|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effect of preoperative FOLFOX chemotherapy on CCL20/CCR6 expression in colorectal liver metastases显示文摘AIM:To evaluate the influence of preoperative FOLFOX chemotherapy on CCL20/CCR6 expression in liver metastases of stage Ⅳ colorectal cancer(CRC) patients.METHODS:Using Real Time-PCR,enzyme-linked immunosorbent assay,Western Blots and immunohistochemistry,we have analyzed the expression of CCL20,CCR6 and proliferation marker Ki-67 in colorectal liver metastasis(CRLM) specimens from stage Ⅳ CRC patients who received preoperative FOLFOX chemotherapy(n = 53) and in patients who did not receive FOLFOX chemotherapy prior to liver surgery(n = 29).RESULTS:Of the 53 patients who received FOLFOX,time to liver surgery was ≤ 1 mo in 14 patients,≤ 1 year in 22 patients and > 1 year in 17 patients,respectively.In addition,we investigated the proliferation rate of CRC cells in liver metastases in the different patient groups.Both CCL20 and CCR6 mRNA and protein expression levels were significantly increased in patients who received preoperative FOLFOX chemotherapy ≤ 12 mo before liver surgery(P < 0.001) in comparison to patients who did not undergo FOLFOX treatment.Further,proliferation of CRLM cells as measured by Ki-67 was increased in patients who underwent FOLFOX treatment.CCL20 and CCR6 expression levels were significantly increased in CRLM patients who had undergone preoperative FOLFOX chemotherapy.CONCLUSION:This chemokine/receptor up-regulation could lead to increased proliferation/migration through an autocrine mechanism which might be used by surviving metastatic cells to escape cell death caused by FOLFOX. | Claudia Rubie Vilma Oliveira Frick Pirus Ghadjar Mathias Wagner Christoph Justinger Stefan Graeber Jens Sperling Otto Kollmar Martin K Schilling | 2011 | World Journal of Gastroenterology2011，17，26： | 5 |
| 2 | A misdiagnosed case of caesarean scar pregnancy显示文摘 | Jens Einenkel Patrick Stumpp Sabrina K?sling Lars-Christian Horn Michael H?ckel | 2005 | Archives of Gynecology and Obstetrics2005，，2： | 2 |
| 3 | No difference in portal and hepatic venous bacterial DNA in patients with cirrhosis undergoing transjugular intrahepatic portosystemic shunt insertion显示文摘 | Christian Mortensen Stine Karlsen Henning Gr?nb?k Dennis T. Nielsen Susanne Frevert Jens O. Clemmesen S?ren M?ller J?rgen S. Jensen Flemming Bendtsen | 2013 | Liver Int2013，，9： | 2 |
| 4 | Enucleation and Limited Pancreatic Resection Provide Long-Term Cure for Insulinoma in Multiple Endocrine Neoplasia Type 1显示文摘 | Bartsch Detlef K Albers Max Knoop Richard Kann Peter H Fendrich Volker Waldmann Jens | 2014 | Neuroendocrinology2014，，4： | 2 |
| 5 | Development and test of small-scale batch fired Straw boilers in Denmark显示文摘 | Erik F K Jens K K | 2004 | Biomass and Bioenergy2004，26，： | 1 |
| 6 | Relationship between water mobility and distribution and sensory attributes in pork slaughtered at an age between 90 and 180 days 显示文摘 | Hanne Christine Bertram Ida K Straadt Jens A Jensen Margit Dall Aaslyng | 2007 | Meat Science2007，77，： | 1 |
| 7 | Physical properties of R-PET/ CD-PET poly blended hollow filaments their kinetics of alkaline hydrolysis显示文摘 | Hsiao K J Jen Z F Yang J C | 2002 | J Polym Res2002，9，12： | 1 |
| 8 | Polymeric materials andtheir orientation techniques for second-order nonlinear optics显示文摘 | Lee K S Jen AKY | 2003 | ADV POLYM SCI2003，161，： | 1 |
| 9 | Preconditioning with ischemia:a delay of lethal cell injury in myocardium显示文摘 | MURRY C E JENNINGS R B REIMER K A | 1986 | Circulation1986，74，： | 1 |
| 10 | Ascorbic acid and L-gulonolactone oxidase in lagomorphs显示文摘 | Jenness R Birney E C Ayaz K L | 1978 | Comparative Biochemistry and Physiology1978，61，3： | 1 |
| 11 | Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium显示文摘 | Murry C E Jennings R B Reimer K A | 1986 | Circulation1986，74，5： | 1 |
| 12 | A roadmap of agent research and development显示文摘 | Jennings N R Sycara K Wooldridge M J | 1998 | Journal of Autonomous Agents and Multi- Agent Systems1998，1，1： | 1 |
| 13 | Physics and kinetics of alkaline hydrolysis of cationic dyeable poly ( ethylene terephthalate ) (CDPET) and polyethylene glycol (PEG)-modified CDPET polymers: Effects of dimethyl 5-sulfoisophthalate sodium salt / PEG content and the number average molecular weight of the PEG显示文摘 | Hsiao K J Jen Z F Tang J W | 2005 | J Appl Polym Sci2005，98，2： | 1 |
| 14 | Ontogenetic development of L-gulonolactone oxidase activity in several vertebrates显示文摘 | Jenness R Birney E C Ayaz K L | 1984 | Comparative Biochemistry and Physiology-Part B:Biochemistry & Molecular Biology1984，78，： | 1 |
| 15 | A novel route for the preparation of dimeric tetraorganodistannoxanes 显示文摘 | JENS B DAINIS D VONG S K | 2002 | J Organomet Chem2002，659，： | 1 |
| 16 | Metabolic flux analysis in mammalian cell culture 显示文摘 | Lake E Q Stefanie D Jens 0 K | 2010 | Metab Eng2010，12，： | 1 |
| 17 | Simulation of Microstructure Development During the Hydration of a Cement Compound 显示文摘 | Jennings H M Johnson S K | 1986 | Journal of the American Ceramic Society1986，69，11： | 1 |
| 18 | Call to needle times after acute myocardial infarction, in urban and rural areas in northeast Scotland : prospective observational study显示文摘 | Rawles J Sinclair C Jennings K | 1998 | BMJ1998，317，8： | 1 |
| 19 | Characterization of alumina-supported Pt and Pt-Pd NO oxidation catalysts with advanced electron microscopy显示文摘 | Ezekoye O K Drews A R Jen H-W | 2011 | J Catal2011，280，： | 1 |
| 20 | A generalized powertrain design optimization methodology to reduce fuel economy variability in hybrid electric vehicles显示文摘 | ROY H K MCGORDON A JENNINGS P A | 2014 | IEEE Transactions on Vehicular Technology2014，63，63： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员