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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Sustained elevation of Epstein-Barr virus antibody levels preceding clinical onset of nasopharyngeal carcinoma显示文摘 | Ji M F Wang D K Yu Y L | 2007 | British J Cancer2007，96，4： | 1 |
| 3 | Cooperative anti-diabetic effects of deoxynojirimycin-polysaccharide by inhibiting glucose absorption and modulating glucose metabolism in streptozocin-induced diabetic mice 显示文摘 | Li Y G Ji D F Zhong S | 2013 | PLoS One2013，8，65： | 1 |
| 4 | Activation of P27kipl-cyclin D1/E- CDK2 pathway by polysaccharide from Phellinus linteus leads to S- phase arrest in HT-29 cells显示文摘 | Shi Z Ji D F Li Y G | 2013 | Chem Biol Interact2013，206，2： | 1 |
| 5 | Adakites from continental collision zones: Melting of thickened lower crust beneath southern Tibet 显示文摘 | Chung S L Liu D Y Ji J Q Chu M F Lee H Y Wen D J Lo C H Lee T Y Qian Q Zhang Q | 2003 | Geology2003，31，11： | 1 |
| 6 | Ty-3, a begomovirus resistance locus near the tomato yellow leaf curl virus resistance locus Ty-1 on chromosome 6 of tomato显示文摘 | Ji Y F Schuster D J Scott J W | 2007 | Molecular Breeding2007，20，： | 1 |
| 7 | Minimally invasive percutaneous plate osteosynthesis (MIPPO) technique applied in the treatment of humeral shaft distal fractures through a lateral approach显示文摘 | Ji F Tong D Tang H | 2009 | Int Orthop2009，33，2： | 1 |
| 8 | Enhanced cold - season winching in semi - arid regions显示文摘 | Huang J P Guan X D Ji F | 2012 | Atmospheric Chemistry and Physics2012，，12： | 1 |
| 9 | Efficiency droop due to electron spill-over and limited hole injection in Ⅲ-nitride visible light-emitting diodes employing lattice-matched InAlN electron blocking layers显示文摘 | Choi S Ji M H Kim J Kim H J Satter M M Yoder P D Ryou J H Dupuis R D Fischer A M Ponce F A | | 0，，16： | 1 |
| 10 | Effect of fermentation on nitrate, nitrite and organic acid contents in traditional pickled chinese cabbage 显示文摘 | Ji F D Ji B P Li B | 2009 | Journal of Food Processing and Preservation2009，，33： | 1 |
| 11 | Anti-tumor effects of proteoglycan from Phellinus linteus by immunomodulating and inhibiting Reg IV/EGFR/Akt signaling pathway in colorectal carcinoma显示文摘 | Li Y G Ji D F Zhong S | 2011 | Int J Bio Macromol2011，48，： | 1 |
| 12 | Molecular mapping of Ty-4, a new tomato yellow leaf eurlvirus resistance locus on chro- mosome 3 of tomato显示文摘 | Ji Y F Scott J W Schuster D J | 2009 | J Amer Soc Hort Sci2009，134，2： | 1 |
| 13 | A report on the nuclear cytoplasmic male sterility from a cross between two soybean cultivars显示文摘 | Gai J Y Cui Z L Ji D F | 1995 | Soybean Genetic Newsletters1995，22，： | 1 |
| 14 | Enhanced cooperation and harmonious population in a evolutionary N-person snowdrift game显示文摘 | Ji M Xu C Zheng D F | 2009 | Physica A2009，389，： | 1 |
| 15 | Hybrid of 1-deoxynojirimycin and polysaccharide from mulberry leaves treat diabetes mellitus by activating PDX-1/Insulin-1 signaling pathway and regulating the expression of glucokinase, phosphoenolpyruvate carboxykinase and gIucose45-phosphatase in alloxan-induced diabetic mice 显示文摘 | Li Y G Ji D F Zhong S | 2011 | J Ethnopharmacol2011，134，3： | 1 |
| 16 | TLR4 mediates lunginjury and inflammation in intestinal ischemia-reperfusion显示文摘 | BEN D F YU X Y JI G Y | 2012 | J Surg Res2012，174，2： | 1 |
| 17 | Polysaccharide from Phellinus linteus induces S-phase arrest in HepG2 cells by decreasing calreticulin expression and activating the P27kip1-cyclin A/D1/ E-CDK2 pathway显示文摘 | Li Y G Ji D F Zhong S | 2013 | J Ethnopharmacol2013，150，1： | 1 |
| 18 | Minimally invasive percutaneous plateosteosynthesis(MIPPO) technique applied in the treat- ment of humeralshaft distal fractures through a lateral ap- proach 显示文摘 | Ji F Tong D Tang H | 2009 | Int Orthop2009，33，2： | 1 |
| 19 | Effect of fermentation on nitrate, nitrite and organic acid contents in traditional pickled Chinese cabbage 显示文摘 | Ji F D Ji B P Bo L | 2009 | Journal of Food Processing and Preservation2009，33，： | 1 |
| 20 | Network characteristics, absorptive capacity and technological innovation per- formance 显示文摘 | Liu X F Wang J B Ji D K | 2011 | International Journal of Technology Policy and Management2011，11，2： | 1 |
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