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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | Hepatitis B virus surface antigen can activate human monocyte-derived dendritic cells by nuclear factor kappa B and p38 mitogen-activated protein kinase medi- ated signaling显示文摘 | Jan R H Lin Y L Chen C J | 2012 | Microbiol Immunol2012，5610，： | 1 |
| 3 | Finding the most vital edge with respect to minimum spanning tree in weighted graphs显示文摘 | Hsu L H Jan R H Lee Y C | 1991 | Information Processing Letters1991，39，1： | 1 |
| 4 | Contribution of water content and bulk density to field soil penetration resistance as measured by a combined cone penetrometer-TDR probe显示文摘 | Vaz M P C Bassoi H L Hopmans W Jan | 2001 | Soil and Tillage Research2001，60，12： | 1 |
| 5 | Job Shop Scheduling by Simulated Annealing显示文摘 | Peter J M Van Laarhoven Emile H L Aatrs and Jan Karel Lenstra | 1992 | Operations Research1992，20，1： | 1 |
| 6 | Conserved function of lincRNAs in vertebrate embryonic development despite rapid sequence evolution 显示文摘 | Ulitsky L Shkumatava A Jan C H | 2011 | Cell2011，147，7： | 1 |
| 7 | A pilot study of a thiazolidinedione, troglitazone, in nonalcoholic steatohepatitis显示文摘 | Stephen H Caldwell Elizabeth E Hespenheide Jan A Redick Julia C Iezzoni Emily H Battle Bonnie L Sheppard | 2001 | The American Journal of Gastroenterology2001，，2： | 1 |
| 8 | GA-based multi objective PID control for a linear brushless DC motor显示文摘 | Lin C L Jan H Y Shieh N C | 2003 | Mechatronics IEEE/ASME Transactions on2003，8，1： | 1 |
| 9 | Dimethylsulfoniopropi- onate cleavage by marine phytoplankton in response to mechani- cal,chemical or dark stress显示文摘 | Gordon V W Suzanne L S Jan L H | 2002 | Journal of Phycology2002，38，： | 1 |
| 10 | Piezomechanics using intelligent variable-structure control显示文摘 | Hwang C L Jan C Chen Y H | 2001 | IEEE Trans Indust Electron2001，48，： | 1 |
| 11 | Development of human protein reference database as an initial platform for approaching systems biology in humans 显示文摘 | PERI S NAVARRO J D AMANCHY R KRISTIANSEN T Z JONNALAGADDA C K SURENDRANATH V NIRAN JAN V MUTHUSAMY B GANDHI T K GRONBORG M IBARROLA N DESHPANDE N SHANKER K SHIVASHANKAR H N RASHMI B P RAMYA M A ZHAO Z CHANDRIKA K N PADMA N HARSHA H C YATISH A J KAVITHA M P MENEZES M CHOUDHURY D R SURESH S GHOSH N SARAVANA R CHANDRAN S KRISHNA S JoY M ANAND S K MADAVAN V JOSEPH A WONG G W SCHIEMANN W P CONSTANTINESCU S N HUANG L KHOSRAVI-FAR R STEEN H TEWARI M GHAFFARI S BLOBE G C DANG C V GARCIA J G PEVSNER J JENSEN O N ROEPSTORFF P DESHPANDE K S CHINNAIYAN A M HAMOSH A CHAKRAVARTI A PANDEY A | 2003 | Genome Research2003，13，10： | 1 |
| 12 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 13 | Trace measurement of dithiocarbamate based pesticide by adsorptive stripping voltammetry显示文摘 | Lin M S Jan B l Leu H J | 1999 | Analytica Chimica ACTA1999，388，12： | 1 |
| 14 | Finding the most vital edge with respect to minimum spanning tree in weighted graphs显示文摘 | Jan R H Lee Y C | 1991 | Information Processing Letters1991，39，5： | 1 |
| 15 | Measuring system for cracks in concrete using multitemporal images显示文摘 | CHEN L C SHAO Y C JAN H H | 2006 | Journal of Surveying Engineering2006，132，2： | 1 |
| 16 | GA- based multiobjective PID control for a linear brushless DC motor显示文摘 | Lin C L Jan H Y Shieh N C | 2003 | IEEE Transactions on Mechatronics2003，8，1： | 1 |
| 17 | Two types of limit cycles of a resonant converter modelled by a three-dimensional systems显示文摘 | Jan M Anders H Torsten L | 2008 | Nonlinear Analysis: Hybrid Systems2008，2，4： | 1 |
| 18 | GA-based multi-objective PID con trol for a linear brushless DC motor显示文摘 | Lin C L Jan H Y Shieh N C | 2003 | IEEE Transactions on Mechatronics2003，8，1： | 1 |
| 19 | Analysis of impairmentsinfluencing gait velocity and asymmetry of hemiplegic patientsafter mild to moderate stroke显示文摘 | HSU A L TANG P F JAN M H | 2003 | Arch Phys Med Rehabil2003，84，8： | 1 |
| 20 | Analysis of impairments influencing gant velocity and asymmentry of hemiplegic patients after mild to moderate stroke 显示文摘 | Hsu A L Tang P F Jan M H | 2003 | Arch Phys Rehabil2003，84，8： | 1 |
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