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| 1 | 心力衰竭的诊断与评估显示文摘心力衰竭是常见的临床综合征,以呼吸困难、疲乏和容量超负荷为特点,也可出现外周性水肿及肺部哕音。心力衰竭有较高的发病率和病死率,尤其是老年人。许多疾病,如冠状动脉疾病(CAD)、高血压、瓣膜性心脏病和糖尿病均可引起或导致慢性心力衰竭的失代偿。40%~50%的心力衰竭患者为左心室功能保留的舒张性心力衰竭,其总病死率与收缩性心力衰竭相似。初始评估包括病史、体检、胸部X线片、心电图(ECG)和实验室评估,以识别原因或诱因。心尖移位、第三心音和胸部X线片显示静脉充血或间质水肿常有助于识别心力衰竭。 | 周淑新 朱翠明 King M Kingery JE Casey B | 2012 | 中国全科医学2012，15，36： | 38 |
| 2 | 干扰素调节因子5通过损伤胞葬作用控制动脉粥样硬化病变中的坏死核心形成显示文摘髓系细胞是动脉粥样硬化病变发展和易损斑块形成的核心。动脉吞噬细胞吸收凋亡细胞(胞葬作用)的能力受损,可促进病变生长并建立坏死核心。干扰素调节因子(interferon regulatory factor,IRF)5是髓系细胞功能的重要调节因子。该研究试图确定IRF5是否影响动脉粥样硬化病变的形成和表型。方法:通过两种互补模型,研究IRF5在动脉粥样硬化中的作用: | Seneviratne AN Edsfeldt AO Cole JE Kassiteridi C Swart M Park I Green P Khoyratty TE Saliba DG Goddard ME Sansom SN Goncalves I Krams R Udalova IA Monaco C 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，8： | 9 |
| 3 | 心脏病及非心脏病患者降低舒张压的效果:收缩压干预试验结果分析显示文摘收缩压和舒张压低于何种阈值时心血管事件增多仍然不明确。应用收缩压干预试验(systolic blood pressure intervention trial,SPRINT)的数据,研究者评估了1519例心血管病患者和7574位非心血管病者的收缩压和舒张压与心血管事件之间的关系。 | 刘青 叶鹏 Khan NA Rabkin SW Zhao Y McAlister FA Park JE Guan M Chan S Humphries KH | 2018 | 中华高血压杂志2018，26，6： | 3 |
| 4 | The endoscopic assessment of esophagitis: A progress report on observer agreement显示文摘 | D Armstrong JR Bennett AL Blum J Dent FT De Dombal JP Galmiche L Lundell M Margulies JE Richter SJ Spechler GN Tytgat L Wallin | 1996 | Gastroenterology1996，，1： | 2 |
| 5 | Genetic transformation of wheat mediated by agrobacterium tumefaciens显示文摘 | Cheng M Fry JE Pang S | 1997 | Plant Physiol1997，115，3： | 2 |
| 6 | Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits显示文摘 | Chatterton JE Awobuluyi M Premkumar LS | 2002 | Nature2002，415，： | 2 |
| 7 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 8 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 9 | Muein7 and eytokeratin 20 as new diagnostic urinary markers for bladder tumor显示文摘 | Retz M Lehmann JE | 2003 | J Urol2003，169，： | 1 |
| 10 | Functional analysis of ssaJ and the ssaK/U operon, 13 genes encoding components of the type Ⅲ secretion apparatus of Salmonella pathogenicity island 2 显示文摘 | Hensel M Shea JE Raupach B | 1997 | Mol Microbiol1997，24，1： | 1 |
| 11 | Integrons:mobilizable platforms that promote genetic diversity in bacteria显示文摘 | Boucher Y Labbate M Koenig JE | 2007 | Trends Microbiol2007，15，7： | 1 |
| 12 | Cross-talk between epidermal growth factor receptor c-Met signal pathways in transformed cells 显示文摘 | Jo M Stolz DB Esplen JE | 2000 | J Biol Chem2000，275，12： | 1 |
| 13 | High efficiency initiation of regenerable embryogenic callus from anther filaments of 19-grapevine genotypes grown worldwide显示文摘 | PERRIN M GERTZ C MASSON JE | 2004 | Plant Science2004，167，： | 1 |
| 14 | Liver-specific RNA metabolism in hepatoma cells:variations in transcription rates and mRNA levels显示文摘 | Clayton DF Weiss M Darnell JE | 1985 | Molecular Cellular Biology1985，5，： | 1 |
| 15 | The mutational spectrum of the sonic hedgehog gene in holorosencephaly: SHH mutations cause a significant proportion of autosomal dominant holorosencephaly显示文摘 | Nanni L Ming JE Bocian M | 1999 | Hum Mol Genet1999，8，13： | 1 |
| 16 | Initiation of apoptosis by granzyme B requires direct cleavage of bid,but not direct granzyme B-mediated caspase activation 显示文摘 | Sutton VR Davis JE Cancilla M | 2000 | J Exp Med2000，192，10： | 1 |
| 17 | Detection of Mycoplasma pneumoniae in the airways of adults with chronic asthma 显示文摘 | Kraft M Cassell GH Henson JE | 1998 | Am J Respir Crit Care Med1998，158，3： | 1 |
| 18 | Biliverdin protects against polymicrobial sepsis by modulating inflammatory mediators显示文摘 | Overhaus M Moore BA Barbato JE | 2006 | Am J Physiol Gastrointest Liver Physiol2006，290，4： | 1 |
| 19 | Task force of the european society of cardiology and North American society of pacing and eleetrophysiology, Heart rate varicbility standards of measurement, physiological interpretation and clinical use 显示文摘 | Camm AI Malik M Bigger JE et al | 1996 | Circulation1996，93，： | 1 |
| 20 | Use of permanent hair dyes and bladder-cancer risk 显示文摘 | GAGO-DOMINGUEZ M CASTELAO JE YUAN JM | 2001 | Int J Cancer2001，91，4： | 1 |
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