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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Fluid flow and pumping efficiency in an ejector-venturi scrubber 显示文摘 | XAVIER G SARRA M JAVIER LAFUENTE F | 2004 | Chemical and Engineering Processing2004，43，2： | 1 |
| 3 | Genetic variability related to serum uric acid concentration and risk of Parkinson’s disease显示文摘 | Isabel González‐Aramburu Pascual Sánchez‐Juan Silvia Jesús Ana Gorostidi Eduardo Fernández‐Juan Fátima Carrillo María Sierra Pilar Gómez‐Garre María T. Cáceres‐Redondo José Berciano Javier Ruiz‐Martínez Onofre Combarros Pablo Mir Jon Infante | 2013 | Mov Disord2013，，： | 1 |
| 4 | A posteriori error estimates for fully discrete nonlinear parabolic problems显示文摘 | Javier F Bosco G A Julia N | 2007 | Comput Methods Appl Mech Engrg2007，196，： | 1 |
| 5 | To adipocyte: a model for integration of endocrine and metabolic signaling, in energy metabolism regulation 显示文摘 | Gema F Javier G A Francisco J M | 2001 | Am J Physiol Endocrinol Metab2001，280，： | 1 |
| 6 | Antimicrobial activity of reuterin in combination with nisin against food-borne pathogens显示文摘 | JUAN L A JAVIER F PILAR G | 2004 | International Journal of Food Microbiology2004，95，2： | 1 |
| 7 | Fast algorithms for free-space diffraction patterns calculation显示文摘 | DAVID M JAVIER G CARLOS F | | 0，，4： | 1 |
| 8 | Materials, operational energy inputs, and net energy ratio for photobiological hydrogen production 显示文摘 | GREG B JAVIER G F | 2007 | International Journal of Hydrogen Energy2007，32，9： | 1 |
| 9 | Reconstruction of Particle-size Distributions form Light-scattering Patterns Using Three Inversion Methods 显示文摘 | JAVIER V U AGUILAR J F DAVID M G | 2007 | Applied Optics2007，46，1： | 1 |
| 10 | Antimicrobial activity of reuterin in combination with nisin against food-borne pathogens显示文摘 | Juan L A Javier F Pilar G | 2004 | International Journal of Food Microbiology2004，95，2： | 1 |
| 11 | Endemic seed plant species from Hainan Island: A checklist 显示文摘 | Javier F Wang F G Wang Z S et ol | 2010 | The Bot revi2010，76，3： | 1 |
| 12 | Rejection after conversion to a proliferation signal inhibitor in chronic heart transplantation显示文摘 | Francisco González‐Vílchez José A. Vázquez de Prada María J. Paniagua Luis Almenar Sonia Mirabet Manuel Gómez‐Bueno Beatriz Díaz‐Molina Jose M. Arizón Juan Delgado Félix Pérez‐Villa María G. Crespo‐Leiro Luis Martínez‐Dolz Eulalia Roig Javier Segovia José | 2013 | Clin Transplant2013，，6： | 1 |
| 13 | Inhibition of angiotensin converting enzyme activity by flavanol-rich foods显示文摘 | Lucas A G Javier I O Cesar G F | 2006 | Journal of Agricultural and Food Chemistry2006，54，1： | 1 |
| 14 | One-dimensional models for slender axisymmetric viscous liquid bridges 显示文摘 | Javier F Castellanos G A | 1996 | Phys Fluids1996，8，11： | 1 |
| 15 | Development and validation of a prognostic nomogram for recurrence-free survival after complete surgical resection of localised primary gastrointestinal stromal tumour: a retrospective analysis显示文摘 | Jason S Gold Mithat G?nen Antonio Gutiérrez Javier Martín Broto Xavier García-del-Muro Thomas C Smyrk Robert G Maki Samuel Singer Murray F Brennan Cristina R Antonescu John H Donohue Ronald P DeMatteo | 2009 | Lancet Oncology2009，，11： | 1 |
| 16 | To adipocyte :a model for integration of endocrine and metabolic signaling in energy metabolism regulation显示文摘 | Gema F Javier G A Francisco J M | 2001 | Am J Physiol Endocrinol Metab2001，280，： | 1 |
| 17 | Wireless sensor network deployment for integrating video surveillance and datamonitoring in precision agriculture over distributed crops显示文摘 | Javier A Sanchez G Sanchez F G | 2011 | Computer and Electronics in Agriculture2011，75，2： | 1 |
| 18 | The effect of shot blasting and heat treatment on the fatigue behavior of titanium for dental implant applications 显示文摘 | JAVIER G F PLANELL J A PADROS A APARICIO C | 2007 | Dental Materials2007，23，4： | 1 |
| 19 | The effect of environmental and meteorological variables on atmospheric corrosion of carbon steel,copper,zinc and aluminium in a limited geographic zone with different types of environment显示文摘 | Santana R J J Javier S H F Gonzalez J E G | 2003 | Corrosion Science2003，45，： | 1 |
| 20 | Cancer‐associated fibroblast and M 2 macrophage markers together predict outcome in colorectal cancer patients显示文摘 | Mercedes Herrera Alberto Herrera Gemma Domínguez Javier Silva Vanesa García José M. García Irene Gómez Beatriz Soldevilla Concepción Mu?oz Mariano Provencio Yolanda Campos‐Martin Antonio García de Herreros Ignacio Casal Félix Bonilla Cristina Pe?a | 2013 | Cancer Sci2013，，4： | 1 |
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