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| 1 | Enzyme-catalyzed crosslinkable hydrogels: Emerging strategies for tissue engineering显示文摘 | Liliana S. Moreira Teixeira Jan Feijen Clemens A. van Blitterswijk Pieter J. Dijkstra Marcel Karperien | 2011 | Biomaterials2011，，5： | 2 |
| 2 | Controlled and stereoselective polymerization of lactide: Kinetics, selectivity, and microstructures显示文摘 | Zhong Zhiyuan Dijkstra P J Jan Feijen | 2003 | J Am Chem Soc2003，125，11： | 1 |
| 3 | In Situ Polymerisation of Pyrrole in Nanochannels Produced by Means of AFM Lithography显示文摘 | Shahab Jahromi Jan Dijkstra Eric van der Vegte and Ben Mostert | 2002 | ChemPhysChem2002，，8： | 1 |
| 4 | The effect of platelet lysate supplementation of a dextran-based hydrogel on cartilage formation显示文摘 | Liliana S. Moreira Teixeira Jeroen C.H. Leijten Jos W.H. Wennink Anindita G. Chatterjea Jan Feijen Clemens A. van Blitterswijk Pieter J. Dijkstra Marcel Karperien | 2012 | Biomaterials2012，，14： | 1 |
| 5 | Hydrogels in a historical perspective: From simple networks to smart materials显示文摘 | Sytze J. Buwalda Kristel W.M. Boere Pieter J. Dijkstra Jan Feijen Tina Vermonden Wim E. Hennink | 2014 | Journal of Controlled Release2014，，： | 1 |
| 6 | Beyond the class norm : bullying behavior of popular adolescents and its relation to peer acceptance and rejection 显示文摘 | Jan Kornelis Dijkstra Siegwart Lindenberg ReneVeen-stra | 2008 | Journal of abnormal child psychology2008，，8： | 1 |
| 7 | Determination of the stereoselectivity factor for an asymmetric enantiomer-differentiating polymerization :a revisit 显示文摘 | Zhong Zhiyuan Dijkstra Pieter J Feijen Jan | 2003 | Macromolecules2003，36，21： | 1 |
| 8 | Rapid gelation of injectable hydrogels based on hyaluronic acid and poly (ethylene glycol) via Michael-type addition显示文摘 | Rong J Dijkstra PJ Jan F | 2010 | Journal of Controlled Release2010，148，1： | 1 |
| 9 | The role of dynamic modelingin understanding the microbial contribution to rumen function显示文摘 | Dijkstra J Mills JAN France J | 2002 | Nutr Res Rev2002，15，： | 1 |
| 10 | MRCKα is a novel regulator of prolactin-induced lactogenesis in bovine mammary epithelial cells显示文摘Myotonic dystrophy-related Cdc42-binding kinase alpha(MRCKα)is an integral component of signaling pathways controlling vital cellular processes,including cytoskeletal reorganization,cell proliferation and cell survival.In this study,we investigated the physiological role of MRCKα in milk protein and fat production in dairy cows,which requires a dynamic and strict organization of the cytoskeletal network in bovine mammary epithelial cells(BMEC).Within a selection of 9 Holstein cows,we found that both mRNA and protein expression of MRCKα in the mammary gland were upregulated during lactation and correlated positively(r>0.89)with the mRNA and protein levels of b-casein.Similar positive correlations(r>0.79)were found in a primary culture of BMEC stimulated with prolactin for 24 h.In these cells,silencing of MRCKα decreased basal b-casein,sterol-regulatory element binding protein(SREBP)-1 and cyclin D1 protein level,phosphorylation of mTOR,triglyceride secretion,cell number and viabilitydwhile overexpression of MRCKα displayed the reversed effect.Notably,silencing of MRCKα completely prevented the stimulatory action of prolactin on the same parameters.These data demonstrate that MRCKα is a critical mediator of prolactin-induced lactogenesis via stimulation of the mTOR/SREBP1/cyclin D1 signaling pathway. | Fang Wang Jürgen van Baal Lu Ma Xuejun Gao Jan Dijkstra Dengpan Bu | 2022 | Animal Nutrition2022，，3： | 1 |
| 11 | Impact of post-ruminally infused macronutrients on bovine mammary gland expression of genes involved in fatty acid synthesis, energy metabolism, and protein synthesis measured in RNA isolated from milk fat显示文摘Background: Characterising the regulation of milk component synthesis in response to macronutrient supply is critical for understanding the implications of nutritional interventions on milk production. Gene expression in mammary gland secretory cells was measured using RNA isolated from milk fat globules from 6 Holstein-Friesian cows receiving 5-d abomasal infusions of saline, essential amino acids(AA), or glucose(GG) or palm olein(LG)without(LAA) or with(HAA) essential AA, according to a 6 × 6 Latin square design. RNA was isolated from milk fat samples collected on d 5 of infusion and subjected to real-time quantitative PCR. We hypothesised that m RNA expression of genes involved in de novo milk fatty acid(FA) synthesis would be differently affected by GG and LG,and that expression of genes regulating transfer of tricarboxylic acid cycle intermediates would increase at the HAA level. We also hypothesised that the HAA level would affect genes regulating endoplasmic reticulum(ER)homeostasis but would not affect genes related to the mechanistic target of rapamycin complex 1(m TORC1) or the integrated stress response(ISR) network.Results: Infusion of GG did not affect de novo milk FA yield but decreased expression of FA synthase(FASN).Infusion of LG decreased de novo FA yield and tended to decrease expression of acetyl-Co A carboxylase 1(ACC1).The HAA level increased both de novo FA yield and expression of ACC1, and tended to decrease expression of mitochondrial phosphoenolpyruvate carboxykinase(PCK2). m RNA expression of m TORC1 signaling participants was not affected by GG, LG, or AA level. Expression of the ε subunit of the ISR constituent eukaryotic translation initiation factor 2 B(EIF2 B5) tended to increase at the HAA level, but only in the presence of LG. X-box binding protein 1(XBP1) m RNA was activated in response to LG and the HAA level.Conclusions: Results show that expression of genes involved in de novo FA synthesis responded to glucogenic,lipogenic, and aminogenic substrates, whereas genes regulating intermediate flux through the tricarboxylic acid cycle were not majorly affected. Results also suggest that after 5 d of AA supplementation, milk protein synthesis is supported by enhanced ER biogenesis instead of signaling through the mTORC1 or ISR networks. | Kelly Nichols AndréBannink Jurgen van Baal Jan Dijkstra | 2020 | Journal of Animal Science and Biotechnology2020，11，4： | 0 |
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