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| 1 | Patients with inflammatory bowel disease have increased risk of autoimmune and inflammatory diseases显示文摘AIM To investigate whether immune mediated diseases(IMD) are more frequent in patients with inflammatory bowel disease(IBD).METHODS In this population based registry study,a total of 47325 patients with IBD were alive and registered in the Danish National Patient Registry on December 16,2013. Controls were randomly selected from the Danish Civil Registration System(CRS) and matched for sex,age,and municipality. We used ICD 10 codes to identify the diagnoses of the included patients. The IBD population was divided into three subgroups: Ulcerative colitis(UC),Crohn's disease(CD) and Both the latter referring to those registered with both diagnoses. Subsequently,odds-ratios(OR) and 95%CI were obtained separately for each group and their respective controls. The use of Bonferoni post-test correction adjusted the significance level to P < 0.00125. P-values were estimated using Fisher's exact test.RESULTS There were significantly more women than men in the registry,and a greater percentage of comorbidity in the IBD groups(P < 0.05). Twenty different IMDs were all significantly more frequent in the IBD group. Sixteen were associated with UC versus twelve with CD. In both UC and CD ORs were significantly increased(P < 0.00125) for primary sclerosing cholangitis(PSC),celiac disease,type 1 diabetes(T1D),sarcoidosis,asthma,iridocyclitis,psoriasis,pyoderma gangrenosum,rheumatoid arthritis,and ankylosing spondylitis. Restricted to UC(P < 0.00125) were autoimmune hepatitis,primary biliary cholangitis,Grave's disease,polymyalgia rheumatica,temporal arteritis,and atrophic gastritis. Restricted to CD(P < 0.00125) were psoriatic arthritis and episcleritis. Restricted to women with UC(P < 0.00125) were atrophic gastritis,rheumatoid arthritis,temporal arteritis,and polymyalgia rheumatica. Restricted to women with CD were episcleritis,rheumatoid arthritis,and psoriatic arthritis. The only disease restricted to men(P < 0.00125) was sarcoidosis. CONCLUSION Immune mediated diseases were significantly more frequent in patients with IBD. Our results strengthen the hypothesis that some IMDs and IBD may have overlapping pathogenic pathways. | Morten L Halling Jens Kjeldsen Torben Knudsen Jan Nielsen Lars Koch Hansen | 2017 | World Journal of Gastroenterology2017，23，33： | 9 |
| 2 | Autoregulation of Cerebral Blood Flow in Patients Resuscitated From Cardiac Arrest显示文摘 | Claus Sundgreen Fin Stolze Larsen Tina Maria Herzog Gitte Moos Knudsen Soren Boesgaard Jan Aldershvile | 2001 | Stroke: Journal of the American Heart Association2001，，1： | 1 |
| 3 | Influencing cocoa flavour using Pichia kluyveri and Kluyveromyces marxianus in a defined mixed starter culture for cocoa fermentation显示文摘 | Michael Crafack Morten B. Mikkelsen Sofie Saerens Morten Knudsen Andreas Blennow Samuel Lowor Jemmy Takrama Jan H. Swiegers Gert B. Petersen Hanne Heimdal Dennis S. Nielsen | 2013 | International Journal of Food Microbiology2013，，： | 1 |
| 4 | On-line monitoring and controlling emissions in amine post combustion carbon capture: A field test显示文摘 | Jan Mertens Jacob Knudsen Marie-Laure Thielens Jimmy Andersen | 2011 | International Journal of Greenhouse Gas Control2011，，： | 1 |
| 5 | Prosocial family processes and the quality of life of persons with schizophrenia显示文摘 | Jan S Greenberg K J Knudsen K A | 2006 | Psychiatric Services2006，57，12： | 1 |
| 6 | Interplay of Adsorbate-Adsorbate and Adsorbate-Substrate Interactions in Self-Assembled Molecular Surface Nanostructures显示文摘The adsorption of 2,6-naphthalenedicarboxylic acid(NDCA)molecules on the Ag(110),Cu(110),and Ag(111)surfaces at room temperature has been studied by means of scanning tunnelling microscopy(STM).Further supporting results were obtained using X-ray photoelectron spectroscopy(XPS)and soft X-ray absorption spectroscopy(XAS).On the Ag(110)support,which had an average terrace width of only 15 nm,the NDCA molecules form extended one-dimensional(1-D)assemblies,which are oriented perpendicular to the step edges and have lengths of several hundred nanometres.This shows that the assemblies have a large tolerance to monatomic surface steps on the Ag(110)surface.The observed behaviour is explained in terms of strong intermolecular hydrogen bonding and a strong surface-mediated directionality,assisted by a sufficient degree of molecular backbone flexibility.In contrast,the same kind of step-edge crossing is not observed when the molecules are adsorbed on the isotropic Ag(111)or more reactive Cu(110)surfaces.On Ag(111),similar 1-D assemblies are formed to those on Ag(110),but they are oriented along the step edges.On Cu(110),the carboxylic groups of NDCA are deprotonated and form covalent bonds to the surface,a situation which is also achieved on Ag(110)by annealing to 200°C.These results show that the formation of particular self-assembled molecular nanostructures depends significantly on a subtle balance between the adsorbate-adsorbate and adsorbate-substrate interactions and that kinetic factors play an important role. | Joachim Schnadt Wei Xu Ronnie T.Vang Jan Knudsen Zheshen Li Erik Lægsgaard Flemming Besenbacher | 2010 | Nano Research2010，3，7： | 0 |
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