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| 1 | Usefulness of staging systems and prognostic scores for hepatocellular carcinoma treatments显示文摘Therapeutic management of hepatocellular carcinoma(HCC) is quite complex owing to the underlying cirrhosis and portal vein hypertension. Different scores or classification systems based on liver function and tumoral stages have been published in the recent years. If none of them is currently 'universally' recognized, the Barcelona Clinic Liver Cancer(BCLC) staging system has become the reference classification system in Western countries. Based on a robust treatment algorithm associated with stage stratification, it relies on a high level of evidence. However, BCLC stage B and C HCC include a broad spectrum of tumors but are only matched with a single therapeutic option. Some experts have thus suggested to extend the indications for surgery or for transarterial chemoembolization. In clinical practice, many patients are already treated beyond the scope of recommendations. Additional alternative prognostic scores that could be applied to any therapeutic modality have been recently proposed. They could represent complementary tools to the BCLC staging system and improve the stratification of HCC patients enrolled in clinical trials, as illustrated by the NIACE score. Prospective studies are needed to compare these scores and refine their role in the decision making process. | Xavier Adhoute Guillaume Penaranda Jean Luc Raoul Patrice Le Treut Emilie Bollon Jean Hardwigsen Paul Castellani Hervé Perrier Marc Bourlière | 2016 | World Journal of Hepatology2016，8，17： | 7 |
| 2 | Early plasmapheresis and rituximab for acute humoral rejection after ABO-compatible liver transplantation显示文摘Acute humoral rejection (AHR) is uncommon after ABO-compatible liver transplantation. Herein, we report two cases of AHR treated with plasmapheresis and rituximab in two ABO-compatible liver-transplant patients with preformed anti-human leukocyte antigen donor-specif ic antibodies. Patient 1 experienced a biopsy-proven AHR at day 10 post-transplant. She was treated by steroid pulses, and OKT3. Because of persisting signs of biopsy-proven AHR at day 26, she was treated by plasmapheresis and rituximab. Liver enzyme levels did not improve, and she died on day 41. Patient 2 experienced a biopsy-proven AHR on day 10 post-transplant. She was treated by steroid pulses, plasmapheresis, and rituximab. Liver enzymes returned to within normal range 18 d after diagnosis. Liver biopsies, at 3 and 9 mo post-transplant, showed complete resolution of AHR. We conclude that plasmapheresis should be started as soon as AHR is diagnosed, and be associated with a B-cell depleting agent. Rituximab may be considered as a first-line therapy. | Nassim Kamar Laurence Lavayssière Fabrice Muscari Janick Selves Céline Guilbeau-Frugier Isabelle Cardeau Laure Esposito Olivier Cointault Marie Béatrice Nogier Jean Marie Peron Philippe Otal Marylise Fort Lionel Rostaing | 2009 | World Journal of Gastroenterology2009，15，27： | 6 |
| 3 | 廉价石油时代的终结显示文摘 | Colin J.Cambell Jean H.Laherrre 赵林 赵庆飞 冯连勇 | 2005 | 石油科技论坛2005，24，4： | 5 |
| 4 | Comparative Evaluation of 29 Commercial H elicobacter pylori Serological Kits显示文摘 | Christophe Burucoa Jean‐Charles Delchier Anne Courillon‐Mallet Jean‐Dominique Korwin Francis Mégraud Frank Zerbib Josette Raymond Jean‐Louis Fauchère | 2013 | Helicobacter2013，，3： | 3 |
| 5 | Fluorouracil-based adjuvant chemotherapy after preoperative chemoradiotherapy in rectal cancer: long-term results of the EORTC 22921 randomised study显示文摘 | Jean-Fran?ois Bosset Gilles Calais Laurent Mineur Philippe Maingon Suzana Stojanovic-Rundic René-Jean Bensadoun Etienne Bardet Alexander Beny Jean-Claude Ollier Michel Bolla Dominique Marchal Jean-Luc Van Laethem Vincent Klein Jordi Giralt Pierre Clavère | 2014 | Lancet Oncology2014，，2： | 2 |
| 6 | 原发性血小板增多症巨核系祖细胞体外自主性生长及Tpo作用的探讨显示文摘目的 研究原发性血小板增多症 (ET)巨核系祖细胞的体外自主性生长以及Tpo对其生长的作用。方法 用ET患者骨髓纯化CD3 4+ 细胞以及不同浓度的骨髓和外周血单个核细胞进行体外培养 ,检测其对自发性CFU MK形成的影响 ;用RT PCR技术检测液体培养自发性生长细胞的Tpo的自主分泌和旁分泌 ;观察CD3 4+ 细胞培养中加入Tpo对CFU MK形成的影响。结果 体外培养纯化CD3 4+ 细胞无自发性CFU MK形成 ,单个核细胞稀释到一定浓度 (10 4 /ml或 10 3 /ml)时自发性集落消失 ;液体培养自发性生长细胞无TpomRNA的表达 ;CD3 4+ 细胞培养中加入Tpo后可形成CFU MK。结论 ET患者的体外自发性CFU MK形成并非巨核系祖细胞的自主性生长所致 ,与Tpo的自主分泌或旁分泌也无关。 | 李艳 Jean Brière 翟明 | 2001 | 中华血液学杂志2001，22，6： | 2 |
| 7 | Feasibility of Robotic Laparoscopic Surgery: 146 Cases显示文摘 | Guy-Bernard Cadière M.D. Ph.D. Jacques Himpens M.D. Olivier Germay Rachel Izizaw Michel Degueldre M.D. Jean Vandromme M.D. Elie Capelluto M.D. Jean Bruyns M.D | 2001 | World Journal of Surgery2001，，11： | 1 |
| 8 | Expedited blood pressure control with initial angiotensin II antagonist/diuretic therapy compared with stepped-care therapy in patients with ambulatory systolic hypertension显示文摘 | Yves Lacourcière Luc Poirier Jean Lefebvre | 2007 | Canadian Journal of Cardiology2007，，5： | 1 |
| 9 | Ammonia: Key factor in the pathogenesis of hepatic encephalopathy显示文摘 | Roger F. Butterworth Jean-Fran?ois Giguère Jean Michaud Jo?l Lavoie Gilles Pomier Layrargues | 1987 | Neurochemical Pathology (-)1987，，1： | 1 |
| 10 | Thalidomide in systemic mastocytosis: results from an open‐label, multicentre, phase II study显示文摘 | Bérengère Gruson Olivier Lortholary Danielle Canioni Olivia Chandesris Fanny Lanternier Julie Bruneau Bernard Grosbois Cristina Livideanu Claire Larroche Isabelle Durieu Stéphane Barete Henri Sevestre Momar Diouf Guillaume Chaby Jean‐Pierre Marolleau Patr | 2013 | Br J Haematol2013，，3： | 1 |
| 11 | Production and characterization of olyclonal antibodies against cholecalciferol (vitamin D3) 显示文摘 | Jean J Turcotte C Simard RE | 1999 | J Immunol Methods1999，223，2： | 1 |
| 12 | Does social capital ?To what ex- tent? 显示文摘 | Re'jean L Nabil A | 2002 | Technological Forecasting & Social Change2002，69，7： | 1 |
| 13 | Thermal, chemical and thermo‐chemical pre‐treatment of waste activated sludge for anaerobic digestion显示文摘 | AlexandreValo HélèneCarrère Jean PhilippeDelgenès | 2004 | Biotechnol2004，，11： | 1 |
| 14 | Does social capital determine innovation?To what extent?显示文摘 | Re?jean Landry Nabil Amara Moktar Lamari | 2002 | Technological Forecasting & Social Change2002，，69： | 1 |
| 15 | Imaging Changes in the Pancreas in Cystic Fibrosis: A Retrospective Evaluation of 55 Cases Seen Over a Period of 9 Years显示文摘 | Jean Feigelson Yvette Pécau Myriam Poquet Patricia Terdjman Jacqueline Carrère Jean-Pierre Chazalette Claude Ferec | 2000 | Journal of Pediatric Gastroenterology and Nutrition2000，，2： | 1 |
| 16 | Protease inhibitor‐based triple therapy in chronic hepatitis C: guidelines by the French Association for the Study of the Liver显示文摘 | Vincent Leroy Lawrence Serfaty Marc Bourlière Jean‐Pierre Bronowicki Patrick Delasalle Alexandre Pariente Stanislas Pol Fabien Zoulim Georges‐Philippe Pageaux | 2012 | Liver Int2012，，10： | 1 |
| 17 | Antibacterial and antioxidant activities of Artemisia annua essential oil显示文摘 | Fabien Juteau Veronique Masotti Jean Marie Bessière Michel Dherbomez Josette Viano | 2002 | Fitoterapia2002，，6： | 1 |
| 18 | Production and characterization of polyclonal antibodies against cholecaleiferol(vitamin D3)显示文摘 | Jean J Turcotte C Simard RE | 1999 | J Immunol Methods1999，223，2： | 1 |
| 19 | Interleukin-18 and the Risk of Coronary Heart Disease in European Men: The Prospective Epidemiological Study of Myocardial Infarction (PRIME)显示文摘 | Stefan Blankenberg Gérald Luc Pierre Ducimetière Dominique Arveiler Jean Ferrières Philippe Amouyel Alun Evans Fran?ois Cambien Laurence Tiret | 2003 | Circulation: Journal of the American Heart Association2003，，20： | 1 |
| 20 | Endometriomas as a possible cause of reduced ovarian reserve in women with endometriosis显示文摘 | Michio Kitajima Sylvie Defrère Marie-Madeleine Dolmans Sebastien Colette Jean Squifflet Anne Van Langendonckt Jacques Donnez | 2011 | Fertility and Sterility2011，，3： | 1 |
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