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| 1 | Bioreductive prodrugs as cancer therapeutics:targeting tumor hypoxia显示文摘Hypoxia, a state of low oxygen, is a common feature of solid tumors and is associated with disease progression as well as resistance to radiotherapy and certain chemotherapeutic drugs. Hypoxic regions in tumors, therefore, represent attractive targets for cancer therapy. To date, five distinct classes of bioreactive prodrugs have been developed to target hypoxic cells in solid tumors. These hypoxia-activated prodrugs, including nitro compounds, N-oxides, quinones, and metal complexes, generally share a common mechanism of activation whereby they are reduced by intracellular oxidoreductases in an oxygensensitive manner to form cytotoxins. Several examples including PR-104, TH-302, and EO9 are currently undergoing phase II and phase III clinical evaluation. In this review, we discuss the nature of tumor hypoxia as a therapeutic target, focusing on the development of bioreductive prodrugs. We also describe the current knowledge of how each prodrug class is activated and detail the clinical progress of leading examples. | Christopher P.Guise Alexandra M.Mowday Amir Ashoorzadeh Ran Yuan Wan-Hua Lin Dong-Hai Wu Jeff B.Smaill Adam V.Patterson Ke Ding | 2014 | Chinese Journal of Cancer2014，33，2： | 9 |
| 2 | The Glutamatergic Postrhinal Cortex–Ventrolateral Orbitofrontal Cortex Pathway Regulates Spatial Memory Retrieval显示文摘A deficit in spatial memory has been taken as an early predictor of Alzheimer’s disease(AD) or mild cognitive impairment(MCI). The uncinate fasciculus(UF) is a long-range white-matter tract that connects the anterior temporal lobe with the orbitofrontal cortex(OFC)in primates. Previous studies have shown that the UF impairment associated with spatial memory deficits may be an important pathological change in aging and AD, but its exact role in spatial memory is not well understood. The pathway arising from the postrhinal cortex(POR) and projecting to the ventrolateral orbitofrontal cortex(vlOFC)performs most of the functions of the UF in rodents.Although the literature suggests an association between spatial memory and the regions connected by the POR–vlOFC pathway, the function of the pathway in spatialmemory is relatively unknown. To further illuminate the function of the UF in spatial memory, we dissected the POR–vlOFC pathway in mice. We determined that the POR–vlOFC pathway is a glutamatergic structure, and that glutamatergic neurons in the POR regulate spatial memory retrieval. We also demonstrated that the POR–vlOFC pathway specifically transmits spatial information to participate in memory retrieval. These findings provide a deeper understanding of UF function and dysfunction related to disorders of memory, as in MCI and AD. | Xinyang Qi Zhanhong Jeff Du Lin Zhu Xuemei Liu Hua Xu Zheng Zhou Cheng Zhong Shijiang Li Liping Wang Zhijun Zhang | 2019 | Neuroscience Bulletin2019，35，3： | 7 |
| 3 | Cefuroxime-Impregnated Cement in Primary Total Knee Arthroplasty:A Prospective, Randomized Study of Three Hundred and Forty Knees显示文摘 | Fang-Yao Chiu Chuan-Mu Chen Chien-Fu Jeff Lin | 2002 | Journal of Bone & Joint Surgery-American Volume2002，84，5： | 1 |
| 4 | Transient three- dimensional side-load analysis of out-of-round film- cooled nozzles 显示文摘 | WANG Ten-See LIN Jeff RUF Joe | 2011 | Journal of Propulsion and Power2011，27，4： | 1 |
| 5 | Comparison of a minimally invasive technique with open tension band wiring for displaced transverse patellar fractures显示文摘 | Chiang CC Chen WM Jeff Lin CF | 2011 | J Chin Med Assoc2011，74，7： | 1 |
| 6 | Comparison of a minimally invasive tech- nique with open tension band wiring for displaced transverse patellar fractures显示文摘 | Chiang CC Chen WM Jeff Lin CF | 2011 | J Chin Med Assoc2011，74，： | 1 |
| 7 | Comparison of a minimally invasive technique with open tension band wiring for displaced transverse patellar fractures显示文摘 | Chiang CC Chen WM Jeff Lin CF | 2011 | JCMA2011，74，7： | 1 |
| 8 | Purification and in vitro anti-proliferative effect of novel neutral polysaccharides from Lentinus edodes显示文摘 | JEFF I B YUAN Xia-wen SUN Lin | 2013 | International Journal of Biological Macromolecules2013，52，1： | 1 |
| 9 | Comparison of a minimally invasive technique with open tension band wiring for displaced transverse patellar fractures 显示文摘 | Chiang CC Chen WM Jeff Lin CF | 2011 | J Chin Med Assoc2011，74，7： | 1 |
| 10 | Transient side-load analysis of out-of-round film-cooled nozzle extensions显示文摘 | Ten See Wang Jeff Lin Mike Guidos | 2013 | Journal of Propulsion and Power2013，29，4： | 1 |
| 11 | Comparison of a minimally invasive technique with open tension band wiring for displaced transverse patella fractures显示文摘 | Chiang C C Chen W M Jeff Lin C F | 2011 | J Chin Med Assoc2011，74，7： | 1 |
| 12 | Oxidative decomposition of chlorinated hydrocarbons by glow discharge in PACT (plasma and catalyst integrated technologies) reactors显示文摘 | Jeff Rozak Jung-Chou Lin | 2001 | Applied Catalysis A: General2001，219，： | 1 |
| 13 | Comparison of a minimally inva-sive technique with open tension band wiring for dis-placed transverse patellar fractures显示文摘 | Chiang C C Chen W M Jeff Lin C F Chen C F HuangC K’Tzeng Y H | 2011 | J Chin Med As-soc2011，74，： | 1 |
| 14 | Comparison of a minimally invasive technique with open tension band wiring for displaced transverse patellar fractures 显示文摘 | Chiang CC Chen WM Jeff Lin CF | 2011 | J Chin Med Assoc2011，74，7： | 1 |
| 15 | Crop yield responses to climate change in the Huang-Huai-Hai Plain of China显示文摘 | Suxia Liu Xingguo Mo Zhonghui Lin Yueqing Xu Jinjun Ji Gang Wen Jeff Richey | 2010 | Agricultural Water Management2010，，8： | 1 |
| 16 | Closed humeral shaft fractures: a prospective evaluation of surgical treatment显示文摘 | Fang - Yao Chiu Chuan - Mu Chen Chien - Fu Jeff Lin | 1997 | The Journal of Trauma: Injury Infection and Critical Care1997，43，： | 1 |
| 17 | Comparison of a minimally invasive technique with open tension band wiring for displaced transverse patellar fractures显示文摘 | Chiang CC Chen WM Jeff Lin CF | 2011 | J Chin Med Assoe2011，74，： | 1 |
| 18 | Genetic variants in fas signaling pathway genes and risk of gastric cancer显示文摘 | Paula L. Hyland Shih‐Wen Lin Nan Hu Han Zhang Lemin Wang Hua Su Chaoyu Wang Ti Ding Ze‐Zhong Tang Jin‐Hu Fan You‐Lin Qiao Xiaoqin Xiong William Wheeler Carol Giffen Kai Yu Jeff Yuenger Laurie Burdett Zhaoming Wang Stephen J. Chanock Margaret A. Tucker San | 2014 | Int J Cancer2014，，4： | 1 |
| 19 | Diagnosis and management of primary aldosteronism: An updated review显示文摘 | Chia-Ter Chao Vin-Cent Wu Chin-Chi Kuo Yen-Hung Lin Chin-Chen Chang S. Jeff Chueh Kwan-Dun Wu Eduardo Pimenta Michael Stowasser | 2013 | Annals of Medicine2013，，4： | 1 |
| 20 | Comparison of a minimally invasive technique with open tension band wiring for displaced transverse patellar fracture显示文摘 | Chiang CC Chen WM Jeff Lin CF | | 0，，07： | 1 |
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