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| 1 | M0S2 dual-gate transistors with electrostatically doped contacts显示文摘Two-dimensional(2D)transition metal dichalcogenides(TMDs)such as molybdenum disulfide(M0S2)have been intensively investigated because of their exclusive physical properties for advaneed electronics and optoelectronics.In the present work,we study the M0S2 transistor based on a novel tri-gate device architecture,with dual-gate(Dual-G)in the channel and the buried side-gate(Side-G)for the source/drain regi ons.All gates can be in depe ndently con trolled without in terfere nee.For a MoS2 sheet with a thick ness of 3.6 nm,the Schottky barrier(SB)and non-overlapped channel region can be effectively tuned by electrostatically doping the source/drain regions with Side-G.Thus,the extri nsic resista nee can be effectively lowered,and a boost of the ON-state cur re nt can be achieved.Mean while,the cha nn el c ontrol remai ns efficient under the Dual-G mode,with an ON-OFF current ratio of 3 x 107 and subthreshold swing of 83 mV/decade.The corresponding band diagram is also discussed to illustrate the device operati on mechanism.This no vel device structure ope ns up a new way toward fabricati on of high-performance devices based on 2D-TMDs. | Fuyou Liao Yaocheng Sheng Zhongxun Guo Hongwei Tang Yin Wang Lingyi Zong Xinyu Chen Antoine Riaud Jiahe Zhu Yufeng Xie Lin Chen Hao Zhu Qingqing Sun Peng Zhou Xiangwei Jiang Jing Wan Wenzhong Bao David Wei Zhang | 2019 | Nano Research2019，12，10： | 2 |
| 2 | Control of presacral hemorrhage with electrocautery through a muscle fragment pressed on the bleeding vein显示文摘 | Jiahe Xu Jianjiang Lin | 1994 | J Am Coll Surg1994，179，3： | 1 |
| 3 | The value of vesicant 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) in gastric malignancies显示文摘 | Jiahe Tian Lin Chen Bo Wei Mingzhe Shao Yong Ding Dayi Yin Shulin Yao | 2004 | Nuclear Medicine Communications2004，，8： | 1 |
| 4 | Cyclic di-adenosine monophosphate regulates the osteogenic and adipogenic differentiation of hPDLSCs via MAPK and NF-κB signaling显示文摘Cyclic di-adenosine monophosphate(c-di-AMP)is a bacterial second messenger that can be recognized by infected host cells and activate the immunoinflammatory response.The purpose of this study is to demonstrate the effect of c-di-AMP on the differentiation of human periodontal ligament stem cells(hPDLSCs)and its underlying mechanisms.In the present study,we find that the gingival crevicular fluid(GCF)of patients with chronic periodontitis has a higher expression level of c-di-AMP than that of healthy people.In vitro,c-di-AMP influences the differentiation of hPDLSCs by upregulating Toll-like receptors(TLRs);specifically,it inhibits osteogenic differentiation by activating NF-κB and ERK/MAPK and promotes adipogenic differentiation through the NF-κB and p38/MAPK signaling pathways.Inhibitors of TLRs or activated pathways reduce the changes induced by c-di-AMP.Our results establish the potential correlation among bacterial c-di-AMP,periodontal tissue homeostasis and chronic periodontitis pathogenesis. | Sirui Chen Zuping Wu Yuying He Li Zhu Jiahe Wang Hengyi Lin Jing Xie Chenchen Zhou Shujuan Zou | 2023 | Acta Biochimica et Biophysica Sinica2023，55，3： | 1 |
| 5 | Fabrication and Characterization of 3D Graded PDMS Scaffolds Using Vacuum-Assisted Resin Transfer Moulding显示文摘Graded porous scaffold can be applied to study the interactions between cells and scaffold with different pore sizes. Polydimethylsiloxane(PDMS) scaffold with an axial pore size grade was successfully manufactured via vacuum-assisted resin transfer moulding(VARTM) and particle leaching technologies. The properties of graded PDMS scaffolds, including porosity, water absorption, interconnectivity, compression modulus, as well as compression strength were investigated. The results showed that the smaller the size of the NaCl particles is, the higher the porosity and water absorption of graded PDMS scaffolds would be. The graded PDMS scaffold fabricated had a compressive modulus and a compressive strength of 19.69±1.42 kPa and 4.76±0.22 kPa, respectively. Moreover, the graded chitosan(CS)-coated PDMS scaffolds were prepared by using dip-coating technique under low vacuum and their hydrophilicity was examined. It is found that the water contact angle(WCA) will decrease with an increase in the CS solution concentration and the coating time, which indicates that CS-coated PDMS scaffolds exhibit noticeable hydrophilicity compared with graded PDMS scaffold. | 司军辉 LIN Jiahe ZHENG Zifeng CUI Zhixiang WANG Qianting | 2018 | Journal of Wuhan University of Technology(Materials Science)2018，33，5： | 1 |
| 6 | Hedgehog signaling in tissue homeostasis, cancers, and targeted therapies显示文摘The past decade has seen significant advances in our understanding of Hedgehog(HH)signaling pathway in various biological events.HH signaling pathway exerts its biological effects through a complex signaling cascade involved with primary cilium.HH signaling pathway has important functions in embryonic development and tissue homeostasis.It plays a central role in the regulation of the proliferation and differentiation of adult stem cells.Importantly,it has become increasingly clear that HH signaling pathway is associated with increased cancer prevalence,malignant progression,poor prognosis and even increased mortality.Understanding the integrative nature of HH signaling pathway has opened up the potential for new therapeutic targets for cancer.A variety of drugs have been developed,including small molecule inhibitors,natural compounds,and long non-coding RNA(LncRNA),some of which are approved for clinical use.This review outlines recent discoveries of HH signaling in tissue homeostasis and cancer and discusses how these advances are paving the way for the development of new biologically based therapies for cancer.Furthermore,we address status quo and limitations of targeted therapies of HH signaling pathway.Insights from this review will help readers understand the function of HH signaling in homeostasis and cancer,as well as opportunities and challenges of therapeutic targets for cancer. | Junjun Jing Zhuoxuan Wu Jiahe Wang Guowen Luo Hengyi Lin Yi Fan Chenchen Zhou | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 0 |
| 7 | Application of synthetic biology in bladder cancer显示文摘Bladder cancer(BC)is the most common malignant tumor of the genitourinary system.The age of individuals diagnosed with BC tends to decrease in recent years.A variety of standard therapeutic options are available for the clinical management of BC,but limitations exist.It is difficult to surgically eliminate small lesions,while radiation and chemotherapy damage normal tissues,leading to severe side effects.Therefore,new approaches are required to improve the efficacy and specificity of BC treatment.Synthetic biology is a field emerging in the last decade that refers to biological elements,devices,and materials that are artificially synthesized according to users’needs.In this review,we discuss how to utilize genetic elements to regulate BC-related gene expression periodically and quantitatively to inhibit the initiation and progression of BC.In addition,the design and construction of gene circuits to distinguish cancer cells from normal cells to kill the former but spare the latter are elaborated.Then,we introduce the development of genetically modified T cells for targeted attacks on BC.Finally,synthetic nanomaterials specializing in detecting and killing BC cells are detailed.This review aims to describe the innovative details of the clinical diagnosis and treatment of BC from the perspective of synthetic biology. | Mengting Ding Jiaxing Lin Caipeng Qin Ping Wei Jiahe Tian Tianxin Lin Tao Xu | 2022 | Chinese Medical Journal2022，135，18： | 0 |
| 8 | Review and Prospect of Single-Shot Ultrafast Optical Imaging by Active Detection显示文摘In the recent decade,single-shot ultrafast optical imaging by active detection,called single-shot active ultrafast optical imaging(SS-AUOI)here,has made great progress,e.g.,with a temporal resolution of 50 fs and a frame rate beyond 10 trillion frames per second.Now,it has become indispensable for charactering the nonrepeatable and difficult-to-reproduce events and revealing the underlying physical,chemical,and biological mechanisms.On the basis of this delightful status,we would like to make a review of SS-AUOI.On the basis of a brief introduction of SS-AUOI,our review starts with discussing its characteristics and then focuses on the survey and prospect of SS-AUOI technology. | Xuanke Zeng Xiaowei Lu Congying Wang Kaipeng Wu Yi Cai Hongmei Zhong Qinggang Lin Jiahe Lin Ruiwei Ye Shixiang Xu | 2023 | Ultrafast Science2023，3，3： | 0 |
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