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| 1 | 来自一项艾日布林联合吉西他滨对比紫杉醇联合吉西他滨作为HER2阴性转移性乳腺癌的一线化疗的Ⅱ期、多中心、随机试验的包含神经病变相关量表的生活质量结果:韩国癌症研究组试验(KCSG BR13-11)显示文摘背景与目的一项比较艾日布林联合吉西他滨(eribulin plus gemcitabine,EG)或紫杉醇联合吉西他滨(paclitaxel plus gemcitabine,PG)作为转移性乳腺癌(metastatic breast cancer,MBC)患者一线化疗方案的II期临床试验发现,EG方案的神经毒性较低,但疗效与PG方案相似。在本研究中,我们分析了该临床实验中的癌症患者生命质量测评量表–紫杉烷(functional assessment of cancer therapy-taxane,FACT-Taxane)问卷评分以确定他们的生活质量(quality of life,QoL)。方法使用韩国版的FACT-Taxane问卷评估QoL。在评估基线之后,前12个疗程中每2个疗程评估1次QoL,之后每3个疗程评估1次QoL。使用线性混合模型评估EG组和PG组QoL的差异。结果在118例入组患者中,117例在基线时回复了FACT-Taxane问卷,PG组中有1例患者没有回复。EG组和PG组之间的基线QoL评分没有差异。在治疗期间,除了第11个疗程外,在第2–13个化疗疗程后,PG组紫杉烷亚量表评分显著高于EG组(均P<0.05)。神经病变特异性分析显示PG组患者的神经病症状比EG组患者更早出现且更严重(P<0.001)。结论在我们的QoL分析中,与PG方案相比,EG方案延迟并减少神经病变的发生。因此,艾日布林是MBC一线化疗药物紫杉醇的合理替代品。 | Ji‑Yeon Kim Seri Park Seock‑Ah Im Sung‑Bae Kim Joohyuk Sohn Keun Seok Lee Yee Soo Chae Ki Hyeong Lee Jee Hyun Kim Young‑Hyuck Im Tae‑Yong Kim Kyung‑Hun Lee Jin‑Hee Ahn Gun Min Kim In Hae Park Soo Jung Lee Hye Sook Han Se Hyun Kim Kyung Hae Jung Yeon Hee Park Korean Cancer Study Group | 2019 | 癌症2019，38，8： | 2 |
| 2 | Expression of Cancer-Testis Antigens MAGE-A3/6 and NY-ESO-1 in Non-Small-Cell Lung Carcinomas and Their Relationship with Immune Cell Infiltration显示文摘 | Sang Hyun Kim Sangyull Lee Chang Hun Lee Min Ki Lee Young Dae Kim Dong Hoon Shin Kyung Un Choi Jee Yeon Kim Do Youn Park Mee Young Sol | 2009 | Lung2009，，6： | 1 |
| 3 | Perfusion abnormality of the caudate nucleus in patients with paroxysmal kinesigenic choreoathetosis显示文摘 | Eun Yeon Joo Seung Bong Hong Woo Suk Tae Jee Hyun Kim Sun Jung Han Dae Won Seo Kyung-Han Lee Myoung-Hee Kim Seunghwan Kim Mann Hyung Lee Byung Tae Kim | 2005 | European Journal of Nuclear Medicine and Molecular Imaging2005，，10： | 1 |
| 4 | Akt3 knockdown induces mitochondria dysfunction in human cancer cells显示文摘 | Minjee Kim Young Yeon Kim Hye Jin Jee Sun Sik Bae Na Young Jeong Jee-Hyun Um Jeanho Yun | 2016 | Acta Biochimica et Biophysica Sinica2016，48，5： | 1 |
| 5 | S-1 plus oxaliplatin versus capecitabine plus oxaliplatin for first-line treatment of patients with metastatic colorectal cancer: a randomised, non-inferiority phase 3 trial显示文摘 | Yong Sang Hong Young Suk Park Ho Yeong Lim Jeeyun Lee Tae Won Kim Kyu-pyo Kim Sun Young Kim Ji Yeon Baek Jee Hyun Kim Keun-Wook Lee Ik-Joo Chung Sang-Hee Cho Kyung Hee Lee Sang Joon Shin Hye Jin Kang Dong Bok Shin Sook Jung Jo Jae Won Lee | 2012 | Lancet Oncology2012，，11： | 1 |
| 6 | Quality of life outcomes including neuropathy-associated scale from a phase II,multicenter,randomized trial of eribulin plus gemcitabine versus paclitaxel plus gemcitabine as first-line chemotherapy for HER2-negative metastatic breast cancer:Korean Cancer Study Group Trial(KCSG BR13-11)显示文摘Background: A phase II clinical trial of the comparison between eribulin plus gemcitabine (EG) and paclitaxel plus gemcitabine (PG) as first-line chemotherapy for patients with metastatic breast cancer (MBC) found that the EG regimen was less neurotoxic, but was similar in efficacy to the PG regimen. In the present study, we analyzed functional assessment of cancer therapy-taxane (FACT-Taxane) questionnaires from patients in this clinical trial to determine their quality of life (QoL). Methods: QoL was assessed using the Korean version of the FACT-Taxane questionnaires. After baseline assessment, QoL was assessed every 2 cycles for 12 cycles and every 3 cycles thereafter. The linear mixed model was used to evaluate the difference in QoL between the EG and PG arms. Results: Of the 118 enrolled patients, 117 responded to the FACT-Taxane questionnaires at baseline, 1 in the PG arm did not. Baseline QoL scores were not different between the EG and PG arms. During treatment, taxane subscale scores were significantly higher in the PG arm than in the EG arm after 2-13 cycles of chemotherapy (all P < 0.05), except for the 11th cycle. Neuropathy-specific analysis showed that patients in the PG arm had earlier and more severe neuropathic symptoms than those in the EG arm (P < 0.001). Conclusions: In our QoL analysis, the EG regimen delayed and decreased neuropathy as compared with the PG regimen. Therefore, eribulin would be a reasonable substitute for paclitaxel as first-line chemotherapy for MBC. | Ji-Yeon Kim Seri Park Seock-Ah Im Sung-Bae Kim Joohyuk Sohn Keun Seok Lee Yee Soo Chae Ki Hyeong Lee Jee Hyun Kim Young-Hyuck Im Tae-Yong Kim Kyung-Hun Lee Jin-Hee Ahn Gun Min Kim In Hae Park Soo Jung Lee Hye Sook Han Se Hyun Kim Kyung Hae Jung Yeon Hee Park Korean Cancer Study Group | 2019 | Cancer Communications2019，39，1： | 1 |
| 7 | Epigenetic changes in estrogen receptor β gene in atherosclerotic cardiovascular tissues and in-vitro vascular senescence显示文摘 | Jei Kim Jee Yeon Kim Kyu Sang Song Young Ho Lee Joong Seok Seo Jaroslav Jelinek Pascal J. Goldschmidt-Clermont Jean-Pierre J. Issa | 2006 | BBA - Molecular Basis of Disease2006，，1： | 1 |
| 8 | Association of MICA polymorphism with rheumatoid arthritis pa- tients in Koreans 显示文摘 | Jee Won Mok Yun Jong Lee Jeong Yeon Kim | 2003 | Human Immunology2003，64，12： | 1 |
| 9 | Antitumor activity of cytokine-induced killer cells in nude mouse xenograft model显示文摘 | Hwan Mook Kim Jong Soon Kang Jaeseung Lim Jee Youn Kim Yeon Jin Kim Soo Jae Lee Sukgil Song Jin Tae Hong Youngsoo Kim Sang-Bae Han | 2009 | Archives of Pharmacal Research2009，，5： | 1 |
| 10 | Real-time contrast-enhanced ultrasound-guided biopsy of focal hepatic lesions not localised on B-mode ultrasound显示文摘 | Soon Ho Yoon Kyoung Ho Lee So Yeon Kim Young Hoon Kim Jee Hyun Kim Sang Hyub Lee Tae Kyoung Kim | 2010 | European Radiology2010，，8： | 1 |
| 11 | Comparative study of laparoscopic L5–S1 fusion versus open mini-ALIF, with a minimum 2-year follow-up显示文摘 | Sang Ki Chung Sang Ho Lee Sang Rak Lim Dong-Yun Kim Jee Soo Jang Ki-Se Nam Ho Yeon Lee | 2003 | European Spine Journal2003，，6： | 1 |
| 12 | Staphylococcus aureus enterotoxin B-induced endoplasmic reticulum stress response is associated with chronic rhinosinusitis with nasal polyposis显示文摘 | Yong-Min Kim Jun Jin Ji-Ae Choi Soo-Na Cho Yun-Ji Lim Jung-Hwan Lee Jee Yeon Seo Hai Yue Chen Ki-Sang Rha Chang-Hwa Song | 2014 | Clinical Biochemistry . 2014 (1-2)2014，，1： | 1 |
| 13 | Association between osteoprotegerin (OPG), receptor activator of nuclear factor-κB (RANK), and RANK ligand (RANKL) gene polymorphisms and circulating OPG, soluble RANKL levels, and bone mineral density in Korean postmenopausal women显示文摘 | Jung Gu Kim Jung Hwa Kim Ja Yeon Kim Seung Yup Ku Byung Chul Jee Chang Suk Suh Seok Hyun Kim Young Min Choi | 2007 | Menopause2007，，5： | 1 |
| 14 | Cerebral perfusion changes in mesial temporal lobe epilepsy: SPM analysis of ictal and interictal SPECT显示文摘 | Woo Suk Tae Eun Yeon Joo Jee Hyun Kim Sun Jung Han Yeon-Lim Suh Byung Tae Kim Seung Chyul Hong Seung Bong Hong | 2004 | Neuroimage2004，，1： | 1 |
| 15 | Multicenter phase II study of second-line bevacizumab plus doublet combination chemotherapy in patients with metastatic colorectal cancer progressed after upfront bevacizumab plus doublet combination chemotherapy显示文摘 | Yong Sang Hong Jeeyun Lee Kyu-pyo Kim Jae-Lyun Lee Young Suk Park Joon Oh Park Se Hoon Park Sun Young Kim Ji Yeon Baek Jee Hyun Kim Keun-Wook Lee Tae-You Kim Tae Won Kim | 2013 | Investigational New Drugs2013，，1： | 1 |
| 16 | Perfusion abnormality of the caudate nucleus in patients with paroxysmal kinesigenic choreoathetosis显示文摘 | Eun Yeon Joo Seung Bong Hong Woo Suk Tae Jee Hyun Kim Sun Jung Han Dae Won Seo Kyung-Han Lee Myoung-Hee Kim Seunghwan Kim Mann Hyung Lee Byung Tae Kim | 2005 | European Journal of Nuclear Medicine and Molecular Imaging2005，，10： | 1 |
| 17 | Polycomb protein EZH2 expression in diffuse large B-cell lymphoma is associated with better prognosis in patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone显示文摘 | Hyun Jung Lee Dong Hoon Shin Kyung Bin Kim Nari Shin Won Young Park Jung Hee Lee Kyung Un Choi Jee Yeon Kim Chang Hun Lee Mee Young Sol | 2014 | Leukemia & Lymphoma2014，，9： | 1 |
| 18 | Male metaplastic breast cancer with poor prognosis:A case report显示文摘BACKGROUND Metaplastic breast cancer(MBC)is a rare subtype of breast cancer.They constitute less than 1%of breast cancer cases and are much rarer in males.There are few reports of MBC because of its rarity.MBC,an aggressive type of cancer,is refractory to common treatment modalities of breast cancer and has a poor prognosis.CASE SUMMARY We report a case of MBC in a 78-year-old man.He visited our clinic with a palpable mass on the left breast with no masses in the axillary areas.He had previously undergone robot-assisted laparoscopic radical prostatectomy for prostate cancer,but there was no family history of malignancy.The breast mass was visible on ultrasonography,mammography,and magnetic resonance imaging,and chest computed tomography revealed a lung mass in the posterior basal segment of the right lower lobe.The patient was diagnosed with metaplastic carcinoma on core needle biopsy with lung metastasis.Total mastectomy with sentinel lymph node biopsy and video-assisted segmentectomy of the right lung was performed.However,multiple metastases appeared 3 mo after surgery in the brain,chest,and abdomen,and the patient died 5 mo after the initial diagnosis.CONCLUSION MBC is an aggressive and extremely rare breast cancer type.Further case reports are needed to determine the optimal treatment. | Hyun Yul Kim Seungju Lee Dong-il Kim Chang Shin Jung Jee Yeon Kim Kyung Jin Nam Ki Seok Choo Youn Joo Jung | 2022 | World Journal of Clinical Cases2022，10，15： | 0 |
| 19 | Pathologic etiology and predictors of malignancy in children with cervical lymphadenopathy显示文摘Cervical lymphadenopathy in children is a common disease entity that is accompanied by a variety of processes,ranging from benign disease to malignancy.Although the cause of cer-vical lymphadenopathy in children is often benign[1-4],the presence of enlarged lymph nodes can cause anxiety to parents because of its association with malignancy.Biopsy should be considered for the histologic diagnosis of persistent or unex-plained cervical lymphadenopathy in children.However,biopsy is an invasive examination method,and it is difficult to clinically determine whether biopsy is needed in children with unexplained cervical lymphadenopathy.Therefore,clini-cians should be aware of the differential diagnosis of lymph node enlargement in children and should identify situations in which malignancy may be suspected.In this study,we aimed to identify the etiology of pediatric cervical lymphadenopathy using biopsy and to analyze the risk factors associated with malignancy in children with cervical lymphadenopathy. | Jee Woo Kim Jee Yeon Baek Ji Young Lee Sung Min Lim Ji-Man Kang Won Kee Ahn Seung Min Hahn Jung Woo Han Chuh Joo Lyu Jong Gyun Ahn | 2023 | World Journal of Pediatrics2023，19，3： | 0 |
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