成细胞的行为影响的适当调整房间命运。调停 Importin 的 nucleocytoplasmic 运输依靠他们货物的特定的识别,与到不同、重叠的蛋白质子集的每 importin 绑定。importin 功能的知识关于三个关键发展系统实质地膨胀了:胚胎的干细胞,肌肉房间和细菌排队。自从为调整 nucleocytoplasmic 运输的潜力被建议贡献精子发生,在十年,我们和其它证明了进原子核的渡船抄写因素执行的 importins 另外的角色,它控制房间命运。这评论从哺乳动物的精子发生的研究介绍关键调查结果揭示男富饶和不孕由产生的潜在的新小径。germline 开始的这些研究照亮 importin 蛋白质在管理细胞的区别的新方法,经由指导到不同细胞内部的分隔空间并且由决定细胞的压力回答的蛋白质包括。Kate L Loveland Andrew T Major Romaly Butler Julia C Young David A Jan Yoichi Miyamoto 2015Asian Journal of Andrology2015,17,4:3
12Adenoma detection with cap-assisted colonoscopy versus regular colonoscopy: a randomised controlled trial显示文摘Thomas R de Wijkerslooth Esther M Stoop Patrick M Bossuyt Elisabeth M H Mathus-Vliegen Jan Dees Kristien M A J Tytgat Monique E van Leerdam Paul Fockens Ernst J Kuipers Evelien Dekker 2012Gut2012,,10:3
13Ethanol metabolism and its effects on the intestinal epithelial barrier显示文摘Elhaseen E Elamin Ad A Masclee Jan Dekker Daisy M Jonkers 2013Nutr Rev2013,,7:3
14Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) 2006英国医学杂志中文版2006,9,5:3
15Microstructural analysis of pineal volume using trueFISP imaging显示文摘AIM:To determine the spectrum of pineal microstructures (solid/cystic parts) in a large clinical population using a high-resolution 3D-T2-weighted sequence. METHODS:A total of 347 patients enrolled for cranial magnetic resonance imaging were randomly included in this study. Written informed consent was obtained from all patients. The exclusion criteria were artifacts or mass lesions prohibiting evaluation of the pineal gland in any of the sequences. True-FISP-3D-imaging (1.5-T, isotropic voxel 0.9 mm) was performed in 347 adults (55.4 ± 18.1 years). Pineal gland volume (PGV), cystic volume, and parenchyma volume (cysts exclud- ed) were measured manually. RESULTS:Overall, 40.3% of pineal glands were cystic. The median PGV was 54.6 mm 3 (78.33 ± 89.0 mm 3 ), the median cystic volume was 5.4 mm 3 (15.8 ± 37.2mm 3 ), and the median parenchyma volume was 53.6 mm 3 (71.9 ± 66.7 mm 3 ). In cystic glands, the standard deviation of the PGV was substantially higher than in solid glands (98% vs 58% of the mean). PGV declined with age (r = -0.130, P = 0.016). CONCLUSION:The high interindividual volume variation is mainly related to cysts. Pineal parenchyma volume decreased slightly with age, whereas genderrelated effects appear to be negligible.Jan M Bumb Marc A Brockmann Christoph Groden Ingo Nolteb 2013World Journal of Radiology2013,5,4:2
16二甲双胍长期治疗2型糖尿病患者以及维生素B12缺乏的危险性:随机安慰剂对照研究(摘要)显示文摘目的 研究接受胰岛素治疗的2型糖尿病患者中,二甲双胍所致维生素B12缺乏(〈150pmol/L)、低浓度维生素B12(150—220pmol/L)的发生率,以及叶酸和同型半胱氨酸的浓度。Jolien de Jager Adriaan Kooy Philippe Lehert Michiel G Wulffele Jan van der Kolk Daniel Bets Joop Verburg Ab J M Donker Coen D A Stehouwer 许翎岭(译) 2010英国医学杂志中文版2010,13,5:2
17Extent of lymphadenectomy has no impact on postoperative complications after gastric cancer surgery in Sweden显示文摘Objective: Curative gastric cancer surgery entails removal of the primary tumor with adequate margins including regional lymph nodes. European randomized controlled trials with recruitment in the 1990's reported increased morbidity and mortality for D2 compared to D1. Here, we examined the extent of lymphadenectomy during gastric cancer surgery and the associated risk for postoperative complications and mortality using the strengths of a population-based study.Methods: A prospective nationwide study conducted within the National Register of Esophageal and Gastric Cancer. All patients in Sweden from 2006 to 2013 who underwent gastric cancer resections with curative intent were included. Patients were categorized into D0, D1, or D1+/D2, and analyzed regarding postoperative morbidity and mortality using multivariable logistic regression.Results: In total, 349(31.7%) patients had a D0, 494(44.9%) D1, and 258(23.4%) D1+/D2 lymphadenectomy.The 30-d postoperative complication rates were 25.5%, 25.1% and 32.2%(D0, D1 and D1+/D2, respectively), and 90-d mortality rates were 8.3%, 4.3% and 5.8%. After adjustment for confounders, in multivariable analysis, there were no significant differences in risk for postoperative complications between the lymphadenectomy groups. For90-d mortality, there was a lower risk for D1 vs. D0.Conclusions: The majority of gastric cancer resections in Sweden have included only a limited lymphadenectomy(D0 and D1). More extensive lymphadenectomy(D1+/D2) seemed to have no impact on postoperative morbidity or mortality.chih-han kung huan song weimin ye magnus nilsson jan johansson ioannis rouvelas tomoyuki irino lars lundell jon a tsai mats lindblad 2017Chinese Journal of Cancer Research2017,29,4:2
18An experimental multivalent bovine virus diarrhea virus E2 subunit vaccine and two experimental conventionally inactivated vaccines induce partial fetal protection in sheep显示文摘Christianne J.M Bruschke Jan T van Oirschot Piet A van Rijn 1999Vaccine1999,,15:2
19A sensing mechanism for the detection of carbon nanotubes using selective photoluminescent probes based on ionic complexes with organic dyes显示文摘The multifunctional properties of carbon nanotubes(CNTs)make them a powerful platform for unprecedented innovations in a variety of practical applications.As a result of the surging growth of nanotechnology,nanotubes present a potential problem as an environmental pollutant,and as such,an efficient method for their rapid detection must be established.Here,we propose a novel type of ionic sensor complex for detecting CNTs–an organic dye that responds sensitively and selectively to CNTs with a photoluminescent signal.The complexes are formed through Coulomb attractions between dye molecules with uncompensated charges and CNTs covered with an ionic surfactant in water.We demonstrate that the photoluminescent excitation of the dye can be transferred to the nanotubes,resulting in selective and strong amplification(up to a factor of 6)of the light emission from the excitonic levels of CNTs in the near-infrared spectral range,as experimentally observed via excitation-emission photoluminescence(PL)mapping.The chirality of the nanotubes and the type of ionic surfactant used to disperse the nanotubes both strongly affect the amplification;thus,the complexation provides sensing selectivity towards specific CNTs.Additionally,neither similar uncharged dyes nor CNTs covered with neutral surfactant form such complexes.As model organic molecules,we use a family of polymethine dyes with an easily tailorable molecular structure and,consequently,tunable absorbance and PL characteristics.This provides us with a versatile tool for the controllable photonic and electronic engineering of an efficient probe for CNT detection.Petro Lutsyk Raz Arif Jan Hruby Anatolii Bukivskyi Olexander Vinijchuk Mykola Shandura Viktor Yakubovskyi Yuri Kovtun Graham A Rance Michael Fay Yuri Piryatinski Oleksiy Kachkovsky Anatoli Verbitsky Aleksey Rozhin 2016Light(Science & Applications)2016,5,1:2
20Importance of mechanisms and processes of the stabilisation of soil organic matter for modelling carbon turnover 显示文摘EVELYN S K JEFFREY A B JAN O S 2003Functional Plant Biology2003,30,2:1
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