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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | Introduction of laparoscopic gastrectomy for gastric cancer in a Western tertiary referral centre:A prospective cost analysis during the learning curve显示文摘AIM To evaluate the costs of the introduction of a laparoscopic surgery program for gastric cancer in a Western community training hospital and tertiary referral centre for gastric cancer surgery. METHODS All patients who underwent surgery for gastric cancer with curative intent in 2013 and 2014 were prospectively included. Primary outcomes were costs regarding surgery and hospital stay. RESULTS Laparoscopic gastrectomy was used in 52 patients [mean age 68 years(± 9, range 50 to 87) years] and open gastrectomy was used in 25 patients [mean age 70 years(± 10, range 46 to 85)]. Mean costs(in euro's) of surgical instrumentation were significantly higher for laparo-scopic surgery: 2270 ± 670 vs 1181 ± 680 in the open approach(P < 0.001). Costs of theatre use were higher in the laparoscopic group: mean 3818 ± 865 vs 2545± 1268 in the open surgery(P < 0.001). Total costs of hospitalization(i.e., costs of surgery and admission)were not different between laparoscopic and open surgery, 8187 ± 4864 and 6152 ± 2680 respectively(P= 0.729). Mean length of hospital stay was 9 ± 12 d in the laparoscopic group vs 14 ± 14 d in the open group(P= 0.044). CONCLUSION The introduction of laparoscopic gastrectomy for gastric cancer coincided with higher costs for theatre use and surgical instrumentation compared to the open technique. Total costs were not significantly different due to shorter length of stay and less intensive care unit(ICU) admissions and shorter ICU stay in the laparoscopic group. | Juul J Tegels Charlotte E Silvius Frederique E Spauwen Karel W Hulsewé Anton G Hoofwijk Jan H Stoot | 2017 | World Journal of Gastrointestinal Oncology2017，9，5： | 2 |
| 3 | Development of human protein reference database as an initial platform for approaching systems biology in humans 显示文摘 | PERI S NAVARRO J D AMANCHY R KRISTIANSEN T Z JONNALAGADDA C K SURENDRANATH V NIRAN JAN V MUTHUSAMY B GANDHI T K GRONBORG M IBARROLA N DESHPANDE N SHANKER K SHIVASHANKAR H N RASHMI B P RAMYA M A ZHAO Z CHANDRIKA K N PADMA N HARSHA H C YATISH A J KAVITHA M P MENEZES M CHOUDHURY D R SURESH S GHOSH N SARAVANA R CHANDRAN S KRISHNA S JoY M ANAND S K MADAVAN V JOSEPH A WONG G W SCHIEMANN W P CONSTANTINESCU S N HUANG L KHOSRAVI-FAR R STEEN H TEWARI M GHAFFARI S BLOBE G C DANG C V GARCIA J G PEVSNER J JENSEN O N ROEPSTORFF P DESHPANDE K S CHINNAIYAN A M HAMOSH A CHAKRAVARTI A PANDEY A | 2003 | Genome Research2003，13，10： | 1 |
| 4 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 5 | Photocatalytic activities of porous titania and titania/ zirconia structures formed by using a polymer gel templating technique显示文摘 | Jan H Dmitry S Shchukin G | 2002 | Chemistry Material2002，14，15： | 1 |
| 6 | Inhibition of gibberellin biosynthesis by paclobutrazol in cell-free homogenates of Cucurbita maxima Endosperm and Malus pumila Embryos显示文摘 | Peter H Jan E G | 1985 | J Plant Growth Regul1985，，4： | 1 |
| 7 | Intronic microRNA precursors that bypass Drosha processing显示文摘 | Ruby J G Jan C H Bartel D P | 2007 | Nature2007，448，7149： | 1 |
| 8 | On the Existence of an Optimal Capital Structure: Theory and Evidence显示文摘 | Bradley M Jan'ell G A Kim E H | 1984 | The Journal of Finance1984，39，3： | 1 |
| 9 | Different approaches to superhard coatings and nanocomposites显示文摘 | STAN V MARITZA G J V H PAVLA K JAN P | 2005 | Thin Solid Films2005，476，： | 1 |
| 10 | Intronie microR- NA precursors that bypass Drosha processing显示文摘 | Ruby J G Jan C H Bartel D P | 2007 | Nature2007，448，7149： | 1 |
| 11 | Cognitive impairment and 7 -year mortality in dialysis patients显示文摘 | Konstadina G Jan S Matthew H | 2010 | Am J kidney Dis2010，56，4： | 1 |
| 12 | Thermal stability of lithium-rich manganese-based cathode显示文摘 | Jan G Jay H S Sun H K | 2014 | Solid State I- onics2014，268，： | 1 |
| 13 | Maximum exposure levels for xylene, formaldehyde and acetaldehyde in cars 显示文摘 | Thomas S Hermann M B Jan G H | 2005 | Toxicology2005，206，3： | 1 |
| 14 | Serum antibodies to helicobacter pylori in resacea patients显示文摘 | NEUBERT U JAN SEN T H PLEWIG G | 1998 | J Dermatol Sci1998，16，2： | 1 |
| 15 | Evaluation of follicular oxidant - antioxidant balance and oxidative damage during reproductive aeyclicity in water Buffalo 显示文摘 | JAN M H DAS G K KHAN F A | 2014 | Asian Pacific Journal of Reproduction2014，3，1： | 1 |
| 16 | Growth and trace metal absorption by Phragmites australis in wetlands constructed for landfill leachate treatment显示文摘 | JOHN H P JAN M S WANG T G | 1995 | Ecological Engineering1995，5，1： | 1 |
| 17 | Intronic microRNA precursors that bypass drosha processing 显示文摘 | Ruby J G Jan C H Bartel D P | 2007 | Nature2007，448，7149： | 1 |
| 18 | A direct PCR detection method for clostridium tyrobutyricum spores in up to 100 Milliliters of raw milk显示文摘 | LIEVE M F H JAN H G E De B GUIDO M A V J W | 1995 | Appl Environ Microbiol1995，12，61： | 1 |
| 19 | Indrcion lf NAD(P)Hoxidaxe Low-Density Lioprotein in Human Endothelial Cells显示文摘 | Uwe R Jan G Juergen H | 2001 | Circulation2001，104，： | 1 |
| 20 | Defining the rebound effect显示文摘 | Peter H G Berkhout Jos CMuskens Jan W Vehhuijsen | 2000 | Energy Policqy2000，28，： | 1 |
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