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| 1 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 2 | Isolation and characterization of the gene encoding glyceraldehyde - 3 - phosphate dehydrogenase显示文摘 | Jeong M J Park S C Kwon H B | 2000 | Biochem Biophys Res Commun2000，，1： | 1 |
| 3 | Support for seamless data exchan- ges between Web services through information mapping analy- sis using kernel methods 显示文摘 | Jeong B Lee D Lee J | 2009 | Expert Systems with Applica- tions2009，36，1： | 1 |
| 4 | Transgenic Panax ginseng inhibits the production of TNF-alpha, IL-6, and IL-8 as well as COX-2 expression in human mast cells 显示文摘 | Kim S J Jeong HJ Yi B J | 2007 | Am J Chin Med2007，35，： | 1 |
| 5 | Effective overhead hoisttransport dispatching based on the Hungarian algorithm for alarge semiconductor FAB 显示文摘 | Kim B I Shin J Jeong S | 2009 | International Journal ofProduction Research2009，47，10： | 1 |
| 6 | An assessment methodology for in-vessel corium retention by external reactor vessel cooling during severe accidents in PWRs显示文摘 | Park J H Jeong Y H Won-pil B | 2001 | Annals of Nuclear Energy2001，28，： | 1 |
| 7 | Free vibrations of tapered piles embedded partially in Winkler type foundations显示文摘 | LEE B K JEONG J S FAN L G JIN T K | 1999 | J Civil Engrg1999，3，2： | 1 |
| 8 | Fault diagnoais d a power tnmorm- cr using an improved frequency - response analysis 显示文摘 | Kim J W Park B Jeong S | 2005 | IEEE Transactions on Power Delivery2005，20，1： | 1 |
| 9 | Bcl-x (L)sequesters its C-terminal membrane anchor in soluble,cytosolic homodimers显示文摘 | Jeong S Y Gaume B Lee Y J | | 0，，10： | 1 |
| 10 | An improved par- ticle swarm optimization for nonconvex economic dispatch problems显示文摘 | PARK J B JEONG Y W SHIN J R | 2010 | IEEE Transactions on Power Systems2010，25，1： | 1 |
| 11 | Inhibition of core histone acetylation by the cancer preventive peptide Lunasin显示文摘 | Jeong H J Jeong J B Kim D S | 2007 | J Agric Food Chem2007，55，3： | 1 |
| 12 | Pretreatment of rocuro- nium reduces the frequency and severity of etomidate - induced myoclonus显示文摘 | CHOI J M CHOI I C JEONG Y B | 2008 | J Clin Anesth2008，20，8： | 1 |
| 13 | An Isolated DC/DC Converter Using High-Frequency Unregulated LLC Resonant Converter for Fuel Cell Applications显示文摘 | LEE J Y JEONG Y S HAN B M | 2011 | IEEE Transactions on Industrial Electronics2011，58，7： | 1 |
| 14 | Multiplex PCR for the diagnosis of red sea bream iridovims isolated in Korea 显示文摘 | Jeong J B Park K H Kim H Y | 2004 | Aquaculture2004，235，14： | 1 |
| 15 | State-of-the- art IVEF service based on e-Navigation system显示文摘 | OYUNCHIMEG B JEONG J S PARK G | 2013 | Jour- nal of Korean Institute of Intelligent Systems2013，23，6： | 1 |
| 16 | Fault diagnosis of a power transformer using an improved frequency- response analysis显示文摘 | Kim J W Park B K Jeong S C | 2005 | IEEE Transactions on Power Delivery2005，20，1： | 1 |
| 17 | Barley lunasin suppresses rasinduced colony formation and inhibits core histone acetylation in mammalian cells显示文摘 | Jeong H J Lam Y de Lumen B O | 2002 | J Agric Food Chem2002，50，21： | 1 |
| 18 | Prevention of ginsenosideinduced desensitization of Ca2 + activated Cl-current by microinjection of inositol hexakisphosphate in xenopus laevis oocytes显示文摘 | LEE J H JEONG S M LEE B H | 2004 | J Bio Chem2004，279，11： | 1 |
| 19 | Molecular cloning of cytochrome 17450 aromatases in the protogynous wrasse, Halichoeres tenuispinis 显示文摘 | Choi J Y Park J G Jeong H B | 2005 | Comp Biochem Physiol Pt B2005，141，1： | 1 |
| 20 | The cancer preventive peptide lunasin from wheat inhibits core histone acetylation显示文摘 | Jeong H J Jeong J B Kim D S | 2007 | Cancer Lett2007，255，1： | 1 |
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